The following statement about histamine is not correct: A. It is the sole mediator of immediate hypersensitivity reaction B. It plays no role in delayed hypersensitivity reaction C. It serves as a neurotransmitter in the brain D. All types of histamine receptors are G protein coupled receptors

The following statement about histamine is not correct: A. It is the sole mediator of immediate hypersensitivity reaction B. It plays no role in delayed hypersensitivity reaction C. It serves as a neurotransmitter in the brain D. All types of histamine receptors are G protein coupled receptors
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A. It is the sole mediator of immediate hypersensitivity reaction
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The following statement about histamine is not correct: A. It is the sole mediator of immediate hypersensitivity reaction B. It plays no role in delayed hypersensitivity reaction C. It serves as a neurotransmitter in the brain D. All types of histamine receptors are G protein coupled receptors

Description : The following statement about histamine is not correct: A. It is the sole mediator of immediate hypersensitivity reaction B. It plays no role in delayed hypersensitivity reaction C. It serves as a neurotransmitter in the brain D. All types of histamine receptors are G protein coupled receptors

Last Answer : A. It is the sole mediator of immediate hypersensitivity reaction

Histamine is involved as a mediator in the following pathological condition: A. Delayed hypersensitivity reaction B. Inflammation C. Carcinoid syndrome D. Variant angina

Description : Histamine is involved as a mediator in the following pathological condition: A. Delayed hypersensitivity reaction B. Inflammation C. Carcinoid syndrome D. Variant angina

Last Answer : B. Inflammation

Histamine is involved as a mediator in the following pathological condition: A. Delayed hypersensitivity reaction B. Inflammation C. Carcinoid syndrome D. Variant angina

Description : Histamine is involved as a mediator in the following pathological condition: A. Delayed hypersensitivity reaction B. Inflammation C. Carcinoid syndrome D. Variant angina

Last Answer : B. Inflammation

The following are true about cell-mediated immunity: a. antigen-specific function is the role of the T-lymphocytes b. cell-mediated immunity can activate the complement system c. it is responsible for the delayed hypersensitivity reaction. d. Gamma interferon is an important mediator of B-cell activation.

Description : The following are true about cell-mediated immunity: a. antigen-specific function is the role of the T-lymphocytes b. cell-mediated immunity can activate the complement system c. it is ... the delayed hypersensitivity reaction. d. Gamma interferon is an important mediator of B-cell activation.

Last Answer : cell-mediated immunity can activate the complement system

Agonist induced autophosphorylation, internalization and down regulation is a distinctive feature of: A. G-protein coupled receptors B. Intrinsic ion channel containing receptors C. Tyrosine protein kinase receptors D. Receptors regulating gene expression

Description : Agonist induced autophosphorylation, internalization and down regulation is a distinctive feature of: A. G-protein coupled receptors B. Intrinsic ion channel containing receptors C. Tyrosine protein kinase receptors D. Receptors regulating gene expression

Last Answer : C. Tyrosine protein kinase receptors

An intradermal penicillin sensitivity test has been performed on a patient and found to be negative. This indicates that: A. Penicillin antibodies are not present in his body B. He will not develop any reaction when full dose of penicillin is injected C. He will not develop anaphylactic reaction when full dose of penicillin is injected D. He is unlikely to develop immediate type of hypersensitivity reaction when full dose of penicillin is injected

Description : An intradermal penicillin sensitivity test has been performed on a patient and found to be negative. This indicates that: A. Penicillin antibodies are not present in his body B. He will ... He is unlikely to develop immediate type of hypersensitivity reaction when full dose of penicillin is injected

Last Answer : D. He is unlikely to develop immediate type of hypersensitivity reaction when full dose of penicillin is injected

a1 – receptors are coupled with _______ G protein. (a) Gs (b) Gi (c) Gq (d) Go

Description : a1 – receptors are coupled with _______ G protein. (a) Gs (b) Gi (c) Gq (d) Go

