Description : Select the opioid antagonist that is preferred for long term opioid blockade therapy of post addicts: A. Nalorphine B. Naloxone C. Naltrexone D. Nalbuphine
Last Answer : C. Naltrexone
Description : The following are pure opioid antagonists except: A. Nalmfene B. Nalbuphine C. Naloxone D. Naltrexone
Last Answer : B. Nalbuphine
Description : Lower dose of naloxone is required to: A. Antagonise the actions of nalorphine B. Antagonise the actions of pentazocine C. Precipitate withdrawal in mildly morphine dependent subjects D. Precipitate withdrawal in highly morphine dependent subjects
Last Answer : D. Precipitate withdrawal in highly morphine dependent subjects
Description : Lower dose of naloxone is required to (a) Antagonise the actions of nalorphine (b) Antagonise the actions of pentazocine (c) Precipitate withdrawal in mildly morphine dependent subjects (d) Precipitate withdrawal in highly morphine dependent subjects
Last Answer : Ans: D
Description : Nalorphine is nearly equipotent analgesic as morphine, but is not used clinically as an analgesic because: A. It causes more marked respiratory depression B. It has higher abuse potential C. It antagonises the action of morphine D. It produces prominent dysphoric effects
Last Answer : D. It produces prominent dysphoric effects
Description : The following is not true of naltrexone: A. It produces agonistic actions of its own in the absence of morphine B. It is active orally C. It has a long duration of action D. It can reduce craving for alcohol in chronic alcoholics
Last Answer : A. It produces agonistic actions of its own in the absence of morphin
Description : Which action of morphine is incompletely reversed by naloxone: A. Analgesia B. Respiratory depression C. Sedation D. Miosis
Last Answer : C. Sedation
Description : The following is true of buprenorphine: A. It is an agonist-antagonist type of opioid analgesic B. Its subjective effects are different from those of morphine C. Naloxone is largely ineffective in reversing its effects D. It produces mydriasis
Last Answer : C. Naloxone is largely ineffective in reversing its effects
Description : Pentazocine differs from morphine in that: A. It is inactive by the oral route B. It does not produce physical dependence C. It has a lower ceiling of analgesic effect D. Its action is not blocked by naloxone
Last Answer : C. It has a lower ceiling of analgesic effec
Description : Patient with morphine coma; what is the medication of choice to reverse its act: a. Bradykinin. b. Epinephrine. c. Amphetamine. d. Naloxone.
Last Answer : d. Naloxone.
Description : In patients with morphine coma, what is the medication of choice to reverse its act: A. Bradykinin B. Epinephrine C. Amphetamine D. Naloxone
Last Answer : D. Naloxone
Description : This drug, which does not activate opioid receptors, has been proposed as a maintenance drug in treatment programs for opioid addicts; a singly oral dose will block the effects of injected heroin for up to 48 hours (a) Amphetamine (b) Buprenorphine (c) Naloxone (d) Naltrexone (e) Propoxyphene
Description : Select the correct statement about flumazenil: A. It is a CNS stimulant used as an antidote for benzodiazepine poisoning B. It is a CNS depressant but blocks the action of diazepam C. It has ... of its own but blocks the depressant effect of diazepam as well as stimulant effect of beta carbolines
Last Answer : D. It has no CNS effect of its own but blocks the depressant effect of diazepam as well as stimulant effect of beta carbolines
Description : The most effective antidote for belladonna poisoning is: A. Neostigmine B. Physostigmine C. Pilocarpine D. Methacholine
Last Answer : B. Physostigmine
Description : 2 In a conscious patient of poisoning, use of an emetic is permissible in case the ingested poison is: A. Ferrous sulfate B. Sodium hydroxide C. Kerosine D. Morphine
Last Answer : A. Ferrous sulfate
Description : In a comatose patient suspected of poisoning, which of the following findings would be against the drug being morphine: A. Mydriasis B. Marked respiratory depression C. Cyanosis D. Fall in blood pressure
