What is significance of high unconjugated bilirubin?

What is significance of high unconjugated bilirubin?
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Unconjugated bilirubin in serum is soluble in (A) Water (B) Alkalis (C) Acids (D) Methanal

Description : Unconjugated bilirubin in serum is soluble in (A) Water (B) Alkalis (C) Acids (D) Methanal

Last Answer : Answer : D

A mixture of conjugated and unconjugated bilirubin is found in the circulation in (A) Hemolytic jaundice (B) Hepatic jaundice (C) Obstructive jaundice (D) Post hepatic jaundice

Description : A mixture of conjugated and unconjugated bilirubin is found in the circulation in (A) Hemolytic jaundice (B) Hepatic jaundice (C) Obstructive jaundice (D) Post hepatic jaundice

Last Answer : Answer : B

An increase in serum unconjugated bilirubin occurs in (A) Hemolytic jaundice (B) Obstructive jaundice (C) Nephritis (D) Glomerulonephritis

Description : An increase in serum unconjugated bilirubin occurs in (A) Hemolytic jaundice (B) Obstructive jaundice (C) Nephritis (D) Glomerulonephritis

Last Answer : Answer : A

The normal range of indirect (unconjugated) bilirubin in serum is (A) 0–0.1 mg/100 ml (B) 0.1–0.2 mg/100 ml (C) 0.2–0.7 mg/100 ml (D) 0.8–1.0 mg/100 ml

Description : The normal range of indirect (unconjugated) bilirubin in serum is (A) 0–0.1 mg/100 ml (B) 0.1–0.2 mg/100 ml (C) 0.2–0.7 mg/100 ml (D) 0.8–1.0 mg/100 ml

Last Answer : Answer : C

Markedly increased concentration responsible for kernicterus in hemolytic disease of the newborn. A A. Unconjugated bilirubin B. Conjugated bilirubin C. Both D. None of these

Description : Markedly increased concentration responsible for kernicterus in hemolytic disease of the newborn. A A. Unconjugated bilirubin B. Conjugated bilirubin C. Both D. None of these

Last Answer : Unconjugated bilirubin

Serum concentration is increased when destruction of erythrocytes is increased A A. Unconjugated bilirubin B. Conjugated bilirubin C. Both D. None of these

Description : Serum concentration is increased when destruction of erythrocytes is increased A A. Unconjugated bilirubin B. Conjugated bilirubin C. Both D. None of these

Last Answer : Unconjugated bilirubin

Unconjugated bilirubin is derived principally from: C A. glucuronyl transferase activity B. toxic liver injury C. breakdown of senescent red blood cells D. None of these

Description : Unconjugated bilirubin is derived principally from: C A. glucuronyl transferase activity B. toxic liver injury C. breakdown of senescent red blood cells D. None of these

Last Answer : breakdown of senescent red blood cells

Predominantly unconjugated hyperbilirubinemia is typical of: A A. intravascular hemolysis B. carcinoma of common bile ducts C. carcinoma of gall bladder D. None of these

Description : Predominantly unconjugated hyperbilirubinemia is typical of: A A. intravascular hemolysis B. carcinoma of common bile ducts C. carcinoma of gall bladder D. None of these

Last Answer : intravascular hemolysis

How much lower and how much higher than the normal range can Bilirubin be? See detail.

Description : How much lower and how much higher than the normal range can Bilirubin be? See detail.

Last Answer : I should add (too late for editing) “by how much higher or lower than the normal range can it be acceptable?

Where is bilirubin made ?

Description : Where is bilirubin made ?

Last Answer : Bilirubin is made in the liver.

What causes bilirubin to be released in human body ?

Description : What causes bilirubin to be released in human body ?

Last Answer : Bilirubin is excreted through human feces.

What makes bilirubin ?

Last Answer : : Bilirubin is made in the spleen.

Bilirubin and biliverdin are derived from

Description : Bilirubin and biliverdin are derived from

Last Answer : Bilirubin and biliverdin are derived from A. Globin B. Heam C. Iron D. Fat.

Bilirubin and Biliverdin are present in `:`

Description : Bilirubin and Biliverdin are present in `:`

Last Answer : Bilirubin and Biliverdin are present in `:` A. Pancreatic Juice B. Saliva C. Bile Juice D. Intestinal juice

Bilirubin - blood?

Description : Bilirubin - blood?

