Description : Binding of growth hormone to its receptor results in increased transcription of (A) c-fos gene (B) c-myc gene (C) p-53 gene (D) None of these
Last Answer : Answer : A
Description : Phosphorylated IRS-1 activates GRB-2 which is (A) G-protein receptor binding protein-2 (B) Growth factor receptor binding protein-2 (C) Growth hormone receptor binding protein-2 (D) Glucocorticoid receptor binding protein-2 226 MCQs IN BIOCHEMISTRY
Last Answer : Answer : B
Description : The only correct statement about hormone receptors is (A) Receptors for protein hormones are present in cytosol (B) Receptors for steroid hormones are membrane bound (C) Hormone-receptor binding is irreversible (D) Receptors can undergo down regulation and up regulatoin
Last Answer : Answer : D
Description : `Ca^(+2),IP_(3),C-AMP` etc. Are generated after binding of hormone on receptor present on membrane thus these are termed as
Last Answer : `Ca^(+2),IP_(3),C-AMP` etc. Are generated after binding of hormone on receptor present on membrane thus these are termed as
Description : Most hormone receptors are localized on the cell membrane and transduce hormone binding into altered levels of intracellular messengers. A limited number of intracellular receptors do exist. Which of ... protein serves as an inhibitor protein blocking the DNA-binding domain of the steroid receptor
Last Answer : Answer: a, d Although most hormone and other messenger receptors are extracellular, intracellular receptors have been identified. The hormone messengers involved for these receptors are primarily ... DNA-binding domain of the receptor. Activation involves the dissociation of the inhibitor protein
Description : G-proteins: a. are activated by the binding of an extracellular ligand to a membrane receptor b. can be mutated in tumour cells c. mediate the action of glucocorticoid hormone d. they are inactivated by cholera toxins
Last Answer : are activated by the binding of an extracellular ligand to a membrane receptor
Description : Which is associated with a steroid hormone? A) cyclic AMP B) the second messenger system C) production of new proteins D) activation of proteins present in an inactive form E) binding of a protein to a surface receptor on the plasma membrane
Last Answer : C) production of new proteins
Description : Binding of insulin to its receptor activates (A) Adenylate cyclase (B) Guanylate cyclase (C) Phospholipase C (D) Tyrosine kinase
Description : Which of the following regulates lipolysis in adipocytes? (A) Activation of fatty acid synthesis mediated by CAMP (B) Glycerol phosphorylation to prevent futile esterification of fatty acids (C) ... result of hormone stimulated increases in CAMP levels (D) Activation of CAMP production by Insulin
Last Answer : Answer : C
Description : Fibronectin has binding sites for all of the following except (A) Glycophorin (B) Collagen (C) Heparin (D) Integrin receptor
Description : Insulin binding sites are present on the (A) α-subunits of insulin receptor (B) β-subunits of insulin receptor (C) γ-subunits of insulin receptor (D) α-and β−subunits of insulin receptor
Description : Acromegaly results from overproduction of (A) ACTH during childhood (B) TSH during adult life (C) Growth hormone during childhood (D) Growth hormone during adult life HORMONE METABOLISM 219
Description : Acromegaly results due to excessive release of (A) Thyroxine (B) Growth hormone (C) Insulin (D) Glucagon
Description : Hormone that bind to cell surface receptor and require the second messenger camp is (A) Antidiuretic hormone (B) Cholecystokinin (C) Calcitriol (D) Gastrin
Description : Hormone that binds to intracellular receptor is (A) Adrenocorticotropic hormone (B) Thyroxine (C) Follicle stimulating hormone (D) Glucagon
Description : The _____ cell contains on its surface a CD4 receptor site that enhances binding to the macrophage. a. Helper T b. molecular patterns (PAMPs) c. plasma d. B
Last Answer : a. IgG
Description : Hormone receptors that stimulate cAMP production (A) are part of a complex of two proteins that transform the external signal into internal cAMP production (B) are proteins distinct and separate from those ... binding of the hormone (D) are not very specific and bind a number of different hormones
Description : Progesterone is transported in blood by (A) Transcortin (B) Sex hormone binding globulin (C) Albumin (D) Testosterone estrogen binding globulin
Description : When thyroxine binding globulin and thyroxine binding pre-albumin are saturated with thyroxine, the excess hormone is transported by (A) Albumin (B) Gamma globulins (C) Transcortin (D) None of these
Description : Which of the following statement(s) is/are true concerning cell membrane receptors? a. The largest family of cell surface receptors are the G-protein-linked receptors b. Activities of the ... through the use adenylate cyclase d. Tyrosine kinase receptors are considered G-protein-linked receptors
Last Answer : Answer: a, c All water-soluble regulatory molecules bind to the cell surface receptor proteins. Binding of the appropriate ligand evokes an intracellular signal which usually regulates ... are adenylate cyclase, which converts ATP to cAMP, and the polyphosphoinositide-specific phospholipase C
Description : _____ cells have antibodies on their surface that perform receptor functions by binding to antigen (epitope). a. T b. B c. NK d. A-C are correct
Last Answer : b. B
Description : Clonal selection includes a. Antigen-receptor binding on B cells. b. Antibody secretion recognizing same epitope as on B cell receptors. c. Differentiation of B cells into plasma cells and memory cells. d. All the above (A—C) are correct.