Last Answer : Ans: C

Which one of the following drugs does NOT act through G-Protein coupled receptors? (A) Epinephrine (B) Insulin (C) Dopamine (D) TSH

Description : Which one of the following drugs does NOT act through G-Protein coupled receptors? (A) Epinephrine (B) Insulin (C) Dopamine (D) TSH

Last Answer : (B) Insulin

Agonist induced autophosphorylation, internalization and down regulation is a distinctive feature of: A. G-protein coupled receptors B. Intrinsic ion channel containing receptors C. Tyrosine protein kinase receptors D. Receptors regulating gene expression

Description : Agonist induced autophosphorylation, internalization and down regulation is a distinctive feature of: A. G-protein coupled receptors B. Intrinsic ion channel containing receptors C. Tyrosine protein kinase receptors D. Receptors regulating gene expression

Last Answer : C. Tyrosine protein kinase receptors

The insulin receptor is a: A. Ion channel regulating receptor B. Tyrosine protein kinase receptor C. G-protein coupled receptor D. None of the above

Description : The insulin receptor is a: A. Ion channel regulating receptor B. Tyrosine protein kinase receptor C. G-protein coupled receptor D. None of the above

Last Answer : B. Tyrosine protein kinase receptor

Which of the following is a G protein coupled receptor: A. Muscarinic cholinergic receptor B. Nicotinic cholinergic receptor C. Glucocorticoid receptor D. Insulin receptor

Description : Which of the following is a G protein coupled receptor: A. Muscarinic cholinergic receptor B. Nicotinic cholinergic receptor C. Glucocorticoid receptor D. Insulin receptor

Last Answer : A. Muscarinic cholinergic receptor

The following receptor type has 7 helical membrane spanning amino acid segments with 3 extracellular and 3 intracellular loops: A. Tyrosine protein kinase receptor B. Gene expression regulating receptor C. Intrinsic ion channel containing receptor D. G protein coupled receptor

Description : Receptors perform the following function/functions: A. Ligand recognition B. Signal transduction C. Both ligand recognition and signal transduction D. Disposal of agonists and antagonists

Last Answer : D. Disposal of agonists and antagonists

The following 5-HT receptor is not a G protein coupled receptor: A. 5-HT1 B. 5-HT2 C. 5-HT3 D. 5-HT4

Description : The following 5-HT receptor is not a G protein coupled receptor: A. 5-HT1 B. 5-HT2 C. 5-HT3 D. 5-HT4

Last Answer : C. 5-HT3

Histamine H2 blockers attenuate the gastric secretory response to acetylcholine and pentagastrin as well because: A. H2 blockers block gastric mucosal cholinergic and gastrin receptors as well B. H2 blockers inhibit the proton pump in gastric mucosa C. Acetylcholine and gastrin act partly by releasing histamine in gastric mucosa D. Histamine, acetylcholine and gastrin all act through the phospholipase C-IP3:DAG pathway in gastric mucosa

Description : Histamine H2 blockers attenuate the gastric secretory response to acetylcholine and pentagastrin as well because: A. H2 blockers block gastric mucosal cholinergic and gastrin receptors as well B. H2 ... acetylcholine and gastrin all act through the phospholipase C-IP3:DAG pathway in gastric mucosa

Last Answer : C. Acetylcholine and gastrin act partly by releasing histamine in gastric mucosa

The neurotransmitter system in the brain most affected in Alzheimer’s disease is: A. Glutaminergic B. Gabaergic C. Dopaminergic D. Cholinergic

Description : The neurotransmitter system in the brain most affected in Alzheimer’s disease is: A. Glutaminergic B. Gabaergic C. Dopaminergic D. Cholinergic

Last Answer : D. Cholinergic

The most important reason for highly restricted use of penicillin G injections in present day therapeutics is its: A. Narrow spectrum of activity B. Potential to cause hypersensitivity reaction C. Short duration of action D. Neurotoxicity

