Husband-wife blood group is not a problem. We have a misconception that the child has thalassemia if the husband and wife have the same blood group. But it is wrong. Thalassemia is a chromosomal disorder. It is hereditary. Maybe not again. If the blood group is husband and wife (+) (-), that is, if the Rh factor is only in one, then the other factor is free, then there will be a problem which is called Rh Isoimmunization .