What is true of thalidomide:
A. It exerts antitumour activity in some solid
malignant tumours
B. It ameliorates cancer associated cachexia
C. It exerts antileprotic action
D. All of the above

1 Answer

Answer :

B. It ameliorates cancer associated cachexia

Related questions

Description : What is true of tamoxifen: A. It can induce endometrial proliferation in postmenopausal women B. It exerts antiestrogenic activity in bone C. It raises LDL-cholesterol levels D. It is ineffective in estrogen receptor-negative breast cancer

Last Answer : A. It can induce endometrial proliferation in postmenopausal women

Description : Biological response modifiers like GM-CSF are used in conjunction with anticancer drugs for the following purpose(s): A. To enhance antitumour activity of the drug B. To prevent hypersensitivity reactions to ... . To hasten recovery from drug induced myelosuppression D. Both A' and C' are correct

Last Answer : C. To hasten recovery from drug induced myelosuppressio

Description : The following is true of raloxifene except: A. It acts as an estrogen agonist in bone B. It exerts estrogen antagonistic action on endometrium C. It increases risk of developing breast cancer D. It can induce/aggravate menopausal hot flushes

Last Answer : C. It has additional androgenic acitivity

Description : The following is true of loperamide except: A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action B. It acts on the opioid receptors in the gut C. It increases ... of the intestines D. It inhibits intestinal secretion by binding to calmodulin in the mucosal cells

Last Answer : A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action

Description : Select the macrolide antibiotic having clinically useful antileprotic activity: A. Azithromycin B. Clarithromycin C. Erythromycin D. Roxithromycin

Last Answer : B. Clarithromycin

Description : The tetracycline with highest antileprotic activity is: A. Minocycline B. Doxycycline C. Demeclocycline D. Oxytetracycline

Last Answer : A. Minocycline

Description : The following does not apply to cancer chemotherapy: A. Each treatment with a cytotoxic drug kills a constant number of malignant cells B. Drugs are generally used at maximum tolerated ... D. Combination regimens using several drugs in succession are superior to single drug used continuously

Last Answer : A. Each treatment with a cytotoxic drug kills a constant number of malignant cells

Description : Which one of the following statements is correct? (a) Benign tumours show the property of metastasis. (b) Heroin accelerates body functions. (c) Malignant tumours may exhibit metastasis. (d) Patients who have undergone surgery are given cannabinoids to relieve pain.

Last Answer : (c) Malignant tumours may exhibit metastasis

Description : Carcinoma refers to (a) malignant tumours of the connective tissue (b) malignant tumours of the skin or mucous membrane (c) malignant tumours of the colon (d) benign tumours of the connective tissue.

Last Answer : (b) malignant tumours of the skin or mucous membrane

Description : The most common characteristic symptom of malignant tumours occurring in lower jaw is, A. Pain B. Bleeding C. Paraesthesia

Last Answer : C. Paraesthesia

Description : The following is/are true of mesalazine: A. It exerts mainly local antiinflammatory action in the lower gut B. It is a broad spectrum antidiarrhoeal drug C. It can be administered as a retention enema D. Both 'A' and 'C

Last Answer : D. Both 'A' and 'C

Description : The following is true about actions of ethylalcohol: A. It exerts anticonvulsant action followed by lowering of seizure threshold B. It lowers pain threshold C. It increases confidence and reduces number of errors D. It increases heat production and helps to keep warm in cold weather

Last Answer : A. It exerts anticonvulsant action followed by lowering of seizure threshold

Description : What is true of nimesulide: A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition B. It is preferred for long-term use in rheumatoid arthritis C. It is contraindicated in aspirin intolerant asthma patients D. All of the above

Last Answer : A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition

Description : Which antileprotic drug suppresses lepra reaction and reversal reaction as well: A. Dapsone B. Rifampin C. Clofazimine D. Minocycline

Last Answer : C. Clofazimine

Description : In parkinsonian patients levodopa exerts the following effects except: A. Reduces skeletal muscle contractility B. Decreases muscle tone C. Increases locomotor activity D. Inhibits muscle tremor

Last Answer : A. Reduces skeletal muscle contractility

Description : Hyoscine differs from atropine in that it: A. Exerts depressant effects on the CNS at relatively low doses B. Exerts more potent effects on the heart than on the eye C. Is longer acting D. Has weaker antimotion sickness activity

Last Answer : A. Exerts depressant effects on the CNS at relatively low doses

Description : Omeprazole exerts practically no other action except inhibition of gastric acid secretion because: A. It transforms into the active cationic forms only in the acidic pH of the gastric juice B. Its ... forms are unable to diffuse out from the gastric parietal cell canaliculi D. All of the above

