Description : 11. Which route of drug administration is most likely to lead to the first-pass effect? a) Sublingual b) Oral c) Intravenous d) Intramuscular
Last Answer : b) Oral
Description : 12. What is characteristic of the oral route? a) Fast onset of effect b) Absorption depends on GI tract secretion and motor function c) A drug reaches the blood passing the liver d) The sterilization of medicinal forms is obligatory
Last Answer : b) Absorption depends on GI tract secretion and motor function
Description : 08. What does the term bioavailability mean? a) Plasma protein binding degree of substance b) Permeability through the brain-blood barrier c) Fraction of an uncharged drug reaching the systemic ... following any route administration d) Amount of a substance in urine relative to the initial doze
Last Answer : C
Description : 07. What is implied by «active transport»? a) Transport of drugs trough a membrane by means of diffusion b) Transport without energy consumption c) Engulf of drug by a cell membrane with a new vesicle formation
Last Answer : d) Transport against concentration gradient
Description : 04. The main mechanism of most drugs absorption in GI tract is: a) Active transport (carrier-mediated diffusion) b) Filtration (aqueous diffusion) c) Endocytosis and exocytosis d) Passive diffusion (lipid diffusion)
Last Answer : PHARMACOKINETICS
Description : 02. What does “pharmacokinetics” include? a) Pharmacological effects of drugs b) Unwanted effects of drugs c) Chemical structure of a medicinal agent d) Distribution of drugs in the organism
Last Answer : d) Distribution of drugs in the organism
Description : 02. What does “pharmacokinetics” include? a) Complications of drug therapy b) Drug biotransformation in the organism c) Influence of drugs on metabolism processes d) Influence of drugs on genes
Last Answer : b) Drug biotransformation in the organism
Description : Pharmacokinetics is: a) The study of biological and therapeutic effects of drugs b) The study of absorption, distribution, metabolism and excretion of drugs c) The study of mechanisms of drug action d) The study of methods of new drug development
Last Answer : b) The study of absorption, distribution, metabolism and excretion of drugs
Description : Drug administered through the following route is most likely to be subjected to first-pass metabolism: A. Oral B. Sublingual C. Subcutaneous D. Rectal
Last Answer : A. Oral
Description : 06. A hydrophilic medicinal agent has the following property: a) Low ability to penetrate through the cell membrane lipids b) Penetrate through membranes by means of endocytosis c) Easy permeation through the blood-brain barrier d) High reabsorption in renal tubules
Last Answer : a) Low ability to penetrate through the cell membrane lipids
Description : For the treatment of hypogonadism and impotence, testosterone/dihydrotestosterone can be administered by the following route/routes: A. Oral B. Intramuscular C. Transdermal D. Both 'B' and 'C
Last Answer : D. Both 'B' and 'C'
Description : 09. The reasons determing bioavailability are: a) Rheological parameters of blood b) Amount of a substance obtained orally and quantity of intakes c) Extent of absorption and hepatic first-pass effect d) Glomerular filtration rate
Description : 05. What kind of substances can’t permeate membranes by passive diffusion? a) Lipid-soluble b) Non-ionized substances c) Hydrophobic substances d) Hydrophilic substances 06. A hydrophilic medicinal agent
Last Answer : d) Hydrophilic substances
Description : 03. What does “pharmacokinetics” include? a) Localization of drug action b) Mechanisms of drug action c) Excretion of substances d) Interaction of substances
Last Answer : c) Excretion of substances
Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/ ... (a) Sublingual (b) Oral (c) Intravenous bolus injection (d) Slow intravenous infusion
Last Answer : Ans: D
Description : Fentanyl transdermal patches have been used postoperatively to provide transdermal analgesia. The most dangerous adverse effect of this mode of administration is (a) Cutaneous reactions (b) Diarrhea (c) Hypertension (d) Relaxation of skeletal muscle (e) Respiratory depression
Last Answer : Ans: E
Description : In addition to slow intravenous infusion, which of the following routes of administration allows for titration of the dose of a drug with the response: A. Sublingual B. Transdermal C. Inhalational D. Nasal insufflation
Last Answer : C. Inhalational
Description : Nitrate tolerance is least likely to develop with the use of: A. Sustained release oral glyceryl trinitrate B. Sublingual glyceryl trinitrate C. Transdermal glyceryl trinitrate D. Oral pentaerythritol tetranitrate
Last Answer : B. Sublingual glyceryl trinitrate
Description : Transdermal estradiol differs from oral estrogen therapy in that it: A. Causes less induction of hepatic synthesis of clotting factors B. Does not inhibit FSH secretion C. Does not affect vaginal cytology D. All of the above are correct
Last Answer : A. Causes less induction of hepatic synthesis of clotting factors
Description : Ganglion blocking drugs are no longer used in therapeutics because: A. They have few and weak pharmacological actions B. They produce many side effects C. They are inactive by oral route D. They have short duration of action
Last Answer : A. They have potent antiovulatory action of their own
Last Answer : B. They produce many side effects
Description : The preferred drug for suppressing febrile convulsions is: A. Intramuscular phenobarbitone B. Intravenous phenytoin C. Rectal diazepam D. Oral sodium valproate
Last Answer : C. Rectal diazepam
Description : The most appropriate route of administration for adrenaline in a case of anaphylactic shock is: A. Intracardiac B. Intravenous C. Intramuscular D. Subcutaneous
Last Answer : A. Intracardiac
Description : Which one of the following characteristics pertains to hepatitis A? a. Transmission is by the fecal-oral route. b. The incubation period is 2 to 4 weeks. c. It is an acute, inflammatory liver disease. d. All of the above (A—C) are correct.
Last Answer : d. All of the above (A—C) are correct.
