Description : The following class(es) of drugs are clinically beneficial in bronchial asthma: A. Histamine H1 receptor antagonists B. Platelet activating factor (PAF) antagonists C. Leukotriene ( cys LT1) receptor antagonists D. All of the above
Last Answer : C. Leukotriene ( cys LT1) receptor antagonists
Description : Choose the correct statement(s) about ipratropium bromide: A. It preferentially dilates peripheral bronchioles B. It produces additional bronchodilatation when added to nebulized salbutamol C. As metered dose inhaler it is used for terminating asthma attacks D. Both 'B' and 'C'
Last Answer : B. It produces additional bronchodilatation when added to nebulized salbutamol
Description : Which of the following is not the basis for subclassifying β adrenergic receptors into β1 and β2 : A. Selectivity of agonists B. Selectivity of antagonists C. Transducer pathway of response effectuation D. Organ selective location
Last Answer : C. Transducer pathway of response effectuation
Description : The most consistent, pronounced and sustained relief of symptoms in chronic bronchial asthma is afforded by: A. β2 sympathomimetics B. Anticholinergics C. Sodium cromoglycate D. Corticosteroids
Last Answer : D. Corticosteroids
Description : In patients of bronchial asthma inhaled corticosteroids achieve the following except (a) Reduce the need for bronchodilator medication (b) Control an attack of refractory asthma (c) Reduce bronchial hyperreactivity (d) Reverse diminished responsiveness to sympathomimetic bronchodilators
Last Answer : Ans: B
Description : In patients of bronchial asthma inhaled corticosteroids achieve the following except: A. Reduce the need for bronchodilator medication B. Control an attack of refractory asthma C. Reduce bronchial hyperreactivity D. Reverse diminished responsiveness to sympathomimetic bronchodilators
Last Answer : B. Control an attack of refractory asthma
Description : Inhaled salbutamol is useful in bronchial asthma for: A. Aborting/terminating asthma attacks B. Round the clock prophylaxis of asthma C. Status asthmaticus D. All of the above
Last Answer : A. Aborting/terminating asthma attacks
Description : In comparison to inhaled β 2 adrenergic agonists, the inhaled anticholinergics: A. Are more effective in bronchial asthma B. Are better suited for control of an acute attack of asthma C. Produce slower response in bronchial asthma D. Produce little benefit in chronic obstructive lung disease
Last Answer : C. Produce slower response in bronchial asthma
Description : Adrenergic β2 agonists produce muscle tremor by: A. Facilitating neuromuscular transmission B. Incomplete fusion of contractile response of individual fibres C. Enhanced firing of muscle spindles D. Both (b) and (c) are correct
Last Answer : D. Both (b) and (c) are correct
Description : The following statement is not true of log dose-response curve: A. It is almost linear except at the ends B. It is a rectangular hyperbola C. It facilitates comparison of different agonists D. It can help in discriminating between competitive and noncompetitive antagonists
Last Answer : B. It is a rectangular hyperbola
Description : Down regulation of receptors can occur as a consequence of: A. Continuous use of agonists B. Continuous use of antagonists C. Chronic use of CNS depressants D. Denervation
Last Answer : A. Continuous use of agonists
Description : Receptors perform the following function/functions: A. Ligand recognition B. Signal transduction C. Both ligand recognition and signal transduction D. Disposal of agonists and antagonists
Last Answer : C. Both ligand recognition and signal transduction
Description : The bladder trigone and prostatic muscles are relaxed by: A. Adrenergic α1 agonists B. Adrenergic α1 antagonists C. Adrenergic α2 agonists D. Adrenergic α2 antagonists
Last Answer : B. Adrenergic α1 antagonists
Description : Which of the following is not the basis for subclassifying β adrenergic receptors into β 1 and β 2: A. Selectivity of agonists B. Selectivity of antagonists C. Transducer pathway of response effectuation D. Organ selective location