Last Answer : D. All of the above

Description : In patients with benign prostatic hypertrophy, finasteride exerts the following action/actions: A. Reduces size of the prostate gland B. Increases peak urinary flow rate C. Relaxes vesical sphincter D. Both 'A' and 'B' are correct

Last Answer : D. Both 'A' and 'B' are correct

Description : A 65-year old patient has colon carcinoma metastatic to the liver and lungs. He has had a weight loss of 10 kg. Cytokine-dependent tumor cachexia is attributable to which of the ... is impaired e. Partial reversal of differentiated adipocytes to pre-adipocyte morphology and gene expression occurs

Last Answer : Answer: a, b, c, d, e Tumor cachexia appears to be mediated by TNFa. Lipopolysaccharide (LPS), as well as other cytokines, activate a variety of inflammatory cells, most ... chronic syndromes of anorexia, weight loss, and cachexia that are associated with both chronic infection and malignancy

Description : For limiting cerebral edema due to brain tumour, the preferred corticosteroids are betamethasone/dexamethasone because: A. They do not cause Na+ and water retention B. They are more potent C. They can be administered intravenously D. They inhibit brain tumours

Last Answer : A. They do not cause Na+ and water retention

Description : As a plasma expander, dextran has the following advantages except: A. It exerts oncotic pressure similar to plasma proteins B. It keeps plasma volume expanded for about 24 hours C. It is nonpyrogenic D. It does not interfere with grouping and cross matching of blood

Last Answer : D. It does not interfere with grouping and cross matching of blood

Description : Hydrocortisone exerts the following actions: A. Increases both K+ and Ca2+ excretion B. Decreases both K+ and Ca2+ excretion C. Decreases K+ but increases Ca2+ excretion D. Increases K+ but decreases Ca2+ excretion

Last Answer : A. Increases both K+ and Ca2+ excretion

Description : Thyrotropin exerts the following actions on the thyroid gland except: A. Increases vascularity B. Inhibits proteolysis of thyroglobulin C. Induces hyperplasia and hypertrophy D. Promotes iodide trappin

Last Answer : B. Inhibits proteolysis of thyroglobulin

Description : 16.18 Thyrotropin exerts the following actions on the thyroid gland except: A. Increases vascularity B. Inhibits proteolysis of thyroglobulin C. Induces hyperplasia and hypertrophy D. Promotes iodide trapping

Last Answer : B. Inhibits proteolysis of thyroglobulin

Description : Histamine exerts the following actions except: A. Dilatation of large blood vessels B. Dilatation of small blood vessels C. Stimulation of isolated guineapig heart D. Itching

Last Answer : A. Dilatation of large blood vessels

Description : Histamine exerts the following actions except: A. Dilatation of large blood vessels B. Dilatation of small blood vessels C. Stimulation of isolated guineapig heart D. Itching

Last Answer : A. Dilatation of large blood vessels

Description : Which of the following neoplastic diseases is almost curable by chemotherapy: A. Bronchogenic carcinoma B. Choriocarcinoma C. Malignant melanoma D. Colorectal carcinoma

Last Answer : B. Choriocarcinoma

Description : The following adverse effect can occur even long after withdrawal of the offending drug: A. Paradoxical tachycardia B. Tardive dyskinesia C. Malignant hyperthermia D. Gynaecomastia

Last Answer : B. Tardive dyskinesia

Description : Malignant hyperthermia is a rare complication of use of the following anaesthetic: A. Ketamine B. Thiopentone sodium C. Halothane D. Ether

Last Answer : D. Ether

Description : Selective inhibition of thromboxane A2 synthesis by low dose aspirin therapy might retard the progression of: A. Pregnancy induced hypertension B. Steroid induced hypertension C. Renal hypertension D. Malignant hypertension

Last Answer : A. Pregnancy induced hypertension

Description : The following effect(s) of tamoxifen citrate indicate(s) that it possesses tissue specific estrogenic action as well: A. Inhibition of breast cancer cells B. Endometrial proliferation C. Hot flushes in premenopausal women D. All of the above

Last Answer : B. Endometrial proliferation

Description : The most important reason for highly restricted use of penicillin G injections in present day therapeutics is its: A. Narrow spectrum of activity B. Potential to cause hypersensitivity reaction C. Short duration of action D. Neurotoxicity

