Description : All the following are drugs or drug classes blocking cell wall synthesis except: a. Cephalosporins. b. Carbapenems. c. Monobactams. d. Tetracyclines.
Last Answer : a. Cephalosporins.
Description : Drug destroying type of bacterial resistance is important for the following antibiotics except: A. Cephalosporins B. Tetracyclines C. Chloramphenicol D. Aminoglycosides
Last Answer : B. Tetracyclines
Description : Methicillin resistant staphylococci do not respond to β-lactam antibiotics because: A. They produce a β-lactamase which destroys methicillin and related drugs B. They elaborate an amidase which destroys ... low affinity for β-lactam antibiotics D. They are less permeable to β-lactam antibiotics
Last Answer : C. They have acquired penicillin binding protein which has low affinity for β-lactam antibioti
Description : Antibacterial agents can be classified with regard to their structure, mechanism of action, and activity pattern against various types of bacterial pathogens. Which of the following ... are both bacteriostatic d. Sulfonamides and trimethoprim act synergistically to inhibit purine synthesis
Last Answer : Answer: a, b, d Penicillins, cephalosporins, and monobactams possess a b-lactam ring of some type and act to bind bacterial division plate proteins, thus inhibiting cell wall ... act in different mechanisms to inhibit protein synthesis, therefore two agents in combination act synergistically
Description : The use of prophylactic antibiotics has become commonplace. Which of the following statement(s) is/are true concerning the prophylactic use of antibiotics? a. The appropriate use of prophylactic ... d. The topical use of antimicrobial agents is of no advantage in the prophylactic setting
Last Answer : Answer: a Intravenous administration of an antibiotic is clearly indicated for patients undergoing clean contaminated operations. These antibiotics should be administered prior to surgery ... of antimicrobial agents is equivalent to the administration of intravenous antimicrobial agent antibiotics
Description : Methicillin resistant staphylococci do not respond to ß-lactam antibiotics because (a) They produce a ß-lactamase which destroys methicillin and related drugs (b) They elaborate an amidase which destroys ... low affinity for ß-lactam antibiotics (d) They are less permeable to ß-lactam antibiotics
Last Answer : Ans: C
Description : The third generation cephalosporins differ from the first generation cephalosporins in that they are: A. More active against gram positive cocci B. More active against gram negative enterobacteriaceae C. Nonimmunogenic D. Not excreted by tubular secretion
Last Answer : B. More active against gram negative enterobacteriaceae
Description : The following statements are true about imipenem except: A. It is a β-lactam antibiotic, but neither a penicillin nor a cephalosporin B. It is rapidly degraded in the kidney C. It is safe in epileptics D. It is always given in combination with cilastatin
Last Answer : C. It is safe in epileptics
Description : The β-lactam antibiotic(s) that prolong(s) bleeding time by altering surface receptors on platelets is/are: A. Carbenicillin B. Piperacillin C. Cefotaxime D. Both `A’ and `B’ are correct
Last Answer : A. Carbenicillin
Description : The polyene antibiotics act by: A. Inhibiting fungal cytochrome P450 enzyme B. Binding to ergosterol and creating micropores in fungal cell membrane C. Inhibiting fungal DNA synthesis D. Disorienting microtubules in fungal cells
Last Answer : B. Binding to ergosterol and creating micropores in fungal cell membrane
Description : What is true of Quinupristin-Dalfopristin: A. It is a synergistic combination of two similar antibiotics B. It acts by inhibiting bacterial protein synthesis C. It is active against most resistant coccal infections D. All of the above are correct
Last Answer : D. All of the above are correct
Description : Bactericidal action of aminoglycoside antibiotics is due to: A. Inhibition of bacterial protein synthesis B. Alteration of bacterial cell membrane permeability C. Damage to bacterial cell wall D. Inhibition of bacterial oxidative metabolism
Last Answer : B. Alteration of bacterial cell membrane permeability
Description : Aminoglycoside antibiotics exert the following action(s) on sensitive bacteria: A. Induce synthesis of defective proteins B. Make bacterial cell membrane more leaky C. Augment their own carrier mediated entry into the bacteria D. All of the above
Last Answer : D. All of the above
Description : The antibacterial action of aminoglycoside antibiotics is characterized by: A. Concentration dependent rate of bacterial cell killing B. Concentration dependent prolonged postantibiotic effect C. More pronounced bactericidal effect in anaerobic medium D. Both 'A' and 'B' are correct
Last Answer : D. Both 'A' and 'B' are correct
Description : Select the class of antibiotics which act by interfering with bacterial protein synthesis, but are bactericidal: A. Tetracyclines B. Aminoglycosides C. Macrolides D. Lincosamides
Last Answer : B. Aminoglycosides