Description : The most consistent, pronounced and sustained relief of symptoms in chronic bronchial asthma is afforded by (a) ß2 sympathomimetics (b) Anticholinergics (c) Sodium cromoglycate (d) Corticosteroids
Last Answer : Ans: D
Description : The following is true of multidrug therapy of leprosy except: A. It has been highly successful in paucibacillary but not in multibacillary cases B. Relapse rate is very low in both paucibacillary ... use once a month D. Prevalence of lepra reaction is not higher compared to dapsone monotherapy
Last Answer : A. It has been highly successful in paucibacillary but not in multibacillary cases
Description : A combination of two or more antiepileptic drugs is used: A. Routinely in all types of epilepsy B. In all cases of complex partial seizures C. In all cases of secondarily generalized seizures D. Only when monotherapy with first/second choice drugs fails
Last Answer : D. Only when monotherapy with first/second choice drugs fails
Description : Which of the following β 2 agonist bronchodilators is given by inhalation, and is suitable for both terminating asthma attacks as well as for twice daily prophylaxis: A. Terbutaline B. Bambuterol C. Salmeterol D. Formoterol
Last Answer : D. Formoterol
Description : In an asthma patient treated with systemic corticosteroids, bronchodilator drugs: A. Are not needed B. Are contraindicated C. May be used on ‘as and when required’ basis D. Are ineffective
Last Answer : C. May be used on ‘as and when required’ basis
Description : A patient of bronchial asthma maintained on theophylline developed upper respiratory tract infection. Which antimicrobial if used can increase the risk of developing theophylline toxicity: A. Ampicillin B. Cephalexin C. Cotrimoxazole D. Erythromycin
Last Answer : D. Erythromycin
Description : Use of morphine in the following category of patients does not carry any special risk: A. Ischaemic heart disease patients B. Bronchial asthma patients C. Elderly male patients D. Biliary colic patients
Last Answer : A. Ischaemic heart disease patients
Description : A patient of chronic bronchial asthma maintained on oral prednisolone 20 mg daily and inhaled salbutamol as required develops chest infection. Which of the following measures is recommended: A. ... mg/day C. No change/increase in prednisolone dose D. Substitute prednisolone with inhaled budesonid
Last Answer : C. No change/increase in prednisolone dose
Description : 6 A patient of chronic bronchial asthma was maintained on oral prednisolone 20 mg/day for 3 months. It was decided to switch him over to inhaled beclomethasone dipropionate 200 μg 4 times a day. What should ... week and then tapered D. Its dose should be doubled for one week and then tapered (p. 2
Last Answer : C. It should be given at the same dose for one week and then tapered
Description : Sodium cromoglycate has a role in the treatment of the following conditions except: A. Chronic bronchial asthma B. Chronic urticaria C. Chronic allergic rhinitis D. Chronic allergic conjunctivitis
Last Answer : B. Chronic urticaria
Description : Choose the correct statement about use of gold sod. thiomalate in rheumatoid arthritis: A. It affords more rapid symptomatic relief than NSAIDs B. The NSAIDs therapy is discontinued when it is ... D. It is used only in severe cases when other diseases modifying antirheumatic drugs have failed
Last Answer : D. It is used only in severe cases when other diseases modifying antirheumatic drugs have failed
Description : Leukotrienes: 1) Are formed from the cyclooxygenase pathway 2) Are synthesized by fibroblasts 3) Decrease vascular permeability 4) Leukotriene D4 has been identified as SRS-A which causes bronchial wall smooth muscle relaxation 5) Stimulate mucus secretion
Last Answer : Answers-5 Leukotrienes are synthesized by leucocytes.They are mediators of allergic reaction. They increase vascular permeability and attract neutrophils and eosinophils to inflammatory sites. ... stimulate mucus production, an important consideration in the pathophysiology of bronchial asthma.
