Lidocaine is the preferred antiarrhythmic for emergency control of cardiac arrhythmias following acute myocardial infarction because (a) It has a rapidly developing and titratable antiarrhythmic action (b) It casues little myocardial depression and hypotension (c) It has broad spectrum antiarrhythmic efficacy in atrial as well as ventricular arrhythmias (d) Both (a) and (b)

Lidocaine is the preferred antiarrhythmic for emergency control of cardiac arrhythmias following acute myocardial infarction because (a) It has a rapidly developing and titratable antiarrhythmic action (b) It casues little myocardial depression and hypotension (c) It has broad spectrum antiarrhythmic efficacy in atrial as well as ventricular arrhythmias (d) Both (a) and (b)
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Lignocaine is the preferred antiarrhythmic for emergency control of cardiac arrhythmias following acute myocardial infarction because: A. It has a rapidly developing and titratable antiarrhythmic action B. It causes little myocardial depression and hypotension C. It has broad spectrum antiarrhythmic efficacy in atrial as well as ventricular arrhythmias D. Both ‘A’ and ‘B’ are correct

Description : Lignocaine is the preferred antiarrhythmic for emergency control of cardiac arrhythmias following acute myocardial infarction because: A. It has a rapidly developing and titratable antiarrhythmic action B. It causes ... atrial as well as ventricular arrhythmias D. Both A' and B' are correct

Last Answer : D. Both ‘A’ and ‘B’ are correct

Choose the antiarrhythmic drug which prolongs action potential, can aggravate atrioventricular block but not heart failure, and has broad spectrum utility in acute as well as chronic, and ventricular as well as supraventricular arrhythmias: A. Quinidine B. Amiodarone C. Mexiletine D. Diltiazem

Description : Choose the antiarrhythmic drug which prolongs action potential, can aggravate atrioventricular block but not heart failure, and has broad spectrum utility in acute as well as chronic, and ventricular as well as supraventricular arrhythmias: A. Quinidine B. Amiodarone C. Mexiletine D. Diltiazem

Last Answer : B. Amiodarone

The limitations of quinidine in the treatment of cardiac arrhythmias include the following except: A. It has narrow spectrum antiarrhythmic activity B. It is not tolerated by many patients C. It can precipitate myocardial decompensation D. It can cause marked hypotension

Description : The limitations of quinidine in the treatment of cardiac arrhythmias include the following except: A. It has narrow spectrum antiarrhythmic activity B. It is not tolerated by many patients C. It can precipitate myocardial decompensation D. It can cause marked hypotension

Last Answer : A. It has narrow spectrum antiarrhythmic activity

A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/method of administration would be most suitable. (a) Sublingual (b) Oral (c) Intravenous bolus injection (d) Slow intravenous infusion

Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/ ... (a) Sublingual (b) Oral (c) Intravenous bolus injection (d) Slow intravenous infusion

Last Answer : Ans: D

Which of the following is the drug of choice for management of cardiac arrhythmias that occur in digitalis toxicity? (a) Amiodarone (b) Lidocaine (c) Propranolol (d) Sotalol (e) Prazosin

Description : Which of the following is the drug of choice for management of cardiac arrhythmias that occur in digitalis toxicity? (a) Amiodarone (b) Lidocaine (c) Propranolol (d) Sotalol (e) Prazosin

Last Answer : Ans: B

Which of the following drugs is a class III antiarrhythmic agent that is effective in the acute management of atrial fibrillation or atrial flutter of recent onset ? (a) Bretylium (b) Lbutilide (c) Metoprolol (d) Disopyramide

Description : Which of the following drugs is a class III antiarrhythmic agent that is effective in the acute management of atrial fibrillation or atrial flutter of recent onset ? (a) Bretylium (b) Lbutilide (c) Metoprolol (d) Disopyramide

Last Answer : Ans: B

If a fibrinolytic drug is used for treatment of acute myocardial infarction, the adverse drug effect that is most likely to occur is (a) Acute renal failure (b) Development of antiplatelet antibodies (c) Encephalitis secondary to liver dysfunction (d) Hemorrhagic stroke (e) Neutropenia

