A drug which preferentially dilates autoregulatory coronary arterioles with little effect on large conducting vessels is likely to: A. Evoke coronary steal phenomenon B. Mitigate classical angina but not variant angina C. Decrease total coronary blood flow in healthy subjects D. Avert ECG changes of ischaemia

A drug which preferentially dilates autoregulatory
coronary arterioles with little effect on large conducting vessels is likely to:
A. Evoke coronary steal phenomenon
B. Mitigate classical angina but not variant
angina
C. Decrease total coronary blood flow in
healthy subjects
D. Avert ECG changes of ischaemia
by

1 Answer

Answer :

A. Evoke coronary steal phenomenon
by

Related questions

Choose the correct statement about the action of nitrates on coronary vessels: A. They mitigate angina pectoris by increasing total coronary flow B. They preferentially dilate conducting arteries without affecting resistance arterioles C. They preferentially dilate autoregulatory arterioles without affecting the larger arteries D. They increase subepicardial blood flow without affecting subendocardial blood flow

Description : Choose the correct statement about the action of nitrates on coronary vessels: A. They mitigate angina pectoris by increasing total coronary flow B. They preferentially dilate conducting ... the larger arteries D. They increase subepicardial blood flow without affecting subendocardial blood flow

Last Answer : B. They preferentially dilate conducting arteries without affecting resistance arterioles

Choose the correct statement about the action of nitrates on coronary vessels (a) They mitigate angina pectoris by increasing total coronary flow (b) They preferentially dilate conducting arteries without affecting resistance arterioles (c) They preferentially dilate autoregulatory arterioles without affecting the larger arteries (d) They increase subepicardial blood flow without affecting subendocardial blood flow

Description : Choose the correct statement about the action of nitrates on coronary vessels (a) They mitigate angina pectoris by increasing total coronary flow (b) They preferentially dilate conducting ... the larger arteries (d) They increase subepicardial blood flow without affecting subendocardial blood flow

Last Answer : Ans: B

The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is: A. Increase in total coronary blood flow B. Redistribution of coronary blood flow C. Reduction of cardiac preload D. Reduction of cardiac afterload

Description : The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is: A. Increase in total coronary blood flow B. Redistribution of coronary blood flow C. Reduction of cardiac preload D. Reduction of cardiac afterload

Last Answer : C. Reduction of cardiac preload

Major beneficial effect of nitrates in classical angina is due to (a) Dilation of veins more than arteries (b) Increase in total coronary blood flow (c) An increase in the end diastolic size of the heart (d) An increase in the heart rate

Description : Major beneficial effect of nitrates in classical angina is due to (a) Dilation of veins more than arteries (b) Increase in total coronary blood flow (c) An increase in the end diastolic size of the heart (d) An increase in the heart rate

Last Answer : Ans: A

The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is (a) Increase in total coronary blood flow (b) Redistribution of coronary blood flow (c) Reduction of cardiac preload (d) Reduction of cardiac after load

Description : The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is (a) Increase in total coronary blood flow (b) Redistribution of coronary blood flow (c) Reduction of cardiac preload (d) Reduction of cardiac after load

Last Answer : Ans: C

Choose the correct statement(s) about ipratropium bromide: A. It preferentially dilates peripheral bronchioles B. It produces additional bronchodilatation when added to nebulized salbutamol C. As metered dose inhaler it is used for terminating asthma attacks D. Both 'B' and 'C'

Description : Choose the correct statement(s) about ipratropium bromide: A. It preferentially dilates peripheral bronchioles B. It produces additional bronchodilatation when added to nebulized salbutamol C. As metered dose inhaler it is used for terminating asthma attacks D. Both 'B' and 'C'

Last Answer : B. It produces additional bronchodilatation when added to nebulized salbutamol

Aspirin in small doses (50 to 150 mg per day) (a) Is of benefit in patients of unstable angina (b) Has thrombolytic action (c) PREFerentially inhibits prostacyclin synthetase enzyme (d) MAY Alleviate need for Verapamil in variant angina

