Description : The protein IRS-1 is phosphorylated by (A) Protein kinase A (B) Protein kinase C (C) Tyrosine kinase activity of insulin receptor (D) Tyrosine kinase activity of IGF-1 receptor
Last Answer : Answer : B
Description : Insulin receptor is made up of (A) One α-and one β-subunit (B) Two α-and two β-subunit (C) Two, α two β-and two γ-subunit (D) One α, one β-one γ-and one δ-subunit
Description : Binding of insulin to its receptor activates (A) Adenylate cyclase (B) Guanylate cyclase (C) Phospholipase C (D) Tyrosine kinase
Last Answer : Answer : D
Description : In the insulin receptor, tyrosine kinase domain is present in (A) α-Subunits (B) β-Subunits (C) γ-Subunits (D) δ-Subunits
Description : β-Subunits of insulin receptor are present (A) Outside the cell membrane (B) In the cell membrane (C) Across the cell membrane (D) In the cytosol
Last Answer : Answer : C
Description : α-Subunits of insulin receptor are present (A) Outside the cell membrane (B) In the cell membrane (C) Across the cell membrane (D) In the cytosol
Last Answer : Answer : A
Description : Insulin binding sites are present on the (A) α-subunits of insulin receptor (B) β-subunits of insulin receptor (C) γ-subunits of insulin receptor (D) α-and β−subunits of insulin receptor
Description : Insulin receptor is a (A) Monomer (B) Dimer (C) Trimer (D) Tetramer
Description : What are the salient structural features of insulin?
Last Answer : Insulin is a protein hormone with two poly peptide chains, the A chain with 21 amino acids and the B chain with 30 amino acids are joined together by a pair of disulfide bonds. It has a total of 51 amino acids.
Description : Study of drug-receptor interaction has now shown that: A. Maximal response occurs only when all receptors are occupied by the drug B. Drugs exert an all or none' action on a ... lock and key' structural features D. Properties of affinity' and intrinsic activity' are independently variable
Last Answer : D. Properties of ‘affinity’ and ‘intrinsic activity’ are independently variable
Description : Which one of the following pairs of hormones are the examples of those that can easily pass through the cell membrane of the target cell and bind to a receptor inside it (mostly in the nucleus)? (a) Insulin, glucagon (b) Thyroxine, insulin (c) Somatostatin, oxytocin (d) Cortisol, testosterone
Last Answer : (d) Cortisol, testosterone
Description : Choose the correct statement(s) about pioglitazone: A. It acts as an agonist on nuclear paroxisome proliferator receptor γ B. It enhances transcription of insulin responsive genes C. It lowers blood sugar in type 2 diabetes mellitus without causing hyperinsulinemia D. All of the above
Last Answer : D. All of the above
Description : The insulin receptor is a: A. Ion channel regulating receptor B. Tyrosine protein kinase receptor C. G-protein coupled receptor D. None of the above
Last Answer : B. Tyrosine protein kinase receptor
Description : A receptor which itself has enzymatic property is: A. Insulin receptor B. Progesterone receptor C. Thyroxine receptor D. Glucagon receptor
Last Answer : A. Insulin receptor
Description : Which of the following is a G protein coupled receptor: A. Muscarinic cholinergic receptor B. Nicotinic cholinergic receptor C. Glucocorticoid receptor D. Insulin receptor
Last Answer : A. Muscarinic cholinergic receptor
Description : 81. Which one of the following pairs of hormones are the examples of those that can easily pass through the cell membrane of the target cell and bind to a receptor inside it (mostly in the nucleus) (1) Cortisol, testosterone (2) Insulin, glucagon (3) Thyroxin, Insulin (4) Somatostatin, oxytocin
Last Answer : Cortisol, testosterone
Description : A characteristic feature of marasmus is (A) Severe hypoalbuminemia (B) Normal epinephrine level (C) Mild muscle wasting (D) Low insulin and high cortisol level
Description : A characteristic feature of Kwashiorkar is (A) Fatty liver (B) Emaciation (C) Low insulin lever (D) Occurrence in less than 1 year infant
Description : Compared to other antipsychotic drugs, the distinctive feature of penfluridol is: A. Very long duration of action B. Weak dopamine D2 blocking activity C. Lack of extrapyramidal side effects D. Additional 5-HT2 receptor blocking activity
Last Answer : A. Very long duration of action
Description : The dopamine D2 receptor has the following feature: A. It is excitatory in nature B. It is negatively coupled to adenyl cyclase C. It is selectively blocked by bromocriptine D. It is not blocked by metoclopramide
Last Answer : B. It is negatively coupled to adenyl cyclase
Description : The following is not a feature of competitive antagonists: A. Chemical resemblance with the agonist B. Parallel rightward shift of the agonist log doseresponse curve C. Suppression of maximal agonist response D. Apparent reduction in agonist affinity for the receptor
Last Answer : C. Suppression of maximal agonist response
Description : What structural feature of their atoms is characteristic of elements in a group of the periodic table?
