Description : Prazosin is an effective antihypertensive while nonselective α adrenergic blockers are not because: A. It is the only orally active α blocker B. It improves plasma lipid profile C. It does not concurrently enhance noradrenaline release D. It improves urine flow in males with prostatic hypertrophy
Last Answer : C. It does not concurrently enhance noradrenaline release
Description : A 40-year-old politician suffered from attacks of chest pain diagnosed as angina pectoris. He had a tense personality, resting heart rate was 96/min, blood pressure 170/104 mm Hg, but ... antihypertensive for initial therapy in his case: A. Nifedipine B. Hydrochlorothiazide C. Atenolol D. Methyldopa
Last Answer : C. Atenolol
Description : Prazosin is an effective antihypertensive while nonselective a adrenergic blockers are not because (a) It is the only orally active a blocker (b) It improves plasma lipid profile (c) It does not concurrently enhance noradrenaline release (d) It improves urine flow in males with prostatic hypertrophy
Last Answer : Ans: C
Description : Choose the most suitable antihypertensive drug for a 45-year-old male company executive who has a travelling job. His blood pressure is 160/100 mm Hg, and he is a diabetic ... → rebound hypertension. Hydrochlorothiazide: May worsen diabetes; more likely to produce weakness, fatigue and impotenc
Last Answer : B. Enalapril
Description : A woman in the 28th week of pregnancy has developed pregnancy induced hypertension with a blood pressure reading of 150/100 mm Hg. Select the most appropriate antihypertensive drug for her: A. Furosemide B. Methyldopa C. Propranolol D. Captopril
Last Answer : B. Methyldopa
Description : Loss of taste sensation can be a side effect of the following antihypertensive drug: A. Clonidine B. Captopril C. Verapamil D. Prazosin
Last Answer : B. Captopril
Description : Use of potassium sparing diuretics in patients receiving the following drug needs close monitoring: A. Furosemide B. Hydrochlorothiazide C. Captopril D. Verapami
Last Answer : C. Captopril
Description : The principles of antihypertensive drug usage enunciated in JNC VI and WHO-ISH guidelines include the following except: A. Therapy for grade I and II hypertension should be initiated with a single drug ... initially fails to lower BP, it should be replaced by a drug/combination from another class
Last Answer : C. All subjects with BP higher than 140/90 mmHg should be put on antihypertensive medication immediately
Description : Used alone the following antihypertensive drug tends to increase cardiac work and can precipitate angina: A. Clonidine B. Hydralazine C. Captopril D. Prazosin
Last Answer : B. Hydralazine
Description : The following antihypertensive drug has been found to suppress certain manifestations of morphine withdrawal syndrome and to block postoperative pain when injected intrathecally: A. Prazosin B. Clonidine C. Reserpine D. Ketanserin
Last Answer : B. Clonidine
Description : Which of the following feature(s) limit(s) the use of prazosin as a first line antihypertensive drug: A. Higher incidence of disturbing side effects B. Unfavourable metabolic effects C. Development of tolerance when used alone D. Both ‘A’ and ‘C’ are correct
Last Answer : D. Both ‘A’ and ‘C’ are correct
Description : Advantages of angiotensin converting enzyme inhibitors as antihypertensive include the following except: A. They tend to reverse left ventricular hypertrophy B. Their efficacy is not reduced by nonsteroidal ... . They do not worsen blood lipid profile D. They do not impair work performance
Last Answer : B. Their efficacy is not reduced by nonsteroidal antiinflammatory drugs
Description : Select the drug which can markedly potentiate the vasodilator action of organic nitrates: A. Propranolol B. Fluoxetine C. Hydrochlorothiazide D. Sildenafil
Last Answer : D. Sildenafil
Description : Rebound hypertension on sudden stoppage of medication is most likely to occur with: A. Hydrochlorothiazide B. Prazosin C. Clonidine D. Lisinopri
Last Answer : C. Clonidine
Description : Spironolactone can be usefully combined with the following diuretics except: A. Furosemide B. Amiloride C. Hydrochlorothiazide D. Chlorthalidone
Last Answer : B. Amiloride
Description : At equinatriuretic doses which diuretic causes the maximum K+ loss: A. Furosemide B. Hydrochlorothiazide C. Acetazolamide D. Amiloride
Last Answer : C. Acetazolamide
Description : The following diuretic abolishes the corticomedullary osmotic gradient in the kidney: A. Acetazolamide B. Furosemide C. Hydrochlorothiazide D. Spironolactone
Last Answer : B. Furosemide
Description : The preferred diuretic for mobilizing edema fluid in CHF is: A. Hydrochlorothiazide B. Furosemide C. Metolazone D. Amiloride
Description : Renal excretion of lithium is reduced by: A. Furosemide B. Hydrochlorothiazide C. Indomethacin D. All of the above
Last Answer : D. All of the above
Description : The following antihypertensive combination is irrational, and therefore should not be used: A. Nifedipine + hydralazine B. Amlodipine + atenolol C. Enalapril + clonidine D. Enalapril + hydrochlorothiazide
Last Answer : TA. Nifedipine + hydralazine
Description : The following antihypertensive is used topically to treat alopacia areata: A. Hydralazine B. Prazosin C. Minoxidil D. Indapamide
Last Answer : C. Minoxidil
Description : The hypoglycaemic action of sulfonylureas is likely to be attenuated by the concurrent use of: A. Hydrochlorothiazide B. Propranolol C. Theophylline D. Aspirin
Last Answer : A. Hydrochlorothiazide
Description : The following antihypertensive drug tends to lower plasma renin activity: A. Clonidine B. Hydralazine C. Nifedipine D. Captopril
Last Answer : A. Clonidine
