Write short note on i. Metafilter. ii. Additives used in tablet formulation.

Write short note on i. Metafilter. ii. Additives used in tablet formulation.
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1 Answer

Answer :

Metafilter:

Construction:

It consists of grooved, drainage rod on which a number of metallic ring are packed.

The rings are usually of stainless steel and have 0.8 mm outer thickness, 15 mm inside diameter & 22 mm outer diameter.

The rings have a number of semicircular projections on one surface and when they are packed on the rod, the opening between the rings about 0.2 mm.

Working:

The entire assembly is placed inside a pressure vessel, containing the liquid to be

filtered.

When vacuum is applied liquid will flow from outside to inside.

In this form a metafilter can only be used as strainer for coarse particle, but for

separation of fine particle a bed of suitable material kieselguhr is used.

In this way pack of ring act as a base on which the fine filtration medium is supported.

Diagram:

image
OR
Additives in tablet formulation:
1. Diluents: To increase the bulk e.g. Lactose, sucrose etc.
2. Disintegrates: To break the tablet e.g. Potato, maize, wheat starch etc.
3. Granulating agents:To make a cohesive mass e.g Starch paste,IPA etc.
4. Glidants: To improve the flow property e.g magnesium stearate &Talc
5. Lubricants: To reduce the friction e.g. Talc & magnesium stearate.
6. Binding agents: Keep tablet intact e.g. gum tragacanth, methyl cellulose etc.
7. Adsorbing agents: Prevent sticking e.g. Mg stearate, steraric acid etc.
8. Colors, flavors and sweetening agents: 
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