The organophosphates produce irreversible inhibition of cholinesterase because: A. They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind acetylcholine B. Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules C. Phosphorylation results in rapid degradation of enzyme molecules D. They are neither metabolized nor excreted from the body

The organophosphates produce irreversible inhibition
of cholinesterase because:
A. They bind to an allosteric site of the enzyme
resulting in unfavourable conformation of esteratic site to bind acetylcholine
B. Regeneration time of the phosphorylated
enzyme is longer than the turnover time of the
enzyme molecules
C. Phosphorylation results in rapid degradation
of enzyme molecules
D. They are neither metabolized nor excreted
from the body
by

1 Answer

Answer :

B. Regeneration time of the phosphorylated
enzyme is longer than the turnover time of the
enzyme molecules
by

Related questions

The organophosphates produce irreversible inhibition of cholinesterase because: A. They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind acetylcholine B. Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules C. Phosphorylation results in rapid degradation of enzyme molecules D. They are neither metabolized nor excreted from the body

Description : The organophosphates produce irreversible inhibition of cholinesterase because: A. They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind ... degradation of enzyme molecules D. They are neither metabolized nor excreted from the body

Last Answer : B. Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules

Inhibition of thromboxane synthesis by aspirin in platelets lasts for 5-7 days because: A. Aspirin persists in the body for 5-7 days B. Aspirin induced depletion of arachidonic acid lasts 5-7 days C. Regeneration of aspirin inhibited cyclooxygenase takes 5-7 days D. Platelets cannot generate fresh thromboxane synthetase and their turnover time is 5-7 days

Description : Inhibition of thromboxane synthesis by aspirin in platelets lasts for 5-7 days because: A. Aspirin persists in the body for 5-7 days B. Aspirin induced depletion of arachidonic acid lasts 5-7 ... 5-7 days D. Platelets cannot generate fresh thromboxane synthetase and their turnover time is 5-7 days

Last Answer : D. Platelets cannot generate fresh thromboxane synthetase and their turnover time is 5-7 days

Which one of the following regulatory actions involves a reversible covalent modification of the enzyme? (A) Phosphorylation of ser-OH on the enzyme (B) Allosteric modulation (C) Competitive inhibition (D) Non-competitive inhibition

Description : Which one of the following regulatory actions involves a reversible covalent modification of the enzyme? (A) Phosphorylation of ser-OH on the enzyme (B) Allosteric modulation (C) Competitive inhibition (D) Non-competitive inhibition

Last Answer : Answer : A

Which of the following regulatory reactions involves a reversible covalent modification of an enzyme? (A) Phosphorylation of serine OH on the enzyme (B) Allosteric modulation (C) Competitive inhibition (D) Non-competitive inhibition

Description : Which of the following regulatory reactions involves a reversible covalent modification of an enzyme? (A) Phosphorylation of serine OH on the enzyme (B) Allosteric modulation (C) Competitive inhibition (D) Non-competitive inhibition

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Aspirin in low doses produces longlasting inhibition of platelet cyclooxygenase (COX) because: A. Platelets contain low quantity of COX B. Platelets cannot synthesize fresh COX molecules C. Platelets bind aspirin with high affinity D. Platelet COX is inducible

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An example of enzyme inhibition: (A) Reversible inhibition (B) Irreversible inhibition (C) Allosteric inhibition (D) All of these ENZYMES 151

Description : An example of enzyme inhibition: (A) Reversible inhibition (B) Irreversible inhibition (C) Allosteric inhibition (D) All of these ENZYMES 151

Last Answer : Answer : D

Pseudocholinesterase differs from true cholinesterase in that: A. It does not hydrolyse acetylcholine B. It hydrolyses acetylcholine at a slower rate C. It is more susceptible to inhibition by physostigmine D. It is the only form of circulating cholinesterase

Description : Pseudocholinesterase differs from true cholinesterase in that: A. It does not hydrolyse acetylcholine B. It hydrolyses acetylcholine at a slower rate C. It is more susceptible to inhibition by physostigmine D. It is the only form of circulating cholinesterase