Description : If a fibrinolytic drug is used for treatment of acute myocardial infarction, the adverse drug effect that is most likely to occur is (a) Acute renal failure (b) Development of antiplatelet antibodies (c) Encephalitis secondary to liver dysfunction (d) Hemorrhagic stroke (e) Neutropenia

Last Answer : Ans: D

A patient receiving a class I antiarrhythmic agent on a chronic basis complains of fatigue, low-grade fever, and joint pain suggestive of systemic lupus erythematosus (SLE). The patient is most likely receiving (a) Lidocaine (b) Procainamide (c) Quinidine (d) Flecainide (e) Propranolol

Description : A patient receiving a class I antiarrhythmic agent on a chronic basis complains of fatigue, low-grade fever, and joint pain suggestive of systemic lupus erythematosus (SLE). The patient is most likely receiving (a) Lidocaine (b) Procainamide (c) Quinidine (d) Flecainide (e) Propranolol

Last Answer : Ans: B

Acute renal failure (ARF) may be caused by all of the following except (a) Acute tubular necrosis (ATN) due to drug therapy (e.g., aminoglycosides, contrast media) (b) Severe hypotension or circulatolry collapse (c) Decreased cardiac output, as from congestive heart failure (d) Hemolysis, myoglobinuria (e) Hyperkalemia

Description : Acute renal failure (ARF) may be caused by all of the following except (a) Acute tubular necrosis (ATN) due to drug therapy (e.g., aminoglycosides, contrast media) (b) Severe hypotension ... (c) Decreased cardiac output, as from congestive heart failure (d) Hemolysis, myoglobinuria (e) Hyperkalemia

Last Answer : Ans: E

Quinidine is now used primarily for (a) Conversion of auricular fibrillation to sinus rhythm (b) Control of ventricular rate in atrial flutter (c) Termination of ventricular tachycardia (d) Prevention of recurrences of atrial and ventricular extrasystoles/tachycardias

Description : Quinidine is now used primarily for (a) Conversion of auricular fibrillation to sinus rhythm (b) Control of ventricular rate in atrial flutter (c) Termination of ventricular tachycardia (d) Prevention of recurrences of atrial and ventricular extrasystoles/tachycardias

Last Answer : Ans: D

In a patient of myocardial infarction, β adrenergic blockers are used with the following aim/aims: A. To reduce the incidence of reinfarction B. To prevent cardiac arrhythmias C. To limit size of the infarct D. All of the above

Description : In a patient of myocardial infarction, β adrenergic blockers are used with the following aim/aims: A. To reduce the incidence of reinfarction B. To prevent cardiac arrhythmias C. To limit size of the infarct D. All of the above

Last Answer : D. All of the above

Which one of the following drugs predictably prolongs the PR interval and increases cardiac contractility? (a) Digoxin (b) Lidocaine (c) Propranolol (d) Quinidine (e) Verapamil

Description : Which one of the following drugs predictably prolongs the PR interval and increases cardiac contractility? (a) Digoxin (b) Lidocaine (c) Propranolol (d) Quinidine (e) Verapamil

Last Answer : Ans: A

In post-myocardial infarction and other high cardiovascular risk subjects but without hypertension or heart failure, prolonged ACE inhibitor medication has been found to: A. Increase the chances of sudden cardiac death B. Reduce the incidence of fatal as well as nonfatal myocardial infarction or stroke C. Lower the risk of developing heart failure and diabetes D. Both ‘B‘ and ‘C’

Description : In post-myocardial infarction and other high cardiovascular risk subjects but without hypertension or heart failure, prolonged ACE inhibitor medication has been found to: A. Increase the chances of sudden cardiac death ... Lower the risk of developing heart failure and diabetes D. Both B and C'

Last Answer : D. Both ‘B‘ and ‘C

Higher incidence of myocardial infarction and increased mortality has been noted with the use of the following antihypertensive drug (a) Nifedipine (b) Verapamil (c) Diltiazem (d) Lisinopril

Description : Higher incidence of myocardial infarction and increased mortality has been noted with the use of the following antihypertensive drug (a) Nifedipine (b) Verapamil (c) Diltiazem (d) Lisinopril