Last Answer : A. Mydriasis
Description : The following opioids are κ (kappa) receptor analgesics except: A. Buprenorphine B. Butorphanol C. Nalbuphine D. Pentazocine
Last Answer : A. Buprenorphine
Description : Which action of morphine is incompletely reversed by naloxone ? (a) Analgesia (b) Respiratory depression (c) Sedation (d) Miosis
Last Answer : Ans: C
Description : Pentazocine differs from morphine in that (a) It is inactive by the oral route (b) It does not produce physical dependence (c) It has a lower ceiling of analgesic effect (d) Its action is not blocked by naloxone
Description : Select the drug that has been found to reduce alcohol craving and chances of resumed heavy drinking by alcoholics after they have undergone a detoxification programme: A. Chlordiazepoxide B. Chlorpromazine C. Methadone D. Naltrexone
Last Answer : D. Naltrexone
Description : The following statement is true about endogenous opioid peptides: A. They activate only μ opioid recepors B. They do not occur in peripheral tissues C. They mediate stress induced analgesia D. Naloxone fails to antagonise their actio
Last Answer : C. They mediate stress induced analgesia
Description : Select the correct statement about Naloxone: A. It equally blocks μ, κ and δ opioid receptors B. It blocks μ receptors at lower doses than those needed for others C. It blocks κ receptors at lower doses than those needed for others D. It blocks δ receptors at lower doses than those needed for others
Last Answer : B. It blocks μ receptors at lower doses than those needed for others
Description : Why egg white and milk are use as an antidote for heavy metal poisoning?
Last Answer : What is the answer ?
Description : The most effective antidote for belladonna poisoning is (a) Neostigmine (b) Physostigmine (c) Pilocarpine (d) Methacholine
Last Answer : Ans: B
Description : Antidote for lead poisoning is (a) nickel (b) cisplatin (c) white of egg (d) EDTA
Last Answer : Ans:(d)
Description : Which thing acts as an antidote to HgCl2 poisoning?
Last Answer : White of egg
Description : Tranexaemic acid is a specific antidote of: A. Fibrinolytic drugs B. Organophosphates C. Barbitur
Last Answer : A. Fibrinolytic drugs
Description : Morphine poisoning causes (A) Metabolic acidosis (B) Respiratory acidosis (C) Metabolic alkalosis (D) Respiratory alkalosis
Last Answer : Answer : B
Description : In a comatose patient suspected of poisoning, which of the following findings would be against the drug being morphine (a) Selegiline (b) Chlorgiline (c) Moclobemide (d) Tranylcypromine
Last Answer : Ans: A
Description : The greatest threat from morphine poisoning is (a) Renal shutdown (b) Paralysis of spinal cord (c) Respiratory depression (d) Cardiovascular collapse (e) None of the above
Description : The following antihypertensive drug has been found to suppress certain manifestations of morphine withdrawal syndrome and to block postoperative pain when injected intrathecally: A. Prazosin B. Clonidine C. Reserpine D. Ketanserin
Last Answer : B. Clonidine
Description : Choose the correct statement about pentazocine: A. It causes bradycardia and fall in blood pressure B. Its subjective effects are pleasurable at low doses but turn unpleasant at high doses C. It induces vomiting frequently D. It substitutes for morphine in dependent subjects
Last Answer : B. Its subjective effects are pleasurable at low doses but turn unpleasant at high doses
Description : Morphine has high affinity for the following opioid receptor(s): A. μ (Mu) B. κ (Kappa) C. δ (Delta) D. All of the above
Last Answer : A. μ (Mu
Description : Morphine affords symptomatic relief of dyspnoea in acute left ventricular failure by the following mechanisms except: A. Bronchodilatation B. Depression of respiratory centre C. Reduction in cardiac preload D. Shift of blood from pulmonary to systemic circuit
Last Answer : A. Bronchodilatation
