answer:Pretty much all chronic illness and pain cause some depression. I think there is probably some sort if neuroscience you can apply there. Also, there is a morning period as someone goes through realizing their life might be different forever. Usual stages if anger, denial, bargaining, and acceptance. Moreover, people are dismissive and don’t take the illness seriously. I actually resent depression as being listed as though it’s part of the disease, whichever you pick, because the focus on depression and how someone handles it, including medicating them for anxiety and depression, sometimes takes away from curing the underlying cause, that the patient has something physically wrong. We don’t see this so much with cancer, but definitely with rheumatic conditions, many female conditions, and even simple things like chronic back pain. I think treating the whole patient is important, but what most patients want most is to actually be physically better.