Last Answer : Ans: A

What drug is used to prevent embolism in the lung and during myocardial infarction? (a) Alteplase (b) Human growth hormone (c) Granulocyte–macrophage colony – stimulating factor (GM–CSF) (d) EPOGEN (EPO) (e) None of the above

Description : What drug is used to prevent embolism in the lung and during myocardial infarction? (a) Alteplase (b) Human growth hormone (c) Granulocyte–macrophage colony – stimulating factor (GM–CSF) (d) EPOGEN (EPO) (e) None of the above

Last Answer : Ans: A

The chief use of levoarterenol is to treat (a) Shock (b) Diabetes (c) Hypertension (d) Cardiac arrhythmias (e) Iron deficiencies

Description : The chief use of levoarterenol is to treat (a) Shock (b) Diabetes (c) Hypertension (d) Cardiac arrhythmias (e) Iron deficiencies

Last Answer : Ans: A

The term ischemic heart disease (IHD) is used to designate all of the following conditions except (a) Angina pectoris (b) Sudden cardiac death (c) Congestive heart failur (CHF) (d) Arrhythmias

Description : The term ischemic heart disease (IHD) is used to designate all of the following conditions except (a) Angina pectoris (b) Sudden cardiac death (c) Congestive heart failur (CHF) (d) Arrhythmias

Last Answer : Ans: C

Which of the following are not determinants of a postoperative cardiac complication? A. Myocardial infarct 4 months previously. B. Clinical evidence of congestive heart failure in a patient with 8.5 gm. per dl. hemoglobin. C. Premature atrial or ventricular contractions on electrocardiogram. D. A harsh aortic systolic murmur. E. Age over 70 years.

Description : Which of the following are not determinants of a postoperative cardiac complication? A. Myocardial infarct 4 months previously. B. Clinical evidence of congestive heart failure in a patient with 8.5 gm ... on electrocardiogram. D. A harsh aortic systolic murmur. E. Age over 70 years.

Last Answer : Answer: B DISCUSSION: Clinical evidence of congestive heart failure in a patient with 8.5 gm. per dl. hemoglobin concentration is a misleading sign. Evidence of congestive ... or ventricular contractions on the electrocardiogram are less strong determinants of a postoperative cardiac complication

Thrombolytic therapy instituted within 3-6 hours of onset of acute myocardial infarction affords the following benefit(s): A. Reduces mortality B. Reduces area of myocardial necrosis C. Preserves ventricular function D. All of the above

Description : Thrombolytic therapy instituted within 3-6 hours of onset of acute myocardial infarction affords the following benefit(s): A. Reduces mortality B. Reduces area of myocardial necrosis C. Preserves ventricular function D. All of the above

Last Answer : D. All of the above

A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/method of administration would be most suitable: A. Sublingual B. Oral C. Intravenous bolus injection D. Slow intravenous infusion

Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route ... suitable: A. Sublingual B. Oral C. Intravenous bolus injection D. Slow intravenous infusion

Last Answer : D. Slow intravenous infusion

Digoxin given for cardiac failure is extremely valuable in patients of (a) Thyrotoxicosis (b) Beriberi (c) Cor pulmonale (d) Atrial fibrillation

Description : Digoxin given for cardiac failure is extremely valuable in patients of (a) Thyrotoxicosis (b) Beriberi (c) Cor pulmonale (d) Atrial fibrillation

Last Answer : Ans: D

Following statement is true about lidocaine (a) Reduce the slope of Phase 4 (b) Threshold excitability is not altered (c) Action potential is not affected (d) All of the above

Description : Following statement is true about lidocaine (a) Reduce the slope of Phase 4 (b) Threshold excitability is not altered (c) Action potential is not affected (d) All of the above

Last Answer : Ans: A

Therapeutic dose of digoxin in a normal individual has the following effects, except (a) Increase in the speed of myocardial contractility (b) No significant change in cardiac output (c) Relaxation of peripheral vascular bed (d) Increase in the force of myocardial contractility

