Define 'Incompatibility’. What is adjusted type of Incompatibility, explain with example.

Define 'Incompatibility’. What is adjusted type of Incompatibility, explain with
example.
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1 Answer

Answer :

Definition:
Incompatibility occurs as a result of two or more antagonistic substances & an undesirable
product is formed which may affect the safety, efficacy & appearance of the pharmaceutical
preparation.
Adjusted type of Incompatibility In this type of incompatibility, change in the
formulation is needed with a compound of equal therapeutic value
e.g. In the mixture of caffeine citrate and sodium salicylate, caffeine citrate is replaced with
caffeine.
Example (any one example)
Rx
Caffeine citrate …………… 1g
Sodium salicylate ………. 3g
Water …………………..…. 90ml
 Caffeine citrate is a mixture of equal weights of caffeine and citric acid. the citric
acid present in caffeine citrate reacts with sodium salicylate to liberate salicylic acid
which get precipitated as indiffusible solid . If caffeine is used instead of caffeine citrate
it forms a soluble complex with sodium salicylates. Hence substitute caffeine citrate
with half as much caffeine as that of caffeine citrate to form a clear mixture.
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