Description : Aminoglycoside antibiotics have the following property common to all members: A. They are primarily active against aerobic gram negative bacilli B. They are more active in acidic medium C. They ... cells and are distributed in total body water D. They are nearly completely metabolized in liver
Last Answer : A. They are primarily active against aerobic gram negative bacilli
Description : The most important mechanism by which tetracycline antibiotics exert antimicrobial action is: A. They chelate Ca2+ ions and alter permeability of bacterial cell membrane B. They bind to 30S ribosomes ... peptide chain in the bacteria D. They interfere with DNA mediated RNA synthesis in bacteria
Last Answer : B. They bind to 30S ribosomes and inhibit bacterial protein synthesis
Description : Prophylactic use of antibiotics is not justified in the following condition: A. To prevent secondary infection in common cold B. Thoroughly cleaned contaminated wound C. Rheumatic fever in a child of 10 years D. Catheterization of urethra in an elderly male
Last Answer : A. To prevent secondary infection in common cold
Description : Superinfections are more common with: A. Use of narrow spectrum antibiotics B. Short courses of antibiotics C. Use of antibiotics that are completely absorbed from the small intestines D. Use of antibiotic combinations covering both gram positive and gram negative bacteria
Last Answer : D. Use of antibiotic combinations covering both gram positive and gram negative bacteria
Description : Widespread and prolonged use of an antibiotic leads to emergence of drug resistant strains because antibiotics: A. Induce mutation in the bacteria B. Promote conjugation among bacteria C. Allow resistant strains to propagate preferentially D. All of the above
Last Answer : C. Allow resistant strains to propagate preferentially
Description : Beta - lactamase production by strains of Haemophilus influenzae, Moraxella catarrhalis, and Neissera gonorrhoeae confers resistance against penicillin G.which one of the following antibiotics is most likely to be ... ? (a) Ampicillin (b) Ceftriaxone (c) Clindamycin (d) Gentamicin (e) Piperacillin
Last Answer : Ans: B
Description : Clavulanic acid is combined with amoxicillin because: A. It kills bacteria that are not killed by amoxicillin B. It retards renal excretion of amoxicillin C. It counteracts the adverse effects of amoxicillin D. It inhibits beta lactamases that destroy amoxicillin
Last Answer : D. It inhibits beta lactamases that destroy amoxicillin
Description : n the treatment of hypertension the beta adrenergic blockers have the following advantage: A. They have minimal effect on work capacity, sleep quality and libido B. They do not cause ... high ceiling antihypertensive efficacy D. They can be used in combination with any other antihypertensive drug
Last Answer : B. They do not cause postural hypotension
Description : Select the correct statement about flumazenil: A. It is a CNS stimulant used as an antidote for benzodiazepine poisoning B. It is a CNS depressant but blocks the action of diazepam C. It has ... of its own but blocks the depressant effect of diazepam as well as stimulant effect of beta carbolines
Last Answer : D. It has no CNS effect of its own but blocks the depressant effect of diazepam as well as stimulant effect of beta carbolines
Description : Which racial difference in response to drugs has been mentioned incorrectly below: A. Africans require higher concentration of atropine to dilate pupils B. Black races are more responsive ... SMON due to halogenated hydroxyquinolines D. Chloramphenicol induced aplastic anaemia is rare among Indians
Last Answer : B. Black races are more responsive to antihypertensive action of beta blockers
Description : Which of the antibiotic is not used as a food preservative ? A- Pimaricin B- Nisin C- Tylosin D- β-lactam antibiotic
Last Answer : β-lactam antibiotic
Description : The following statement(s) is/are true concerning gram-negative bacterial sepsis. a. Mortality due to this condition has almost been eliminated due to therapeutic intervention with antibiotics, aggressive ... sepsis is generally considered a more serious problem than sepsis due to a single organism
Last Answer : Answer: c, e Gram-negative bacterial sepsis is a serious disease process that produces substantial morbidity and mortality in both normal and immunocompromised patients (10% to 20% and ... and most investigators agree that polymicrobial sepsis is more lethal than infection with a single organism
Description : New approaches to antibiotic therapy include a. Carbohydrate targets in the wall LPS. b. unregulating DNA replication. c. Discovering new and unique antibiotics. d. All of the above (A—C) are correct.
Last Answer : d. All of the above (A—C) are correct.
Description : Antibiotics inhibiting nucleic acid synthesis include a. Rifampin and quinolones. b. Aminoglycosides and tetracyclines. c. Lincosamides and streptogramins. d. Macrolides and ami noglycosides.
Last Answer : a. Rifampin and quinolones.
Description : Organisms that normally inhabit the body a. include Treponema pallidum. b. cause endogenous diseases. c. may be detected by Donovan bodies. d. resist the effects of antibiotics.
Last Answer : b. cause endogenous diseases.