Description : The most important reason for highly restricted use of penicillin G injections in present day therapeutics is its: A. Narrow spectrum of activity B. Potential to cause hypersensitivity reaction C. Short duration of action D. Neurotoxicity

Last Answer : B. Potential to cause hypersensitivity reaction

Which of the following statements concerning perioperative nutrition is true concerning the above-described patient? a. Since the patient’s weight had been stable with no preoperative nutritional deficit, 5% dextrose intravenous solutions are adequate for the initial postoperative source of nutrition b. Preoperative immunologic status should be determined including total peripheral lymphocyte count and delayed hypersensitivity reaction to determine skin-test response to common antigens c. Routine postoperative fluid administration with intravenous 5% glucose solutions can provide the calories to meet basal energy requirements d. A jejunal feeding catheter should be placed at the time of surgery for postoperative enteral feeding

Description : Which of the following statements concerning perioperative nutrition is true concerning the above-described patient? a. Since the patient's weight had been stable with no preoperative nutritional deficit ... feeding catheter should be placed at the time of surgery for postoperative enteral feeding

Last Answer : Answer: a Most patients undergoing elective operations are adequately nourished. Unless the patient has suffered significant preoperative malnutrition, characterized by weight loss greater than ... gastrointestinal surgery, this technique would not appear indicated in the patient described above

In which of the following cell mediated immunity (CMI) participates? A.Delayed hypersensitivity reaction B.Graft versus host reaction C.Allograft rejection D.All of the above

Description : In which of the following cell mediated immunity (CMI) participates? A.Delayed hypersensitivity reaction B.Graft versus host reaction C.Allograft rejection D.All of the above

Last Answer : D.All of the above

In which of the following cell mediated immunity (CMI) participates? A.Delayed hypersensitivity reaction B.Graft versus host reaction C.Allograft rejection D.All of the above

Description : In which of the following cell mediated immunity (CMI) participates? A.Delayed hypersensitivity reaction B.Graft versus host reaction C.Allograft rejection D.All of the above

Last Answer : .All of the above

Which of the following statements describes the clinical manifestations of a delayed hypersensitivity (type IV) allergic reaction to latex? a) Signs and symptoms are localized to the area of exposure, usually the back of the hands. Clinical manifestations of a delayed hypersensitivity reaction are localized to the area of exposure.

Description : Which of the following statements describes the clinical manifestations of a delayed hypersensitivity (type IV) allergic reaction to latex? a) Signs and symptoms are localized to the area of ... minutes after exposure to latex, an immediate hypersensitivity (type I) allergic reaction has occurred.

Last Answer : a) Signs and symptoms are localized to the area of exposure, usually the back of the hands. Clinical manifestations of a delayed hypersensitivity reaction are localized to the area of exposure.

Most hormone receptors are localized on the cell membrane and transduce hormone binding into altered levels of intracellular messengers. A limited number of intracellular receptors do exist. Which of the following statement(s) is/are true concerning intracellular receptors? a. The messengers or hormones must by lipophilic b. These intracellular receptors generally regulate protein synthesis c. The intracellular receptors are located entirely in the nucleus of the cell d. A heat-shock protein serves as an inhibitor protein blocking the DNA-binding domain of the steroid receptor

Description : Most hormone receptors are localized on the cell membrane and transduce hormone binding into altered levels of intracellular messengers. A limited number of intracellular receptors do exist. Which of ... protein serves as an inhibitor protein blocking the DNA-binding domain of the steroid receptor

Last Answer : Answer: a, d Although most hormone and other messenger receptors are extracellular, intracellular receptors have been identified. The hormone messengers involved for these receptors are primarily ... DNA-binding domain of the receptor. Activation involves the dissociation of the inhibitor protein

Histamine is involved as a mediator in the following pathological conditon (a) Cocaine (b) Dibucaine (c) Lidocaine (d) Procaine

Description : Histamine is involved as a mediator in the following pathological conditon (a) Cocaine (b) Dibucaine (c) Lidocaine (d) Procaine

