Description : Adrenergic β2 agonists produce muscle tremor by: A. Facilitating neuromuscular transmission B. Incomplete fusion of contractile response of individual fibres C. Enhanced firing of muscle spindles D. Both (b) and (c) are correct
Last Answer : D. Both (b) and (c) are correct
Description : Which of the following is not the basis for subclassifying β adrenergic receptors into β1 and β2 : A. Selectivity of agonists B. Selectivity of antagonists C. Transducer pathway of response effectuation D. Organ selective location
Last Answer : C. Transducer pathway of response effectuation
Description : Which of the following is not the basis for subclassifying β adrenergic receptors into β 1 and β 2: A. Selectivity of agonists B. Selectivity of antagonists C. Transducer pathway of response effectuation D. Organ selective location
Description : Leukotriene antagonists are used in bronchial asthma: A. For terminating acute attacks B. As monotherapy in place of β2 agonists C. As adjuvants to β2 agonists for avoiding corticosteroids D. As nebulized powder in refractory cases
Last Answer : C. As adjuvants to β2 agonists for avoiding corticosteroids
Description : In comparison to inhaled β 2 adrenergic agonists, the inhaled anticholinergics: A. Are more effective in bronchial asthma B. Are better suited for control of an acute attack of asthma C. Produce slower response in bronchial asthma D. Produce little benefit in chronic obstructive lung disease
Last Answer : C. Produce slower response in bronchial asthma
Description : The muscle spindles: a. are extrafusal fibres b. are innervated by type Ia and II fibres c. received motor innervation from the gamma fibres. d. respond to tension in the muscle
Last Answer : are innervated by type Ia and II fibres
Description : Insulin release from pancreatic β cells is augmented by the following except: A. Ketone bodies B. Glucagon C. Vagal stimulation D. Alfa adrenergic agonists
Last Answer : D. Alfa adrenergic agonist
Description : Currently, the first choice drug for open angle glaucoma is: A. Miotic eye drops B. Ocular α2 adrenergic agonists C. Ocular prostaglandin analogues D. Ocular β adrenergic blockers
Last Answer : D. Ocular β adrenergic blockers
Description : The bladder trigone and prostatic muscles are relaxed by: A. Adrenergic α1 agonists B. Adrenergic α1 antagonists C. Adrenergic α2 agonists D. Adrenergic α2 antagonists
Last Answer : B. Adrenergic α1 antagonists
Description : Choose the correct statement(s) about dofetilide: A. It is a pure class III antiarrhythmic B. It has no adrenergic/cholinergic receptor blocking property C. It selectively depresses the rapid component of delayed rectifier K+ current in myocardial fibres D. All of the above
Last Answer : D. All of the above
Description : CHOOSE THE MOST APPROPRIATE RESPONSE 23.1 Which of the following drugs is a nondepolarizing neuromuscular blocker: A. Succinylcholine B. Vecuronium C. Decamethonium D. Dantrolene sodium
Last Answer : B. Vecuronium
Description : ostoperative muscle soreness may be a side effect of the following neuromuscular blocker: A. d-tubocurarine B. Succinylcholine C. Pancuronium D. Atracurium
Last Answer : B. Succinylcholine
Description : Depolarizing neuromuscular blockers differ from competitive blockers in the following attributes except: A. They induce contraction of isolated frog rectus abdominis muscle B. Ether anaesthesia ... produces well sustained contraction D. Neostigmine does not reverse block produced by them
Last Answer : B. Ether anaesthesia intensifies block produced by them
Description : In parkinsonian patients levodopa exerts the following effects except: A. Reduces skeletal muscle contractility B. Decreases muscle tone C. Increases locomotor activity D. Inhibits muscle tremor
Last Answer : A. Reduces skeletal muscle contractility
Description : The most prominent and dose related side effect of salbutamol is: A. Rise in blood pressure B. Muscle tremor C. Hyperglycaemia D. Central nervous system stimulation
Last Answer : B. Muscle tremor
Description : Propranolol does not block the following action of adrenaline: A. Bronchodilatation B. Lipolysis C. Muscle tremor D. Mydriasis
Last Answer : D. Mydriasis
Description : The following statement is not true of log dose-response curve: A. It is almost linear except at the ends B. It is a rectangular hyperbola C. It facilitates comparison of different agonists D. It can help in discriminating between competitive and noncompetitive antagonists
Last Answer : B. It is a rectangular hyperbola
Description : Select the correct statement with respect to disorders of muscles in humans. (a) Failure of neuromuscular transmission in myasthenia gravis can prevent normal swallowing. (b) Accumulation of ... of vitamin D causes osteoporosis. (d) Rapid contractions of skeletal muscles cause muscle dystrophy
Last Answer : (a) Failure of neuromuscular transmission in myasthenia gravis can prevent normal swallowing.