Description : Aspirin in small doses (50 to 150 mg per day) (a) Is of benefit in patients of unstable angina (b) Has thrombolytic action (c) PREFerentially inhibits prostacyclin synthetase enzyme (d) MAY Alleviate need for Verapamil in variant angina

Last Answer : Ans: A

‘Coronary steal phenomenon’ has been noted most frequently with: A. Glyceryl trinitrate B. Dipyridamole C. Propranolol D. Diltiazem

Description : ‘Coronary steal phenomenon’ has been noted most frequently with: A. Glyceryl trinitrate B. Dipyridamole C. Propranolol D. Diltiazem

Last Answer : B. Dipyridamole

The short acting dihydropyridine preparations can aggravate myocardial ischaemia by invoking: A. Coronary vasospasm B. Thrombus formation C. Vagal activation D. Reflex sympathetic discharge to the hear

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Last Answer : D. Reflex sympathetic discharge to the heart

Select the vasodilator that is administered only by slow intravenous infusion and dilates both resistance as well as capacitance vessels: A. Minoxidil B. Diazoxide C. Sodium nitroprusside D. Glyceryl trinitrate

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Last Answer : C. Sodium nitroprusside

Though nitrates and calcium channel blockers are both vasodilators, they are used concurrently in angina pectoris, because: A. They antagonise each other’s side effects B. Nitrates primarily reduce preload while calcium channel blockers primarily reduce after-load C. Nitrates increase coronary flow while calcium channel blockers reduce ca

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Last Answer : B. Nitrates primarily reduce preload while calcium channel blockers primarily reduce after-load

Specific drug therapy to lower serum triglycerides (TG) in a subject with normal LDL-cholesterol level is indicated: A. In all subjects with serum TG> 150 mg/dl B. In subjects with existing coronary artery disease and serum TG > 150 mg/dl C. In subjects with HDL-cholesterol < 40 mg/dl and serum TG > 150 mg/dl D. Both 'B' and 'C' are correct

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Last Answer : D. Both 'B' and 'C' are correct

Select the drug that may improve myocardial tolerance to ischaemia and reduce anginal attacks without altering heart rate, blood pressure or myocardial O2 consumption: A. Trimetazidine B. Nicorandil C. Dipyridamole D. Nicotinic acid

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Last Answer : A. Trimetazidine

Which of the following adrenergic inhibitors acts directly on the blood vessels, producing vasodilation? a) Prazosin hydrochloride (Minipress) Minipress is a peripheral vasodilator acting directly on the blood vessel. It is not used in angina and coronary artery disease, however, because it induces tachycardia if not preceded by administration of propranolol and a diuretic.

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Last Answer : a) Prazosin hydrochloride (Minipress) Minipress is a peripheral vasodilator acting directly on the blood vessel. It is not used in angina and coronary artery disease, however, because it induces tachycardia if not preceded by administration of propranolol and a diuretic.

Histamine is involved as a mediator in the following pathological condition: A. Delayed hypersensitivity reaction B. Inflammation C. Carcinoid syndrome D. Variant angina

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Last Answer : B. Inflammation

Histamine is involved as a mediator in the following pathological condition: A. Delayed hypersensitivity reaction B. Inflammation C. Carcinoid syndrome D. Variant angina

Description : Histamine is involved as a mediator in the following pathological condition: A. Delayed hypersensitivity reaction B. Inflammation C. Carcinoid syndrome D. Variant angina

Last Answer : B. Inflammation

‘Coronary steal phenomenon’ has been noted most frequently with (a) Glyceryl trinitrate (b) Dipyridamole (c) Propranolol (d) Diltiazem

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Last Answer : Ans: B

A patient with coronary artery disease has raised serum triglyceride level (500 mg/dl) but normal total cholesterol level (150 mg/dl). Which hypolipidemic drug should be prescribed: A. Probucol B. Gemfibrozil C. Cholestyramine D. Lovastatin