Description : Therapeutic dose of digoxin in a normal individual has the following effects, except (a) Increase in the speed of myocardial contractility (b) No significant change in cardiac output (c) Relaxation of peripheral vascular bed (d) Increase in the force of myocardial contractility

Last Answer : Ans: C

The preferred route of administration of streptokinase in acute myocardial infarction is: A. Intravenous B. Subcutaneous C. Intracoronary

Description : The preferred route of administration of streptokinase in acute myocardial infarction is: A. Intravenous B. Subcutaneous C. Intracoronary

Last Answer : A. Intravenous

The following is an orally active lignocaine congener used for both acute as well as chronic ventricular arrhythmias: A. Mexiletine B. Flecainide C. Moricizine D. Propafenone

Description : The following is an orally active lignocaine congener used for both acute as well as chronic ventricular arrhythmias: A. Mexiletine B. Flecainide C. Moricizine D. Propafenone

Last Answer : A. Mexiletine

A hypertensive patient has been using nifedipine for some time without untoward effects. If he experiences a rapidly developing enhancement of the antihypertensive effect of the drug, it is probably due to (a) Concomitant use of antacids (b) Fods containing tyramine (c) Grapefruit juice (d) Induction of drug metabolism (e) Over – the – counter decongestants

Description : A hypertensive patient has been using nifedipine for some time without untoward effects. If he experiences a rapidly developing enhancement of the antihypertensive effect of the drug, it is probably due to ... ) Grapefruit juice (d) Induction of drug metabolism (e) Over - the - counter decongestants

Last Answer : Ans: C

The most significant feature of the antiarrhythmic action of lignocaine is: A. Suppression of phase-4 depolarization in ventricular ectopic foci B. Prolongation of action potential duration C. Prolongation of effective refractory period D. Depression of membrane responsiveness

Description : The most significant feature of the antiarrhythmic action of lignocaine is: A. Suppression of phase-4 depolarization in ventricular ectopic foci B. Prolongation of action potential duration C. Prolongation of effective refractory period D. Depression of membrane responsiveness

Last Answer : A. Suppression of phase-4 depolarization in ventricular ectopic foci

Which of the following agents has a direct effect on the AV mode, delaying calciumchannel depolarization? (a) Lidocaine (b) Diltiazem (c) Bretylium (d) Quinidine (e) Lbutilide

Description : Which of the following agents has a direct effect on the AV mode, delaying calciumchannel depolarization? (a) Lidocaine (b) Diltiazem (c) Bretylium (d) Quinidine (e) Lbutilide

Last Answer : Ans: B

Which one of the following drugs increase digoxin plasma concentration by a pharmacokinetic mechanism? (a) Captopril (b) Hydrochorothiazide (c) Lidocaine (d) Quinidine (e) Sulfasalazine

Description : Which one of the following drugs increase digoxin plasma concentration by a pharmacokinetic mechanism? (a) Captopril (b) Hydrochorothiazide (c) Lidocaine (d) Quinidine (e) Sulfasalazine

Last Answer : Ans: D

Vasodilators are used to treat: A. Acute heart failure attending myocardial infarction B. Chronic heart failure due to diastolic dysfunction C. Chronic heart failure due to both systolic as well as diastolic dysfunction D. All of the above

Description : Vasodilators are used to treat: A. Acute heart failure attending myocardial infarction B. Chronic heart failure due to diastolic dysfunction C. Chronic heart failure due to both systolic as well as diastolic dysfunction D. All of the above

Last Answer : D. All of the above

During Phase 2 of action potential in cardiac cell, depolarizing current through calcium channels is balanced by (a) Delayed rectifier potassium current (b) outward chloride channel (c) Both (a) and (b) (d) None of the above

Description : During Phase 2 of action potential in cardiac cell, depolarizing current through calcium channels is balanced by (a) Delayed rectifier potassium current (b) outward chloride channel (c) Both (a) and (b) (d) None of the above

Last Answer : Ans: A

Which of the following drugs is a class IV antiarrhythmic that is primarily indicated for the treatment of supraventricular tachyarrhythmias? (a) Lbutilide (b) Mexiletine (c) Diltiazem (d) Quinidine (e) Propranolol

