11. Which route of drug administration is most likely to lead to the first-pass effect? a) Sublingual b) Oral c) Intravenous d) Intramuscular

11.    Which route of drug administration is most likely to lead to the first-pass effect?
a)    Sublingual
 

b)    Oral
c)    Intravenous
d)    Intramuscular
by

1 Answer

Answer :

b)    Oral
by

Related questions

12. What is characteristic of the oral route? a) Fast onset of effect b) Absorption depends on GI tract secretion and motor function c) A drug reaches the blood passing the liver d) The sterilization of medicinal forms is obligatory

Description : 12. What is characteristic of the oral route? a) Fast onset of effect b) Absorption depends on GI tract secretion and motor function c) A drug reaches the blood passing the liver d) The sterilization of medicinal forms is obligatory

Last Answer : b) Absorption depends on GI tract secretion and motor function

10. Pick out the appropriate alimentary route of administration when passage of drugs through liver is minimized: a) Oral b) Transdermal c) Rectal d) Intraduodenal

Description : 10. Pick out the appropriate alimentary route of administration when passage of drugs through liver is minimized: a) Oral b) Transdermal c) Rectal d) Intraduodenal

Last Answer : c) Rectal

08. What does the term “bioavailability” mean? a) Plasma protein binding degree of substance b) Permeability through the brain-blood barrier c) Fraction of an uncharged drug reaching the systemic circulation following any route administration d) Amount of a substance in urine relative to the initial doze

Description : 08. What does the term bioavailability mean? a) Plasma protein binding degree of substance b) Permeability through the brain-blood barrier c) Fraction of an uncharged drug reaching the systemic ... following any route administration d) Amount of a substance in urine relative to the initial doze

Last Answer : C

A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/method of administration would be most suitable. (a) Sublingual (b) Oral (c) Intravenous bolus injection (d) Slow intravenous infusion

Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/ ... (a) Sublingual (b) Oral (c) Intravenous bolus injection (d) Slow intravenous infusion

Last Answer : Ans: D

Glyceryl trinitrate is administratered by all of the following routes except (a) Oral (b) Sublingual (c) Intramuscular (d) Intravenous

Description : Glyceryl trinitrate is administratered by all of the following routes except (a) Oral (b) Sublingual (c) Intramuscular (d) Intravenous

Last Answer : Ans: C

Glyceryl trinitrate is administered by the following routes except: A. Oral B. Sublingual C. Intramuscular D. Intravenous

Description : Glyceryl trinitrate is administered by the following routes except: A. Oral B. Sublingual C. Intramuscular D. Intravenous

Last Answer : C. Intramuscular

Drug administered through the following route is most likely to be subjected to first-pass metabolism: A. Oral B. Sublingual C. Subcutaneous D. Rectal

Description : Drug administered through the following route is most likely to be subjected to first-pass metabolism: A. Oral B. Sublingual C. Subcutaneous D. Rectal

Last Answer : A. Oral

Drug administered through the following route is most likely to be subjected to first-pass metabolism: A. Oral B. Sublingual C. Subcutaneous D. Rectal

Description : Drug administered through the following route is most likely to be subjected to first-pass metabolism: A. Oral B. Sublingual C. Subcutaneous D. Rectal

Last Answer : A. Oral

Ketorolac: A. Is a nonsteroidal anti-inflammatory drug (NSAID) approved for intravenous, intramuscular, and oral administration. B. Can be used indefinitely for postoperative analgesia. C. Can cause renal dysfunction. D. May decrease surgical blood loss.

Description : Ketorolac: A. Is a nonsteroidal anti-inflammatory drug (NSAID) approved for intravenous, intramuscular, and oral administration. B. Can be used indefinitely for postoperative analgesia. C. Can cause renal dysfunction. D. May decrease surgical blood loss.

Last Answer : Answer: AC DISCUSSION: Ketorolac tromethamine, an NSAID, is approved by the FDA for intravenous, intramuscular, and oral administration. The agent is an effective analgesic with minimal side ... Additionally, it is recommended that ketorolac should not be used for more than 5 consecutive days

A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/method of administration would be most suitable: A. Sublingual B. Oral C. Intravenous bolus injection D. Slow intravenous infusion

Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route ... suitable: A. Sublingual B. Oral C. Intravenous bolus injection D. Slow intravenous infusion

Last Answer : D. Slow intravenous infusion

The preferred route of administration of medication in the most acute care situations is which of the following routes? a) Intravenous The IV route is the preferred parenteral route in most acute care situations because it is much more comfortable for the patient, and peak serum levels and pain relief occur more rapidly and reliably. b) Epidural Epidural administration is used to control postoperative and chronic pain. c) Subcutaneous Subcutaneous administration results in slow absorption of medication. d) Intramuscular Intramuscular administration of medication is absorbed more slowly than intravenously administered medication.

