The prothrombin time
a. assess the extrinsic pathway of the blood coagulation
cascade
b. is prolonged in patients with fat absorption
c. is increased by warfarin
d. is increased by heparin

1 Answer

Answer :

assess the extrinsic pathway of the blood coagulation
cascade

Related questions

Description : The prothrombin time a. assess the extrinsic pathway of the blood coagulation cascade b. is prolonged in patients with fat absorption c. is increased by warfarin d. all above

Last Answer : all above

Description : Tests of coagulation are used to monitor anticoagulation treatment and detect intrinsic abnormalities in coagulation. Which of the following statement(s) is/are true concerning ... is used to monitor heparin levels intraoperatively during cardiovascular and peripheral vascular operations

Last Answer : Answer: a, c, d Coagulation tests include prothrombin time (PT), which measures the intrinsic and extrinsic pathways of fibrinogen production and is the most common method for ... more while for peripheral vascular applications, values of 250 seconds or greater are considered appropriate

Description : Which of the following is not true about warfarin, a. INR of 3 is enough to start any extraction. b. Affects extrinsic system and increases prothrombin time. c. Heparin can be given subcutaneously ... rapidly. d. It takes at least 12 hours for Vitamin K to reverse the effects of coumarin.

Last Answer : d. It takes at least 12 hours for Vitamin K to reverse the effects of coumarin.

Description : Which of the following is not true about warfarin, ** A. INR of 3 is enough to start any extraction B. Affects extrinsic system and decreases prothrombin time C. Heparin can be given subcutaneously and acts rapidly D. It takes up to 12 hours for Vitamin K to reverse the effects of warfarin

Last Answer : B. Affects extrinsic system and decreases prothrombin time

Description : Low concentrations of heparin selectively interfere with the following coagulation pathway(s): A. Intrinsic pathway B. Extrinsic pathway C. Common pathway D. Both ‘A’ and ‘C’

Last Answer : A. Intrinsic pathway

Description : he primary mechanism by which heparin prevents coagulation of blood is: A. Direct inhibition of prothrombin to thrombin conversion B. Facilitation of antithrombin III mediated inhibition of factor Xa and ... of antithrombin III to inhibit factors IX and XI D. Inhibition of factors XIIa and XIIIa

Last Answer : B. Facilitation of antithrombin III mediated inhibition of factor Xa and thrombi

Description : The transfusion of fresh frozen plasma (FFP) is indicated for which of the following reasons? A. Volume replacement. B. As a nutritional supplement. C. Specific coagulation factor deficiency ... the correction of abnormal PT secondary to warfarin therapy, vitamin K deficiency, or liver disease.

Last Answer : Answer: CD DISCUSSION: The use of FFP as a volume expander is not indicated. There are currently several preparations (both crystalloid and colloid) that are equally effective and do not carry the infectious and ... vitamin K-dependent factors II, VII, IX, and X, as well as protein C and protein S

Description : All the following statements about obstructive jaundice are true except (A) Prothrombin time may be prolonged due to impaired absorption of vitamin K (B) Serum alkaline phosphatase may be raised ... systemic circulation due to biliary obstruction (D) There is no defect in conjugation of bilirubin

Last Answer : Answer : B

Description : Which of the following statement(s) concerning laboratory studies used in monitoring a patient with intravenous heparinization is/are correct? a. The platelet count should be followed because of the ... serum creatinine should be measured daily to allow adjustments in dose based on renal function

Last Answer : Answer: a, c In monitoring the effect of heparin, an activated partial thromboplastin time (aPTT) of 1.5 control or a thrombin clotting time (TCT) of 2 times control reflects adequate ... system. Therefore the dose of heparin need not be adjusted in cases of liver or renal dysfunction

Description : Which of the following statements about the coagulation cascade is/are true? A. The intrinsic pathway of coagulation is the predominant pathway in vivo for hemostasis and coagulation. ... coagulation abnormalities. D. Deficiencies of factor XII cause severe clinical bleeding syndromes.

