Description : The β3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins
Last Answer : A. Is not blocked by the conventional doses of propranolol
Description : The following is true of β-adrenergic blocker therapy in CHF: A. They are added to conventional therapy after cardiac compensation is restored B. They are indicated only in severe (NYHA class IV) heart failure C. They are to be used only at low doses D. All of the above
Last Answer : A. They are added to conventional therapy after cardiac compensation is restored
Description : The dopamine D2 receptor has the following feature: A. It is excitatory in nature B. It is negatively coupled to adenyl cyclase C. It is selectively blocked by bromocriptine D. It is not blocked by metoclopramide
Last Answer : B. It is negatively coupled to adenyl cyclase
Description : In a patient of hypertension, the dose of propranolol that normalized blood pressure, reduced resting heart rate to 50/min. Which of the following β blockers will be most suitable for him as an ... so that heart rate is not markedly reduced: A. Pindolol B. Celiprolol C. Bisoprolol D. Atenolol
Last Answer : A. Pindolol
Description : Choose the most suitable antihypertensive drug for a 45-year-old male company executive who has a travelling job. His blood pressure is 160/100 mm Hg, and he is a diabetic ... → rebound hypertension. Hydrochlorothiazide: May worsen diabetes; more likely to produce weakness, fatigue and impotenc
Last Answer : B. Enalapril
Description : Hyoscine differs from atropine in that it: A. Exerts depressant effects on the CNS at relatively low doses B. Exerts more potent effects on the heart than on the eye C. Is longer acting D. Has weaker antimotion sickness activity
Last Answer : A. Exerts depressant effects on the CNS at relatively low doses
Description : The insulin receptor is a: A. Ion channel regulating receptor B. Tyrosine protein kinase receptor C. G-protein coupled receptor D. None of the above
Last Answer : B. Tyrosine protein kinase receptor
Description : Which of the following is a G protein coupled receptor: A. Muscarinic cholinergic receptor B. Nicotinic cholinergic receptor C. Glucocorticoid receptor D. Insulin receptor
Last Answer : A. Muscarinic cholinergic receptor
Description : Receptors perform the following function/functions: A. Ligand recognition B. Signal transduction C. Both ligand recognition and signal transduction D. Disposal of agonists and antagonists
Last Answer : D. Disposal of agonists and antagonists
Description : The following 5-HT receptor is not a G protein coupled receptor: A. 5-HT1 B. 5-HT2 C. 5-HT3 D. 5-HT4
Last Answer : C. 5-HT3
Description : Beneficial effects of β-adrenoceptor blockers in CHF include the following except: A. Antagonism of ventricular wall stress enhancing action of sympathetic overactivity B. Antagonism ... Prevention of pathological remodeling of ventricular myocardium D. Prevention of dangerous cardiac arrhythmias
Last Answer : B. Antagonism of vasoconstriction due to sympathetic overactivity
Description : Adrenergic neurone blocking drugs: A. Block the action of adrenaline on neuronal α2 adrenoceptors B. Block both α and β adrenoceptor mediated effects of injected adrenaline C. Do not block any effect of injected adrenaline D. Do not block the effects of sympathetic nerve
Last Answer : C. Do not block any effect of injected adrenaline
Description : Adrenergic neurone blocking drugs: A. Block the action of adrenaline on neuronal α2 adrenoceptors B. Block both α and β adrenoceptor mediated effects of injected adrenaline C. Do not block any effect of injected adrenaline D. Do not block the effects of sympathetic nerve stimulation
Description : Fall in blood pressure caused by larger doses of histamine is blocked by: A. H1 antihistaminics alone B. H2 antagonists alone C. Combination of H1 and H2 antagonists D. None of the above
Last Answer : C. Combination of H1 and H2 antagonists
Description : ndapamide differs from other diuretics in that: A. It has selective antihypertensive action at doses which cause little diuresis B. It is a more efficacious antihypertensive C. Its antihypertensive action develops more rapidly D. All of the above