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Combined therapy with dipyridamole and warfarin is recommended in subjects with the following: A. Risk factors for coronary artery disease B. Prosthetic heart valves C. Cerebral thrombosis D. Buerger's disease

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Match the column - I with column - II. Column-I Column-II (A) P-wave (i) Depolarisation of ventricles (B) QRS complex (ii) Repolarisation of ventricles (C) T-wave (iii) Coronary ischaemia (D) Reduction in the size of T- wave (iv) Depolarisation of atria (v) Repolarisation of atria Select the correct option. (A) (B) (C) (D) (a) (ii) (iii) (v) (iv) (b) (iv) (i) (ii) (iii) (c) (iv) (i) (ii) (v) (d) (ii) (i) (v) (iii)

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Last Answer : (b) (iv) (i) (ii) (iii)

Adrenergic β1 selective blockers offer the following advantages except: A. Lower propensity to cause bronchospasm B. Less prone to produce cold hands and feet as side effect C. Withdrawal is less likely to exacerbate angina pectoris D. Less liable to impair exercise capacity

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Last Answer : C. Withdrawal is less likely to exacerbate angina pectoris

Adrenergic β 1 selective blockers offer the following advantages except: A. Lower propensity to cause bronchospasm B. Less prone to produce cold hands and feet as side effect C. Withdrawal is less likely to exacerbate angina pectoris D. Less liable to impair exercise capacity

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Last Answer : C. Withdrawal is less likely to exacerbate angina pectoris

Your patient is to receive a selective ß2 stimulant drug ß2 selective stimulant are often effective in (a) Angina due to coronary insufficiency (b) Asthma (c) Chronic heart failure (d) Delayed or insufficiently strong labor (e) All of the above

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Last Answer : Ans: B

The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: A. Reduction of circulating blood volume B. Reduction in cardiac output C. Decreased sympathetic tone D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

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Last Answer : D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

Though nitrates and calcium channel blockers are both vasodilators, they are used concurrently in angina pectoris because (a) They antagonize each other’s side effects (b) Nitrates primarily reduce preload while calcium channel blockers primarily reduce after load (c) Nitrates increase coronary flow while calcium (d) Both (b) and (c)

Description : Though nitrates and calcium channel blockers are both vasodilators, they are used concurrently in angina pectoris because (a) They antagonize each other's side effects (b) Nitrates primarily reduce preload while calcium ... load (c) Nitrates increase coronary flow while calcium (d) Both (b) and (c)

Last Answer : Ans: B

Use of the following antimalarial drug carries high risk of adverse effect in subjects with G-6-PD deficiency: A. Pyrimethamine B. Artemisinin C. Primaquine D. Mefloquine

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Last Answer : C. Primaquine

Which blood vessels have the smallest diameter? (1) Capillaries (2) Arterioles (3) Venules (4) Lymphatic

Description : Which blood vessels have the smallest diameter? (1) Capillaries (2) Arterioles (3) Venules (4) Lymphatic

Last Answer : (1) Capillaries Explanation: Blood is carried through the body by Blood Vessels. With the help of perfusion process capillaries supplies blood to the tissues.

Extract of the following plant has platelet activating factor (PAF) antagonistic activity and is claimed to benefit cognitive disorders due to cerebral ischaemia: A. Ginkgo biloba B. Claviceps purpurea C. Amanita muscaria D. Artemisia annua (p. 440) 33.12 3 3 . 1 2 A Aim4aii

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Last Answer : A. Ginkgo biloba

Blood flow in the following vascular bed generally decreases under the influence of glyceryl trinitrate: A. Coronary B. Cutaneous C. Renal D. Cranial

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Antianginal drugs afford the following benefit/benefits: A. Terminate anginal attacks B. Decrease the frequency of anginal attacks C. Retard the progression of coronary artery disease D. Both ‘A’ and ‘B’ are correct