Last Answer : B. It hydrolyses acetylcholine at a slower rate

Pseudocholinesterase differs from true cholinesterase in that: A. It does not hydrolyse acetylcholine B. It hydrolyses acetylcholine at a slower rate C. It is more susceptible to inhibition by physostigmine D. It is the only form of circulating cholinesterase

Description : Pseudocholinesterase differs from true cholinesterase in that: A. It does not hydrolyse acetylcholine B. It hydrolyses acetylcholine at a slower rate C. It is more susceptible to inhibition by physostigmine D. It is the only form of circulating cholinesterase

Last Answer : B. It hydrolyses acetylcholine at a slower rate

An allosteric enzyme influences the enzyme activity by (A) Competiting for the catalytic site with the substrate (B) Changing the specificity of the enzyme for the substrate (C) Changing the conformation of the enzyme by binding to a site other than catalytic site (D) Changing the nature of the products formed

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Last Answer : Answer : C

Edrophonium is more suitable for differentiating myasthenic crisis from cholinergic crisis because of its: A. Shorter duration of action B. Longer duration of action C. Direct action on muscle end-plate D. Selective inhibition of true cholinesterase

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Edrophonium is more suitable for differentiating myasthenic crisis from cholinergic crisis because of its: A. Shorter duration of action B. Longer duration of action C. Direct action on muscle end-plate D. Selective inhibition of true cholinesterase

Description : Edrophonium is more suitable for differentiating myasthenic crisis from cholinergic crisis because of its: A. Shorter duration of action B. Longer duration of action C. Direct action on muscle end-plate D. Selective inhibition of true cholinesterase

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The most probable mechanism of action of imidazole antifungal drugs is: A. They bind to ergosterol in fungal cell membrane and make it leaky B. They interfere with ergosterol synthesis by fungi C. They interfere with fungal mitosis D. They block oxidative phosphorylation in fungi

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Which one of the following statements regarding enzyme inhibition is correct? (a) Competitive inhibition is seen when a substrate competes with an enzyme for binding to an inhibitor protein. (b) Competitive inhibition is seen when the substrate and the inhibitor compete for the active site on the enzyme. (c) Non-competitive inhibition of an enzyme can be overcome by adding large amount of substrate. (d) Non-competitive inhibitors often bind to the enzyme irreversibly.

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Last Answer : (b) Competitive inhibition is seen when the substrate and the inhibitor compete for the active site on the enzyme

What is it called when an enzyme is blocked at its active site so the normal substrate can't bind? a. Competitive Inhibition b. Feedback Inhibition c. Noncompetitive Inhibition d. Pathway Modulation

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Last Answer : a. Competitive Inhibition

Microsomal enzyme induction has one of the following features: A. Takes about one week to develop B. Results in increased affinity of the enzyme for the substrate C. It is irreversible D. Can be used to treat acute drug poisonings

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Last Answer : A. Takes about one week to develop

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Pralidoxime can reactivate cholinesterase enzyme that has been inactivated by: A. Carbamate anticholinesterases B. Organophosphate anticholinesterases C. Both carbamate and organophosphate anticholinesterases D. Reversible anticholinesterases

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The following is true of sulfonamides except: A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble B. They are primarily metabolized by acetylation C. They may exert bactericidal action in the urinary tract D. Used alone, they have become therapeutically unreliable for serious infections

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Aspirin in low doses produces longlasting inhibition (a) Platelets contain low quantity of COX (b) Platelets cannot synthesize fresh COX molecules (c) Platelets bind aspirin with high affinity (d) Platelet COX is inducible

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The ability of CTP to bind to aspartate carbamoyltransferase and shut down the synthesis of more A- enzyme induction B- enzyme repression C- feedback inhibition of enzyme activity D- none of these

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The following enzymes on the left are responsible for the synthesis of the neurotransmitters on the right: a. monoamine oxidase: noradrenaline b. cholinesterase: acetylcholine c. catechol-o-methyl transferase: dopamine d. dopa decarboxylase: adrenaline

