Define the term ‘Closures’. Write in detail about different types of closures commonly used in pharmaceutical industry.

1 Answer

Answer :

CLOSURES are devices by means of which containers can be opened and closed.

TYPES OF CLOSURES WITH EXAMPLES:

1. Plug type – It is a push-fit into the neck of the container. E.g. cork or glass stopper.

Nowadays plastic stoppers being flexible and unbreakable are used to ensure a good fit into the container.

2. Crown cap – The cap is commonly used as crimped closure for beverage bottles.

E.g.Cap of glass beverage bottle.

3. Push-fit cap – These are simple slide fit over the neck of the container. These are made of plastic and are shaped in such a way that these must be stretched over the neck to fit on the container. It provides tight fit.

4. Screw closures – It consists of three components – i) Cap: It is made of tin plate of aluminium. The container is simply closed by screwing the cap on the container. Ii)

Wad: it is a seal which prevents contamination of the product. Made of rubber or silicone rubber, however cork or cardboard wads are also used. Iii) Liner: It is made of metal foils, rubber, plastic films, and paper impregnated with a suitable resin, wax or plastic.

E.g. Caps of pharmaceutical liquid dosage forms.

Related questions

Description : Materials used in pharmaceutical closures.

Last Answer : Following are material used in pharmaceutical closures 1) Rubber Cork is obtained from the bark of oak tree. Cork is chemically inert and it does not impart any odour or flavour to ... of closure meant for vials, transfusion fluid bottles. Rubber, two types natural or synthetic, 

Description : Mention different types of closures. Comment on materials used for making closures.

Last Answer : Types of closures with examples:  1. Plug type. 2. Crown cap. 3. Push-fit cap. 4. Screw closures. Materials used in pharmaceutical closures:   1) Rubber Cork is obtained ... the construction of closure meant for vials, transfusion fluid bottles. Rubber, two types natural or synthetic, 

Description : Name various types of closures.

Last Answer : i. Plug type. ii. Crown type. iii. Push-fit cap. iv. Screw closure

Description : Explain the importance of closures.

Last Answer : Closures are used: To prevent loss of material. To avoid contamination. To prevent deterioration. To prevents spoilage. 

Description : Define pharmaceutical container. Give qualities of an ideal container.

Last Answer : Definition: Pharmaceutical container  A device that holds the drug and it may or may not be in direct contact with the pharmaceutical dosage form or preparations. Qualities of an ideal container:  1 ... and temperature. 7. Labelled easily 8. Non-toxic. 9. Closure easily removable/replaceable.

Description : Define: (1) Sieve number (2) Pharmaceutical Aid

Last Answer : (1) Sieve number: It is the number of mesh in 2.54cm transverse direction parallel to wire.  (2) Pharmaceutical Aid: Pharmaceutical aids are the substances which have no or little pharmacological effect but they are essentially used in the preparation of pharmaceutical dosage form.

Description : Give advantages and disadvantages of glass as a material used for pharmaceutical container and state its types.

Last Answer : Advantages:   Economical. Available in variety of sizes and shapes. Chemically inert, impermeable, strong and rigid. Does not deteriorate with age. Easy to label. Excellent barrier against light. ... -lime glass or Alkali glass (Type-III). 4. General Purpose soda-lime glass (Type-IV).

Description : Define ‘Homogenisation’. Write the principle of homogenisation. Write in detail about ‘Colloidal Mill’.

Last Answer : Homogenization is the process of preparing fine emulsion from a coarse emulsion by converting the large globules in to small globules. Principle: These work on the principal of braking large ... thus reduced to fine particle size The material is thrown outward due to centrifugal action

Description : List the importance of size reduction in pharmaceutical industries. 

Last Answer : Importance of size reduction ;-  i) To increase the rate of solution in case of chemical substance because reduction of particle size,increases the surface area for the action of solvent. ii) To allow ... form. vi) To help in the process of suppression of solid form liquids by filtration.

Description : Write in detail about moist heat method of sterilization

Last Answer : Principle: The steam has more penetration power than dry heat and thermal capacity of steam is more than thermal capacity of dry heat. The method is useful for killing of bacterial spores. ... for powder or oils. It is not suitable for sterilization of plastic which melt at 1150C.

Description : Write in detail about modified percolation process. 