Description : Which of the following drugs is a class IV antiarrhythmic that is primarily indicated for the treatment of supraventricular tachyarrhythmias? (a) Lbutilide (b) Mexiletine (c) Diltiazem (d) Quinidine (e) Propranolol

Last Answer : Ans: C

Strong anticholinergic effects limit the antiarrhythmic use of (a) Quinidine (b) Procainamide (c) Tocainide (d) Flecainide (e) Disopyramide

Description : Strong anticholinergic effects limit the antiarrhythmic use of (a) Quinidine (b) Procainamide (c) Tocainide (d) Flecainide (e) Disopyramide

Last Answer : Ans: E

Morphine affords symptomatic relief of dyspnoea in acute left ventricular failure by the following mechanisms except: A. Bronchodilatation B. Depression of respiratory centre C. Reduction in cardiac preload D. Shift of blood from pulmonary to systemic circuit

Description : Morphine affords symptomatic relief of dyspnoea in acute left ventricular failure by the following mechanisms except: A. Bronchodilatation B. Depression of respiratory centre C. Reduction in cardiac preload D. Shift of blood from pulmonary to systemic circuit

Last Answer : A. Bronchodilatation

In cardiac cells, adenosine (a) Causes shortening of action potential duration (b) Depolarization (c) Increase in normal automaticity (d) All of the above

Description : In cardiac cells, adenosine (a) Causes shortening of action potential duration (b) Depolarization (c) Increase in normal automaticity (d) All of the above

Last Answer : Ans: A

The action of quinidine differs from that of digitalis in (a) Decreasing irritability of cardiac muscle (b) Preventing passage of impulses to the ventricle (c) Increasing irritability of heart muscle (d) Reducing conductivity (e) None of the above

Description : The action of quinidine differs from that of digitalis in (a) Decreasing irritability of cardiac muscle (b) Preventing passage of impulses to the ventricle (c) Increasing irritability of heart muscle (d) Reducing conductivity (e) None of the above

Last Answer : Ans: A

Relative to fexofenadine, diphenhydramine is more likely to (a) Be used for treatment of asthma (b) Be used for treatment of gastroesophageal reflux disease (c) Cause cardiac arrhythmias in overdose (d) Have efficacy in the prevention of motion sickness (e) Increase the serum concentration of warfarin

Description : Relative to fexofenadine, diphenhydramine is more likely to (a) Be used for treatment of asthma (b) Be used for treatment of gastroesophageal reflux disease (c) Cause cardiac arrhythmias in ... ) Have efficacy in the prevention of motion sickness (e) Increase the serum concentration of warfarin

Last Answer : Ans: D

Streptokinase therapy of myocardial infarction is contraindicated in the presence of the following except: A. Peptic ulcer B. Ventricular extrasystoles C. History of recent trauma D. Severe hypertension

Description : Streptokinase therapy of myocardial infarction is contraindicated in the presence of the following except: A. Peptic ulcer B. Ventricular extrasystoles C. History of recent trauma D. Severe hypertension

Last Answer : B. Ventricular extrasystoles

Ventricular remodeling after myocardial infarction involves the mediation of: A. Angiotensin II B. Prostaglandin C. Bradykinin D. Thromboxane A2

Description : Ventricular remodeling after myocardial infarction involves the mediation of: A. Angiotensin II B. Prostaglandin C. Bradykinin D. Thromboxane A2

Last Answer : A. Angiotensin II

Prostaglandins play pathophysiological role in the following except: A. Patency of ductus arteriosus B. Regulation of renal tubular salt absorption C. Ventricular remodeling after myocardial infarction D. Initiation of labour

Description :  Prostaglandins play pathophysiological role in the following except: A. Patency of ductus arteriosus B. Regulation of renal tubular salt absorption C. Ventricular remodeling after myocardial infarction D. Initiation of labour

Last Answer : C. Ventricular remodeling after myocardial infarction 

When used as an antiarrhythmic drug, Lidocaine typically (a) Increases action potential duration (b) Increases contractility (c) Increses PR interval (d) Reduces abnormal automaticity (e) Reduces resting potential