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Tranexaemic acid is a specific antidote of: A. Fibrinolytic drugs B. Organophosphates C. Barbitur

Description : Tranexaemic acid is a specific antidote of: A. Fibrinolytic drugs B. Organophosphates C. Barbitur

Last Answer : A. Fibrinolytic drugs

Allosteric inhibition (A) Makes active site unifit for substrate (B) Controls excess formation and end product (C) Both (A) and (B) (D) None of these

Description : Allosteric inhibition (A) Makes active site unifit for substrate (B) Controls excess formation and end product (C) Both (A) and (B) (D) None of these

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Aminoglycoside antibiotics have the following property common to all members: A. They are primarily active against aerobic gram negative bacilli B. They are more active in acidic medium C. They readily enter cells and are distributed in total body water D. They are nearly completely metabolized in liver

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Last Answer : A. They are primarily active against aerobic gram negative bacilli

Localized rapid bone turnover, most commonly affecting the skull, femur, tibia, pelvic bones, and vertebrae, characterizes which of the following bone disorders? a) Osteitis deformans Osteitis deformans (Paget’s disease) results in bone that is highly vascularized and structurally weak, predisposing to pathologic fractures.

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Adrenaline is inactive orally because it is: A. Not absorbed from the gastrointestinal tract B. Destroyed by gastric acid C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation D. Taken up by adrenergic nerve endings of the intestinal wall, liver and lungs

Description : Adrenaline is inactive orally because it is: A. Not absorbed from the gastrointestinal tract B. Destroyed by gastric acid C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation D. Taken up by adrenergic nerve endings of the intestinal wall, liver and lungs

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Adrenaline is inactive orally because it is: A. Not absorbed from the gastrointestinal tract B. Destroyed by gastric acid C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation D. Taken up by adrenergic nerve endings of the intestinal wall, liver and lungs

Description : Adrenaline is inactive orally because it is: A. Not absorbed from the gastrointestinal tract B. Destroyed by gastric acid C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation D. Taken up by adrenergic nerve endings of the intestinal wall, liver and lungs

Last Answer : C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation

Select the inhalational general anaesthetic which is metabolized in the body to a significant extent: A. Sevoflurane B. Isoflurane C. Ether D. Halothane

Description : Select the inhalational general anaesthetic which is metabolized in the body to a significant extent: A. Sevoflurane B. Isoflurane C. Ether D. Halothane

Last Answer : D. Halothane

Succinylcholine is the preferred muscle relaxant for tracheal intubation because: A. It produces rapid and complete paralysis of respiratory muscles with quick recovery B. It does not alter heart rate or blood pressure C. It does not cause histamine release D. It does not produce postoperative muscle soreness

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Last Answer : A. It produces rapid and complete paralysis of respiratory muscles with quick recovery

The antiviral action of amantadine is exerted through: A. Interaction with the viral M2 protein B. Interaction with a virus directed thymidine kinase C. Inhibition of a viral protease enzyme D. Inhibition of viral RNA mediated DNA synthesi

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Last Answer : A. Interaction with the viral M2 protein

The following inhibitor binds only to the ani-onic site of the cholinesterase enzyme: A. Neostigmine B. Physostigmine C. Edrophonium D. Dyflos

Description : The following inhibitor binds only to the ani-onic site of the cholinesterase enzyme: A. Neostigmine B. Physostigmine C. Edrophonium D. Dyflos

Last Answer : C. Edrophonium

The following inhibitor binds only to the ani-onic site of the cholinesterase enzyme: A. Neostigmine B. Physostigmine C. Edrophonium D. Dyflos

Description : The following inhibitor binds only to the ani-onic site of the cholinesterase enzyme: A. Neostigmine B. Physostigmine C. Edrophonium D. Dyflos

Last Answer : C. Edrophonium

‘Lock’ and ‘Key’ model of enzyme action proposed by Fisher implies that (A) The active site is flexible and adjusts to substrate (B) The active site requires removal of PO4 group (C) The active site is complementary in shape to that of the substrate (D) Substrates change conformation prior to active site interaction