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Last Answer : D. Both ‘A’ and ‘B’ are correct

When therapeutic effects decline both below and above a narrow range of doses, a drug is said to exhibit: A. Ceiling effect B. Desensitization C. Therapeutic window phenomenon D. Nonreceptor mediated action

Description : When therapeutic effects decline both below and above a narrow range of doses, a drug is said to exhibit: A. Ceiling effect B. Desensitization C. Therapeutic window phenomenon D. Nonreceptor mediated action

Last Answer : C. Therapeutic window phenomenon

Exertion–induced angina, which is relieved by rest, nitroglycerin, or both, is referred to as (a) Prinzmetal’s angina (b) Unstable angina (c) Classic angina (d) Variant angina (e) Preinfarction angina

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Last Answer : Ans: C

Used alone the following antihypertensive drug tends to increase cardiac work and can precipitate angina: A. Clonidine B. Hydralazine C. Captopril D. Prazosin

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Last Answer : B. Hydralazine

The following drug is used to reduce the frequency of angina pectoris as well as to terminate an acute attack: A. Isosorbide dinitrate B. Pentaerythritol tetranitrate C. Diltiazem D. Dipyridamole

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Last Answer : A. Isosorbide dinitrate

Which of the following agents used in prinzmetal’s angina has spasmolytic actions, which increase coronary blood supply? (a) Nitroglycerin (b) Nifedipine (c) Timolol (d) Isosorbide mononitrate (e) Propranolol

Description : Which of the following agents used in prinzmetal’s angina has spasmolytic actions, which increase coronary blood supply? (a) Nitroglycerin (b) Nifedipine (c) Timolol (d) Isosorbide mononitrate (e) Propranolol

Last Answer : Ans: B

Select the drug which reduces cholesterol synthesis in liver, increases expression of LDL receptors on hepatocytes and has been found to reduce mortality due to coronary artery disease: A. Simvastatin B. Nicotinic acid C. Gemfibrozil D. Colestipol (p. 577, 578) 43.1 4 3 . 1 D 43.2 4 3 . 2 C 43.3 4 3 . 3 A 43.4 4 3 . 4 A Ai

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Last Answer : A. Simvastatin

Which of the following drugs is most likely to accentuate varient (Prinzmetal) angina: A. Propranolol B. Atenolol C. Verapamil D. Dipyridamole

Description : Which of the following drugs is most likely to accentuate varient (Prinzmetal) angina: A. Propranolol B. Atenolol C. Verapamil D. Dipyridamole

Last Answer : A. Propranolol

A patient has developed a sever chest pain and difficulties in breathing while in the dental chair. Your initial response is: a. Administer glycerine trinitrate and monitor patient in upright position. b. Patient has an acute episode of angina as demonstrated by curve in ECG c. No treatment is required until confirmed as MI by ECG d. Patient has myocardial infarction as confirmed by ECG

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Last Answer : a. Administer glycerine trinitrate and monitor patient in upright position.

A patient has developed a sever chest pain and difficulties in breathing while in the dental chair. Your initial response is: A. Administer glycerine trinitrate and monitor patient in upright position B. Patient has an acute episode of angina as demonstrated by curve in ECG C. No treatment is required until confirmed as MI by ECG D. Patient has myocardial infarction as confirmed by ECG

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Last Answer : A. Administer glycerine trinitrate and monitor patient in upright position

What are arterial vessels, arteries and arterioles?

Description : What are arterial vessels, arteries and arterioles?