Last Answer : A. It has selective antihypertensive action at doses which cause little diuresis
Description : Hydralazine is a directly acting vasodilator, but is not used alone as an antihypertensive because: A. By itself, it is a low efficacy antihypertensive B. Effective doses cause marked ... mechanisms D. It primarily reduces systolic blood pressure with little effect on diastolic blood pressure
Last Answer : C. Tolerance to the antihypertensive action develops early due to counterregulatory mechanisms
Description : Labetalol differs from propranolol in that: A. It has additional α1 blocking property B. It is a selective β1 blocker C. It does not undergo first pass metabolism D. All of the above
Last Answer : A. It has additional α1 blocking property
Description : The GABAB receptor: A. Is an intrinsic ion channel containing receptor B. Mediates neuronal depolarization C. Is insensitive to blockade by bicuculline D. Regulates intracellular cAMP
Last Answer : C. Is insensitive to blockade by bicuculline
Description : Pentazocine differs from morphine in that: A. It is inactive by the oral route B. It does not produce physical dependence C. It has a lower ceiling of analgesic effect D. Its action is not blocked by naloxone
Last Answer : C. It has a lower ceiling of analgesic effec
Description : All of the following subserve as intracellular second messengers in receptor mediated signal transduction except: A. Cyclic AMP B. Inositol trisphosphate C. Diacyl glycerols D. G proteins
Last Answer : D. G proteins
Description : The preferred class of drugs for long term treatment of severe anxiety disorder with intermittent panic attacks is: A. Phenothiazine (chlorpromazine like) B. Azapirone (buspirone like) C. β-blocker (propranolol like) D. Selective serotonin reuptake inhibitor (sertraline like)
Last Answer : DD. Selective serotonin reuptake inhibitor (sertraline like)
Description : Select the correct statement about benzodiazepines (BZDs): A. All BZDs facilitate GABA mediated Cl¯ influx into neurones B. Different BZDs exert the same degrees of hypnotic, anxiolytic and anticonvulsant ... at all neuronal sites D. The muscle relaxant action of BZDs is not blocked by flumazenil
Last Answer : A. All BZDs facilitate GABA mediated Cl¯ influx into neurones
Description : Select the β adrenergic blocker that is primarily eliminated unchanged by renal excretion: A. Propranolol B. Metoprolol C. Esmolol D. Atenolol
Last Answer : D. Atenolol
Description : Select the β adrenergic blocker that is primarily eliminated unchanged by renal excretion: A. Propranolol B. Metoprolol C. Esmolol D. Atenolol Select the β adrenergic blocker that is primarily eliminated unchanged by renal excretion: A. Propranolol B. Metoprolol C. Esmolol D. Atenolol
Description : The mechanism of action of barbiturates differs from that of benzodiazepines in that they: A. Do not affect the GABA-benzodiazepine receptor-chloride channel complex B. Act as inverse agonists at the ... without affecting its life time D. Have both GABA-facilitatory as well as GABA-mimetic actions
Last Answer : D. Have both GABA-facilitatory as well as GABA-mimetic actions
Description : The following kinin action is mediated primarily by the kinin B1 receptor: A. Intestinal contraction B. Bronchoconstriction C. EDRF release and vasodilatation D. Production of Interleukin, TNFα and other inflammatory mediators
Last Answer : . Production of Interleukin, TNFα and other inflammatory mediators
Description : Sulbactam differs from clavulanic acid in that: A. It is not a progressive inhibitor of β-lactamase B. It does not inhibit β-lactamase produced by gram negative bacilli C. It is quantitatively more potent D. It per se inhibits N.gonorrhoeae
Last Answer : D. It per se inhibits N.gonorrhoeae
Description : Select the opioid analgesic which acts primarily through κ (kappa) opioid receptor: A. Pentazocine B. Methadone C. Buprenorphine D. Pethidine
Last Answer : A. Pentazocine
Description : Choose the correct statement about use of βadrenergic blockers in CHF: A. All β blockers are equally effective in CHF B. They are used as alternative to conventional therapy with ... dysfunction due to dilated cardiomyopathy D. They are indicated only in asymptomatic left ventricular dysfunction
