The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is (a) Increase in total coronary blood flow (b) Redistribution of coronary blood flow (c) Reduction of cardiac preload (d) Reduction of cardiac after load

The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is (a) Increase in total coronary blood flow (b) Redistribution of coronary blood flow (c) Reduction of cardiac preload (d) Reduction of cardiac after load
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The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is: A. Increase in total coronary blood flow B. Redistribution of coronary blood flow C. Reduction of cardiac preload D. Reduction of cardiac afterload

Description : The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is: A. Increase in total coronary blood flow B. Redistribution of coronary blood flow C. Reduction of cardiac preload D. Reduction of cardiac afterload

Last Answer : C. Reduction of cardiac preload

Though nitrates and calcium channel blockers are both vasodilators, they are used concurrently in angina pectoris because (a) They antagonize each other’s side effects (b) Nitrates primarily reduce preload while calcium channel blockers primarily reduce after load (c) Nitrates increase coronary flow while calcium (d) Both (b) and (c)

Description : Though nitrates and calcium channel blockers are both vasodilators, they are used concurrently in angina pectoris because (a) They antagonize each other's side effects (b) Nitrates primarily reduce preload while calcium ... load (c) Nitrates increase coronary flow while calcium (d) Both (b) and (c)

Last Answer : Ans: B

Major beneficial effect of nitrates in classical angina is due to (a) Dilation of veins more than arteries (b) Increase in total coronary blood flow (c) An increase in the end diastolic size of the heart (d) An increase in the heart rate

Description : Major beneficial effect of nitrates in classical angina is due to (a) Dilation of veins more than arteries (b) Increase in total coronary blood flow (c) An increase in the end diastolic size of the heart (d) An increase in the heart rate

Last Answer : Ans: A

The agent given sublingually in an acute attack of angina pectoris is (a) Glyceryl trinitrate (b) Amyl nitrite (c) Erythrital tetranitrate (d) Pentaerythritol tetranitrate

Description : The agent given sublingually in an acute attack of angina pectoris is (a) Glyceryl trinitrate (b) Amyl nitrite (c) Erythrital tetranitrate (d) Pentaerythritol tetranitrate

Last Answer : Ans: A

A patient suffers from spisodic pain diffusely localized over the chest and upper abdomen, which is relieved by sublingual glyceryl trinitrate. He could be suffering from (a) Angina pectoris (b) Biliary colic (c) Esophageal spasm (d) All of the above

Description : A patient suffers from spisodic pain diffusely localized over the chest and upper abdomen, which is relieved by sublingual glyceryl trinitrate. He could be suffering from (a) Angina pectoris (b) Biliary colic (c) Esophageal spasm (d) All of the above

Last Answer : Ans: D

Choose the correct statement about the action of nitrates on coronary vessels (a) They mitigate angina pectoris by increasing total coronary flow (b) They preferentially dilate conducting arteries without affecting resistance arterioles (c) They preferentially dilate autoregulatory arterioles without affecting the larger arteries (d) They increase subepicardial blood flow without affecting subendocardial blood flow

Description : Choose the correct statement about the action of nitrates on coronary vessels (a) They mitigate angina pectoris by increasing total coronary flow (b) They preferentially dilate conducting ... the larger arteries (d) They increase subepicardial blood flow without affecting subendocardial blood flow

Last Answer : Ans: B

Though nitrates and calcium channel blockers are both vasodilators, they are used concurrently in angina pectoris, because: A. They antagonise each other’s side effects B. Nitrates primarily reduce preload while calcium channel blockers primarily reduce after-load C. Nitrates increase coronary flow while calcium channel blockers reduce ca

Description : Though nitrates and calcium channel blockers are both vasodilators, they are used concurrently in angina pectoris, because: A. They antagonise each other's side effects B. Nitrates primarily ... primarily reduce after-load C. Nitrates increase coronary flow while calcium channel blockers reduce ca

Last Answer : B. Nitrates primarily reduce preload while calcium channel blockers primarily reduce after-load

