That could be a sign of renal problem. or maybe simply edema. . . . Idiopathic Edema is a common disorder that occurs almost exclusively in women. It is characterized by salt retention in the absence of heart, kidney, or liver disease. The swelling (edema) may be episodic or persistent. Swelling of the face, hands, and feet develops rapidly, frequently accompanied by headache, irritability, and depression. Weight gain also occurs.