The following is true of multidrug therapy of leprosy
except:
A. It has been highly successful in paucibacillary but not in multibacillary cases
B. Relapse rate is very low in both paucibacillary and multibacillary cases
C. No resistance to rifampin develops despite
its use once a month
D. Prevalence of lepra reaction is not higher
compared to dapsone monotherapy

1 Answer

Answer :

A. It has been highly successful in paucibacillary but not in multibacillary cases

Related questions

Description : If a multibacillary leprosy patient treated with standard fixed duration multidrug therapy relapses, he should be treated with: A. The same rifampin + dapsone + clofazimine regimen B. ... + minocycline C. Clofazimine + ofloxacin + clarithromycin D. Ofloxacin + minocycline + clarithromycin

Last Answer : . The same rifampin + dapsone + clofazimine regimen

Description : Multidrug therapy with dapsone + rifampin ± clofazimine is the treatment of choice for: A. Multibacillary leprosy B. Paucibacillary leprosy C. Dapsone resistant leprosy D. All forms of leprosy

Last Answer : D. All forms of leprosy

Description : Currently, monotherapy of leprosy with dapsone is recommended for: A. Paucibacillary leprosy only B. Multibacillary leprosy only C. Both paucibacillary and multibacillary leprosy D. Neither paucibacillary nor multibacillary leprosy

Last Answer : D. Neither paucibacillary nor multibacillary leprosy

Description : he multidrug therapy of leprosy is superior to monotherapy on the following account(s): A. It prevents emergence of dapsone resistance B. It is effective in cases with primary dapsone resistance C. It shortens the total duration of drug therapy and improves compliance D. All of the above

Last Answer : D. All of the above

Description : Currently, under the mass programme (WHO/NLEP), the duration of multidrug therapy for multibacillary leprosy is: A. Two years fixed duration for all cases B. One year fixed duration for all cases C. ... for cases with bacillary index 3 or less and two years for cases with bacillary index 4 or more

Last Answer : B. One year fixed duration for all cases

Description : Which antileprotic drug suppresses lepra reaction and reversal reaction as well: A. Dapsone B. Rifampin C. Clofazimine D. Minocycline

Last Answer : C. Clofazimine

Description : A single dose rifampin + ofloxacin + minocycline treatment has been recommended for: A. All cases of paucibacillary leprosy B. All relapse cases of paucibacillary leprosy C. Single skin lesion paucibacillary leprosy D. None of the above

Last Answer : C. Single skin lesion paucibacillary leprosy

Description : Combination therapy with two (or more) antimicrobials is superior to monotherapy with any single effective drug in case of the following diseases except: A. Typhoid fever B. Leprosy C. AIDS D. Subacute bacterial endocarditis

Last Answer : A. Typhoid fever

Description : In the multidrug therapy of leprosy, rifampicin is given: A. Daily B. On alternate days C. Weekly D. Monthly

Last Answer : D. Monthly

Description : Multidrug resistant (MDR) tuberculosis is defined as resistance to: A. Any two or more antitubercular drugs B. Isoniazid + any other antitubercular drug C. Isoniazid + Rifampin + any one or more antitubercular drugs D. All five first line antitubercular drugs

Last Answer : C. Isoniazid + Rifampin + any one or more antitubercular drugs

Description : Which fluoroquinolone is highly active against Mycobact. leprae and is being used in alternative multidrug therapy regimens: A. Norfloxacin B. Ofloxacin C. Ciprofloxacin D. Lomefloxacin

Last Answer : B. Ofloxacin

Description : The following is true of anti-H.pylori therapy except: A. It is indicated in all patients of peptic ulcer B. Resistance to any single antimicrobial drug develops rapidly C. Concurrent ... efficacy of the regimen D. Colloidal bismuth directly inhibits H.pylori but has poor patient acceptability

Last Answer : A. It is indicated in all patients of peptic ulcer

Description : Chloroquine is indicated in the following disorders except: A. Rheumatic fever B. Discoid lupus erythematosus C. Photogenic skin reactions D. Lepra reaction

Last Answer : B. Discoid lupus erythematosus

Description : Under the WHO guidelines for treatment of new cases of tuberculosis, when isoniazid + ethambutol are used in the continuation phase instead of isoniazid + rifampin,, the duration of this phase is: A. 2 months B. 4 months C. 6 months D. 8 month

Last Answer : C. 6 months

Description : Clarithromycin is used for the following: A. Multidrug resistant M.tuberculosis infection B. M.avium complex infection in AIDS patient C. M.tuberculosis infection in a patient who develops jaundice due to first line antitubercular drugs D. Both ‘A’ and ‘B’ are correct

Last Answer : B. M.avium complex infection in AIDS patient

Description : As per WHO guidelines, treatment of failure or relapse (category II) patients of smear positive pulmonary tuberculosis differs from that of new cases in the following respect(s): A. All 5 first line antitubercular drugs ... are given in the continuation phase instead of two (HR) D. Both 'A' and 'C'

Last Answer : D. Both 'A' and 'C'