Last Answer : Modified Percolation: In percolation process for tinctures drug\ percolate (d/p) ratio is 1:4.The drug/percolate ratio is reduced to 1:3 by modifying percolation process. Thus saves lot of heat, ... evaporated and then mixed with main percolate.  Final volume is made by adding more menstrum. 

Description : Why plastic containers are more commonly used now a days? Write its demerits.

Last Answer : Plastic containers are more commonly used now a days for following advantages: 1.They are light in weight and can be handled easily 2.They are poor conductor of heat . 3.They have sufficient ... solution. 5.They are relatively expensive. 6.Special type of gum or adhesive required for labelling.

Description : Define The term Clarification. Write the working of filter candle with neat diagram.

Last Answer : Clarification:-  When solids are present in a very small proportion i.e. not exceeding 1.0 % the process of its separation from liquid, is called clarification. Working :-   1) These are ... the candle & gets collected inside the candle from where it is removed. Diagram :

Description : Explain in detail evaporating still with its advantage and disadvantages.

Last Answer : It consist of a hemispherical pan made from copper or stainless steel. It is surrounded by a steam jacket. Still is covered from top and connected to condenser. Hemispherical shape ... heat transfer is poor. Heating surface is limited. Not suitable for thermolabile material.

Description : Describe in detail various oral cavity tablet.

Last Answer : Oral cavity tablet:  i. Buccal Tablet. ii. Sublingual Tablet. iii. Lozenge tablet and tracheas. iv. Dental cones. 1] Buccal Tablet's - a. These tablets are to be placed in buccal pouch or ... Chloride or it may be amines acid. f. These cones generally get dissolved in 20 to 40 min time.

Description : Explain in detail about maceration with adjustment. How does it differ from simple maceration process?

Last Answer : Maceration with adjustment: This process is carried out for unorganized drug. Method: i) Place unorganized drug with 4/5th of the menstruum in a close vessel for 2-7 days. ii) ... of Capsicum Examples of tinctures: Compound Tincture of Benzoin, Tincture of Tolu, Tincture of Myrrh

Description : Describe dry heat method of sterilization in detail.

Last Answer : Principle: All the microorganism including spores are destroyed. Principle of killing is by dehydration and oxidation of essential metabolites. In hot air oven heating is done at 1600 C for 2 hours. ... off the oven. Allow to cool. Take out the material.  Diagram:

Description : What are the equipments used for mixing of liquids? Give in detail about ‘Propeller Mixer’.

Last Answer : Equipments used for mixing of Liquids i .Propeller mixer ii .Turbine mixer iii .Paddle mixer Propeller Mixers Construction: .It consists of vessel and propeller, Propeller usually operates at ... : Application: It is used for mixing of liquids having low viscosity.

Description : Mention all Q.C. tests to be performed on tablets. Explain any one in detail. 

Last Answer : Q.C. Tests:  1. Size and shape of tablet. 2. Appearance. 3. Content of active ingredient. 4. Uniformity of weight/weight variation test 5. Uniformity of content 6. Disintegration. 7. ... are considered to be of good quality if the loss in weight is less than 1%.  Diagram:

Description : Define immunity. What are the different types of immunity?

Last Answer : Definition: Immunity is the power of body to resist effect of invasion of micro organisms Active Immunity-Antigens are injected in human body; as a result antibodies are formed. It ... are injected in human body. It develops quickly, it remains for short period treatment is therapeutic

Description : Define drug. Classify different types of dosage forms with examples

Last Answer : Drug- A chemical agent intended for use in the diagnosis, mitigation, treatment, cure or prevention of disease in man or in other animals.

Description : Define and discuss different types of container

Last Answer : Container is a device that holds the drug and it may or may not be in direct contact with the pharmaceutical preparations. containers are divided into following types on the basis of ... : These containers have adequate mechanical strength in order to bear the pressure of aerosol packing

Description : Define and classify different types of tablets

Last Answer : Definition : Tablets are solid unit dosage form containing medicament or medicaments usually circular flat or biconvex. OR Tablet is a solid unit dosage form prepared by compression. ... solutions a) Effervescence tablets b) Dispensing tablets c) Hypodermic tablets d) Tablet triturates

Description : What are different types of vaccines? Write method of preparation of small pox vaccine.