Last Answer : B. Potential to cause hypersensitivity reaction

Description : Methyldopa differs from clonidine in the following respect: A. It is less likely to cause rebound hypertension on sudden discontinuation B. It does not reduce plasma renin activity C. It has a central as well as peripheral site of antihypertensive action D. It does not produce central side effect

Last Answer : A. It is less likely to cause rebound hypertension on sudden discontinuation

Description : Procainamide differs from quinidine in the following respect(s): A. It does not cause paradoxical tachycardia B. It has no α adrenergic blocking activity C. It has little antivagal action D. Both ‘B’ and ‘C’ are corre

Last Answer : D. Both ‘B’ and ‘C’ are correct

Description : Procainamide differs from quinidine in the following respect(s): A. It does not cause paradoxical tachycardia B. It has no α adrenergic blocking activity C. It has little antivagal action D. Both ‘B’ and ‘C’ are correct

Last Answer : D. Both ‘B’ and ‘C’ are correct

Description : Morphine induced constipation involves the following mechanisms except: A. Increase in tone and decrease in propulsive activity of intestinal muscles B. Antivagal action C. Spasm of gastrointestinal sphincters D. Reduction of gastrointestinal secretions

Last Answer : B. Antivagal action

Description : Which of the following is a long acting neuroleptic having specific antidopaminergic action, but little adrenergic or cholinergic blocking activity: A. Triflupromazine B. Thioridazine C. Clozapine D. Pimozide

Last Answer : D. Pimozide

Description : Compared to other antipsychotic drugs, the distinctive feature of penfluridol is: A. Very long duration of action B. Weak dopamine D2 blocking activity C. Lack of extrapyramidal side effects D. Additional 5-HT2 receptor blocking activity

Last Answer : A. Very long duration of action

Description : e primary mechanism by which general anaesthetics produce their action is: A. Affecting receptor operated ion channels in cerebral neurones B. Blocking voltage sensitive Na+ channels in neuronal ... activity of cerebral neurones D. Blocking production of high energy phosphates in the brain

Last Answer : A. Affecting receptor operated ion channels in cerebral neurones

Description : The following is not a feature of second generation antihistaminics: A. Nonimpairment of psychomotor performance B. High antimotion sickness activity C. Absence of anticholinergic/anti5 -HTa ctions D. Additional mechanisms of antiallergic action

Last Answer : B. High antimotion sickness activity

Description : Bound moisture is that liquid which exerts an equilibrium vapor pressure __________ that of the pure liquid at the given temperature. (A) Less than (B) More than (C) Equal to (D) Either (A) or (B); depends on the solid

Last Answer : (A) Less than

Description : A small amount of atropine is added to the diphenoxylate tablet/syrup to: A. Suppress associated vomiting of gastroenteritis B. Augment the antimotility action of diphenoxylate C. Block side effects of diphenoxylate D. Discourage overdose and abuse of diphenoxylate

Last Answer : D. Discourage overdose and abuse of diphenoxylate

Description : Adverse consequences of excess mineralocorticoid action include the following except: A. Na+ and water retention B. Acidosis C. Aggravation of CHF associated myocardial fibrosis D. Rise in blood pressure

Last Answer : B. Acidosis

Description : Hyoscine differs from atropine in that it (a) Exerts depressant effects on the CNS at relatively low doses (b) Exerts more potent effects on the heart than on the eye (c) Is longer acting (d) Has weaker antimotion sickness activity

Last Answer : Ans: A

Description : At 60° C, vapour pressure of methanol and water are 84.562 kPa and 19.953 kPa respectively. An aqueous solution of methanol at 60° C exerts a pressure of 39.223 kPa; the liquid phase and vapour phase mole ... respectively. Activity co-efficient of methanol is (A) 1.572 (B) 1.9398 (C) 3.389

Last Answer : (A) 1.572

Description : Hyoscine differs from atropine in that it: A. Exerts depressant effects on the CNS at relatively low doses B. Exerts more potent effects on the heart than on the eye C. Is longer acting D. Has weaker antimotion sickness activity

Last Answer : A. Exerts depressant effects on the CNS at relatively low doses

Description : Amplification of dihydrofolate reductase gene in a cancer cell makes the cell (A) Susceptible to folic acid deficiency (B) Less malignant (C) Resistant to amethopterin therapy (D) Responsive to amethopterin therapy

Last Answer : Answer : C

Description : In human body, the cell growth and differentiation are highly controlled and regulated, but in cancer cells. (a) there is breakdown of these regulatory mechanism leading to formation of benign and malignant ... is mutated and produced in less amount (d) DNA is mutated and produced in less amount

Last Answer : Ans:(a)