Description : A combination of two or more antiepileptic drugs is used: A. Routinely in all types of epilepsy B. In all cases of complex partial seizures C. In all cases of secondarily generalized seizures D. Only when monotherapy with first/second choice drugs fails

Last Answer : D. Only when monotherapy with first/second choice drugs fails

Description : Leukotriene antagonists are used in bronchial asthma: A. For terminating acute attacks B. As monotherapy in place of β2 agonists C. As adjuvants to β2 agonists for avoiding corticosteroids D. As nebulized powder in refractory cases

Last Answer : C. As adjuvants to β2 agonists for avoiding corticosteroids

Description : Use of artemisinin derivatives is restricted to treatment of multidrug resistant falciparum malaria because: A. Wide spread use for all cases of malaria may foster development of resistant strains B. They are not ... P.vivax C. They are more toxic than quinine D. All of the above are correct

Last Answer : A. Wide spread use for all cases of malaria may foster development of resistant strain

Description : Addition of pyrazinamide and ethambutol for the first two months to the isoniazid + rifampin therapy of tuberculosis serves the following purpose(s): A. Reduces the total duration of therapy to 6 months B. ... sputum conversion C. Permits reduction of rifampin dose D. Both A' and B' are correct

Last Answer : D. Both ‘A’ and ‘B’ are correc

Description : ifampin + pyrazinamide for initial 2 months followed by isoniazid + rifampin for another 4 months for the following category of tubercular patients: A. New sputum positive cases of ... pulmonary tuberculosis who have interrupted treatment for more than 2 months D. Tubercular meningitis patients

Last Answer : B. New sputum negative cases of pulmonary tuberculosis

Description : According to the current WHO guidelines, new (untreated) sputum smear positive cases of pulmonary tuberculosis are to be treated with the following regimen: A. Isoniazid + Rifampin + Pyrazinamide ... D. Isoniazid + Rifampin for 6 months with additional Pyrazinamide during the initial 2 months

Last Answer : C. Isoniazid + Rifampin for 6 months with additional Pyrazinamide + Ethambutol/Streptomycin during the initial 2 months

Description : The most important mechanism of concurrent acquisition of multidrug resistance among bacteria is: A. Mutation B. Conjugation C. Transduction D. Transformation

Last Answer : B. Conjugation

Description : The following apply to use of spironolactone in CHF except: A. It is indicated only in NYHA class III/IV cases as additional drug to conventional therapy B. It affords prognostic benefit in ... by ACE inhibitors C. It helps overcome refractoriness to diuretics D. It affords rapid symptomatic relief

Last Answer : D. It affords rapid symptomatic relief

Description : The following statement is true about misoprostol: A. It relieves peptic ulcer pain, but does not promote ulcer healing B. It heals nonsteroidal antiinflammatory drug induced gastric ulcer not responding ... side effects than H2 blockers D. It is the most effective drug for preventing ulcer relapse

Last Answer : B. It heals nonsteroidal antiinflammatory drug induced gastric ulcer not responding to H2 blockers

Description : Occurrence of the following adverse reaction absolutely contraindicates further use of rifampin in the treatment of tuberculosis: A. Respiratory syndrome B. Cutaneous syndrome C. Flu syndrome D. Abdominal syndrome

Last Answer : A. Respiratory syndrome

Description : Eradication of H.pylori along with gastric antisecretory drugs affords the following benefit(s): A. Faster relief of ulcer pain B. Faster ulcer healing C. Reduced chance of ulcer relapse D. Both ‘B’ and ‘C’ are correct

Last Answer : D. Both ‘B’ and ‘C’ are correct

Description : The intermittently multiplying (spurter) tubercle bacilli present within caseous material having low oxygen tension are most susceptible to: A. Ethambutol B. Rifampin C. Streptomycin D. Pyrazinamide

Last Answer : B. Rifampin

Description : Currently, monotherapy with zidovudine is recommended for: A. Asymptomatic HIV positive subjects with CD4 cell count more than 200/μl B. Asymptomatic HIV positive subjects with CD4 cell count less than 200/μl C. HIV positive subjects with opportunistic infection D. None of the above

Last Answer : D. None of the above

Description : Lugol’s iodine is used in hyperthyroidism: A. As long term definitive monotherapy B. Preoperatively for 10-15 days C. Postoperatively for 10-15 days D. As adjuvant to carbimazole for long term therap

Last Answer : B. Preoperatively for 10-15 days

Description : The most important dose dependent toxicity of dapsone is: A. Methemoglobinemia B. Haemolysis C. Hepatitis D. Dermatitis

Last Answer : B. Haemolysi

Description : The principles of antihypertensive drug usage enunciated in JNC VI and WHO-ISH guidelines include the following except: A. Therapy for grade I and II hypertension should be initiated with a single drug ... initially fails to lower BP, it should be replaced by a drug/combination from another class

Last Answer : C. All subjects with BP higher than 140/90 mmHg should be put on antihypertensive medication immediately

Description : Propranolol is used in hyperthyroidism: A. As short-term symptomatic therapy till effect of carbimazole develops B. As long-term therapy after subtotal thyroidectomy C. In patients not responding to carbimazole D. To potentiate the effect of radioactive iodine