Description : Choose the correct statement about topical NSAID preparations: A. They produce high drug levels in the blood by avoiding hepatic first pass metabolism B. They produce high drug levels in ... a strong placebo effect D. Interindividual variability in clinical response to these preparations is minimal
Last Answer : C. They elicit symptomatic relief in soft tissue rheumatism mainly by a strong placebo effect
Description : Neuromuscular blocking drugs do not produce central actions because: A. They do not cross the blood-brain barrier B. Nicotinic receptors are not present in the brain C. They are sequestrated in the periphery by tight binding to the skeletal muscles D. They do not ionise at the brain pH
Last Answer : A. They do not cross the blood-brain barrier
Description : Which of the following statement(s) is/are correct concerning the cardiovascular response to shock? a. Changes in cardiac contractile function shift the Frank Starling curve up and down b. ... d. The total circulating blood volume is equally split between the arterial and venous system
Last Answer : Answer: a Central in the general cardiovascular response to shock is the action of the heart itself. The principle determinants of cardiac function in the normal heart are the volume of blood ... Blood flow to the skin is sacrificed early, followed by that to the kidneys and splanchnic viscera
Description : The antiparkinsonian action of central anticholinergics has the following features except: A. They control tremor more than rigidity B. They produce a low ceiling therapeutic effect C. They are effective in neuroleptic drug induced parkinsonism D. They are the preferred drugs in advanced case
Last Answer : D. They are the preferred drugs in advanced cases
Description : Choose the correct statement from the following about a1 – adrenergic receptor agonists (a) Norepinephrine > isoproterenol > epinephrine (b) Norepinephrine < epinephrine > isoproterenol (c) Epinephrine = norepinephrine >> isoproterenol (d) Epinephrine > isoproterenol > norepinephrine
Last Answer : Ans: C
Description : Select the correct statement from the following about a1 – adrenergic receptor agonists (a) Isoproterenol > epinephrine = norepinephrine (b) Epinephrine > isoproterenol > norepinephrine (c) Isoproterenol = epinephrine = norepinephrine (d) Epinephrine = norepinephrine > isoproterenol
Last Answer : Ans: A
Description : Phosphoinositide cascade is activated on binding of catecholamines to (A) α1-Adrenergic receptors (B) α2-Adrenergic receptors (C) β1-Adrenergic receptors (D) β2-Adrenergic receptors
Last Answer : Answer : A
Description : Astimulatory G-protein transduces the signals from (A) α1-and β1-adrenergic receptors (B) α2-and β2-adrenergic receptors (C) α1-and α2-adrenergic receptors (D) β1-and β2-adrenergic receptors
Last Answer : Answer : D
Description : Dopaminergic D1 and D2 as well as adrenergic α and β1, but not β2 receptors are activated by: A. Dopamine B. Dobutamine C. Methoxamine D. Phenylephrine
Last Answer : A. Dopamine
Description : Agonistic action on which of the following adrenergic receptors located on ciliary epithelial cells reduces aqueous secretion: A. β1 receptor B. β2 receptor C. α1 receptor D. α2 receptor
Last Answer : D. α2 receptor
Description : Beta adrenergic blockers lower intraocular tension by: A. Down regulating adenylyl cyclase in ciliary body through reduced activation of β2 adrenoceptors B. Constricting ciliary blood vessels ... action on trabecular meshwork D. Reducing aqueous formation unrelated to beta adrenoceptor mediation
Last Answer : A. Down regulating adenylyl cyclase in ciliary body through reduced activation of β2 adrenoceptors
Description : The following is a skeletal muscle relaxant that acts as a central α2 adrenergic agonist: A. Tizanidine B. Brimonidine C. Chlormezanone D. Quinine
Last Answer : A. Tizanidine
Description : Adrenergic β1 selective blockers offer the following advantages except: A. Lower propensity to cause bronchospasm B. Less prone to produce cold hands and feet as side effect C. Withdrawal is less likely to exacerbate angina pectoris D. Less liable to impair exercise capacity