Last Answer : There are 4 main types of vaccines: Live-attenuated vaccines Inactivated vaccines Subunit, recombinant, polysaccharide, and conjugate vaccines Toxoid vaccines Small pox vaccine ... to produce homogenized suspension. ↓ Transfer to suitable sterile container and freeze dried

Description : Name the commonly used filter aids.

Last Answer : Commonly used filter aids are as follows: 1) Cellulose 2) Asbestos 3) Carbon 4) Diatomaceous earth 5) Perlite

Description : Define the term “phagocytosis and antibodies”.

Last Answer : Phagocytosis is the process of ingestion of bacteria by certain cells of the body ,which make them harmless.  Antibodies are immunoglobulin produced mainly in the body in response to the presence of foreign proteins and certain other material in tissues(antigens).

Description : Define the term “Pharmacopoeia.” 

Last Answer : Pharmacopoeia: Pharmakon means a drug and poein means to make . Pharmacopoeia is defined as a compressive book which is issued under the authority of government and contains a list of drug ... with description and the tests for those substances and the standards to which they must confirm.

Description : Define the term vaccine. Discuss the method of preparation of small pox vaccine using animals

Last Answer : Definition:   Vaccines are antigenic preparations which stimulate antibody formation and producing immunity. Small pox vaccine is prepared by two methods 1) By using animals 2) By using Eggs ... Filling sealing and storage: filled in final container under aseptic condition and freeze drying. 

Description : Define mixing, explain types and mechanism of mixing.

Last Answer : Definition of Mixing: Mixingis the method in which two or more than two substances are combined together. Types of mixtures-   1) Positive Mixture-When two/more miscible liquids are mixed or ... them to change position relative to one another. It produced by any agitation of powder.

Description : Define ‘Viscosity’. Write the applications in Pharmacy.

Last Answer : Defination of Viscosity: It is the property of liquid to resistance to flow. Applications of Viscosity in Pharmacy: i.Viscosity plays an important role in the stability of emulsions ... certain liquid preparations is increased in order to improve pourability or to make preparation more palatable.

Description : Define Menstrum and Marc. Write the advantages of alcohol as menstrum.

Last Answer : Menstrum :-Solvent used to extract the drug. Marc:-The drug residue which remains behind after extraction. Advantages of alcohol as menstrum   i) The mould and bacteria cannot grow ... is required to concentrate the alcoholic preparations. v) It dissolves selective active ingredients of drugs.

Description : Define: i) Sterilization ii) Disinfection Classify different methods of sterilization.

Last Answer : i) Sterilization: Sterilization is a process of complete destruction of all micro-organisms & their spores present in a system. ii) Disinfection: A process that removes the infection potential by ... ) Seitz filters 3) Sintered glass filters 4) Sintered metal filters 5) Membrane filters

Description : Define Drying .What are different factors affecting to the rate of drying?

Last Answer : Definition: Final removal of liquid from the solid with the help of heat is called drying. Factor affecting the rate of drying: Following factor can affect the rate of drying: 1) Surface area of ... (Hs-Hg) between surface layer and atmospheric: if difference is more rate of drying will be fast.

Description : Define microencapsulation.What are its advantages and different techniques involved in it?

Last Answer : Microencapsulation : it is the technique in which a thin coating is applied on the particles of solids, liquids, resulting in the formation of micro-capsules ranging from micron to ... 4) Electrostatic Deposition 5) Vacuum deposition 6) Polymerization 7) Multiorific Centrifugal Process.

Description : Define size reduction .What are different factors affecting to the rate of size reduction?

Last Answer : Size reduction is the process of reducing drugs into smaller pieces , coarse particles or fine powder. Factor affecting size reduction: 1.Hardness: Soft material easy break than hard. 2. ... size reduction of the material in a machine depends upon the bulk density of the substance.

Description : Define emulsion and list the different emulsifying agents

Last Answer : Definition: Emulsions are biphasic liquid preparation consisting of two immiscible liquid phasesone of which is dispersed as minute globules into other phase that is continuous phase and made miscible by ... monoesters, Milk of magnesia, Mg oxide, Mg trioxide, Carbowax, cholesterol and lecithin.

Description : Define sterilization. Classify different methods used for sterilization.