Description : Lock' and Key' model of enzyme action proposed by Fisher implies that (A) The active site is flexible and adjusts to substrate (B) The active site requires removal of PO4 group ( ... complementary in shape to that of the substrate (D) Substrates change conformation prior to active site interaction

Last Answer : Answer : C

Fischer’s ‘lock and key’ model of the enzyme action implies that (A) The active site is complementary in shape to that of substance only after interaction. (B) The active site is complementary in shape to that of substance (C) Substrates change conformation prior to active site interaction (D) The active site is flexible and adjusts to substrate

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Last Answer : Answer : B

The nonselective α adrenergic blockers produce the following actions except: A. Postural hypotension B. Bradycardia C. Miosis D. Inhibition of ejaculation

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Last Answer : C. Acetylcholine and gastrin act partly by releasing histamine in gastric mucosa

The progestin used in combined oral contraceptive pill is a 19-nortestosterone derivative because: A. They have potent antiovulatory action of their own B. They do not produce any metabolic effects C. They produce fewer side effects D. They are longer acting

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Last Answer : A. They have potent antiovulatory action of their own

Ganglion blocking drugs are no longer used in therapeutics because: A. They have few and weak pharmacological actions B. They produce many side effects C. They are inactive by oral route D. They have short duration of action

Description : Ganglion blocking drugs are no longer used in therapeutics because: A. They have few and weak pharmacological actions B. They produce many side effects C. They are inactive by oral route D. They have short duration of action

Last Answer : A. They have potent antiovulatory action of their own

Ganglion blocking drugs are no longer used in therapeutics because: A. They have few and weak pharmacological actions B. They produce many side effects C. They are inactive by oral route D. They have short duration of action

Description : Ganglion blocking drugs are no longer used in therapeutics because: A. They have few and weak pharmacological actions B. They produce many side effects C. They are inactive by oral route D. They have short duration of action

Last Answer : B. They produce many side effects

All of the following statements about the enzymic complex that carries out the synthesis of ATP during oxidative phosphorylation are correct except (A) It is located on the matrix side of the inner mitochondrial membrane (B) It is inhibited by oligomycin (C) It can exhibit ATPase activity (D) It can bind molecular O2

Description : All of the following statements about the enzymic complex that carries out the synthesis of ATP during oxidative phosphorylation are correct except (A) It is located on the matrix side of the inner ... inhibited by oligomycin (C) It can exhibit ATPase activity (D) It can bind molecular O2

Last Answer : D

Water hammer in a pipeline results from the (A) Bursting of pipelines due to closure by a valve (B) Rapid pressure change due to a rapid change in the rate of flow (C) Pressure increase due to closure of a valve resulting in decrease in rate of flow (D) None of these

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Which of the following feature(s) limit(s) the use of prazosin as a first line antihypertensive drug: A. Higher incidence of disturbing side effects B. Unfavourable metabolic effects C. Development of tolerance when used alone D. Both ‘A’ and ‘C’ are correct

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Thioguanine differs from mercaptopurine in that: A. It is not metabolized by xanthine oxidase B. It does not cause hyperuricemia C. Its dose need not be reduced when allopurinol is given concurrently D. Both ‘A’ and ‘C’ are correc

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5 A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of its action: A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

Description : 5 A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

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Combined tablets of thiazide or high ceiling diuretics with potassium chloride are not recommended because: A. Potassium absorbed while diuresis is occurring is largely excreted out B. Potassium administered concurrently diminishes the diuretic action C. Potassium chloride in tablet formulation is likely to cause gut ulceration D. Both ‘A’ and ‘C’ are correct

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Low concentration of bupivacaine is preferred for spinal / epidural obstetric analgesia because: A. It has a longer duration of action B. It can produce sensory blockade without paralysing abdominal muscles C. It distributes more in maternal tissues so that less reaches the foetus D. All of the above are correct

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