Description : In patients of hepatic cirrhosis: A. The extent of change in pharmacokinetics of drugs can be predicted from the values of liver function tests B. High doses of furosemide can be safely used C. Metformin is the preferred oral hypoglycaemic D. Disposition of atenolol is not significantly affected
Last Answer : D. Disposition of atenolol is not significantly affected
Description : Drugs which undergo high degree of first-pass metabolism in liver: A. Have low oral bioavailability B. Are excreted primarily in bile C. Are contraindicated in liver disease D. Exhibit zero order kinetics of elimination
Last Answer : A. Have low oral bioavailability
Description : In the United States, nurses performing invasive procedures need to be up-to-date with their immunizations, particularly a) Hepatitis B. Hepatitis B is transmitted through contact with infected blood ... infected person. d) Hepatitis C. At present, immunization against hepatitis C is not available.
Last Answer : a) Hepatitis B. Hepatitis B is transmitted through contact with infected blood or plasma.
Description : A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%
Last Answer : (C) 12.5%
Description : (a) Draw a diagram depicting Human Alimentary Canal and label on it: Gall bladder, Liver and Pancreas. (b) State the roles of Liver and Pancreas. (c) Name the organ which performs the following functions in humans: (i) Absorption of digested food (ii) Absorption of water. -Biology
Last Answer : Answer.(a) (b) Liver: It synthesize and store bile juice secreted by gall bladder which breaks down fats into fat globules. (c) The organ which performs the following functions in humans are as ... * (i) Absorption of digested food - Small intestine. (ii)Absorption of water - Large intestine.
Description : Select the correct route for the passage of sperms in male frogs. (a) Testes → Vasa efferentia → Kidney → Seminal vesicle → Urinogenital duct → Cloaca (b) Testes → Vasa efferentia → Bidder's canal ... → Cloaca (d) Testes → Bidder's canal → Kidney → Vasa efferentia → Urinogenital duct → Cloaca
Last Answer : (c) Testes → Vasa efferentia → Kidney → Bidder’s canal → Urinogenital duct → Cloaca
Description : Briefly describe about dosage and route of administration , which make a substance antigenic.
Last Answer : Combination of optical dosage and routes of administration will induce a peak immune response in a given animal. An insufficient dose will not stimulate an immune response. An excessive dose ... it causes a state of immunological unresponsiveness or non-response known as immunological tolerance.
Description : The preferred route of administration of medication in the most acute care situations is which of the following routes? a) Intravenous The IV route is the preferred ... ) Intramuscular Intramuscular administration of medication is absorbed more slowly than intravenously administered medication.
Last Answer : a) Intravenous The IV route is the preferred parenteral route in most acute care situations because it is much more comfortable for the patient, and peak serum levels and pain relief occur more rapidly and reliably.
Description : The preferred route of administration of streptokinase in acute myocardial infarction is: A. Intravenous B. Subcutaneous C. Intracoronary
Last Answer : A. Intravenous
Description : The primary route of administration of insulin is: A. Intradermal B. Subcutaneous C. Intramuscular D. Intravenous
Last Answer : B. Subcutaneous
Description : Select the route of administration which carries the highest risk of adversely affecting vital functions: A. Intra arterial injection B. Intrathecal injection C. Intravenous injection D. Intramuscular injection
Last Answer : C. Intravenous injection
Description : A 7-years-old boy has a significant bedwetting problem. A long-acting indirect sympathomimetic agent sometimes used by the oral route for this and other indications is (a) Dobutamine (b) Ephedrine (c) Epinephrine (d) Isoproterenol (e) Phenylephrine
Last Answer : Ans: B
Description : Which of the following is a direct bronchodilator that is most often used in asthma by the oral route? (a) Aminophyline (b) Cromolyn (c) Epinephrine (d) Ipratropium (e) Metaproterenol
Last Answer : Ans: A
Description : Which of the following is a nonselective but very potent and efficacious bonchodilator that is not active by the oral route? (a) Aminophyline (b) Cromolyn (c) Epinephrine (d) Ipratropium (e) Metaproterenol
Last Answer : Ans: C
Description : Pentazocine differs from morphine in that (a) It is inactive by the oral route (b) It does not produce physical dependence (c) It has a lower ceiling of analgesic effect (d) Its action is not blocked by naloxone
Description : The fecal-oral route is the mode of transmission for the _____. a. Hepatitis A virus. b. Hepatitis B virus. c. Hepatitis A and B viruses. d. All hepatitis viruses.
Last Answer : b. Hepatitis B virus.
Description : Arboviral encephalitis is an example of a a. disease causing gastroenteritis. b. disease spread by the fecal-oral route. c. Zoonosis d. type of hepatitis.
Last Answer : c. Zoonosis
Description : Which of the foLlowing is NOT a transmission mechanism for hepatitis B? a. Sexual contact b. Non-sterile body piercing equipment c. Fecal-oral route d. Blood-contaminated needles
Last Answer : c. Fecal-oral route
Description : Streptococcus pyogenes is highly contagious by _____. a. Unwashed hands b. Oral/fecal route c. Respiratory droplets d. Remaining on surfaces for long periods of time
Last Answer : c. Respiratory droplets
Description : Fluconazole differs from ketoconazole in that: A. It is not active by the oral route B. It is a more potent inhibitor of drug metabolism C. It is not effective in cryptococcal meningitis D. It is unlikely to produce anti-androgenic side effects
Last Answer : D. It is unlikely to produce anti-androgenic side effects
Description : Select the antifungal drug which is administered only by the oral route: A. Amphotericin B B. Ketoconazole C. Griseofulvin D. Tolnaftate
Last Answer : C. Griseofulvin