Last Answer : Answer: AC DISCUSSION: Although it was previously held that two somewhat distinct pathways existed for the activation of the coagulation cascade, it is now recognized that the predominant ... bleeding. This further emphasizes the secondary role that the intrinsic pathway plays in coagulation

Description : The standard management oral anticoagulant therapy for chronic treatment of venous thromboembolism is with the drug warfarin. Which of the following statement(s) is/are true concerning the administration ... warfarin be continued for at least one year after initial episode of deep venous thrombosis

Last Answer : Answer: a, b Warfarin interferes with the vitamin K dependent clotting factors II, VII, IX and X, protein C, and protein S. An important complication of warfarin is skin ... the benefit from anticoagulant therapy and thus is the basis for discontinuing warfarin administration at this time

Description : The most effective drug for prevention of stroke in atrial fibrillation patients is: A. Aspirin B. Warfarin C. Low dose subcutaneous heparin D. Digoxin

Last Answer : B. Warfarin

Description : The termination of heparin activity by protamine sulfate is due to (a) A chelating action (b) The inhibition of gastrointestinal absorption of heparin (c) The displacement of heparin-plasma protein binding (d) An acid-base interaction (e) The prothrombin-like activity of protamine

Last Answer : Ans: D

Description : Blood level of which clotting factor declines most rapidly after the initiation of warfarin therapy: A. Factor VII B. Factor IX C. Factor X D. Prothrombin

Last Answer : A. Factor VII

Description : Blood does not clot in the blood vessels due to the presence of – (1) Thrombin (2) Fibrinogen (3) Heparin (4) Prothrombin

Last Answer : (3) Heparin Explanation: There are two major facets of the clotting mechanism — the platelets, and the thrombin system. The thrombin system consists of several blood proteins that, when bleeding occurs, become activated.

Description : Blood fails to clot white flowing in the blood vessel because of the presence of (1) Heparin (2) Prothrombin (3) Haemoglobin (4) Hirudin

Last Answer : Heparin

Description : Blood does not clot in the blood vessels due to the presence of (1) Thrombin (2) Fibrinogen (3) Heparin (4) Prothrombin

Last Answer : Thrombin

Description : The evaluation of a patient scheduled for elective surgery should always include the following as tests of hemostasis and coagulation: A. History and physical examination. B. Complete blood count ( ... (APTT). D. Studies of platelet aggregation with adenosine diphosphate (ADP) and epinephrine.

Last Answer : Answer: A DISCUSSION: The evaluation of most patients scheduled for elective surgery who do not have a history of significant bleeding disorders is somewhat controversial. An adequate history and ... suspected of having qualitative defects of platelet function (e.g., von Willebrand's disease)

Description : Which of the following would you classify as a pharmacodynamics interaction? a) ACE inhibitors with potassium-sparing diuretics cause life-threatening hyperkalaemia b) Antacids reduce the absorption ... Increased bleeding due to cimetidine and warfarin d) Probenecid increases half-life of penicillin

Last Answer : a) ACE inhibitors with potassium-sparing diuretics cause life-threatening hyperkalaemia

Description : The antidote to heparin is a) protamine sulfate. Protamine sulfate, in the appropriate dosage, acts quickly to reverse the effects of heparin. b) vitamin K. Vitamin K is the antidote to ... and symptoms of medicationinduced narcosis. d) Ipecac. Ipecac is an emetic used to treat some poisonings.

Last Answer : a) protamine sulfate. Protamine sulfate, in the appropriate dosage, acts quickly to reverse the effects of heparin.

Description : Assertion `:` Prothrombinase enzyme act as antiheparin Reason `:` Heparin prevent coagulation of blood in Blood vessels

Last Answer : Assertion `:` Prothrombinase enzyme act as antiheparin Reason `:` Heparin prevent coagulation of blood in ... D. If both Assertion & Reason are false.

Description : The following are true about blood coagulation: a. heparin inhibits blood coagulation through its interference with vitamin K metabolism in the liver b. addition of vitamin K to freshly drawn ... delays clotting c. thrombin converts fibrinogen to fibrin d. platelets are essential for blood clot

Last Answer : thrombin converts fibrinogen to fibrin

Description : Hemostasis and the cessation of bleeding require which of the following processes? A. Adherence of platelets to exposed subendothelial glycoproteins and collagen with subsequent aggregation of platelets and ... conversion of fibrinogen to fibrin. D. Cross-linking of fibrin by factor XIII.

Last Answer : Answer: ABCD DISCUSSION: Hemostasis requires the interaction of platelets with the exposed subendothelial structures at the site of injury followed by aggregation of more platelets in that area. ... form a stable clot that incorporates the platelet plug and fibrin thrombus into a stable clot

Description : Low doses of heparin prolong: A. Bleeding time B. Activated partial thromboplastin time C. Prothrombin time D. Both ‘B’ and ‘C’

Last Answer : B. Activated partial thromboplastin time

Description : Assertion: Heparin is an anticoagulant found in mammals. Reason: Heparin prevents the conversion of prothrombin to thrombin

Last Answer : Assertion: Heparin is an anticoagulant found in mammals. Reason: Heparin prevents the conversion of ... . If both Assertion & Reason are false.