‘Coronary steal phenomenon’ has been noted most frequently with (a) Glyceryl trinitrate (b) Dipyridamole (c) Propranolol (d) Diltiazem

Description : ‘Coronary steal phenomenon’ has been noted most frequently with (a) Glyceryl trinitrate (b) Dipyridamole (c) Propranolol (d) Diltiazem

Last Answer : Ans: B

The term ischemic heart disease (IHD) is used to designate all of the following conditions except (a) Angina pectoris (b) Sudden cardiac death (c) Congestive heart failur (CHF) (d) Arrhythmias

Description : The term ischemic heart disease (IHD) is used to designate all of the following conditions except (a) Angina pectoris (b) Sudden cardiac death (c) Congestive heart failur (CHF) (d) Arrhythmias

Last Answer : Ans: C

A patient suffers from episodic pain diffusely localized over the chest and upper abdomen, which is relieved by sublingual glyceryl trinitrate. He could be suffering from: A. Angina pectoris B. Biliary colic C. Esophageal spasm D. Any of the abov

Description : A patient suffers from episodic pain diffusely localized over the chest and upper abdomen, which is relieved by sublingual glyceryl trinitrate. He could be suffering from: A. Angina pectoris B. Biliary colic C. Esophageal spasm D. Any of the abov

Last Answer : D. Any of the abov

Which of the following agents used in prinzmetal’s angina has spasmolytic actions, which increase coronary blood supply? (a) Nitroglycerin (b) Nifedipine (c) Timolol (d) Isosorbide mononitrate (e) Propranolol

Description : Which of the following agents used in prinzmetal’s angina has spasmolytic actions, which increase coronary blood supply? (a) Nitroglycerin (b) Nifedipine (c) Timolol (d) Isosorbide mononitrate (e) Propranolol

Last Answer : Ans: B

A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/method of administration would be most suitable. (a) Sublingual (b) Oral (c) Intravenous bolus injection (d) Slow intravenous infusion

Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/ ... (a) Sublingual (b) Oral (c) Intravenous bolus injection (d) Slow intravenous infusion

Last Answer : Ans: D

Glyceryl trinitrate is administratered by all of the following routes except (a) Oral (b) Sublingual (c) Intramuscular (d) Intravenous

Description : Glyceryl trinitrate is administratered by all of the following routes except (a) Oral (b) Sublingual (c) Intramuscular (d) Intravenous

Last Answer : Ans: C

Select the organic nitrate which undergoes minimal first-pass metabolism in the liver (a) Glyceryl trinitrate (b) Isosorbide dinitrate (c) Isosorbide mononitrate (d) Erythrityl tetranitrate

Description : Select the organic nitrate which undergoes minimal first-pass metabolism in the liver (a) Glyceryl trinitrate (b) Isosorbide dinitrate (c) Isosorbide mononitrate (d) Erythrityl tetranitrate

Last Answer : Ans: C

Choose the correct statement about the action of nitrates on coronary vessels: A. They mitigate angina pectoris by increasing total coronary flow B. They preferentially dilate conducting arteries without affecting resistance arterioles C. They preferentially dilate autoregulatory arterioles without affecting the larger arteries D. They increase subepicardial blood flow without affecting subendocardial blood flow

Description : Choose the correct statement about the action of nitrates on coronary vessels: A. They mitigate angina pectoris by increasing total coronary flow B. They preferentially dilate conducting ... the larger arteries D. They increase subepicardial blood flow without affecting subendocardial blood flow

Last Answer : B. They preferentially dilate conducting arteries without affecting resistance arterioles

Propranolol should not be prescribed for a patient of angina pectoris who is already receiving (a) Nifedipine (b) Felodipine (c) Verapamil (d) Isosorbide mononitrate

Description : Propranolol should not be prescribed for a patient of angina pectoris who is already receiving (a) Nifedipine (b) Felodipine (c) Verapamil (d) Isosorbide mononitrate

Last Answer : Ans: C

The following drug is used to reduce the frequency of angina pectoris as well as to terminate an acute attack (a) Digoxin (b) Furosemide (c) Enalapril (d) Amrinone