Description : The preferred route of administration of medication in the most acute care situations is which of the following routes? a) Intravenous The IV route is the preferred ... ) Intramuscular Intramuscular administration of medication is absorbed more slowly than intravenously administered medication.

Last Answer : a) Intravenous The IV route is the preferred parenteral route in most acute care situations because it is much more comfortable for the patient, and peak serum levels and pain relief occur more rapidly and reliably.

The primary route of administration of insulin is: A. Intradermal B. Subcutaneous C. Intramuscular D. Intravenous

Description : The primary route of administration of insulin is: A. Intradermal B. Subcutaneous C. Intramuscular D. Intravenous

Last Answer : B. Subcutaneous

The most appropriate route of administration for adrenaline in a case of anaphylactic shock is: A. Intracardiac B. Intravenous C. Intramuscular D. Subcutaneous

Description : The most appropriate route of administration for adrenaline in a case of anaphylactic shock is: A. Intracardiac B. Intravenous C. Intramuscular D. Subcutaneous

Last Answer : A. Intracardiac

Select the route of administration which carries the highest risk of adversely affecting vital functions: A. Intra arterial injection B. Intrathecal injection C. Intravenous injection D. Intramuscular injection

Description : Select the route of administration which carries the highest risk of adversely affecting vital functions: A. Intra arterial injection B. Intrathecal injection C. Intravenous injection D. Intramuscular injection

Last Answer : C. Intravenous injection

Select the route of administration which carries the highest risk of adversely affecting vital functions: A. Intra arterial injection B. Intrathecal injection C. Intravenous injection D. Intramuscular injection

Description : Select the route of administration which carries the highest risk of adversely affecting vital functions: A. Intra arterial injection B. Intrathecal injection C. Intravenous injection D. Intramuscular injection

Last Answer : C. Intravenous injection

09. The reasons determing bioavailability are: a) Rheological parameters of blood b) Amount of a substance obtained orally and quantity of intakes c) Extent of absorption and hepatic first-pass effect d) Glomerular filtration rate

Description : 09. The reasons determing bioavailability are: a) Rheological parameters of blood b) Amount of a substance obtained orally and quantity of intakes c) Extent of absorption and hepatic first-pass effect d) Glomerular filtration rate

Last Answer : C

A semiconscious patient of haemorrhagic cerebral stroke has been brought to the emergency. His blood pressure is 240/120 mmHg. Select the procedure to lower his blood pressure as rapidly as possible: A. Sublingual nifedipine B. Intramuscular injection of hydralazine C. Intravenous infusion of sodium nitroprusside D. Intravenous injection of clonidin

Description : A semiconscious patient of haemorrhagic cerebral stroke has been brought to the emergency. His blood pressure is 240/120 mmHg. Select the procedure to lower his blood pressure as ... injection of hydralazine C. Intravenous infusion of sodium nitroprusside D. Intravenous injection of clonidin

Last Answer : C. Intravenous infusion of sodium nitroprussid

In addition to slow intravenous infusion, which of the following routes of administration allows for titration of the dose of a drug with the response: A. Sublingual B. Transdermal C. Inhalational D. Nasal insufflation

Description : In addition to slow intravenous infusion, which of the following routes of administration allows for titration of the dose of a drug with the response: A. Sublingual B. Transdermal C. Inhalational D. Nasal insufflation

Last Answer : C. Inhalational

In addition to slow intravenous infusion, which of the following routes of administration allows for titration of the dose of a drug with the response: A. Sublingual B. Transdermal C. Inhalational D. Nasal insufflation

Description : In addition to slow intravenous infusion, which of the following routes of administration allows for titration of the dose of a drug with the response: A. Sublingual B. Transdermal C. Inhalational D. Nasal insufflation

Last Answer : C. Inhalational

The preferred drug for suppressing febrile convulsions is: A. Intramuscular phenobarbitone B. Intravenous phenytoin C. Rectal diazepam D. Oral sodium valproate

Description : The preferred drug for suppressing febrile convulsions is: A. Intramuscular phenobarbitone B. Intravenous phenytoin C. Rectal diazepam D. Oral sodium valproate

