Description : Morphine has high affinity for the following opioid receptor(s). (a) µ (Mu) (b) k (Kappa) (c) d (Delta) (d) All of the above
Last Answer : Ans: A
Description : Select the opioid analgesic which acts primarily through κ (kappa) opioid receptor: A. Pentazocine B. Methadone C. Buprenorphine D. Pethidine
Last Answer : A. Pentazocine
Description : Select the correct statement about Naloxone: A. It equally blocks μ, κ and δ opioid receptors B. It blocks μ receptors at lower doses than those needed for others C. It blocks κ receptors at lower doses than those needed for others D. It blocks δ receptors at lower doses than those needed for others
Last Answer : B. It blocks μ receptors at lower doses than those needed for others
Description : The following opioids are κ (kappa) receptor analgesics except: A. Buprenorphine B. Butorphanol C. Nalbuphine D. Pentazocine
Last Answer : A. Buprenorphine
Description : Features of µ (Mu) opioid receptor include the following except: A. Acts by inhibiting cAMP formation B. Mediates miotic action C. Mediates low ceiling respiratory depression D. Mediates high ceiling supraspinal analgesia
Last Answer : C. Mediates low ceiling respiratory depression
Description : Select the receptor that is located intracellularly: A. Opioid μ receptor B. Steroid receptor C. Prostaglandin receptor D. Angiotensin receptor
Last Answer : B. Steroid receptor
Description : The most important receptor involved in cytotoxic drug induced vomiting is: A. Histamine H1 receptor B. Serotonin 5-HT3 receptor C. Dopamine D2 receptor D. Opioid μ receptor
Last Answer : B. Serotonin
Description : Mu opioids have which of the following effects on respiratory rate: a) Stimulation, then depression Mu opioids also cause bradycardia, hypothermia, and constipation. b) No change Kappa opioids result ... nor kappa, nor delta opoids depress respiratory rate as its only effect upon respiratory rate.
Last Answer : a) Stimulation, then depression Mu opioids also cause bradycardia, hypothermia, and constipation.
Description : The following statement is true about endogenous opioid peptides: A. They activate only μ opioid recepors B. They do not occur in peripheral tissues C. They mediate stress induced analgesia D. Naloxone fails to antagonise their actio
Last Answer : C. They mediate stress induced analgesia
Description : The following is true of buprenorphine: A. It is an agonist-antagonist type of opioid analgesic B. Its subjective effects are different from those of morphine C. Naloxone is largely ineffective in reversing its effects D. It produces mydriasis
Last Answer : C. Naloxone is largely ineffective in reversing its effects
Description : Indicate the opioid analgesic that is used as transdermal patch for chronic and cancer pain: A. Morphine B. Pentazocine C. Fentanyl D. Tramadol
Last Answer : The distinctive feature(s) of methadone compared to morphine is/are: A. High oral bioavailability B. High plasma protein and tissue binding C. Delayed and milder withdrawal symptoms in dependent subjects D. All of the above
Description : The following opioid is more potent than morphine: A. Pethidine B. Fentanyl C. Dextropropoxyphene D. Tramadol
Last Answer : B. Fentanyl
Description : he dipole magnetic moment (μ) is directly proportional to nuclear spin (I), connected by a constant called the A. Gyromagnetic ratio (γ) B. Planck's constant (h) C. Nuclear susceptibility (χ) D. Chemical shift (δ)
Last Answer : Gyromagnetic ratio (γ)
Description : Light chains of immunoglobulins are of following types: (A) Alpha and kappa (B) Alpha and gamma (C) Lambda and delta(D) Kappa and lambda
Last Answer : Answer : D
Description : The opioid antidiarrhoeal drugs act by the following mechanism(s): A. They relax the intestinal smooth muscle B. They inhibit intestinal peristalsis C. They promote clearance of intestinal pathogens Aim4aiims.in D. All of the above
Last Answer : B. They inhibit intestinal peristalsis
Description : Opioid analgesics are either contraindicated or must be used with extreme caution in several clinical situations. For morphine, such situations do not include (a) Aqueous diffusion (b) Aqueous hydrolysis (c) Lipid diffusion (d) Pinocytosis or endocytosis (e) Special carrier transport
Last Answer : Ans: E
Description : Fentanyl (Sublimaze) is categorized as which type of intravenous anesthetic agent? a) Neuroleptanalgesic Fentanyl is 75-100 times more potent than morphine and has about 25% of the duration ... morphine and meperidine hydrochloride (Demerol). d) Dissociative agent Ketamine is a dissociative agent.