Description : Patient on anti-coagulant therapy requires an extraction to be performed. Which of the following is NOT true: A. Minor post operative bleedings can be reduced somehow by using tranexamic acid B. ... takes at least 8 hours for heparin to take effects D. Heparin should be administered sub-cutaneous

Last Answer : C. It takes at least 8 hours for heparin to take effects

Description : Prothrombin time is prolonged by administering (A) Vitamin K (B) Dicoumarol (C) Calcium (D) Prothrombin

Last Answer : Answer : B

Description : Prothrombin time is prolonged by administering (A) Vitamin K (B) Dicoumarol (C) Calcium (D) Prothrombin

Last Answer : Answer : A

Description : Prothrombin time is prolonged in (A) Vitamin K deficiency (B) Liver damage (C) Both (A) and (B) (D) None of these

Last Answer : Answer : C

Description : Prothrombin time remains prolonged even after parenterals administration of vitamin K in (A) Haemolytic jaundice (B) Liver damage (C) Biliary obstruction (D) Steatorrhoea

Last Answer : Answer : B

Description : Von Willebrand's disease is a common, congenital bleeding disorder. Which of the following statement(s) is/are true concerning Von Willebrand's disease? a. As in hemophilia, it is ... -treatment for elective surgery require administration of cryoprecipitate to achieve levels of 23-50% of normal

Last Answer : Answer: c, d Von Willebrand's factor is an adhesive protein that mediates platelet adhesion to collagen. In addition, it protects and prevents the rapid removal of factor VIII ... platelet aggregation responses to ristocetin. The most reliable source of Von Willebrand's factor is cryoprecipitate

Description : A 67-year-old male with advanced cholangiocarcinoma develops gram-negative sepsis. Excessive bleeding is noted around vascular catheters and from needle puncture sites. The diagnosis of disseminated ... b. Decreased fibrinogen level c. Normal prothrombin time d. Elevated fibrin split products

Last Answer : Answer: a, b, d Disseminated intravascular coagulation (DIC) is the primary form of acute thrombosis. Causes of this syndrome include abruptio placenta, gram-positive and gram-negative sepsis, ... decline in the platelet count and fibrinogen level, along with an elevation of fibrin split products

Description : Which of the following statement(s) is/are correct concerning the immunoinflammatory response to shock? a. The anaphylactoxins, C3a and C5a, are products of activation of only the classical pathway ... effects d. Platelet-activating factor can be released by both circulating and fixed tissue cells

Last Answer : Answer: d Inflammatory mediators have recently been recognized as playing a significant role in the clinical manifestations and progression of shock and the development ... increased pulmonary vascular resistance, bronchoconstriction, peripheral vasodilatation, and increased vascular permeability

Description : All of the following medications should not be used routinely in pregnant patients during the third trimester except (a) Acetaminophen (b) Nonsteroidal anti-inflammatory drugs (c) Warfarin (d) Lithium (e) Aspirin

Last Answer : Ans: A

Description : Laboratory monitoring of coagulation and anticoagulation includes testing of platelet function. Which of the following statements is/are true concerning tests of platelet function? a. A ... platelet aggregation should be part of the standard preoperative evaluation of patients using aspirin

Last Answer : Answer: a, c Tests of platelet function include peripheral platelet counts, bleeding times, and platelet aggregation. Usually, a platelet count of 50,000/mL or more ensures adequate hemostasis ... is not available in most laboratories, probably because of the observer-dependent nature of the test

Description : Extrinsic (OH) absorption peaks define three regions or windows of preferred operation. List the three windows of operation.

Last Answer : The first, second, and third windows of operation are 850 nm, 1300 nm, and 1550 nm, respectively.

Description : Which of the following statement(s) is/are true concerning hemophilia A? a. Hemophilia A is inherited as a sex-linked recessive deficiency of factor VIII b. A positive family history for ... platelet aggregation d. Spontaneous bleeding is unusual with factor VIII levels greater than 10% of normal

Last Answer : Answer: a, d Hemophilia A is inherited as a sex-linked recessive deficiency of factor VIII although 0% of cases are secondary to spontaneous mutation. The incidence of this abnormality is ... factor levels as low as 1% have been noted and patients are at risk for spontaneous bleeding

Description : Heparin therapy is usually considered therapeutic when the patient's activated partial thromboplasin time (aPTT) is how many times normal? a) 1.5 to 2 The amount of heparin administered is based on aPTT ... value would have to be greater than .25 to .75 times normal to be considered therapeutic.