Description : The distinctive feature(s) of methadone compared to morphine is/are: A. High oral bioavailability B. High plasma protein and tissue binding C. Delayed and milder withdrawal symptoms in dependent subjects D. All of the above
Last Answer : D. All of the above
Description : Indicate the opioid analgesic that is used as transdermal patch for chronic and cancer pain: A. Morphine B. Pentazocine C. Fentanyl D. Tramadol
Last Answer : The distinctive feature(s) of methadone compared to morphine is/are: A. High oral bioavailability B. High plasma protein and tissue binding C. Delayed and milder withdrawal symptoms in dependent subjects D. All of the above
Description : The following opioid is more potent than morphine: A. Pethidine B. Fentanyl C. Dextropropoxyphene D. Tramadol
Last Answer : B. Fentanyl
Description : The following is true of pethidine except: A. At equianalgesic doses it causes less respiratory depression than morphine B. It is less constipating than morphine C. It is a poor antitussive D. In overdose it often produces excitatory effect
Last Answer : A. At equianalgesic doses it causes less respiratory depression than morph
Description : Choose the correct statement about codeine: A. It has a lower oral: parenteral activity ratio than morphine B. It is devoid of abuse liability C. It is a weaker analgesic than morphine D. It is a more potent antitussive than morphine
Last Answer : C. It is a weaker analgesic than morphine
Description : Morphine is contraindicated in head injury because: A. It does not relieve the pain of head injury B. It can raise intracranial tension C. It can cause constipation D. It is liable to cause addiction
Last Answer : B. It can raise intracranial tension
Description : Use of morphine in the following category of patients does not carry any special risk: A. Ischaemic heart disease patients B. Bronchial asthma patients C. Elderly male patients D. Biliary colic patients
Last Answer : A. Ischaemic heart disease patients
Description : Morphine dependence is characterized by: A. Marked drug seeking behaviour B. Physical dependence without psychic dependence C. Physical as well as psychic dependence D. Both ‘A’ and ‘C’ are correc
Last Answer : D. Both ‘A’ and ‘C’ are correc
Description : What is true of tolerance occurring in regular opium abusers: A. Tolerance develops to all actions of morphine B. No tolerance occurs to euphoric and sedative actions of morphine C. No ... to constipating and miotic actions of morphine D. Lethal dose of morphine is not significantly increased
Last Answer : C. No tolerance occurs to constipating and miotic actions of morphine
Description : The following is not true of morphine: A. Its 2-glucuronide metabolite is an active analgesic B. Its active metabolite penetrates blood-brain barrier better than morphine C. Its oral: parenteral activity ratio is 1:4 D. It undergoes enterohepatic cycling
Last Answer : B. Its active metabolite penetrates blood-brain barrier better than morphine
Description : Morphine induced constipation involves the following mechanisms except: A. Increase in tone and decrease in propulsive activity of intestinal muscles B. Antivagal action C. Spasm of gastrointestinal sphincters D. Reduction of gastrointestinal secretions
Last Answer : B. Antivagal action
Description : Instead of depressing, morphine stimulates: A. Vasomotor centre B. Edinger Westphal nucleus C. Temperature regulating centre D. Cough centre
Last Answer : B. Edinger Westphal nucleus
Description : Morphine induced fall in blood pressure involves the following factors except: A. Direct cardiac depression B. Direct reduction of vascular tone C. Vasomotor centre depression D. Histamine release
Last Answer : A. Direct cardiac depression
Description : Actions of morphine include the following except: A. Vagal stimulation B. Miosis C. Antiemetic D. Postural hypotensio
Last Answer : C. Antiemetic
Description : The subjective effects of morphine include the following except: A. Dysphoria in many uninitiated individuals B. Euphoria in dependent subjects C. Visual hallucinations D. Detachment to self and surrounding
Last Answer : C. Visual hallucination