Last Answer : a) Neuroleptanalgesic Fentanyl is 75-100 times more potent than morphine and has about 25% of the duration of morphine (IV).
Description : Prostaglandins are chemical substances thought to a) increase sensitivity of pain receptors. Prostaglandins are believed to increase sensitivity to pain receptors by enhancing the pain-provoking ... opioid medications inhibit the transmission of noxious stimuli by mimicking enkephalin and endorphin.
Last Answer : a) increase sensitivity of pain receptors. Prostaglandins are believed to increase sensitivity to pain receptors by enhancing the pain-provoking effect of bradykinin.
Description : The distinctive feature(s) of methadone compared to morphine is/are: A. High oral bioavailability B. High plasma protein and tissue binding C. Delayed and milder withdrawal symptoms in dependent subjects D. All of the above
Last Answer : D. All of the above
Description : The most important receptor involved in cytotoxic drug induced vomiting is (a) Histamine H1 receptor (b) Serotonin 5-HT3 receptor (c) Dopamine D2 receptor (d) Opioid µ receptor
Last Answer : Ans: B
Description : The following is true of loperamide except: A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action B. It acts on the opioid receptors in the gut C. It increases ... of the intestines D. It inhibits intestinal secretion by binding to calmodulin in the mucosal cells
Last Answer : A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action
Description : 4 Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas: A. They are used to control diarrhoea irrespective of its etiology B. They should ... antimicrobial therapy of diarrhoea D. They are the drugs of choice in irritable bowel syndrome diarrhoea
Last Answer : B. They should be used only as a short-term measure after ensuring that enteroinvasive organisms are not involved
Description : Select the opioid antagonist that is preferred for long term opioid blockade therapy of post addicts: A. Nalorphine B. Naloxone C. Naltrexone D. Nalbuphine
Last Answer : C. Naltrexone
Description : The following are pure opioid antagonists except: A. Nalmfene B. Nalbuphine C. Naloxone D. Naltrexone
Last Answer : B. Nalbuphine
Description : Which of the following is an agonist-antagonist type of opioid analgesic: A. Pethidine B. Pentazocine C. Fentanyl D. Buprenorphine
Last Answer : B. Pentazocine
Description : An opioid analgesic is preferred over aspirin like analgesic in the following condition: A. Acute gout B. Burn C. Toothache D. Neuralgi
Last Answer : B. Burn
Description : Select the analgesic which acts through opioid as well as additional spinal monoaminergic mechanisms: A. Tramadol B. Ethoheptazine C. Dextropropoxyphene D. Alfentanil
Last Answer : A. Tramado
Description : The following opioid analgesic is similar to codeine in pharmacological profile but is less constipating: A. Methadone B. Buprenorphine C. Butorphanol D. Dextropropoxyphene
Last Answer : D. Dextropropoxyphene
Description : Apraclonidine is a clonidine congener which is used: A. To suppress opioid withdrawal syndrome B. To suppress menopausal syndrome C. As Analgesic D. To reduce intraocular tension
Last Answer : D. To reduce intraocular tension
Description : Choose the correct statement about nefopam: A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis B. It is an orally active opioid analgesic C. It is an analgesic with potent antiinflammatory activity D. It is a preferential COX-2 inhibitor
Last Answer : A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis
Description : Insulin receptor is made up of (A) One α-and one β-subunit (B) Two α-and two β-subunit (C) Two, α two β-and two γ-subunit (D) One α, one β-one γ-and one δ-subunit
Last Answer : Answer : B
Description : In the insulin receptor, tyrosine kinase domain is present in (A) α-Subunits (B) β-Subunits (C) γ-Subunits (D) δ-Subunits