Description : The effects of diethyl carbamazine citrate in filariasis include the following except: A. Rapid symptomatic relief in acute filarial attack B. Renders filarial patients noninfective to mosquitoes ... Prolonged treatment may achieve radical cure by killing adult filarial worms lodged in lymphatics
Last Answer : C. Prolonged treatment induces regression of filarial elephantiasis
Description : Drug/drugs effective in filariasis include: A. Ivermectin B. Albendazole C. Diethyl carbamazine citrate D. All of the above
Description : Clinical applications of quinine include the following except: A. Uncomplicated chloroquine resistant malaria B. Cerebral malaria C. To induce abortion D. Nocturnal leg cramps
Last Answer : C. To induce abortion
Description : The regimens recommended for treatment of chloroquine resistant P.falciparum malaria in an adult include the following except: A. Quinine 10 mg/kg/8 hourly+ doxycycline 100 mg/day for 7 days B. Quinine 10 mg/kg ... 7 days D. Artemether 80 mg i.m./twice on first day followed by once daily for 4 days
Last Answer : C. Mefloquine 0.5 g daily for 7 days
Description : Adverse effects of ketoconazole include the following except: A. Gynaecomastia B. Oligozoospermia C. Kidney damage D. Menstrual irregularities
Last Answer : C. Kidney damage
Description : The drugs used to treat Mycobact. avium complex infection in AIDS patients include the following except: A. Isoniazid B. Clarithromycin C. Ethambutol D. Ciprofloxacin
Last Answer : A. Isoniazid
Description : First line antitubercular drugs include the following except: A. Ciprofloxacin B. Streptomycin C. Pyrazinamide D. Ethambutol
Last Answer : A. Ciprofloxacin
Description : Antimicrobials effective against anaerobic bacteria include the following except: A. Tobramycin B. Clindamicin C. Chloramphenicol D. Metronidazole
Last Answer : A. Tobramycin
Description : Features of clindamycin include the following: A. It is primarily active against aerobic gram negative bacilli B. It can be used topically to treat infected acne vulgaris C. It is not absorbed orally D. It is used to treat pseudomembranous enterocolitis
Last Answer : B. It can be used topically to treat infected acne vulgaris
Description : The distinctive features of azithromycin include the following except: A. Efficacy against organisms which have developed resistance to erythromycin B. Marked tissue distribution and intracellular penetration ... D. Low propensity to drug interactions due to inhibition of cytochrome P450 enzymes
Last Answer : A. Efficacy against organisms which have developed resistance to erythromycin
Description : Features of phenoxymethyl penicillin include the following: A. It is acid stable and orally active B. Its antibacterial spectrum is similar to that of benzyl penicillin C. It is used for less serious penicillin G sensitive infections D. All of the above are correct
Description : Distinctive features of gatifloxacin include the following except: A. Higher affinity for the enzyme topoisomerase IV B. Activity restricted to gram negative bacteria C. Potential to prolong QTc interval D. Employed to treat community acquired pneumonia
Last Answer : B. Activity restricted to gram negative bacteria
Description : Important microbiological features of ciprofloxacin include the following except: A. Long postantibiotic effect B. Marked suppression of intestinal anaerobes C. MBC values close to MIC values D. Slow development of resistance
Last Answer : B. Marked suppression of intestinal anaerobes
Description : Features of atorvastatin include the following: A. Dose to dose most potent HMG-CoA reductase inhibitor B. Higher ceiling of LDL-cholesterol lowering action than lovastatin C. Antioxidant property D. All of the above
Description : Indications for the use of antiplatelet drugs include the following except: A. Secondary prophylaxis of myocardial infarction B. Unstable angina pectoris C. Disseminated intravascular coagulation D. Stroke prevention in patients with transient ischaemic attacks
Last Answer : C. Disseminated intravascular coagulation
Description : Features of methylcobalamin include the following: A. It is an active coenzyme form of vit B12 B. It is required for the synthesis of S-adenosyl methionine C. It is specifically indicated for correcting neurological defects of vit B12 deficiency D. All of the above
Description : Indications of desmopressin include the following except: A. Neurogenic diabetes insipidus B. Nephrogenic diabetes insipidus C. Bedwetting in children D. Bleeding due to haemophilia
Last Answer : B. Nephrogenic diabetes insipidus
Description : The vasopressin action(s) mediated by V2 receptors include(s): A. Increased water permeability of collecting duct cells B. Increased urea permeability of collecting duct cells C. Vasoconstriction D. Both 'A' and 'B
Last Answer : D. Both 'A' and 'B
Description : The principles of antihypertensive drug usage enunciated in JNC VI and WHO-ISH guidelines include the following except: A. Therapy for grade I and II hypertension should be initiated with a single drug ... initially fails to lower BP, it should be replaced by a drug/combination from another class
Last Answer : C. All subjects with BP higher than 140/90 mmHg should be put on antihypertensive medication immediately
Description : Actions of adenosine include the following except: A. Depression of A-V node B. Coronary vasodilatation C. Bronchodilatation D. Fall in BP
Last Answer : C. Bronchodilatation