Last Answer : Ans: B

Following is an example of preformed and not lipid derived mast cell mediator of inflammatory process (a) LTC4 (b) PGD2 (c) PAF (d) Histamine

Description : Following is an example of preformed and not lipid derived mast cell mediator of inflammatory process (a) LTC4 (b) PGD2 (c) PAF (d) Histamine

Last Answer : Ans: D

The most important preformed mediator of allergic reactions is/are a. Prostaglandin b. Interleukin c. Histamine d. Leukotrienes

Description : The most important preformed mediator of allergic reactions is/are a. Prostaglandin b. Interleukin c. Histamine d. Leukotrienes

Last Answer : c. Histamine

Choose the correct statement(s) about dofetilide: A. It is a pure class III antiarrhythmic B. It has no adrenergic/cholinergic receptor blocking property C. It selectively depresses the rapid component of delayed rectifier K+ current in myocardial fibres D. All of the above

Description : Choose the correct statement(s) about dofetilide: A. It is a pure class III antiarrhythmic B. It has no adrenergic/cholinergic receptor blocking property C. It selectively depresses the rapid component of delayed rectifier K+ current in myocardial fibres D. All of the above

Last Answer : D. All of the above

The distinctive feature(s) of methadone compared to morphine is/are: A. High oral bioavailability B. High plasma protein and tissue binding C. Delayed and milder withdrawal symptoms in dependent subjects D. All of the above

Description : The distinctive feature(s) of methadone compared to morphine is/are: A. High oral bioavailability B. High plasma protein and tissue binding C. Delayed and milder withdrawal symptoms in dependent subjects D. All of the above

Last Answer : D. All of the above

The β3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins

Description : The β3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins

Last Answer : A. Is not blocked by the conventional doses of propranolol

The β 3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins

Description : The β 3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins

Last Answer : A. Is not blocked by the conventional doses of propranolol

Immediate Allergy is what type of hypersensitivity reaction a) Type I Hypersensitivity b) Type II Hypersensitivity c) Type III Hypersensitivity d) Type IV Hypersensitivity e) Type V Hypersensitivity

Description : Immediate Allergy is what type of hypersensitivity reaction a) Type I Hypersensitivity b) Type II Hypersensitivity c) Type III Hypersensitivity d) Type IV Hypersensitivity e) Type V Hypersensitivity

Last Answer : Ans: A

An immunologically mediated reaction to a drug producing stereotyped symptoms unrelated to its pharmacodynamic actions is: A. Hypersensitivity B. Supersensitivity C. Intolerance D. Idiosyncrasy

Description : An immunologically mediated reaction to a drug producing stereotyped symptoms unrelated to its pharmacodynamic actions is: A. Hypersensitivity B. Supersensitivity C. Intolerance D. Idiosyncrasy

Last Answer : A. Hypersensitivity

Low doses of aspirin prolong bleeding time by selectively inhibiting synthesis of the following mediator in the platelets: A. Thromboxane A2 B. 5-Hydroxytryptamine C. Platelet activating factor D. Prostacyclin

Description : Low doses of aspirin prolong bleeding time by selectively inhibiting synthesis of the following mediator in the platelets: A. Thromboxane A2 B. 5-Hydroxytryptamine C. Platelet activating factor D. Prostacyclin

Last Answer : A. Thromboxane

With regard to the autonomic nervous system: a. the dorsal root ganglia is made up mainly of the cell bodies of the sympathetic nerves b. the preganglionic sympathetic fibres are usually longer than preganglionic parasympathetic fibres c. acetylcholine is the neurotransmitter at the ganglia of both sympathetic and parasympathetic nervous system d. botulin toxin blocks acetylcholine receptors

Description : With regard to the autonomic nervous system: a. the dorsal root ganglia is made up mainly of the cell bodies of the sympathetic nerves b. the preganglionic sympathetic fibres ... the ganglia of both sympathetic and parasympathetic nervous system d. botulin toxin blocks acetylcholine receptors