Description : Morphine analgesia differs from that produced by aspirin in the following respect(s): A. It has a higher ceiling B. It covers both perception as well as psychic processing of the pain C. Visceral and ischaemic pain is relieved better than somatic inflammatory pain D. All of the above are correct
Last Answer : D. All of the above are correct
Description : Metronidazole is selectively active against anaerobic organisms because: A. Aerobes have an active transport mechanism to pump it out of their cell B. Only anaerobes reduce it to generate the reactive ... inactivated in the presence of oxygen D. It binds to DNA of anaerobes with high affinity
Last Answer : B. Only anaerobes reduce it to generate the reactive nitro radical
Description : Trimethoprim inhibits bacteria without affecting mammalian cells because: A. It does not penetrate mammalian cells B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate ... bacterial folate synthetase as well as dihydrofolate reductase enzymes D. All of the above
Last Answer : B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate reductase enzyme
Description : Aspirin in low doses produces longlasting inhibition of platelet cyclooxygenase (COX) because: A. Platelets contain low quantity of COX B. Platelets cannot synthesize fresh COX molecules C. Platelets bind aspirin with high affinity D. Platelet COX is inducible
Last Answer : B. Platelets cannot synthesize fresh COX molecules
Description : Choose the correct statement about pentazocine: A. It causes bradycardia and fall in blood pressure B. Its subjective effects are pleasurable at low doses but turn unpleasant at high doses C. It induces vomiting frequently D. It substitutes for morphine in dependent subjects
Last Answer : B. Its subjective effects are pleasurable at low doses but turn unpleasant at high doses
Description : Choose the correct statement(s) about dofetilide: A. It is a pure class III antiarrhythmic B. It has no adrenergic/cholinergic receptor blocking property C. It selectively depresses the rapid component of delayed rectifier K+ current in myocardial fibres D. All of the above
Description : Choose the correct statement(s) about pioglitazone: A. It acts as an agonist on nuclear paroxisome proliferator receptor γ B. It enhances transcription of insulin responsive genes C. It lowers blood sugar in type 2 diabetes mellitus without causing hyperinsulinemia D. All of the above
Description : The following is not a feature of competitive antagonists: A. Chemical resemblance with the agonist B. Parallel rightward shift of the agonist log doseresponse curve C. Suppression of maximal agonist response D. Apparent reduction in agonist affinity for the receptor
Last Answer : C. Suppression of maximal agonist response
Description : Receptor agonists possess: A. Affinity but no intrinsic activity B. Intrinsic activity but no affinity C. Affinity and intrinsic activity with a + sign D. Affinity and intrinsic activity with a – sign
Last Answer : C. Affinity and intrinsic activity with a + sign
Description : Study of drug-receptor interaction has now shown that: A. Maximal response occurs only when all receptors are occupied by the drug B. Drugs exert an all or none' action on a ... lock and key' structural features D. Properties of affinity' and intrinsic activity' are independently variable
Last Answer : D. Properties of ‘affinity’ and ‘intrinsic activity’ are independently variable
Description : What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor
Last Answer : C. Agonists induce a conformational change in the receptoR
Last Answer : C. Agonists induce a conformational change in the receptor
Description : e primary mechanism by which general anaesthetics produce their action is: A. Affecting receptor operated ion channels in cerebral neurones B. Blocking voltage sensitive Na+ channels in neuronal ... activity of cerebral neurones D. Blocking production of high energy phosphates in the brain
Last Answer : A. Affecting receptor operated ion channels in cerebral neurones