Description : In gastrointestinal tract, serotonin causes (a) Contraction of gastrointestinal muscles (b) Decreased muscle tone (c) Decreased peristalsis (d) All of the above
Last Answer : Ans: A
Description : The termination of heparin activity by protamine sulfate is due to (a) A chelating action (b) The inhibition of gastrointestinal absorption of heparin (c) The displacement of heparin-plasma protein binding (d) An acid-base interaction (e) The prothrombin-like activity of protamine
Last Answer : Ans: D
Description : Which action of morphine is incompletely reversed by naloxone ? (a) Analgesia (b) Respiratory depression (c) Sedation (d) Miosis
Last Answer : Ans: C
Description : Pentazocine differs from morphine in that (a) It is inactive by the oral route (b) It does not produce physical dependence (c) It has a lower ceiling of analgesic effect (d) Its action is not blocked by naloxone
Description : For limiting cerebral edema due to brain tumour, the preferred corticosteroids are betamenthasone/dexamethasone because (a) They do not cause Na+ and water retention (b) They are more potent (c) They can be administered intravenously (d) They inhibit brain tumours
Description : Ondansetron blocks emetogenic impulses at the following site(s): A. Vagal afferents in intestines B. Nucleus tractus solitarius C. Chemoreceptor trigger zone D. All of the above
Last Answer : D. All of the above
Description : 3 Select the antiemetic that prevents activation of emetogenic afferents in the gut and their central relay in chemoreceptor trigger zone/nucleus tractus solitarious, but has no effect on gastric motility: A. Ondansetron B. Domperidone C. Metoclopramide D. Cisaprid
Last Answer : A. Ondansetron
Description : Potential adverse effects associated with aspirin include all of the following except (a) Gastrointestinal ulceration (b) Renal dysfunction (c) Enhanced methotrexate toxicity (d) Cardiac arrhythmias (e) Hypersensitivity asthma
Last Answer : Ans: E
Description : Acute or chronic colchicine toxicity may be identified by which of the following signs/symptoms? (a) Alopecia (b) Blood dyscrasias (c) Severe gastrointestinal upset (d) All of the above (e) None of the above
Description : Which of the following prostaglandin analogs is used specifically for the treatment of NSAID induced gastrointestinal ulcertation? (a) Alprostadil (b) Misoprostol (c) Carboprost (d) Dinoprostone (e) Epoprostenol
Last Answer : Ans: B
Description : The primary objective for designing drugs that selectively inhibit COX - 2 is to (a) Decrease the risk of nephrotoxicity (b) Improve anti-inflammatory effectiveness (c) Lower the ... of treatment of rheumatoid arthritis (e) Selectively decrease thromboxane A2 without effects on other eicosanoids
Description : A 45-year-old surgeon has developed symmetric early morning stiffness in her hands. She wishes to take a nonsteroidal anti-inflammatory drug to relieve these symptoms and wants to avoid gastrointestinal side ... appropriate? (a) Aspirin (b) Celecoxib (c) Ibuprofen (d) Indomethacin (e) Piroxicam
Description : Codeine acts as a cough sedative by (a) Producing mild nausea (b) Depressing bronchiolar secretions (c) Depressing pulmonary action (d) Depressing cough center (e) Paralyzing sensory nerves of bronchi
Description : A very common side effect of morphine is (a) Allergic response (b) Blood dyscrasias (c) Constipation (d) Liver damage (e) Visceral pain
Description : The greatest threat from morphine poisoning is (a) Renal shutdown (b) Paralysis of spinal cord (c) Respiratory depression (d) Cardiovascular collapse (e) None of the above
Description : Which of the following narcotics has the longest duration of effect? (a) Methadone (b) Controlled-release morphine (c) Levorphanol (d) Transdermal fentanyl (e) Dihydromorphone
Description : A drug that decreases blood pressure and has analgesic and spasmolytic effects when given intrathecally is (a) Atenolol (b) Clonidine (c) Morphine (d) Nitroprusside (e) Prazosin
Description : Opioid analgesics are either contraindicated or must be used with extreme caution in several clinical situations. For morphine, such situations do not include (a) Aqueous diffusion (b) Aqueous hydrolysis (c) Lipid diffusion (d) Pinocytosis or endocytosis (e) Special carrier transport
Description : Lower dose of naloxone is required to (a) Antagonise the actions of nalorphine (b) Antagonise the actions of pentazocine (c) Precipitate withdrawal in mildly morphine dependent subjects (d) Precipitate withdrawal in highly morphine dependent subjects
Description : Morphine has high affinity for the following opioid receptor(s). (a) µ (Mu) (b) k (Kappa) (c) d (Delta) (d) All of the above
Description : Which of the following opioids is more potent than morphine ? (a) Pethidine (b) Fentanyl (c) Dextropropoxyphene (d) Tramadol
Description : Morphine is contraindicated in head injury because (a) It does not relieve the pain of head injury (b) It can raise intracranial tension (c) It can cause constipation (d) It is liable to cause addiction
Description : Morphine dependence is characterized by (a) Marked drug seeking behavior (b) Physical dependence without psychic dependence (c) Physical as well as psychic dependence (d) Both (a) and (c)
Description : In a comatose patient suspected of poisoning, which of the following findings would be against the drug being morphine (a) Selegiline (b) Chlorgiline (c) Moclobemide (d) Tranylcypromine
Description : Instead of depressing, morphine stimulates (a) Vasomotor centre (b) Edinger westphal nucleus (c) Temperature regulating centre (d) Cough centre
Description : In man sedation caused by morphine is characterized by (a) Initial excitement (b) Little or no motor incoordination (c) Rise in seizure threshold (d) All of the above
Description : Morphine produces analgesia by acting at (a) Peripheral pain receptors (b) A spinal site (c) Suspraspinal sites (d) Both (b) and (c)
