You may need to check your installers to make sure the proper drivers (directX?) are installed on your system prior to connecting. Usually this is a separate .exe that is included, but just in case, you may also want to go to Presonus’ website and download the latest drivers that are compatible with your OS and your version of Cubase. Sometimes you can’t (or aren’t) supposed to hook up the interface until the software drivers are installed, so make sure you do that first (on a sidenote, I see this was posted some months ago-did you ever resolve this?)