Last Answer : d. All the above (A—C) are correct.
Description : The function of a viral capsid is A.protection against the viral genome from physical and enzymatic destruction B.providing binding sites that enable the virus to attach to specific receptor sites on the host ... C.serving as a vehicle of transmission from one host to another D.all of the above
Last Answer : D.all of the above
Description : Aliskiren acts by (A) inhibiting the conversion of Angiotensin I to II (B) inhibiting the release of rennin (C) inhibiting the binding of Angiotensin II to the receptor (D) inhibiting the action of aldosterone
Last Answer : (B) inhibiting the release of rennin
Description : The organophosphates produce irreversible inhibition of cholinesterase because: A. They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind ... degradation of enzyme molecules D. They are neither metabolized nor excreted from the body
Last Answer : B. Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules
Description : All the following statements about epidermal growth factor are true except (A) It is a protein (B) It possess quaternary structure (C) Its receptor is made up of a single polypeptide chain (D) Its receptor possesses tyrosine kinase domain
Description : Ras proto-oncogene encodes (A) Epidermal growth factor (EGF) (B) Receptor for EGF (C) Signal transducer for EGF (D) Nuclear transcription factor
Description : Retinoic acid can (A) Act as a photo receptor (B) Support growth and differentiation (C) Act as an anti-oxidant (D) None of these
Description : Select the answer which correctly matches the endocrine gland with the hormone it secretes and its function/deficiency symptom. Endocrine Hormone Function/ gland Deficiency symptoms (a) ... child birth (d) Posterior Growth Oversecretion pituitary hormone stimulates (GH) abnormal growth
Last Answer : (a) Thyroid Thyroxine Lack of iodine gland in diet results in goitre
Description : The condition that results when there is an increased production of human growth hormone in an adult is termed A) Cushing's syndrome. B) Addison's disease. C) gigantism. D) dwarfism. E) acromegaly.
Last Answer : E) acromegaly.
Description : Read the following four statements (A - D). (A) Both photophosphorylation and oxidative phosphorylation involve uphill transport of protons across the membrane. (B) In dicot stems, a new cambium ... Petunia are polyandrous. (D) Symbiotic nitrogen fixers occur in free-living state also in soil.
Last Answer : (A) Both photophosphorylation and oxidative phosphorylation involve uphill transport of protons across the membrane.
Description : Hormone which regulate gene expression or chromosome by interation of hormone receptor complex with the genome are
Last Answer : Hormone which regulate gene expression or chromosome by interation of hormone receptor complex with the genome are
Description : The hormone which acts through intracellular receptor protein is
Last Answer : The hormone which acts through intracellular receptor protein is A. Growth hormone B. Prolactin C. Thyroxine D. Adrenaline
Description : The following are true about parathyroid hormone a. it is an 84 amino acid peptide hormone b. it increases calcium absorption from the gastrointestinal tract c. it acts on a cell surface receptor that increases intracellular cyclic AMP d. all above
Last Answer : all above
Description : According to the accepted concept of hormone action, if receptor molecules are removed from target organs, then the target organ will (a) continue to respond to the hormone without any difference ( ... require higher concentration (d) continue to respond to the hormone but in the opposite way.