Last Answer : a) 1.5 to 2 The amount of heparin administered is based on aPTT results, which should be obtained in follow-up to any alteration of dosage.

Description : Which of the following statement(s) is/are true concerning the results of a National Institute of Health Consensus Conference on venous thrombosis and low-dose heparin prophylaxis? a. The odds of ... treated with low-dose heparin d. There was no difference in the incidence of bleeding complications

Last Answer : Answer: a, b, c In a metaanalysis of 70 randomized trials in 16,000 patients comparing low-dose heparin prophylaxis with standard therapy, the odds of developing deep venous thrombosis ... Similarly, the effectiveness of prophylaxis was not influenced by either two or three times daily dosage

Description : Which of the following statement(s) is/are true concerning heparin-associated thrombocytopenia? a. Heparin-associated thrombocytopenia occurs only in the face of over anticoagulation with heparin b. ... d. Heparin-associated thrombocytopenia may be seen within hours of initiation of heparin therapy

Last Answer : Answer: b, c Heparin-associated thrombocytopenia occurs in 0.6% to 30% of patients who receive heparin, although severe thrombocytopenia (platelet counts less than 100,000) is seen in ... as coating on pulmonary artery catheters or low rate infusion into arterial catheters may cause this syndrome

Description : Heparin is contraindicated in patients suffering from the following diseases except: A. Pulmonary tuberculosis B. Bleeding due to defibrination syndrome C. Subacute bacterial endoc

Last Answer : B. Bleeding due to defibrination syndrome

Description : Low dose subcutaneous heparin therapy is indicated for: A. Prevention of leg vein thrombosis in elderly patients undergoing abdominal surgery B. Ischaemic stroke C. Patients undergoing neurosurgery D. Prevention of extention of coronary artery thrombus in acute myocardial infarction

Last Answer : A. Prevention of leg vein thrombosis in eld

Description : Vitamin K is indicated for the treatment of bleeding occurring in patients: A. Being treated with heparin B. Being treated with streptokinase C. Of obstructive jaundice D. Of peptic ulcer

Last Answer : C. Of obstructive jaundice

Description : Bleeding time is increased in: a. massive blood transfusion b. vitamin K deficiency c. von Willebrand's disease d. disseminated intravascular coagulation (DIC)

Last Answer : disseminated intravascular coagulation (DIC)

Description : Select the action of vasopressin exerted through the V1 subtype receptors: A. Release of coagulation factor VIII and von Willebrands factor from vascular endothelium B. Increased peristalsis of gut C. Dilatation of blood vessels D. Increased water permeability of renal collecting ducts

Last Answer : B. Increased peristalsis of gut

Description : The bright-flash ERG: a. comes only from the cones b. is generated in a fully dark adapted eye by the highest intensity of light c. can be used to assess the overall retinal integrity in the presence of media opacity d. is abnormal in patients with age-related macular degeneration

Last Answer : can be used to assess the overall retinal integrity in the presence of media opacity

Description : A 55-year-old renal transplant patient has been hospitalized in a Surgical Intensive Care Unit, receiving a prolonged course of antibiotics following an attack of acute cholecystitis. The ... suggest a dosage reduction in immunosuppressive agents until the infection can be adequately controlled

Last Answer : Answer: a, d Infections due to fungal pathogens have become increasingly common during the past decade, frequently occurring in patients undergoing prolonged hospitalization in the Surgical ... agents should be discontinued until evidence of infection is absolutely controlled or is eradicated

Description : Succinylcholine can produce all except A) Induce malignant hyperthermia in susceptible patients B) Prolonged paralysis occurs in case of butyrylcholinesterase abnormalities (as succinylcholine is not metabolized) C) Tachycardia, particularly in children D) Increase intraocular pressure

Last Answer : Ans: C

Description : Glucose overload results in increased CO 2 production. Which of the following statements are true? A. In patients with respiratory insufficiency, administration of glucose as a principal calorie ... who are supported by respirators in intensive care units and are receiving nutritional support.

Last Answer : Answer: C DISCUSSION: Few papers have excited as much interest as that by Askanazi, Kinney, and co-workers, which demonstrated that glucose calories given to patients with severe respiratory ... the caloric requirement and glucose for the remainder, without much fear of excessive CO 2 production