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The antianginal effect of propranolol may be attributed to which one of the following (a) Block of exercise – induced tachycardia (b) Decreased end – diastolic ventricular volume (c) Dilation of consticted coronary vessels (d) Increased cardiac force (e) Increased resting heart rate

Description : The antianginal effect of propranolol may be attributed to which one of the following (a) Block of exercise – induced tachycardia (b) Decreased end – diastolic ventricular volume (c) Dilation of consticted coronary vessels (d) Increased cardiac force (e) Increased resting heart rate

Last Answer : Ans: A

he following is true of nifedipine except: A. It can aggravate urine voiding difficulty in elderly males with prostatic hypertrophy B. It promotes Na+ retention by a renal tubular action to cause ankle oedema as side effect C. It can inhibit insulin release from pancreas D. At high doses it can paradoxically increase the frequency of angina pectori

Description : he following is true of nifedipine except: A. It can aggravate urine voiding difficulty in elderly males with prostatic hypertrophy B. It promotes Na+ retention by a renal tubular action to ... release from pancreas D. At high doses it can paradoxically increase the frequency of angina pectori

Last Answer : B. It promotes Na+ retention by a renal tubular action to cause ankle oedema as side effect

A 40-year-old politician suffered from attacks of chest pain diagnosed as angina pectoris. He had a tense personality, resting heart rate was 96/min, blood pressure 170/104 mm Hg, but blood sugar level and lipid profile were normal. Select the most suitable antihypertensive for initial therapy in his case: A. Nifedipine B. Hydrochlorothiazide C. Atenolol D. Methyldopa

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Last Answer : C. Atenolol

Histamine exerts the following actions except: A. Dilatation of large blood vessels B. Dilatation of small blood vessels C. Stimulation of isolated guineapig heart D. Itching

Description : Histamine exerts the following actions except: A. Dilatation of large blood vessels B. Dilatation of small blood vessels C. Stimulation of isolated guineapig heart D. Itching

Last Answer : A. Dilatation of large blood vessels

Histamine exerts the following actions except: A. Dilatation of large blood vessels B. Dilatation of small blood vessels C. Stimulation of isolated guineapig heart D. Itching

Description : Histamine exerts the following actions except: A. Dilatation of large blood vessels B. Dilatation of small blood vessels C. Stimulation of isolated guineapig heart D. Itching

Last Answer : A. Dilatation of large blood vessels

Antiretroviral therapy is not recommended in asymptomatic HIV infected subjects with CD4 cell count more than 350/µl because of the following reason(s): A. All antiretroviral drugs lose efficacy after some time B. Adverse effects of antiretroviral drugs compromise the quality of life of asymptomatic subjects C. The treated subjects may produce and transmit drug resistant virus D. All of the above

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Anti-HIV drug therapy is recommended in the following category of HIV exposed subjects: A. HIV positive symptomatic patients with opportunistic infections B. HIV positive asymptomatic subjects with CD4 cell count more than 400/μl C. HIV positive asymptomatic subjects with CD4 cell count less than 200/μl D. Both 'A' and 'C

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Last Answer : C. HIV positive asymptomatic subjects with CD4 cell count less than 200/μl

The principles of antihypertensive drug usage enunciated in JNC VI and WHO-ISH guidelines include the following except: A. Therapy for grade I and II hypertension should be initiated with a single drug B. Dose of thiazide diuretic should be 12.5-25 mg hydrochlorothiazide or equivalent per day C. All subjects with BP higher than 140/90 mmHg should be put on antihypertensive medication immediately D. If the drug chosen initially fails to lower BP, it should be replaced by a drug/combination from another class

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Last Answer : C. All subjects with BP higher than 140/90 mmHg should be put on antihypertensive medication immediately

The vessels that supply blood to the heart are (a) vasa vasorum (b) cardiac (c) coronoid (d) coronary

Description : The vessels that supply blood to the heart are (a) vasa vasorum (b) cardiac (c) coronoid (d) coronary

Last Answer : Ans:(a)

What is the name of the blood vessels to the legs? a) mesenteric (pron: mez-en-TARE-ik) b) coronary c) renal d) iliac (pron: IL-ee-ak) e) hepatic

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Last Answer : ANSWER: D -- ILIAC