Last Answer : the dorsal root ganglia is made up mainly of the cell bodies of the sympathetic nerves

Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl noradrenaline which acts as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors

Description : Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl ... as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors

Last Answer : B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone

Neuromuscular blocking drugs do not produce central actions because: A. They do not cross the blood-brain barrier B. Nicotinic receptors are not present in the brain C. They are sequestrated in the periphery by tight binding to the skeletal muscles D. They do not ionise at the brain pH

Description : Neuromuscular blocking drugs do not produce central actions because: A. They do not cross the blood-brain barrier B. Nicotinic receptors are not present in the brain C. They are sequestrated in the periphery by tight binding to the skeletal muscles D. They do not ionise at the brain pH

Last Answer : A. They do not cross the blood-brain barrier

What is delayed hypersensitivity ?

Description : What is delayed hypersensitivity ?

Last Answer : We can recognize the Symptoms only days after exposure. This is delayed hypersensitivity (DTH).

In AIDS, the following abnormalities are seen: a. persistent lymphopenia b. decreased interleukin-2 production c. impaired delayed cutaneous hypersensitivity reactions d. all above

Description : In AIDS, the following abnormalities are seen: a. persistent lymphopenia b. decreased interleukin-2 production c. impaired delayed cutaneous hypersensitivity reactions d. all above

Last Answer : all above

Hashimoto disease and Graves‘ disease are similar in that both a. Affect the thyroid gland. b. Affect the red blood cells. c. Are forms of cellular hypersensitivity? d. Are accompanied by histamine release.

Description : Hashimoto disease and Graves‘ disease are similar in that both a. Affect the thyroid gland. b. Affect the red blood cells. c. Are forms of cellular hypersensitivity? d. Are accompanied by histamine release.

Last Answer : b. Affect the red blood cells.

During the course of a cellular hypersensitivity a. Antibodies react with antigens in tissues. b. Serotonin and histamine are released by cells. c. Immune complexes form on blood vessel surfacesd. A skin thickening called an induration may form..

Description : During the course of a cellular hypersensitivity a. Antibodies react with antigens in tissues. b. Serotonin and histamine are released by cells. c. Immune complexes form on blood vessel surfaces. d. A skin thickening called an induration may form.

Last Answer : b. Serotonin and histamine are released by cells.

The drug that can directly release histamine from mast cells without involving antigen-antibody reaction is: A. Aspirin B. Procaine C. Morphine D. Sulfadiazine

Description : The drug that can directly release histamine from mast cells without involving antigen-antibody reaction is: A. Aspirin B. Procaine C. Morphine D. Sulfadiazine

Last Answer : C. Morphine

The drug that can directly release histamine from mast cells without involving antigen-antibody reaction is: A. Aspirin B. Procaine C. Morphine D. Sulfadiazine

Description : The drug that can directly release histamine from mast cells without involving antigen-antibody reaction is: A. Aspirin B. Procaine C. Morphine D. Sulfadiazine

Last Answer : C. Morphine

Biological response modifiers like GM-CSF are used in conjunction with anticancer drugs for the following purpose(s): A. To enhance antitumour activity of the drug B. To prevent hypersensitivity reactions to the drug C. To hasten recovery from drug induced myelosuppression D. Both ‘A’ and ‘C’ are correct

Description : Biological response modifiers like GM-CSF are used in conjunction with anticancer drugs for the following purpose(s): A. To enhance antitumour activity of the drug B. To prevent hypersensitivity reactions to ... . To hasten recovery from drug induced myelosuppression D. Both A' and C' are correct

Last Answer : C. To hasten recovery from drug induced myelosuppressio

Angiotensin II plays a key role in the following risk factor for ischaemic heart disease: A. Hypercholesterolemia B. Ventricular hypertrophy C. Carbohydrate intolerance D. Cardiac arrhythmia

Description : Angiotensin II plays a key role in the following risk factor for ischaemic heart disease: A. Hypercholesterolemia B. Ventricular hypertrophy C. Carbohydrate intolerance D. Cardiac arrhythmia

Last Answer : B. Ventricular hypertrophy

Which of the following processes plays the major role in terminating the action of phenobarbitone: A. Biliary excretion B. Renal excretion C. Hepatic metabolism D. Redistribution

Description : Which of the following processes plays the major role in terminating the action of phenobarbitone: A. Biliary excretion B. Renal excretion C. Hepatic metabolism D. Redistribution

Last Answer : B. Renal excretion

How many types of histamine receptors are there and what are they ?