Last Answer : (b) not respond to the hormone
Description : Identify A, B and C in the diagramatic representation of the mechanism of hormone action. B A Response 1 C Physiological Responses Select the correct option from the following. (a) A-Steroid Hormone; B- ... ; C - Second Messenger (d) A-Protein Hormone; B-Cyclic AMP; C-Hormone-receptor Complex
Last Answer : (b) A-Protein Hormone; B-Receptor; C-Cyclic AMP
Description : Which of the following is NOT correct about hormones? A) Hormones are generally found across the animal kingdom. B) Hormones may be used at a distance from where the hormone is made. C) ... target cell. E) Hormones are directed to the target organ and avoid contact with non-target cells.
Last Answer : E) Hormones are directed to the target organ and avoid contact with non-target cells.
Description : Which does NOT occur in a cell stimulated by a steroid hormone? A) The steroid hormone enters the cell by crossing the plasma membrane. B) The hormone binds to a receptor molecule in the ... activates certain genes. E) DNA is transcribed, mRNA is translated, and the result is protein synthesis.
Last Answer : C) The second messenger cyclic AMP is stimulated by the hormone-receptor complex. D) The hormone-receptor complex binds the chromatin and activates certain genes.
Description : Which statement is NOT true about steroid hormones? A) They include hormones such as estrogen. B) They do not bind to cell surface receptors. C) The hormone-receptor complex can enter the ... complex can bind to chromatin. E) Steroid hormones act faster than non-steroid (peptide) hormones.
Last Answer : E) Steroid hormones act faster than non-steroid (peptide) hormones.
Description : 6.2 Which hormone acts through a cytoplasmic receptor: A. Calcitriol B. Prolactin C. Vasopressin D. None of the abov
Last Answer : A.Calcitol binds to cytoplasmic membrane and enhances the absorption of Calcium by increasing the calcium binding proteins-calbindin-D proteins.
Description : A 55 year-old female complaining of vague tiredness is found to have a serum corrected calcium concentration of 2.9 mmol/l. Examination was unremarkable. Which of the following results ... 4) Low normal plasma phosphate concentration 5) Low normal serum 25-hydroxyvitamin D concentration
Last Answer : Answers-3 Bit too easy really. A high or even normal PTH concentration in the presence of hypercalcaemia would support the diagnosis of hyperparathyroidism. A high urinary Calcium concentration may ... but neither confirm the diagnosis. Elevated 1,25 VitD suggests a diagnosis of hypervitaminosis D.
Description : Which of the following statements about septic shock are true? A. A circulating myocardial depressant factor may account for the cardiac dysfunction sometimes seen with shock due to sepsis or ... animal studies that demonstrate a significant improvement in survival with the use of such agents.
Last Answer : Answer: AB DISCUSSION: Shock due to sepsis or SIRS frequently manifests as a hyperdynamic cardiovascular response, consisting of an elevated CI and a decreased SVR or SVRI. Occasionally, ... been encouraging thus far in human clinical trials, despite the promising results from many animal studies
Description : Typical results of beta-receptor activation include which one of the following? (a) Hypoglycemia (b) Lipolysis (c) Glycogen synthesis (d) Decreased skeletal muscle tremor (e) Decreased rennin secretion
Last Answer : Ans: B
Description : How does steroid hormone influence the cellular activities? (a) Using aquaporin channels ‘as second messenger’ (b) Changing the permeability of the cell membrane (c) Binding to DNA and forming a gene-hormone complex (d) Activating cyclic AMP located on the cell membrane
Last Answer : (c) Binding to DNA and forming a gene-hormone complex
Description : UDP and UTP are formed by phosphorylation from (A) AMP (B) ADP (C) ATP (D) GTP
Description : Phosphorylation of adenosine to AMP is catalysed by (A) Adenosine kinase (B) Deoxycytidine kinase (C) Adenylosuccinase (D) Adenylosuccinate synthetase
Description : Which one of the following statements is incorrect? (A) Insulin increases glucose phosphorylation (B) Insulin increases glycolysis (C) Insulin augments HMP shunt (D) Insulin promotes gluconeogenesis
Description : Substrate-linked phosphorylation occurs in (A) Glycolytic pathway(B) Citric acid cycle (C) Both (A) and (B) (D) None of these
Description : The chemical inhibiting oxidative phosphorylation, Adependent on the transport of adenine nucleotides across the inner mitochondrial membrane is (A) Oligomycin (B) Atractyloside (C) Dinitrophenol (D) Pentachlorophenol