Description : The following drug is used to reduce the frequency of angina pectoris as well as to terminate an acute attack (a) Digoxin (b) Furosemide (c) Enalapril (d) Amrinone

Last Answer : Ans: A

In case of acute pain of angina pectoris the most effective treatment would be to administer (a) Mannitol hexanitrate (b) Erythrityl tetranitrate (c) Sodium nitrate (d) Pentaerythritol tetranitrate (e) Nitroglycerin

Description : In case of acute pain of angina pectoris the most effective treatment would be to administer (a) Mannitol hexanitrate (b) Erythrityl tetranitrate (c) Sodium nitrate (d) Pentaerythritol tetranitrate (e) Nitroglycerin

Last Answer : Ans: E

Maximal medical therapy for treating angina pectoris is represented by which of the following choices? (a) Diltiazem, verapamil, nitroglycerin (b) Atenolol, isoproterenol, diltiazem (c) Verapamil, nifedipine, propranolol (d) Isosorbide, atenolol, diltiazem (e) Nitroglycerin, isosorbide, atenolol

Description : Maximal medical therapy for treating angina pectoris is represented by which of the following choices? (a) Diltiazem, verapamil, nitroglycerin (b) Atenolol, isoproterenol, diltiazem (c) Verapamil, nifedipine, propranolol (d) Isosorbide, atenolol, diltiazem (e) Nitroglycerin, isosorbide, atenolol

Last Answer : Ans: D

Regarding verapamil, which one of the following statements is false? (a) Angina pectoris is an important indication for the use of verapamil (b) Contraindicated in the asthmatic patient (c) Relaxes vascular smooth muscle (d) Slows the depolarization phase of the action potential in AV nodal cells (e) Used in management of supraventricular tachycardias

Description : Regarding verapamil, which one of the following statements is false? (a) Angina pectoris is an important indication for the use of verapamil (b) Contraindicated in the asthmatic patient (c) ... phase of the action potential in AV nodal cells (e) Used in management of supraventricular tachycardias

Last Answer : Ans: B

Blood flow in the following vascular bed generally decreases under the influence of glyceryl trinitrate: A. Coronary B. Cutaneous C. Renal D. Cranial

Description : Blood flow in the following vascular bed generally decreases under the influence of glyceryl trinitrate: A. Coronary B. Cutaneous C. Renal D. Cranial

Last Answer : C. Renal

A drug which preferentially dilates autoregulatory coronary arterioles with little effect on large conducting vessels is likely to: A. Evoke coronary steal phenomenon B. Mitigate classical angina but not variant angina C. Decrease total coronary blood flow in healthy subjects D. Avert ECG changes of ischaemia

Description : A drug which preferentially dilates autoregulatory coronary arterioles with little effect on large conducting vessels is likely to: A. Evoke coronary steal phenomenon B. Mitigate classical angina but not ... . Decrease total coronary blood flow in healthy subjects D. Avert ECG changes of ischaemia

Last Answer : A. Evoke coronary steal phenomenon

‘Coronary steal phenomenon’ has been noted most frequently with: A. Glyceryl trinitrate B. Dipyridamole C. Propranolol D. Diltiazem

Description : ‘Coronary steal phenomenon’ has been noted most frequently with: A. Glyceryl trinitrate B. Dipyridamole C. Propranolol D. Diltiazem

Last Answer : B. Dipyridamole

Because of proven beneficial effects on “cardiac remodeling”, these agents are now indicated as first line therapy in CHF patients. Which of the following is representative of this group of drugs? (a) Hydrochlorothiazide (b) Enalapril (c) Furosemide (d) Carvedilol (e) Bumetanide

Description : Because of proven beneficial effects on “cardiac remodeling”, these agents are now indicated as first line therapy in CHF patients. Which of the following is representative of this group of drugs? (a) Hydrochlorothiazide (b) Enalapril (c) Furosemide (d) Carvedilol (e) Bumetanide