Last Answer : A. As short-term symptomatic therapy till effect of carbimazole develops

Description : A patient of vivax malaria was treated with the standard dose of chloroquine. After 6 weeks he reported back with a relapse. Which drug will you use to treat the relapse episode: A. Chloroquine B. Primaquine C. Pyrimethamine + sulfadoxine D. Mefloquin

Last Answer : A. Chloroquine

Description : Select the option that is most nearly OPPOSITE in meaning to the word in BOLD. The heart operation was successful, but complications prolonged his convalescence. (a) Insult (b) Relapse (c) Apologetic (d) Calm

Last Answer : (b) Relapse

Description : The preferred regimen for preventing duodenal ulcer relapse is: A. Maintenance antacid regimen B. Maintenance H2 blocker regimen C. On demand intermittent H2 blocker regimen D. Maintenance sucralfate regimen

Last Answer : B. Maintenance H2 blocker regimen

Description : In peptic ulcer, antacids are now primarily used for: A. Prompt pain relief B. Ulcer healing C. Preventing ulcer relapse D. Control of bleeding from the ulcer

Last Answer : A. Prompt pain relief

Description : Which of NH3 and HCl has higher prevalence rate and why ?

Last Answer : By the rate of diffusion of an object, we mean how much the object has spread through any medium at any given time. The lower the density of an object, the lower the molecular mass, the higher the rate of diffusion ... ( 36.5) is high. Thus the rate of diffusion of NH 3 is higher than that of HCl .

Description : The following is true of heparin except: A. Sudden stoppage of continuous heparin therapy causes rebound increase in blood coagulability B. High doses of heparin inhibit platelet aggregation ... active circulating anticoagulant D. Heparin clears lipemic plasma in vivo but not in vitro

Last Answer : C. Heparin is the physiologically active circulating anticoagulant

Description : Benefits of tamoxifen citrate therapy include the following except: A. Reduction in recurrence rate of breast cancer B. Improved bone mass C. Suppression of menopausal hot flushes D. Improved lipid profile

Last Answer : C. Suppression of menopausal hot flushes

Description : The following is true of levamisole except: A. A single dose cures over 90% cases of round worm infestation B. It is more effective against Necator americanus than against Ancylostoma duodenale C. It has immunomodulating action D. Its prolonged use causes severe reactions

Last Answer : B. It is more effective against Necator americanus than against Ancylostoma duodenale

Description : The following is true of procainamide except: A. It generates an active metabolite in the body B. Its plasma half-life is longer than that of quinidine C. On long-term use, it ... erythematosus like illness D. It is effective in many cases of ventricular extrasystoles, not responding to lignocaine

Last Answer : A. Disopyramide

Description : The following is true of cyclophosphamide except: A. It is highly reactive and a vesicant on contact B. It is a prodrug C. It has marked immunosuppressant property D. It frequently causes alopecia and cystitis

Last Answer : A. It is highly reactive and a vesicant on contac

Description : Choose the correct statement about rifampin: A. It is the most active drug on slow growing tubercle bacilli B. Its antitubercular efficacy is lower than that of isoniazid C. It is active against many atypical mycobacteria D. It does not effectively cross blood-CSF barrier

Last Answer : C. It is active against many atypical mycobacteria

Description : Concurrent use of an aminoglycoside antibiotic should be avoided with the following antibiotic: A. Ampicillin B. Vancomycin C. Ciprofloxacin D. Rifampin

Last Answer : B. Vancomycin

Description : The following is true of cancer chemotherapy: A. Anticancer drugs increase the risk of developing leukaemias and lymphomas several years later B. All anticancer drugs are highly emetogenic C. Growth fraction of ... than any nomral tissue of the body Aim4aiims.in D. All of the above are correct

Last Answer : A. Anticancer drugs increase the risk of developing leukaemias and lymphomas several years later

Description : Mycobact. tuberculosis infection in a HIV infected patient is treated with: A. The same antitubercular regimen as HIV negative patient B. Four first line antitubercular drugs for 2 months followed ... line antitubercular drugs for 9 months D. Clarithromycin + Ciprofloxacin + Rifabutin for 12 months

Last Answer : B. Four first line antitubercular drugs for 2 months followed by a longer continuation phase of 7 months with rifampin + isoniazid

Description : Indicate the second line antitubercular drug that is being preferred to supplement ethambutol + streptomycin in case of hepatotoxicity due to isoniazid/ rifampin/pyrazinamide: A. Ethionamide B. Cycloserine C. Ofloxacin D. Capreomycin

Last Answer : C. Ofloxacin

Description : Which first line antitubercular drug is only tuberculostatic and not tuberculocidal: A. Rifampin B. Isoniazid C. Ethambutol D. Pyrazinamide

Last Answer : C. Ethambutol

Description : Rifampin kills tubercle bacilli by: A. Binding to mycobacterial DNA dependent RNA polymerase B. Inhibiting mycobacterial DNA synthesis C. Inhibiting synthesis of mycolic acids in mycobacteria D. Damaging mycobacterial mitochondria

Last Answer : A. Binding to mycobacterial DNA dependent RNA polymerase