Last Answer : C. They are most useful in mild to moderate cases with systolic dysfunction due to dilated cardiomyopathy
Description : Choose the correct statement(s) about pioglitazone: A. It acts as an agonist on nuclear paroxisome proliferator receptor γ B. It enhances transcription of insulin responsive genes C. It lowers blood sugar in type 2 diabetes mellitus without causing hyperinsulinemia D. All of the above
Last Answer : D. All of the above
Description : Hyoscine differs from atropine in that it (a) Exerts depressant effects on the CNS at relatively low doses (b) Exerts more potent effects on the heart than on the eye (c) Is longer acting (d) Has weaker antimotion sickness activity
Last Answer : Ans: A
Description : The following is a selective α2 adrenoceptor antagonist: A. Prazosin B. Phentolamine C. Yohimbine D. Clonidine
Last Answer : C. Yohimbine
Description : The following is a selective α 2 adrenoceptor antagonist: A. Prazosin B. Phentolamine C. Yohimbine D. Clonidine
Description : The following receptor type has 7 helical membrane spanning amino acid segments with 3 extracellular and 3 intracellular loops: A. Tyrosine protein kinase receptor B. Gene expression regulating receptor C. Intrinsic ion channel containing receptor D. G protein coupled receptor
Last Answer : D. G protein coupled receptor
Description : riiodothyronine differs from thyroxine in that: A. It is more avidly bound to plasma proteins B. It has a shorter plasma half life C. It is less potent D. It has a longer latency of action
Last Answer : B. It has a shorter plasma half life
Description : 17.2 Triiodothyronine differs from thyroxine in that: A. It is more avidly bound to plasma proteins B. It has a shorter plasma half life C. It is less potent D. It has a longer latency of action (
Description : The effect of propranolol on heart rate is least marked under the following condition: A. Physical exercise B. Rest C. Anxiety D. Sick sinus syndrome
Last Answer : B. Rest
Description : The following statement about histamine is not correct: A. It is the sole mediator of immediate hypersensitivity reaction B. It plays no role in delayed hypersensitivity reaction C. It serves as a neurotransmitter in the brain D. All types of histamine receptors are G protein coupled receptors
Last Answer : A. It is the sole mediator of immediate hypersensitivity reaction
Description : Agonist induced autophosphorylation, internalization and down regulation is a distinctive feature of: A. G-protein coupled receptors B. Intrinsic ion channel containing receptors C. Tyrosine protein kinase receptors D. Receptors regulating gene expression
Last Answer : C. Tyrosine protein kinase receptors
Description : Angiotensin converting enzyme inhibitors afford maximum protection against progression of heart failure when used: A. At the higher therapeutic dose range over long term B. At the maximum tolerated dose only till ... restored C. At low doses over long term D. At low doses along with diuretics/digoxi
Last Answer : A. At the higher therapeutic dose range over long term
Description : Fall in blood pressure caused by larger doses of histamine is blocked by (a) H1 antihistaminics alone (b) H2 ANTAgonists alone (c) Combination of H1 and H2 antagonists (d) None of the above
Last Answer : Ans: C
Description : A 40-year-old politician suffered from attacks of chest pain diagnosed as angina pectoris. He had a tense personality, resting heart rate was 96/min, blood pressure 170/104 mm Hg, but ... antihypertensive for initial therapy in his case: A. Nifedipine B. Hydrochlorothiazide C. Atenolol D. Methyldopa
Last Answer : C. Atenolol
Description : Which of the following statements regarding endothelial cells in acute inflammation are true? a. Endothelial cells are characterized by phenotypic homogeneity b. Specific patterns of receptor expression ... blood flow and leukocyte adhesion d. Endothelial cells may be capable of phagocytosis
Last Answer : Answer: b, c, d Endothelial cells are increasingly recognized to be phenotypically heterogeneous. Specific receptor molecules are expressed at various sites where they help to direct lymphocytes and ... rather, they possess the ability to direct and focus many aspects of an inflammatory event