Description : The following adverse effect of corticosteroids is due to their mineralocorticoid action (a) Osteoporosis (b) Rise in blood pressure (c) Moon face (d) Increased susceptibility to infection
Description : Morphine induced constipation involves the following mechanisms except: A. Increase in tone and decrease in propulsive activity of intestinal muscles B. Antivagal action C. Spasm of gastrointestinal sphincters D. Reduction of gastrointestinal secretions
Last Answer : B. Antivagal action
Description : The action of aspirin that results in its greater efficacy as an antithrombotic (anti-platelet) drug is its ability to (a) Inhibit lipoxygenase as well as cyclooxygenase (b) Selectively inhibit ... I (c) Inhibit leukocyte migration (d) Promote uric acid excretion (e) Acetylate cyclooxygenase
Description : 2 In a conscious patient of poisoning, use of an emetic is permissible in case the ingested poison is: A. Ferrous sulfate B. Sodium hydroxide C. Kerosine D. Morphine
Last Answer : A. Ferrous sulfate
Description : Corticosteroids exert anti-inflammatory action by inhibiting the following enzyme (a) Cycloxygenase (b) Lipozygenase (c) Phospholipase - A (d) Phosphodiesterase
Description : Initial bradycardia caused by intramuscular injection of atropine is believed to be caused by: A. Stimulation of medullary vagal centre B. Stimulation of vagal ganglia C. Blockade of M2 receptors on SA nodal cells D. Blockade of muscarinic autoreceptors on vagal nerve endings
Last Answer : D. Blockade of muscarinic autoreceptors on vagal nerve endings
Description : Which of the following statements best describes the usual course of rheumatoid arthritis? (a) It is an acute exacerbation of joint pain treated with short-term anti-inflammatory therapy (b) It is ... characterized by a marked loss of calcium from the bones and a resultant thinning of the bones
Description : A FDA – approved ingredient for protection against painful sensitivity of the teeth due to cold, heat, acids, sweets or contact is (a) Dicalcium phosphate (b) Sodium lauryl sulfate (c) 5% potassium nitrate (d) Zinc chloride (e) Calcium carbonate
Description : Projection of cortex between medullary pyramids is called_____
Last Answer : Projection of cortex between medullary pyramids is called_____
Description : Homonymous hemianopia is due to lesion at: a. Optic tract b. Optic nerve c. Optic chiasma d. Retina e. Occipital cortex
Last Answer : ANSWER: A
Description : Which of the following is true of loss of gastrointestinal secretions? A. Gastric losses are best replaced with a balanced salt solution. B. Potassium supplementation is unnecessary in ... bowel fistula. E. A patient with persistent vomiting usually requires hyperchloremic replacement fluids.
Last Answer : Answer: DE DISCUSSION: Gastric secretions are relatively high in chloride and potassium. Other than an isolated pancreatic fistula, gastrointestinal tract losses below the pylorus ... Although potassium concentrations are low, copious losses require potassium supplementation to prevent hypokalemia
Description : The most common symptom of esophageal disease is a) dysphagia. This symptom may vary from an uncomfortable feeling that a bolus of food is caught in the upper esophagus to acute pain on ... have a variety of causes. d) odynophagia. Odynophagia refers specifically to acute pain on swallowing.
Last Answer : a) dysphagia. This symptom may vary from an uncomfortable feeling that a bolus of food is caught in the upper esophagus to acute pain on swallowing.
Description : The part of the brain controlling the anterior pituitary gland secretions is the A) medulla. B) thalamus. C) cerebral cortex. D) hypothalamus. E) cerebellum. Answer: D ... B) antidiuretic hormone C) gonadotropic hormones D) thyroid-stimulating hormone E) adrenocorticotropic hormone
Last Answer : B) thalamus.
Description : Which of the following durgs is a monamine oxidase inhibitor, but is used to treat hypertension? (a) Tranylcypromine (Parnate) (b) Reserpine (c) Propranolol (Inderal) (d) Pargyline (Eutonyl) (e) Imipramine (Tofranil)
Description : Which type of patient is most likely to hypersensitive to aspirin? (a) Intrinsic asthamatic (b) Extrinsic asthamatic (c) Chronic bronchitic (d) Patient with viral injection (e) Both (c) and (d)
Description : Colchicine is used mainly to treat (a) Gout (b) Arthiritis (c) Diabetes (d) Carcinomas (e) High blood pressure
Description : All of the following facts are true about non-steroidal anti-inflammatory drugs (NSAIDs) except (a) They are antipyretic (b) There is a celling effect to their analgesia (c) They can cause tolerance (d) They do not cause dependence (e) They are anti-inflammatory
Description : All of the following statements concerning an acute gouty arthritis attack are correct except (a) The diagonosis of gout is assured by a good therapeutic response to colchicines because no ... attack usually involves only one joint, most frequently the big toe (first metatarsophalangeal joint)
Description : All of the following medications should not be used routinely in pregnant patients during the third trimester except (a) Acetaminophen (b) Nonsteroidal anti-inflammatory drugs (c) Warfarin (d) Lithium (e) Aspirin
Description : A 65-year-old is interested in taking ginkgo. Which of the following statements is correct regarding ginkgo? (a) Ginkgo is contraindicated in diabetes and pregnancy (b) There is a ... drug-herb interaction between ginkgo and phenelzine (e) Ginkgo is contraindicated in patients with gallstone pain
Description : In addition to their ability to decrease inflammatory prostaglandin synthesis, some non-steroidal anti-inflammatory drugs (NSAIDs) may owe part of their effects to their ability to (a) Inhibit leukocyte migration (b ... (c) Stabilize lysosmal membranes (d) All of the above (e) None of the above