Description : How many types of histamine receptors are there and what are they ?

Last Answer : There are three types of histamine receptors. They are H1, H2 and H3.They has different tissue distributions.

Choose the correct statement about ticlopidine: A. It blocks GPIIb/IIIa receptors on platelet membrane B. It prevents ADP mediated platelet adenylylcyclase inhibition C. It inhibits thromboxane A2 synthesis in platelets D. It does not prolong bleeding time

Description : Choose the correct statement about ticlopidine: A. It blocks GPIIb/IIIa receptors on platelet membrane B. It prevents ADP mediated platelet adenylylcyclase inhibition C. It inhibits thromboxane A2 synthesis in platelets D. It does not prolong bleeding time

Last Answer : B. It prevents ADP mediated platelet adenylylcyclase inhibition

Select the correct statement about Naloxone: A. It equally blocks μ, κ and δ opioid receptors B. It blocks μ receptors at lower doses than those needed for others C. It blocks κ receptors at lower doses than those needed for others D. It blocks δ receptors at lower doses than those needed for others

Description : Select the correct statement about Naloxone: A. It equally blocks μ, κ and δ opioid receptors B. It blocks μ receptors at lower doses than those needed for others C. It blocks κ receptors at lower doses than those needed for others D. It blocks δ receptors at lower doses than those needed for others

Last Answer : B. It blocks μ receptors at lower doses than those needed for others

Choose the correct statement about lamotrigine: A. It is a dopaminergic agonist used in parkinsonism B. It acts by blocking NMDA-type of glutamate receptors C. It is a broad spectrum antiepileptic drug D. It suppresses tonic-clonic seizures, but worsens absence seizures

Description : Choose the correct statement about lamotrigine: A. It is a dopaminergic agonist used in parkinsonism B. It acts by blocking NMDA-type of glutamate receptors C. It is a broad spectrum antiepileptic drug D. It suppresses tonic-clonic seizures, but worsens absence seizures

Last Answer : C. It is a broad spectrum antiepileptic drug

A patient suffers a blow to his maxillary central incisor without resulting in fracture. The pulp may: A. Show immediate necrosis B. Become non-vital but only if treatment is delayed too long C. Become non vital irrespective of treatment D. No changes are seen later if fracture does not occur

Description : A patient suffers a blow to his maxillary central incisor without resulting in fracture. The pulp may: A. Show immediate necrosis B. Become non-vital but only if treatment is delayed too long C. Become non vital irrespective of treatment D. No changes are seen later if fracture does not occur

Last Answer : C. Become non vital irrespective of treatment

Which of the following statement(s) is/are true concerning cell membrane receptors? a. The largest family of cell surface receptors are the G-protein-linked receptors b. Activities of the G-protein involve binding and hydrolysis of ATP c. The G protein receptor generates an intracellular messenger commonly through the use adenylate cyclase d. Tyrosine kinase receptors are considered G-protein-linked receptors

Description : Which of the following statement(s) is/are true concerning cell membrane receptors? a. The largest family of cell surface receptors are the G-protein-linked receptors b. Activities of the ... through the use adenylate cyclase d. Tyrosine kinase receptors are considered G-protein-linked receptors

Last Answer : Answer: a, c All water-soluble regulatory molecules bind to the cell surface receptor proteins. Binding of the appropriate ligand evokes an intracellular signal which usually regulates ... are adenylate cyclase, which converts ATP to cAMP, and the polyphosphoinositide-specific phospholipase C