Last Answer : Sterilization: It is the process of complete destruction of microorganisms present in the system Different methods of Sterilization : I. Physical methods 1. Dry heat sterilization 2. Moist heat ... filters 3. Sintered glass filters 4. Sintered metal filters 5. Membrane filters

Description : Explain the objectives of mixing. Explain the different types of mixtures. 

Last Answer : Objective of mixing 1) To form a uniform mixture. 2)To promote chemical reaction to get uniform product 3) Help in formation of suspension/paste 4) Help in mixing of water and oil .e.g. emulsion. ... not have tendency to mix but once mix, don't separate after mixing. E.g. ointment, paste, cream.

Description : What are the different types of distillation? 

Last Answer : Following are the different types of distillation: 1) Simple distillation 2) Distillation under reduced pressure 3) Fractional distillation 4) Steam distillation 5) Destructive distillation

Description : Explain different types of excipients used in formulation of tablets with suitable examples.

Last Answer : The following are some of the excipients which are generally required in the formulation of tablets: Diluents Granulating agents Binding agents Disintegrating agents Lubricants ,Glidant , Anti ... patient compliance. E.g. approved FD and C dyes, volatile oils and saccharin respectively

Description : Write the advantages of microencapsulation and list different methods of microencapsulation.

Last Answer : Advantages of microencapsulation:  1. To mask the bitter taste of drugs like Paracetamol, Nitrofurantoin etc. 2. To reduce gastric and other gastro intestinal (G.I) tract irritations, ... 4) Electrostatic Deposition 5) Vacuum deposition 6) Polymerization 7) Multiorific Centrifugal Process.

Description : Define aseptic techniques. What are the various sources of contamination?

Last Answer : Definition: Aseptic technique  The method which is used to prevent the access of microorganism during the preparation of parenteral product and their testing are called Aseptic Technique Sources of ... are also a source of contamination. A handkerchief is the richest source of contamination. 

Description : Define drying. Give application of drying in pharmacy.

Last Answer : Definition:  Drying: It is defined as final removal of liquid from solid by vaporization with aid of heat. Application:  1) In pharmaceutical industry it is used as a unit process in the ... of product, when powder is dried it gets solublised fast. 7) Drying ensures free flowing of powders.

Description : Define sterilisation and classify methods of sterilisation.

Last Answer : Definition: Sterilizations is the process of complete destruction of all microorganisms along with their spores present in the system.  Methods of sterilization:  I. Physical methods:  1. Dry heat ... . Seitz filters  3. Sintered glass filters 4. Sintered metal filters  5. Membrane filters

Description : Define Pharmacopoeia. List official books used in India. 

Last Answer : Defination: Pharmakon means a drug and poeia means to make . Pharmacopoeia is defined as a compressive book which is issued under the authority of government and contains a list of drug ...  v) International Pharmacopeia  vi) Japanese Pharmacopoeia (J.P.)  vii) Martindale Extra Pharmacopoeia 

Description : Define ‘menstruum’ and state three ideal qualities of a menstruum.

Last Answer : Menstruum :- Solvent used to extract the drug.  Ideal properties of menstruum: i) Cheap. ii) Non-toxic. iii) Stable chemically and physically. iv) Selective i.e. remove the desired active constituents with minimum amount of inert materials.

Description : Define ‘slurry’ and ‘filter cake’.

Last Answer : i) Slurry: Mixture of insoluble substances suspended in a liquid and intended to filter before use.   ii) Filter cake: The solid which gets collected on the filter is called as filter cake.

Description : Define ‘drug’ and ‘dosage form’. 

Last Answer : i. Drug: A chemical agent intended for use in the diagnosis, mitigation, treatment, cure or prevention of disease in man or in other animals.   ii. Dosage Form: Dosage form is a ... of a pure chemical compound into a predetermined form by admixing drug components with non drug components. 

Description : Define desiccation with two example of Desiccants and draw a diagram of “ Desiccator”

Last Answer : Definition: Desiccation is the process of complete removal of mechanically admixed water from substances. Examples of desiccants:  Silica, activated charcoal, calcium sulfate, calcium chloride, and molecular sieves. Diagram:

Description : Define sieve number and enlist standards for sieves as per IP.

Last Answer : Sieve Number:  It is the number of mesh in 2.54cm transverse direction parallel to wire. According to I.P standards for sieves are as follows  Approximate sieve number Nominal mesh ... size According to I.P. sieves must confirm the above mentioned specifications for the given sieve number.