Last Answer : C. Rectal diazepam

07. What is implied by «active transport»? a) Transport of drugs trough a membrane by means of diffusion b) Transport without energy consumption c) Engulf of drug by a cell membrane with a new vesicle formation

Description : 07. What is implied by «active transport»? a) Transport of drugs trough a membrane by means of diffusion b) Transport without energy consumption c) Engulf of drug by a cell membrane with a new vesicle formation

Last Answer : d) Transport against concentration gradient

03. What does “pharmacokinetics” include? a) Localization of drug action b) Mechanisms of drug action c) Excretion of substances d) Interaction of substances

Description : 03. What does “pharmacokinetics” include? a) Localization of drug action b) Mechanisms of drug action c) Excretion of substances d) Interaction of substances

Last Answer : c) Excretion of substances

02. What does “pharmacokinetics” include? a) Complications of drug therapy b) Drug biotransformation in the organism c) Influence of drugs on metabolism processes d) Influence of drugs on genes

Description : 02. What does “pharmacokinetics” include? a) Complications of drug therapy b) Drug biotransformation in the organism c) Influence of drugs on metabolism processes d) Influence of drugs on genes

Last Answer : b) Drug biotransformation in the organism

Pharmacokinetics is: a) The study of biological and therapeutic effects of drugs b) The study of absorption, distribution, metabolism and excretion of drugs c) The study of mechanisms of drug action d) The study of methods of new drug development

Description : Pharmacokinetics is: a) The study of biological and therapeutic effects of drugs b) The study of absorption, distribution, metabolism and excretion of drugs c) The study of mechanisms of drug action d) The study of methods of new drug development

Last Answer : b) The study of absorption, distribution, metabolism and excretion of drugs

The following procedure for rapid lowering of BP in hypertensive urgency/emergency has been abandoned: A. Sublingual/oral nifedipine B. Intravenous glyceryl trinitrate infusion C. Intravenous sodium nitroprusside infusion D. Intravenous esmolol injection

Description : The following procedure for rapid lowering of BP in hypertensive urgency/emergency has been abandoned: A. Sublingual/oral nifedipine B. Intravenous glyceryl trinitrate infusion C. Intravenous sodium nitroprusside infusion D. Intravenous esmolol injection

Last Answer : A. Sublingual/oral nifedipine

The following regimen is preferred for nonsurgical termination of pregnancy in the first 7 weeks: A. Intravenous oxytocin infusion B. Intramuscular carboprost C. Intravaginal mifepristone followed by intraamniotic dinoprost D. Oral mifepristone followed by oral misoprostol

Description : The following regimen is preferred for nonsurgical termination of pregnancy in the first 7 weeks: A. Intravenous oxytocin infusion B. Intramuscular carboprost C. Intravaginal mifepristone followed by intraamniotic dinoprost D. Oral mifepristone followed by oral misoprostol

Last Answer : D. Oral mifepristone followed by oral misoprosto

___________ absorption in infants and children is noticeably faster than in neonatal period. a) Oral. b) Topical c) Intravenous. d) Intramuscular.

Description : ___________ absorption in infants and children is noticeably faster than in neonatal period. a) Oral. b) Topical c) Intravenous. d) Intramuscular.

Last Answer : a) Oral. 

A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%

Description : A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%

Last Answer : (C) 12.5%

06. A hydrophilic medicinal agent has the following property: a) Low ability to penetrate through the cell membrane lipids b) Penetrate through membranes by means of endocytosis c) Easy permeation through the blood-brain barrier d) High reabsorption in renal tubules

Description : 06. A hydrophilic medicinal agent has the following property: a) Low ability to penetrate through the cell membrane lipids b) Penetrate through membranes by means of endocytosis c) Easy permeation through the blood-brain barrier d) High reabsorption in renal tubules

Last Answer : a) Low ability to penetrate through the cell membrane lipids

05. What kind of substances can’t permeate membranes by passive diffusion? a) Lipid-soluble b) Non-ionized substances c) Hydrophobic substances d) Hydrophilic substances 06. A hydrophilic medicinal agent

Description : 05. What kind of substances can’t permeate membranes by passive diffusion? a) Lipid-soluble b) Non-ionized substances c) Hydrophobic substances d) Hydrophilic substances 06. A hydrophilic medicinal agent

Last Answer : d) Hydrophilic substances

04. The main mechanism of most drugs absorption in GI tract is: a) Active transport (carrier-mediated diffusion) b) Filtration (aqueous diffusion) c) Endocytosis and exocytosis d) Passive diffusion (lipid diffusion)