Last Answer : DefinitionBilirubin is a yellowish pigment found in bile, a fluid produced by the liver.This article discusses the laboratory test done to measure bilirubin in the blood. Total and direct bilirubin ... : Venipuncture.The laboratory specialist spins the blood in a machine called a centrifuge, which s

The Fe containing pigments is (A) Haematoidin (B) Bilirubin (C) Hemasiderin (D) Urobilinogen

Description : The Fe containing pigments is (A) Haematoidin (B) Bilirubin (C) Hemasiderin (D) Urobilinogen

Last Answer : Answer : C

Breakdown of 1gm haemoglobin produces (A) 20 mg of bilirubin (B) 35 mg of bilirubin (C) 50 mg of bilirubin (D) 70 mg of bilirubin

Description : Breakdown of 1gm haemoglobin produces (A) 20 mg of bilirubin (B) 35 mg of bilirubin (C) 50 mg of bilirubin (D) 70 mg of bilirubin

Last Answer : Answer : B

Excretion of conjugated bilirubin from liver cells into biliary canaliculi is defective in (A) Gilbert’s disease (B) Crigler-Najjar syndrome (C) Lucey-Driscoll syndrome (D) Rotor’s syndrome

Description : Excretion of conjugated bilirubin from liver cells into biliary canaliculi is defective in (A) Gilbert’s disease (B) Crigler-Najjar syndrome (C) Lucey-Driscoll syndrome (D) Rotor’s syndrome

Last Answer : Answer : D

Bilirubin UDP-glucuronyl transferase is absent from liver in (A) Crigler-Najjar syndrome, type I (B) Gilbert’s disease (C) Crigler-Najjar syndrome, type II (D) Rotor’s syndrome

Description : Bilirubin UDP-glucuronyl transferase is absent from liver in (A) Crigler-Najjar syndrome, type I (B) Gilbert’s disease (C) Crigler-Najjar syndrome, type II (D) Rotor’s syndrome

Last Answer : Answer : A

The active transport system for hepatic uptake of bilirubin is congenitally defective in (A) Gilbert’s disease (B) Crigler-Najjar syndrome (C) Rotor’s syndrome (D) Dubin-Johnson syndrome

Description : The active transport system for hepatic uptake of bilirubin is congenitally defective in (A) Gilbert’s disease (B) Crigler-Najjar syndrome (C) Rotor’s syndrome (D) Dubin-Johnson syndrome

Last Answer : Answer : A

If results of the serum bilirubin, serum ALP, LDH and AST determinations suggest obstructive jaundice, the best confirmatory test would be the estimation of (A) Serum ALT (B) Serum 5’ nucleotidase (C) Serum Pseudo cholinesterase (D) None of these

Description : If results of the serum bilirubin, serum ALP, LDH and AST determinations suggest obstructive jaundice, the best confirmatory test would be the estimation of (A) Serum ALT (B) Serum 5’ nucleotidase (C) Serum Pseudo cholinesterase (D) None of these

Last Answer : Answer : B

Biluveridin is converted to bilirubin by the process of (A) Oxidation (B) Reduction (C) Conjugation (D) Decarboxylation

Description : Biluveridin is converted to bilirubin by the process of (A) Oxidation (B) Reduction (C) Conjugation (D) Decarboxylation

Last Answer : Answer : B

In hemolytic jaundice, bilirubin in urine is (A) Usually absent (B) Usually present (C) Increased very much (D) Very low

Description : In hemolytic jaundice, bilirubin in urine is (A) Usually absent (B) Usually present (C) Increased very much (D) Very low

Last Answer : Answer : A

In obstructive jaundice, urinary bilirubin is (A) Absent (B) Increased (C) Present (D) Present in small amount

Description : In obstructive jaundice, urinary bilirubin is (A) Absent (B) Increased (C) Present (D) Present in small amount

Last Answer : Answer : B

In hemolytic jaundice, the urinary bilirubin is (A) Normal (B) Absent (C) More than normal (D) Small amount is present

Description : In hemolytic jaundice, the urinary bilirubin is (A) Normal (B) Absent (C) More than normal (D) Small amount is present

Last Answer : Answer : C

All the following statements about obstructive jaundice are true except (A) Prothrombin time may be prolonged due to impaired absorption of vitamin K (B) Serum alkaline phosphatase may be raised due to increased release of the enzyme from liver cells (C) Bile salts may enter systemic circulation due to biliary obstruction (D) There is no defect in conjugation of bilirubin

Description : All the following statements about obstructive jaundice are true except (A) Prothrombin time may be prolonged due to impaired absorption of vitamin K (B) Serum alkaline phosphatase may be raised ... systemic circulation due to biliary obstruction (D) There is no defect in conjugation of bilirubin

Last Answer : Answer : B

All the following statements about obstructive jaundice are true except (A) Conjugated bilirubin in serum is normal (B) Total bilirubin in serum is raised (C) Bile salts are present in urine (D) Serum alkaline phosphatase is raised