Description : When used as an antiarrhythmic drug, Lidocaine typically (a) Increases action potential duration (b) Increases contractility (c) Increses PR interval (d) Reduces abnormal automaticity (e) Reduces resting potential

Last Answer : Ans: D

Oxytocin is preferred over ergometrine for augmenting labour because: A. It has brief and titratable action B. It is less likely to cause foetal anoxia C. It is less likely to impede foetal descent D. All of the above

Description : Oxytocin is preferred over ergometrine for augmenting labour because: A. It has brief and titratable action B. It is less likely to cause foetal anoxia C. It is less likely to impede foetal descent D. All of the above

Last Answer : D. All of the above

The following drug is used to reduce the frequency of angina pectoris as well as to terminate an acute attack (a) Digoxin (b) Furosemide (c) Enalapril (d) Amrinone

Description : The following drug is used to reduce the frequency of angina pectoris as well as to terminate an acute attack (a) Digoxin (b) Furosemide (c) Enalapril (d) Amrinone

Last Answer : Ans: A

The following is applicable to itraconazole except: A. It has largely replaced ketoconazole for treatment of systemic mycosis B. It does not inhibit human steroid hormone synthesis C. It is preferred for the treatment of fungal meningitis D. It can interact with terfenadine to produce ventricular arrhythmias

Description : The following is applicable to itraconazole except: A. It has largely replaced ketoconazole for treatment of systemic mycosis B. It does not inhibit human steroid hormone synthesis C. It is ... the treatment of fungal meningitis D. It can interact with terfenadine to produce ventricular arrhythmias

Last Answer : C. It is preferred for the treatment of fungal meningitis

Quinidine can cause paradoxical tachycardia in a patient of (a) Stick sinus syndrome (b) Auricular extrasystoles (c) Auricular fibrillation (d) Ventricular extrasystoles

Description : Quinidine can cause paradoxical tachycardia in a patient of (a) Stick sinus syndrome (b) Auricular extrasystoles (c) Auricular fibrillation (d) Ventricular extrasystoles

Last Answer : Ans: C

Enhanced automaticity in cardiac cells may occur because of (a) ß-adrenergic stimulation (b) Hypokalemia (c) Mechanical stretch of cardiac muscles (d) All of the above

Description : Enhanced automaticity in cardiac cells may occur because of (a) ß-adrenergic stimulation (b) Hypokalemia (c) Mechanical stretch of cardiac muscles (d) All of the above

Last Answer : Ans: D

Because of proven beneficial effects on “cardiac remodeling”, these agents are now indicated as first line therapy in CHF patients. Which of the following is representative of this group of drugs? (a) Hydrochlorothiazide (b) Enalapril (c) Furosemide (d) Carvedilol (e) Bumetanide

Description : Because of proven beneficial effects on “cardiac remodeling”, these agents are now indicated as first line therapy in CHF patients. Which of the following is representative of this group of drugs? (a) Hydrochlorothiazide (b) Enalapril (c) Furosemide (d) Carvedilol (e) Bumetanide

Last Answer : Ans: B

Myocardial oxygen demand is increased by all of the following factors except (a) Exercise (b) Smoking (c) Cold temperatures (d) Isoproterenol (e) Propranolol

Description : Myocardial oxygen demand is increased by all of the following factors except (a) Exercise (b) Smoking (c) Cold temperatures (d) Isoproterenol (e) Propranolol

Last Answer : Ans: E

Which of the following cyclotron produced radiopharmaceuticals is used for assessing regional myocardial perfusion as part of an exercise stress test? (a) Thallous chloride 201TI USP (b) Sodium iodide 123I (c) Gallium citrate 67Ga USP (d) Indium 111In pentetate (e) Cobalt 57Co cyanocobalamin

Description : Which of the following cyclotron produced radiopharmaceuticals is used for assessing regional myocardial perfusion as part of an exercise stress test? (a) Thallous chloride 201TI USP (b) Sodium iodide 123I (c) Gallium citrate 67Ga USP (d) Indium 111In pentetate (e) Cobalt 57Co cyanocobalamin

Last Answer : Ans: A