Last Answer : Ans: B

Which of the following combinations of drugs, when used together, reduce both preload and afterload? (a) Nitroglycerin and isosorbide dinitrate (b) Hydralazine and isosorbide dinitrate (c) Captopril and methyldopa (d) Prazosin and angiotension II (e) Hydralazine and methyldopa

Description : Which of the following combinations of drugs, when used together, reduce both preload and afterload? (a) Nitroglycerin and isosorbide dinitrate (b) Hydralazine and isosorbide dinitrate (c) Captopril and methyldopa (d) Prazosin and angiotension II (e) Hydralazine and methyldopa

Last Answer : Ans: B

Which vasodilator is most suitable for a patient of CHF who is symptomatic even at rest and has a central venous pressure of 25 mm Hg and cardiac index 1.8 L/min/m2 : A. Glyceryl trinitrate B. Enalapril C. Hydralazine D. Nifedipine

Description : Which vasodilator is most suitable for a patient of CHF who is symptomatic even at rest and has a central venous pressure of 25 mm Hg and cardiac index 1.8 L/min/m2 : A. Glyceryl trinitrate B. Enalapril C. Hydralazine D. Nifedipine

Last Answer : B. Enalapril

Morphine affords symptomatic relief of dyspnoea in acute left ventricular failure by the following mechanisms except: A. Bronchodilatation B. Depression of respiratory centre C. Reduction in cardiac preload D. Shift of blood from pulmonary to systemic circuit

Description : Morphine affords symptomatic relief of dyspnoea in acute left ventricular failure by the following mechanisms except: A. Bronchodilatation B. Depression of respiratory centre C. Reduction in cardiac preload D. Shift of blood from pulmonary to systemic circuit

Last Answer : A. Bronchodilatation

Therapeutic dose of digoxin in a normal individual has the following effects, except (a) Increase in the speed of myocardial contractility (b) No significant change in cardiac output (c) Relaxation of peripheral vascular bed (d) Increase in the force of myocardial contractility

Description : Therapeutic dose of digoxin in a normal individual has the following effects, except (a) Increase in the speed of myocardial contractility (b) No significant change in cardiac output (c) Relaxation of peripheral vascular bed (d) Increase in the force of myocardial contractility

Last Answer : Ans: C

In cardiac cells, adenosine (a) Causes shortening of action potential duration (b) Depolarization (c) Increase in normal automaticity (d) All of the above

Description : In cardiac cells, adenosine (a) Causes shortening of action potential duration (b) Depolarization (c) Increase in normal automaticity (d) All of the above

Last Answer : Ans: A

Aspirin in small doses (50 to 150 mg per day) (a) Is of benefit in patients of unstable angina (b) Has thrombolytic action (c) PREFerentially inhibits prostacyclin synthetase enzyme (d) MAY Alleviate need for Verapamil in variant angina

Description : Aspirin in small doses (50 to 150 mg per day) (a) Is of benefit in patients of unstable angina (b) Has thrombolytic action (c) PREFerentially inhibits prostacyclin synthetase enzyme (d) MAY Alleviate need for Verapamil in variant angina

Last Answer : Ans: A

Which of the following drugs is most likely to accentuate varient (Prinzmetal) angina ? (a) Digoxin (b) Furosemide (c) Enalapril (d) Amrinone

Description : Which of the following drugs is most likely to accentuate varient (Prinzmetal) angina ? (a) Digoxin (b) Furosemide (c) Enalapril (d) Amrinone

Last Answer : Ans: A

Exertion–induced angina, which is relieved by rest, nitroglycerin, or both, is referred to as (a) Prinzmetal’s angina (b) Unstable angina (c) Classic angina (d) Variant angina (e) Preinfarction angina

Description : Exertion–induced angina, which is relieved by rest, nitroglycerin, or both, is referred to as (a) Prinzmetal’s angina (b) Unstable angina (c) Classic angina (d) Variant angina (e) Preinfarction angina