Description : 15.47 The following component of management protocol of status asthmaticus has now been shown to be useless: A. Intravenous aminophylline B. Intravenous hydrocortisone C. Nebulized salbutamol D. Nebulized ipratropium bromid
Last Answer : ntravenous aminophylline
Description : The following statement about lithium is not correct: A. It has a sedative action in normal individuals B. It controls mania, but takes 1-2 weeks to produce the effect C. ... recurrent unipolar depression D. It can be combined with tricyclic antidepressants for refractory cases of major depression
Last Answer : A. It has a sedative action in normal individuals
Description : 4 Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas: A. They are used to control diarrhoea irrespective of its etiology B. They should ... antimicrobial therapy of diarrhoea D. They are the drugs of choice in irritable bowel syndrome diarrhoea
Last Answer : B. They should be used only as a short-term measure after ensuring that enteroinvasive organisms are not involved
Description : Currently, monotherapy with zidovudine is recommended for: A. Asymptomatic HIV positive subjects with CD4 cell count more than 200/μl B. Asymptomatic HIV positive subjects with CD4 cell count less than 200/μl C. HIV positive subjects with opportunistic infection D. None of the above
Last Answer : D. None of the above
Description : Currently, monotherapy of leprosy with dapsone is recommended for: A. Paucibacillary leprosy only B. Multibacillary leprosy only C. Both paucibacillary and multibacillary leprosy D. Neither paucibacillary nor multibacillary leprosy
Last Answer : D. Neither paucibacillary nor multibacillary leprosy
Description : Combination therapy with two (or more) antimicrobials is superior to monotherapy with any single effective drug in case of the following diseases except: A. Typhoid fever B. Leprosy C. AIDS D. Subacute bacterial endocarditis
Last Answer : A. Typhoid fever
Description : Lugol’s iodine is used in hyperthyroidism: A. As long term definitive monotherapy B. Preoperatively for 10-15 days C. Postoperatively for 10-15 days D. As adjuvant to carbimazole for long term therap
Last Answer : B. Preoperatively for 10-15 days
Description : Select the correct statement in relation to drug therapy of migraine: A. Simple analgesics like paracetamol are ineffective in migraine B. Ergot alkaloids are used for prophylaxis as well as treatment ... resistant cases D. Ergot alkaloids should be given till 24 hours after an attack has subsided
Last Answer : C. Use of ergot alkaloids is restricted to severe or resistant cases
Description : A 16-year-old-girl is found to have paroxysmal attacks of rapid heart rate. The antiarrhythmic of choice in most cases of acute AV nodal tachycardia is (a) Adenosine (b) Amiodarone (c) Flecainide (d) Propranolol (e) Quinidine
Last Answer : Ans: A
Description : Which of the following terms best describes the antagonism of leukotriene's bronchoconstrictor effect (mediated at leukotriene receptors) by terbutaline (acting a adrenoceptors) in a patient with ... ) Partial agonist (c) Physiologic antagonist (d) Chemical antagonist (e) Noncompetitive antagonist
Last Answer : Ans: C
Description : The following eicosanoid is generated through the lipoxygenase pathway: A. Prostaglandin E2 B. Thromboxane A2 C. Leukotriene C4 D. Prostacyclin
Last Answer : C. Leukotriene C4
Description : ystemic corticosteroid therapy is not used routinely and is reserved only for severe cases of: A. Exfoliative dermatitis B. Posterior uveitis C. Acute rheumatic fever D. Hodgkin’s disease
Last Answer : C. Acute rheumatic feve
Description : In an asthma patient treated with systemic corticosteroids, bronchodilator drugs (a) Are not needed (b) Are contraindicated (c) May be used on ‘as and when required’ basis (d) Are ineffective
Description : The National Institutes of Health (NIH) guidelines for the treatment of asthma recommended institution of routine inhaled corticosteroids when patients are classified as having greater than or equal to which ... (a) Mild intermittent (b) Mild persistent (c) Moderate persistent (d) Severe persistent
Description : Systemic corticosteroids are indicated in the following conditions except: A. Mild episodic asthma B. Severe chronic asthma C. Status asthmaticus D. To prevent neonatal respiratory distress syndrome
Last Answer : A. Mild episodic asthma
Description : In the intact animal H2 receptor antagonists potentiate the following action of histamine: A. Cardiac stimulation B. Fall in blood pressure C. Uterine relaxation D. Bronchospasm
Last Answer : D. Bronchospasm
Description : Clinically, the angiotensin antagonists share the following features of angiotensin converting enzyme inhibitors except: A. Antihypertensive efficacy B. Potential to reverse left ventricular hypertrophy ... of effect on carbohydrate tolerance D. Potential to induce cough in susceptible individuals
Last Answer : D. Potential to induce cough in susceptible individuals
Description : The following are pure opioid antagonists except: A. Nalmfene B. Nalbuphine C. Naloxone D. Naltrexone
Last Answer : B. Nalbuphine
Description : Fall in blood pressure caused by larger doses of histamine is blocked by: A. H1 antihistaminics alone B. H2 antagonists alone C. Combination of H1 and H2 antagonists D. None of the above
Last Answer : C. Combination of H1 and H2 antagonists