Description : All the following statements about obstructive jaundice are true except (A) Conjugated bilirubin in serum is normal (B) Total bilirubin in serum is raised (C) Bile salts are present in urine (D) Serum alkaline phosphatase is raised

Last Answer : Answer : A

The presence of bilirubin in the urine without urobilinogen suggests (A) Obstructive jaundice (B) Hemolytic jaundice (C) Pernicious anemia (D) Damage to the hepatic parenchyma

Description : The presence of bilirubin in the urine without urobilinogen suggests (A) Obstructive jaundice (B) Hemolytic jaundice (C) Pernicious anemia (D) Damage to the hepatic parenchyma

Last Answer : Answer : A

Increased urobilinogen in urine and absence of bilirubin in the urine suggests (A) Obstructive jaundice (B) Hemolytic jaundice (C) Viral hepatitis (D) Toxic jaundice

Description : Increased urobilinogen in urine and absence of bilirubin in the urine suggests (A) Obstructive jaundice (B) Hemolytic jaundice (C) Viral hepatitis (D) Toxic jaundice

Last Answer : Answer : A

One of the causes of hemolytic jaundice is (A) G-6 phosphatase deficiency (B) Increased conjugated bilirubin (C) Glucokinase deficiency (D) Phosphoglucomutase deficiency

Description : One of the causes of hemolytic jaundice is (A) G-6 phosphatase deficiency (B) Increased conjugated bilirubin (C) Glucokinase deficiency (D) Phosphoglucomutase deficiency

Last Answer : Answer : A

Jaundice is visible when serum bilirubin exceeds (A) 0.5 mg/100 ml (B) 0.8 mg/100 ml (C) 1 mg/100 ml (D) 2.4 mg/100 ml

Description : Jaundice is visible when serum bilirubin exceeds (A) 0.5 mg/100 ml (B) 0.8 mg/100 ml (C) 1 mg/100 ml (D) 2.4 mg/100 ml

Last Answer : Answer : C

The normal range of direct reacting (conjugated) serum bilirubin is (A) 0–0.1 mg/100 ml (B) 0.1–0.4 mg/100 ml (C) 0.4–06 mg/100 ml (D) 0.5–1 mg/100 ml

Description : The normal range of direct reacting (conjugated) serum bilirubin is (A) 0–0.1 mg/100 ml (B) 0.1–0.4 mg/100 ml (C) 0.4–06 mg/100 ml (D) 0.5–1 mg/100 ml

Last Answer : Answer : B

The normal range of total serum bilirubin is (A) 0.2–1.2 mg/100 ml (B) 1.5–1.8 mg/100 ml (C) 2.0–4.0 mg/100 ml (D) Above 7.0 mg/100 ml

Description : The normal range of total serum bilirubin is (A) 0.2–1.2 mg/100 ml (B) 1.5–1.8 mg/100 ml (C) 2.0–4.0 mg/100 ml (D) Above 7.0 mg/100 ml

Last Answer : Answer : A

The end product of amino acid nitrogen metabolism in uricotelic organisms (reptiles and birds) is (A) Bilirubin (B) Urea (C) Uric acid (D) Biliverdin

Description : The end product of amino acid nitrogen metabolism in uricotelic organisms (reptiles and birds) is (A) Bilirubin (B) Urea (C) Uric acid (D) Biliverdin

Last Answer : Answer : C

Which of the following concerning the conjugation of bilirubin is correct? 1) is catalysed by a glucuronyl transferase 2) occurs in the Kupfer cells of the liver 3) is increased by valproate 4) is inhibited by rifampicin 5) is impaired in Dubin-Johnson syndrome

Description : Which of the following concerning the conjugation of bilirubin is correct? 1) is catalysed by a glucuronyl transferase 2) occurs in the Kupfer cells of the liver 3) is increased by valproate 4) is inhibited by rifampicin 5) is impaired in Dubin-Johnson syndrome

Last Answer : Answers-1 b - Hepatocytes. c - Enzyme inhibitor. d - Enzyme inducer. e - Conjugation is OK but excretion from the hepatocyte into the bile is impaired. (Gilbert's syndrome ... bilirubinaemia. Dubin-Johnson syndrome - bilirubin can't Depart from the hepatocyte - conjugated bilirubinaemia.)

Which of the following is true of Gilbert's syndrome? 1) inheritance is autosomal recessive 2) serum conjugated bilirubin levels are elevated 3) serum bilirubin levels are decreased by fasting 4) serum bilirubin levels are decreased by liver enzyme inducers 5) there is bilirubinuria

Description : Which of the following is true of Gilbert's syndrome? 1) inheritance is autosomal recessive 2) serum conjugated bilirubin levels are elevated 3) serum bilirubin levels are decreased by fasting 4) serum bilirubin levels are decreased by liver enzyme inducers 5) there is bilirubinuria

Last Answer : Answers-4 Gilbert's syndrome is inherited in autosomal dominant fashion and affects 2-5% of the population. UDP glucuronyl transferase levels are reduced leading to an unconjugated hyperbilirubinaemia. ... the bilirubin is reabsorbed in the proximal tubule some bilirubin is detectable in the urine.