Last Answer : Ans: C

A treatment of angina that consistently decreases the heart rate and can prevent vasospastic angina attacks is (a) Isosorbide dinitrate (b) NIFedipine (c) Nitroglycerin (d) Propranolol (e) Verapamil

Description : A treatment of angina that consistently decreases the heart rate and can prevent vasospastic angina attacks is (a) Isosorbide dinitrate (b) NIFedipine (c) Nitroglycerin (d) Propranolol (e) Verapamil

Last Answer : Ans: E

A drug lacking vasodilator properties that is useful in angina is (a) Isosorbide dinitrate (b) Metoprolol (c) NIfedipine (d) Nitroglycerin (e) Verapamil

Description : A drug lacking vasodilator properties that is useful in angina is (a) Isosorbide dinitrate (b) Metoprolol (c) NIfedipine (d) Nitroglycerin (e) Verapamil

Last Answer : Ans: B

Antianginal drugs afford the following benefit/benefits (a) Terminate anginal attacks (b) Decrease the frequency of anginal attacks (c) Retard the progression of coronary artery disease (d) Both (a) and (b)

Description : Antianginal drugs afford the following benefit/benefits (a) Terminate anginal attacks (b) Decrease the frequency of anginal attacks (c) Retard the progression of coronary artery disease (d) Both (a) and (b)

Last Answer : Ans: D

Relationship between arterial blood pressure (BP), cardiac outpur (CO) and peripheral vascular resistance (PVR) can be described as (a) BP = COxPVR (b) BP = CO/PVR (c) BP = PVR/CO (d) None of the above

Description : Relationship between arterial blood pressure (BP), cardiac outpur (CO) and peripheral vascular resistance (PVR) can be described as (a) BP = COxPVR (b) BP = CO/PVR (c) BP = PVR/CO (d) None of the above

Last Answer : Ans: A

Which one of the following drugs increase digoxin plasma concentration by a pharmacokinetic mechanism? (a) Captopril (b) Hydrochorothiazide (c) Lidocaine (d) Quinidine (e) Sulfasalazine

Description : Which one of the following drugs increase digoxin plasma concentration by a pharmacokinetic mechanism? (a) Captopril (b) Hydrochorothiazide (c) Lidocaine (d) Quinidine (e) Sulfasalazine

Last Answer : Ans: D

When digoxin is used in a patient with congestive heart failure (CHF), it works by exerting a positive effect on (a) Stroke volume (b) Total peripheral resistance (c) Heart rate (d) Blood pressure (e) Venous return

Description : When digoxin is used in a patient with congestive heart failure (CHF), it works by exerting a positive effect on (a) Stroke volume (b) Total peripheral resistance (c) Heart rate (d) Blood pressure (e) Venous return

Last Answer : Ans: A

Mary has a family history of heart disease and wonders if garlic would be beneficial to her. Which of the following statements is correct about garlic? (a) Enteric-coated tablets release their contents in the stomach (b) Side effects include heartburn, flatulence, and sweating (c) The safety of garlic in pregnancy is unknown (d) Garlic does not interact with warfarin

Description : Mary has a family history of heart disease and wonders if garlic would be beneficial to her. Which of the following statements is correct about garlic? (a) Enteric-coated tablets release their contents in ... (c) The safety of garlic in pregnancy is unknown (d) Garlic does not interact with warfarin

Last Answer : Ans: B

Digoxin given for cardiac failure is extremely valuable in patients of (a) Thyrotoxicosis (b) Beriberi (c) Cor pulmonale (d) Atrial fibrillation

Description : Digoxin given for cardiac failure is extremely valuable in patients of (a) Thyrotoxicosis (b) Beriberi (c) Cor pulmonale (d) Atrial fibrillation

Last Answer : Ans: D

Cardiac glycosides are obtained from following plant source. (a) Rauwolfia serpentina (b) Strophanthus gratus (c) Ricinus commounts. (d) Atropa belladonna

Description : Cardiac glycosides are obtained from following plant source. (a) Rauwolfia serpentina (b) Strophanthus gratus (c) Ricinus commounts. (d) Atropa belladonna