Description : 04. The main mechanism of most drugs absorption in GI tract is: a) Active transport (carrier-mediated diffusion) b) Filtration (aqueous diffusion) c) Endocytosis and exocytosis d) Passive diffusion (lipid diffusion)

Last Answer : PHARMACOKINETICS

02. What does “pharmacokinetics” include? a) Pharmacological effects of drugs b) Unwanted effects of drugs c) Chemical structure of a medicinal agent d) Distribution of drugs in the organism

Description : 02. What does “pharmacokinetics” include? a) Pharmacological effects of drugs b) Unwanted effects of drugs c) Chemical structure of a medicinal agent d) Distribution of drugs in the organism

Last Answer : d) Distribution of drugs in the organism

A patient with a history of angina suffers an attack while in the dental chair. Prompt relief can be anticipated in MOST instances from: A. Oral administration of short acting barbiturates B. Intra muscular administration of morphine sulphate C. Subcutaneous administration of epinephrine D. Sublingual administration of glyceryl tri-nitrate E. Putting the patient in upright position

Description : A patient with a history of angina suffers an attack while in the dental chair. Prompt relief can be anticipated in MOST instances from: A. Oral administration of short acting ... epinephrine D. Sublingual administration of glyceryl tri-nitrate E. Putting the patient in upright position

Last Answer : D. Sublingual administration of glyceryl tri-nitrate

The preferred drug for status epilepticus is: A. Intravenous diazepam B. Intravenous phenytoin sodium C. Intramuscular phenobarbitone D. Rectal diazepam

Description : The preferred drug for status epilepticus is: A. Intravenous diazepam B. Intravenous phenytoin sodium C. Intramuscular phenobarbitone D. Rectal diazepam

Last Answer : A. Intravenous diazepam

The drug used for controlling tetany is: A. Intravenous diazepam B. Intramuscular vitamin D C. Intravenous calcium gluconate D. Intravenous calcitonin

Description : The drug used for controlling tetany is: A. Intravenous diazepam B. Intramuscular vitamin D C. Intravenous calcium gluconate D. Intravenous calcitonin

Last Answer : C. Intravenous calcium gluconate

For the treatment of hypogonadism and impotence, testosterone/dihydrotestosterone can be administered by the following route/routes: A. Oral B. Intramuscular C. Transdermal D. Both 'B' and 'C

Description : For the treatment of hypogonadism and impotence, testosterone/dihydrotestosterone can be administered by the following route/routes: A. Oral B. Intramuscular C. Transdermal D. Both 'B' and 'C

Last Answer : D. Both 'B' and 'C'

The preferred route of administration of streptokinase in acute myocardial infarction is: A. Intravenous B. Subcutaneous C. Intracoronary

Description : The preferred route of administration of streptokinase in acute myocardial infarction is: A. Intravenous B. Subcutaneous C. Intracoronary

Last Answer : A. Intravenous

Nitrate tolerance is least likely to develop with the use of: A. Sustained release oral glyceryl trinitrate B. Sublingual glyceryl trinitrate C. Transdermal glyceryl trinitrate D. Oral pentaerythritol tetranitrate

Description : Nitrate tolerance is least likely to develop with the use of: A. Sustained release oral glyceryl trinitrate B. Sublingual glyceryl trinitrate C. Transdermal glyceryl trinitrate D. Oral pentaerythritol tetranitrate

Last Answer : B. Sublingual glyceryl trinitrate

Noradrenaline is administered by (a) Subcutaneous injection (b) Intramuscular injection (c) Slow intravenous infusion (d) All of the above routes

Description : Noradrenaline is administered by (a) Subcutaneous injection (b) Intramuscular injection (c) Slow intravenous infusion (d) All of the above routes

Last Answer : Ans: C

Noradrenaline is administered by: A. Subcutaneous injection B. Intramuscular injection C. Slow intravenous infusion D. All of the above routes

Description : Noradrenaline is administered by: A. Subcutaneous injection B. Intramuscular injection C. Slow intravenous infusion D. All of the above routes

Last Answer : C. Slow intravenous infusion

Which of the following is the only life saving measure in case of anaphylactic shock: A. Intravenous hydrocortisone hemisuccinate B. Intravenous chlorpheniramine maleate C. Intramuscular adrenaline hydrochloride D. Intravenous glucose-saline