Last Answer : C. Withdrawal is less likely to exacerbate angina pectoris
Description : Adrenergic β 1 selective blockers offer the following advantages except: A. Lower propensity to cause bronchospasm B. Less prone to produce cold hands and feet as side effect C. Withdrawal is less likely to exacerbate angina pectoris D. Less liable to impair exercise capacity
Description : The nonselective α adrenergic blockers produce the following actions except: A. Postural hypotension B. Bradycardia C. Miosis D. Inhibition of ejaculation
Last Answer : B. Bradycardia
Description : Continuous exposure of ctecholaminesensitive cells and tissues to adrenergic agonists causes a progressive diminition in their capacity to respond, this phenomenon is called as (a) Refractoriness (b) Desensitization (c) Tachyphylaxis (d) All of the above
Last Answer : Ans: D
Description : Potassium therapy tends to counteract the cardiac toxicity of digitalis by: A. Reducing the affinity of sarcolemal Na+ K+ATPase for digitalis B. Suppressing ectopic automaticity enhanced by digitalis C. Promoting A-V conduction D. Both 'A' and 'B' are correct
Last Answer : D. Both 'A' and 'B' are correct
Description : The mechanism of action of barbiturates differs from that of benzodiazepines in that they: A. Do not affect the GABA-benzodiazepine receptor-chloride channel complex B. Act as inverse agonists at the ... without affecting its life time D. Have both GABA-facilitatory as well as GABA-mimetic actions
Last Answer : D. Have both GABA-facilitatory as well as GABA-mimetic actions
Description : Receptors perform the following function/functions: A. Ligand recognition B. Signal transduction C. Both ligand recognition and signal transduction D. Disposal of agonists and antagonists
Last Answer : C. Both ligand recognition and signal transduction
Description : Intravenous injection of quinine produces: A. Rise in blood pressure B. Neuromuscular block C. Hyperglycaemia D. Hypoglycaemia
Last Answer : D. Hypoglycaemia
Description : Which of the following is applicable to mivacurium: A. It undergoes Hoffmann elimination B. It is the shortest acting nondepolarizing neuromuscular blocker C. It is excreted unchanged by kidney D. It does not cause histamine release
Last Answer : B. It is the shortest acting nondepolarizing neuromuscular blocker
Description : The neuromuscular blocker that does not need reversal of action by neostigmine at the end of the operation is: A. d-Tubocurarine B. Doxacurium C. Pipecuronium D. Mivacurium
Last Answer : D. Mivacurium
Description : What disease is described by: "the toxin acts at the neuromuscular junction, preventing the release of neurotransmitters needed to inhibit muscle contraction." a. Botulism b. Tetanus c. The Plague d. A-C Are Correct
Last Answer : b. Tetanus
Description : Sodium valproate should be used with caution in young children because they are particularly at risk of developing the following adverse effect: A. Hepatitis B. Loss of hair C. Anorexia D. Tremor
Last Answer : A. Hepatitis
Description : Which of the following is a neuroglucopenic symptom of hypoglycaemia: A. Sweating B. Palpitation C. Tremor D. Abnormal behaviour
Last Answer : D. Type 2 diabetes patients not controlled by a biguanide drug
Description : Select the drug that suppresses essential tremor, but not parkinsonian tremor: A. Procyclidine B. Propranolol C. Promethazine D. Prochlorperazine
Last Answer : B. Propranolol
Description : Strychnine produces convulsions by: A. Stimulating NMDA receptors B. Facilitating the excitatory transmitter glutamate C. Blocking the inhibitory transmitter GABA D. Blocking the inhibitory transmitter glycine
Last Answer : D. Blocking the inhibitory transmitter glycine
Description : Procainamide differs from quinidine in the following respect(s): A. It does not cause paradoxical tachycardia B. It has no α adrenergic blocking activity C. It has little antivagal action D. Both ‘B’ and ‘C’ are correct
Last Answer : D. Both ‘B’ and ‘C’ are correct