Last Answer : Ans: B

Enhanced automaticity in cardiac cells may occur because of (a) ß-adrenergic stimulation (b) Hypokalemia (c) Mechanical stretch of cardiac muscles (d) All of the above

Description : Enhanced automaticity in cardiac cells may occur because of (a) ß-adrenergic stimulation (b) Hypokalemia (c) Mechanical stretch of cardiac muscles (d) All of the above

Last Answer : Ans: D

Lidocaine is the preferred antiarrhythmic for emergency control of cardiac arrhythmias following acute myocardial infarction because (a) It has a rapidly developing and titratable antiarrhythmic action (b) It casues little myocardial depression and hypotension (c) It has broad spectrum antiarrhythmic efficacy in atrial as well as ventricular arrhythmias (d) Both (a) and (b)

Description : Lidocaine is the preferred antiarrhythmic for emergency control of cardiac arrhythmias following acute myocardial infarction because (a) It has a rapidly developing and titratable antiarrhythmic action (b) It casues ... efficacy in atrial as well as ventricular arrhythmias (d) Both (a) and (b)

Last Answer : Ans: D

The chief use of levoarterenol is to treat (a) Shock (b) Diabetes (c) Hypertension (d) Cardiac arrhythmias (e) Iron deficiencies

Description : The chief use of levoarterenol is to treat (a) Shock (b) Diabetes (c) Hypertension (d) Cardiac arrhythmias (e) Iron deficiencies

Last Answer : Ans: A

The action of quinidine differs from that of digitalis in (a) Decreasing irritability of cardiac muscle (b) Preventing passage of impulses to the ventricle (c) Increasing irritability of heart muscle (d) Reducing conductivity (e) None of the above

Description : The action of quinidine differs from that of digitalis in (a) Decreasing irritability of cardiac muscle (b) Preventing passage of impulses to the ventricle (c) Increasing irritability of heart muscle (d) Reducing conductivity (e) None of the above

Last Answer : Ans: A

During Phase 2 of action potential in cardiac cell, depolarizing current through calcium channels is balanced by (a) Delayed rectifier potassium current (b) outward chloride channel (c) Both (a) and (b) (d) None of the above

Description : During Phase 2 of action potential in cardiac cell, depolarizing current through calcium channels is balanced by (a) Delayed rectifier potassium current (b) outward chloride channel (c) Both (a) and (b) (d) None of the above

Last Answer : Ans: A

Acute renal failure (ARF) may be caused by all of the following except (a) Acute tubular necrosis (ATN) due to drug therapy (e.g., aminoglycosides, contrast media) (b) Severe hypotension or circulatolry collapse (c) Decreased cardiac output, as from congestive heart failure (d) Hemolysis, myoglobinuria (e) Hyperkalemia

Description : Acute renal failure (ARF) may be caused by all of the following except (a) Acute tubular necrosis (ATN) due to drug therapy (e.g., aminoglycosides, contrast media) (b) Severe hypotension ... (c) Decreased cardiac output, as from congestive heart failure (d) Hemolysis, myoglobinuria (e) Hyperkalemia

Last Answer : Ans: E

Which of the following is the drug of choice for management of cardiac arrhythmias that occur in digitalis toxicity? (a) Amiodarone (b) Lidocaine (c) Propranolol (d) Sotalol (e) Prazosin

Description : Which of the following is the drug of choice for management of cardiac arrhythmias that occur in digitalis toxicity? (a) Amiodarone (b) Lidocaine (c) Propranolol (d) Sotalol (e) Prazosin

Last Answer : Ans: B

Which one of the following drugs predictably prolongs the PR interval and increases cardiac contractility? (a) Digoxin (b) Lidocaine (c) Propranolol (d) Quinidine (e) Verapamil

Description : Which one of the following drugs predictably prolongs the PR interval and increases cardiac contractility? (a) Digoxin (b) Lidocaine (c) Propranolol (d) Quinidine (e) Verapamil

Last Answer : Ans: A