Description : Sustained/controlled release oral dosage form is appropriate for the following type of drug: A. An antiarthritic with a plasma half life of 24 hr B. A sleep inducing hypnotic with a plasma half life of ... 3 hours D. An analgesic with a plasma half life of 6 hours used for relief of casual headache
Last Answer : C. An antihypertensive with a plasma half life of 3 hours
Description : Monitoring plasma drug concentration is useful while using: A. Antihypertensive drugs B. Levodopa C. Lithium carbonate D. MAO inhibitors
Last Answer : C. Lithium carbonate
Description : All of the following contribute to the antihypertensive action of propranolol except: A. Direct vasodilatation B. Decreased renin release from kidney C. Adaptation of blood vessels to reduced cardiac output D. Less noradrenaline release from sympathetic nerve endings
Last Answer : A. Direct vasodilatation
Description : A 55-year-old patient with severe posthepatitis cirrhosis is started on a diuretic for another condition. Two days later he is found in a coma. The drug most likely to cause coma in a patient with cirrhosis is (a) Acetazolamide (b) Amiloride (c) Furosemide (d) Hydrochlorothiazide (e) Spironolactone
Last Answer : Ans: A
Description : Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)
Last Answer : C. Diazepam (pentobarbitone)
Description : Methyldopa differs from clonidine in the following respect: A. It is less likely to cause rebound hypertension on sudden discontinuation B. It does not reduce plasma renin activity C. It has a central as well as peripheral site of antihypertensive action D. It does not produce central side effect
Last Answer : A. It is less likely to cause rebound hypertension on sudden discontinuation
Description : Select the progestin preparation for coadministration with estrogen for hormone replacement therapy that does not counteract the beneficial effect of the latter on lipid profile due to lack of ... oral progesterone B. Norethindrone C. Lynestrenol D. Medroxyprogesterone acetate (p. 281-282)
Last Answer : Select the indication for which a progestin is used alone without combining with an estrogen: A. Threatened abortion B. Dysfunctional uterine bleeding C. Hormone replacement therapy D. Premenstrual tension
Description : The distinctive features of desogestrel include the following except: A. It is a prodrug B. It has both strong progestational and strong antiovulatory activities C. It has additional androgenic acitivity D. It does not counteract the beneficial effect of estrogen on lipid profile
Last Answer : C. It has additional androgenic acitivity
Description : he distinctive features of desogestrel include the following except: A. It is a prodrug B. It has both strong progestational and strong antiovulatory activities C. It has additional androgenic acitivity D. It does not counteract the beneficial effect of estrogen on lipid profile
Description : A friend has very severe hypertension and asks about a drug her doctor wishes to prescribe. Her physician has explained that this drug is associated with tachycardia and fluid retention (which may be marked ... has described? (a) Captopril (b) Guanethidine (c) Minoxidil (d) Prazosin (e) Propranolol
Description : Which of the following is the drug of choice for management of cardiac arrhythmias that occur in digitalis toxicity? (a) Amiodarone (b) Lidocaine (c) Propranolol (d) Sotalol (e) Prazosin
Last Answer : Ans: B
Description : Select the drug which can impair carbohydrate tolerance in prediabetics but prolongs insulin hypoglycaemia: A. Salbutamol B. Propranolol C. Prazosin D. Nifedipine
Last Answer : B. Propranolol
Description : If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance
Last Answer : D. Total body clearance
Description : 5 A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution
Last Answer : D. Redistribution
Description : n the treatment of hypertension the beta adrenergic blockers have the following advantage: A. They have minimal effect on work capacity, sleep quality and libido B. They do not cause ... high ceiling antihypertensive efficacy D. They can be used in combination with any other antihypertensive drug
Last Answer : B. They do not cause postural hypotension
Description : Persistent dry cough may occur as a side effect of the following antihypertensive drug: A. Enalapril B. Atenolol C. Diltiazem D. Methyldopa
Last Answer : A. Enalapril
Description : The following drug reduces urine volume in both pituitary origin as well as renal diabetes insipidus and is orally active: A. Vasopressin B. Hydrochlorothiazide C. Chlorpropamide D. Carbamazepine
Last Answer : B. Hydrochlorothiazide
Description : n addition to counteracting potassium loss, triamterene also opposes the following consequence of thiazide/furosemide therapy: A. Hyperuricaemia B. Rise in plasma LDL-cholesterol C. Magnesium loss D. Both ‘A’ and ‘C’ are correct
Last Answer : C. Magnesium loss
Description : The following drug has been found to improve urine flow in elderly males with benign prostatic hypertrophy: A. Nifedipine B. Prazosin C. Disopyramide D. Imipramine
Last Answer : B. Prazosin
Description : In a patient of diabetes mellitus maintained on insulin therapy, administration of the following drug can vitiate glycaemia control: A. Prednisolone B. Prazosin C. Paracetamol D. Phenytoin
Last Answer : A. Prednisolone
Description : Select the drug which can improve urinary flow rate in benign prostatic hypertrophy without affecting prostate size: A. Amphetamine B. Prazosin C. Finasteride D. Goserelin
Description : Benefits of tamoxifen citrate therapy include the following except: A. Reduction in recurrence rate of breast cancer B. Improved bone mass C. Suppression of menopausal hot flushes D. Improved lipid profile
Last Answer : C. Suppression of menopausal hot flushes