Description : Which of the following is the only life saving measure in case of anaphylactic shock: A. Intravenous hydrocortisone hemisuccinate B. Intravenous chlorpheniramine maleate C. Intramuscular adrenaline hydrochloride D. Intravenous glucose-saline

Last Answer : C. Intramuscular adrenaline hydrochloride

Noradrenaline is administered by: A. Subcutaneous injection B. Intramuscular injection C. Slow intravenous infusion D. All of the above routes

Description : Noradrenaline is administered by: A. Subcutaneous injection B. Intramuscular injection C. Slow intravenous infusion D. All of the above routes

Last Answer : C. Slow intravenous infusion

Which of the following is the only life saving measure in case of anaphylactic shock: A. Intravenous hydrocortisone hemisuccinate B. Intravenous chlorpheniramine maleate C. Intramuscular adrenaline hydrochloride D. Intravenous glucose-saline

Description : Which of the following is the only life saving measure in case of anaphylactic shock: A. Intravenous hydrocortisone hemisuccinate B. Intravenous chlorpheniramine maleate C. Intramuscular adrenaline hydrochloride D. Intravenous glucose-saline

Last Answer : C. Intramuscular adrenaline hydrochloride

Bioavailability differences among oral formulations of a drug are most likely to occur if the drug: A. Is freely water soluble B. Is completely absorbed C. Is incompletely absorbed D. Undergoes little first-pass metabolism

Description : Bioavailability differences among oral formulations of a drug are most likely to occur if the drug: A. Is freely water soluble B. Is completely absorbed C. Is incompletely absorbed D. Undergoes little first-pass metabolism

Last Answer : C. Is incompletely absorbed

Bioavailability differences among oral formulations of a drug are most likely to occur if the drug: A. Is freely water soluble B. Is completely absorbed C. Is incompletely absorbed D. Undergoes little first-pass metabolism

Description : Bioavailability differences among oral formulations of a drug are most likely to occur if the drug: A. Is freely water soluble B. Is completely absorbed C. Is incompletely absorbed D. Undergoes little first-pass metabolism

Last Answer : C. Is incompletely absorbed

Use of sublingual/oral nifedipine soft geletine capsule for rapid BP lowering in hypertensive urgency has been discarded because of: A. Delayed onset of action B. Inability to control the rate and extent of fall in BP C. Reports of adverse/fatal outcome D. Both 'B' and 'C'

Description : Use of sublingual/oral nifedipine soft geletine capsule for rapid BP lowering in hypertensive urgency has been discarded because of: A. Delayed onset of action B. Inability to control the rate and extent of fall in BP C. Reports of adverse/fatal outcome D. Both 'B' and 'C'

Last Answer : D. Both 'B' and 'C'

Fluconazole differs from ketoconazole in that: A. It is not active by the oral route B. It is a more potent inhibitor of drug metabolism C. It is not effective in cryptococcal meningitis D. It is unlikely to produce anti-androgenic side effects

Description : Fluconazole differs from ketoconazole in that: A. It is not active by the oral route B. It is a more potent inhibitor of drug metabolism C. It is not effective in cryptococcal meningitis D. It is unlikely to produce anti-androgenic side effects

Last Answer : D. It is unlikely to produce anti-androgenic side effects

Select the antifungal drug which is administered only by the oral route: A. Amphotericin B B. Ketoconazole C. Griseofulvin D. Tolnaftate

Description : Select the antifungal drug which is administered only by the oral route: A. Amphotericin B B. Ketoconazole C. Griseofulvin D. Tolnaftate

Last Answer : C. Griseofulvin

The most dependable emetic used to expel ingested poisons is: A. Intramuscular emetine B. Oral syrup ipecacuanha C. Intramuscular apomorphine D. Oral bromocriptine

Description : The most dependable emetic used to expel ingested poisons is: A. Intramuscular emetine B. Oral syrup ipecacuanha C. Intramuscular apomorphine D. Oral bromocriptine

Last Answer : C. Intramuscular apomorphine

Choose the correct statement about iron therapy: A. Haemoglobin response to intramuscular iron is faster than with oral iron therapy B. Iron must be given orally except in pernicious anaemia C. Prophylactic iron therapy must be given during pregnancy D. Infants on breastfeeding do not require medicinal iron

Description : Choose the correct statement about iron therapy: A. Haemoglobin response to intramuscular iron is faster than with oral iron therapy B. Iron must be given orally except in pernicious anaemia C. ... iron therapy must be given during pregnancy D. Infants on breastfeeding do not require medicinal iron

Last Answer : C. Prophylactic iron therapy must be given during pregnancy