On average red blood cells live around 120 days. The spleen is the main organ where old red blood cells are destroyed. During the red blood cell destruction the heme groups turn into bilirubin and this substance is then captured by the liver and later excreted in the bowels as part of the bile.

Description : On average red blood cells live around 120 days. The spleen is the main organ where old red blood cells are destroyed. During the red blood cell destruction the heme groups turn into bilirubin and this substance is then captured by the liver and later excreted in the bowels as part of the bile.

Last Answer : What are the functions of the spleen?

Which one of the following tests would be most effective in ruling out the presence of active hepatocellular disease?A. Serum alanine aminotransferase (ALT) B. Serum total bilirubin C. cell surface markers D. None of these

Description : Which one of the following tests would be most effective in ruling out the presence of active hepatocellular disease? A. Serum alanine aminotransferase (ALT) B. Serum total bilirubin C. cell surface markers D. None of these

Last Answer : Serum alanine aminotransferase (ALT)

The blood - brain barrier: a. is permeable to bilirubin at birth b. is formed by the tight junctions between endothlial cells and the end feet processes of astrocytes c. is permeable to glucose d. all above

Description : The blood - brain barrier: a. is permeable to bilirubin at birth b. is formed by the tight junctions between endothlial cells and the end feet processes of astrocytes c. is permeable to glucose d. all above

Last Answer : all above

The blood - brain barrier: a. is permeable to bilirubin at birth b. is formed by the tight junctions between endothlial cells and the end feet processes of astrocytes c. is permeable to glucose d. all above

Description : The blood - brain barrier: a. is permeable to bilirubin at birth b. is formed by the tight junctions between endothlial cells and the end feet processes of astrocytes c. is permeable to glucose d. all above

Last Answer : all above

Breakdown product of haemoglobin is (a) bilirubin (b) iron (c) biliverdin (d) calcium.

Description : Breakdown product of haemoglobin is (a) bilirubin (b) iron (c) biliverdin (d) calcium.

Last Answer : b) iron

Which type of jaundice in adults is the result of increased destruction of red blood cells? a) Hemolytic Hemolytic jaundice results because, although the liver is functioning normally, it cannot excrete the bilirubin as quickly as it is formed.

Description : Which type of jaundice in adults is the result of increased destruction of red blood cells? a) Hemolytic Hemolytic jaundice results because, although the liver is functioning normally, it cannot ... is the result of liver disease. d) Non-obstructive Non-obstructive jaundice occurs with hepatitis.

Last Answer : a) Hemolytic Hemolytic jaundice results because, although the liver is functioning normally, it cannot excrete the bilirubin as quickly as it is formed.

Reviewing the laboratory findings of the client, the nurse would found which findings are elevated? 1. White blood cell count 2. Total serum bilirubin 3. Alkaline phosphate 4. Red blood cell count 5. Cholesterol 6. Serum amylase A. 1, 2, and 3 B. 2, 3, and 4 C. 3, 5, and 6 D. 1, 2, and 6

Description : Reviewing the laboratory findings of the client, the nurse would found which findings are elevated? 1. White blood cell count 2. Total serum bilirubin 3. Alkaline phosphate 4. Red blood cell count 5. Cholesterol 6. Serum amylase A. 1, 2, and 3 B. 2, 3, and 4 C. 3, 5, and 6 D. 1, 2, and 6

Last Answer : A. 1, 2, and 3

Menadione (vitamin K3) can produce kernicterus in neonates by: A. Inducing haemolysis B. Inhibiting glucuronidation of bilirubin C. Displacing plasma protein bound bilirubin D. Both ‘A’ and ‘B’ are correct

Description : Menadione (vitamin K3) can produce kernicterus in neonates by: A. Inducing haemolysis B. Inhibiting glucuronidation of bilirubin C. Displacing plasma protein bound bilirubin D. Both ‘A’ and ‘B’ are correct

Last Answer : D. Both ‘A’ and ‘B’ are correct

Oxidative product of bile pigment which is responsible for the colouration of faeces is : (a) Bilirubin (b) Biliverdin (c) Stercobili (d) None

Description : Oxidative product of bile pigment which is responsible for the colouration of faeces is : (a) Bilirubin (b) Biliverdin (c) Stercobili (d) None

Last Answer : (c) Stercobili