answer:My mother and close friend have had it since their late teens and both have been able to control it well with Synthroid. I am hypothyroid for the last 12 years, which basically is the same in the end, and I was very difficult to stabilize, plus I’m allergic to something in Synthroid, I take Unithroid instead, it has the same T4 hormone. I have to take 88 five days a week and 100 two days a week, and then every second it third week I increase the 100 to three days a week. I added T3 now, which has helped a lot in controlling my hair staying in my head and any skin or eye dryness. I am very symptomatic when I’m out of my normal range. M normal (feel good) range is a higher TSH than most endocrinologist shoot for. You have to watch your own lab work, do not rely on the doctors. When you feel great run in for a blood test. Learn the range that is optimum for you. When you change your dose, don’t wait 8 weeks for a retest. You will hear generics aren’t as good. The thing about the generics is each thyroid drug as it’s own level. What I mean us 88 in Synthroid might actually have slightly more hormone than 88 in Unithroid or vice versa, but that particular drug stays constant. What is important is you stay with the same drug, same manufacturer, while trying to figure out your optimum dose.