Last Answer : The Periodic Table also has a special name for its vertical columns. Each column is called a group. The elements in each group have the same number of electrons in the outer orbital. Those outer electrons are also called valence electrons.
Description : A common structural feature of vessel elements and sieve tube elements is (a) enucleate condition (b) thick secondary walls (c) pores on lateral walls (d) presence of P-protein
Last Answer : (a) enucleate condition
Description : A common structural feature of vessel elements and sieve tube elements is (a) enucleate condition (b) thick secondary walls (c) pores on lateral walls (d) presence of P-protein.
Description : Which of the following is the main structural feature of proteins? (a) Peptide linkage (b) Ester linkage (c) Ether linkage (d) α,β-Linkage
Last Answer : Peptide linkage
Description : The common structural feature amongst the three categories of anticonvulsant drugs barbiturates, succinimides and hydantoins is (A) ureide (B) imidazolidinone (C) dihydropyrimidine (D) tetrahydropyrimidine
Last Answer : (A) ureide
Description : The following feature disfavours use of oral hypoglycaemics in diabetes mellitus: A. Age at onset of disease over 40 years B. Insulin requirement more than 40 U/day C. Fasting blood sugar level between 100–200 mg/dl D. Associated obesity
Last Answer : B. Insulin requirement more than 40 U/day
Description : Ras proto-oncogene encodes (A) Epidermal growth factor (EGF) (B) Receptor for EGF (C) Signal transducer for EGF (D) Nuclear transcription factor
Description : Fibronectin has binding sites for all of the following except (A) Glycophorin (B) Collagen (C) Heparin (D) Integrin receptor
Description : Phosphorylated IRS-1 activates GRB-2 which is (A) G-protein receptor binding protein-2 (B) Growth factor receptor binding protein-2 (C) Growth hormone receptor binding protein-2 (D) Glucocorticoid receptor binding protein-2 226 MCQs IN BIOCHEMISTRY
Description : Binding of growth hormone to its receptor results in increased transcription of (A) c-fos gene (B) c-myc gene (C) p-53 gene (D) None of these
Description : Binding of growth hormone to its receptor results in phosphorylation of (A) JAK-2 (B) Growth hormone receptor (C) STATs (D) All of these
Description : All the following statements about epidermal growth factor are true except (A) It is a protein (B) It possess quaternary structure (C) Its receptor is made up of a single polypeptide chain (D) Its receptor possesses tyrosine kinase domain
Description : All the following statements about TSH are true except (A) It is a glycoprotein (B) It is made up of α- and β-subunits (C) Receptor recognition involves both the subunits (D) Its subunit is identical with those of FSH and LH
Description : Tyrosine kinase activity is present in (A) Acetylcholine receptor (B) PDGF receptor (C) ADH receptor (D) All of these
Description : The only correct statement about hormone receptors is (A) Receptors for protein hormones are present in cytosol (B) Receptors for steroid hormones are membrane bound (C) Hormone-receptor binding is irreversible (D) Receptors can undergo down regulation and up regulatoin
Description : Hormone that bind to cell surface receptor and require the second messenger camp is (A) Antidiuretic hormone (B) Cholecystokinin (C) Calcitriol (D) Gastrin
Description : Hormone that binds to intracellular receptor is (A) Adrenocorticotropic hormone (B) Thyroxine (C) Follicle stimulating hormone (D) Glucagon
Description : If a coenzyme is required in an enzyme reaction, the former usually has the function of (A) Acting as an acceptor for one of the cleavage products of the substrate (B) Enhancing the specificity ... C) Increasing the number of receptor sites of the apo enzyme (D) Activating the substrate ENZYMES 167
Description : Vitamin A is required for the formation of a light receptor protein known as (A) Globulin (B) Lypoprotein (C) Chomoprotein (D) Rhodospin
Description : Retinoic acid can (A) Act as a photo receptor (B) Support growth and differentiation (C) Act as an anti-oxidant (D) None of these
Description : LDL receptor is specific for (A) Apo B-48 and Apo B 100 (B) Apo B-48 and Apo E (C) Apo B-100 and Apo D (D) Apo B-100 and apo D
Description : Apolipoprotien B-100 acts as (A) Enzyme activator (B) Ligand for receptor (C) Both (A) and (B) (D) None of these
Description : Apolipoprotein A-I acts as (A) Enzyme activator (B) Ligand for receptor (C) Both (A) and (B) (D) None of these
Description : The apolipoprotein which acts as ligand for LDL receptor is (A) B-48 (B) B-100 (C) A (D) C
Description : Which are the cholesterol esters that enter cells through the receptor-mediated endocytosis of lipoproteins hydrolyzed? (A) Endoplasmin reticulum (B) Lysosomes (C) Plasma membrane receptor (D) Mitochondria
Last Answer : B