Description : Which of the following opioids is more potent than morphine ? (a) Pethidine (b) Fentanyl (c) Dextropropoxyphene (d) Tramadol
Last Answer : Ans: B
Description : Indicate the opioid analgesic that is used as transdermal patch for chronic and cancer pain: A. Morphine B. Pentazocine C. Fentanyl D. Tramadol
Last Answer : The distinctive feature(s) of methadone compared to morphine is/are: A. High oral bioavailability B. High plasma protein and tissue binding C. Delayed and milder withdrawal symptoms in dependent subjects D. All of the above
Description : Select the analgesic which acts through opioid as well as additional spinal monoaminergic mechanisms: A. Tramadol B. Ethoheptazine C. Dextropropoxyphene D. Alfentanil
Last Answer : A. Tramado
Description : Which of the following is an agonist-antagonist type of opioid analgesic: A. Pethidine B. Pentazocine C. Fentanyl D. Buprenorphine
Last Answer : B. Pentazocine
Description : Fentanyl (Sublimaze) is categorized as which type of intravenous anesthetic agent? a) Neuroleptanalgesic Fentanyl is 75-100 times more potent than morphine and has about 25% of the duration ... morphine and meperidine hydrochloride (Demerol). d) Dissociative agent Ketamine is a dissociative agent.
Last Answer : a) Neuroleptanalgesic Fentanyl is 75-100 times more potent than morphine and has about 25% of the duration of morphine (IV).
Description : Which of the following is an agonistantagonist type of opioid analgesic (a) Pethidine (b) Pentazocine (c) Fentanyl (d) Buprenorphine
Description : The following opioid analgesic is similar to codeine in pharmacological profile but is less constipating: A. Methadone B. Buprenorphine C. Butorphanol D. Dextropropoxyphene
Last Answer : D. Dextropropoxyphene
Description : Select the opioid analgesic which acts primarily through κ (kappa) opioid receptor: A. Pentazocine B. Methadone C. Buprenorphine D. Pethidine
Last Answer : A. Pentazocine
Description : The following is true of pethidine except: A. At equianalgesic doses it causes less respiratory depression than morphine B. It is less constipating than morphine C. It is a poor antitussive D. In overdose it often produces excitatory effect
Last Answer : A. At equianalgesic doses it causes less respiratory depression than morph
Description : Choose the correct statement about nefopam: A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis B. It is an orally active opioid analgesic C. It is an analgesic with potent antiinflammatory activity D. It is a preferential COX-2 inhibitor
Last Answer : A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis
Description : The following is true of buprenorphine: A. It is an agonist-antagonist type of opioid analgesic B. Its subjective effects are different from those of morphine C. Naloxone is largely ineffective in reversing its effects D. It produces mydriasis
Last Answer : C. Naloxone is largely ineffective in reversing its effects
Description : Morphine has high affinity for the following opioid receptor(s): A. μ (Mu) B. κ (Kappa) C. δ (Delta) D. All of the above
Last Answer : A. μ (Mu
Description : Choose the correct statement about codeine: A. It has a lower oral: parenteral activity ratio than morphine B. It is devoid of abuse liability C. It is a weaker analgesic than morphine D. It is a more potent antitussive than morphine
Last Answer : C. It is a weaker analgesic than morphine
Description : Select the analgesic which acts through opioids as well as additional spinal monoaminergic mechanisms. (a) Tramadol (b) Ethoheptazine (c) Dextropropoxyphene (d) Alfentanil
Last Answer : Ans: A
Description : Which of the following opioid analgesics is similar to codeine in pharmacological profile but is less constipating ? (a) Methadone (b) Buprenorphine (c) Butorphanol (d) Dextropropoxyphene
Last Answer : Ans: D
Description : Which of the following narcotics has the longest duration of effect? (a) Methadone (b) Controlled-release morphine (c) Levorphanol (d) Transdermal fentanyl (e) Dihydromorphone
Description : Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)
Last Answer : C. Diazepam (pentobarbitone)
Description : Norpethidine produced as a metabolite of pethidine is responsible for the following effect: A. Euphoria B. Excitement C. Analgesia D. Respiratory depression
Last Answer : B. Excitement
Description : The following drug is not likely to produce dependence: A. Diazepam B. Chlorpromazine C. Pethidine D. Methadone
Last Answer : B. Chlorpromazine
Description : Intravenous fentanyl is used in balanced anaesthesia to afford: A. Relaxation of chest muscles B. Analgesia C. Unconsciousness D. Suppression of gastric acid secretion
Last Answer : B. Analgesia
Description : Select the anaesthetic that increases cardiac output and blood pressure: A. Halothane B. Fentanyl C. Ketamine D. Diazepam
Last Answer : C. Ketamine
Description : The drug/drugs used mainly for induction of general anaesthesia is/are: A. Thiopentone sodium B. Fentanyl + droperidol C. Ketamine D. All of the above
Last Answer : A. Thiopentone sodium
Description : Morphine has high affinity for the following opioid receptor(s). (a) µ (Mu) (b) k (Kappa) (c) d (Delta) (d) All of the above
Description : Opioid analgesics are either contraindicated or must be used with extreme caution in several clinical situations. For morphine, such situations do not include (a) Aqueous diffusion (b) Aqueous hydrolysis (c) Lipid diffusion (d) Pinocytosis or endocytosis (e) Special carrier transport
Last Answer : Ans: E
Description : Prostaglandins are chemical substances thought to a) increase sensitivity of pain receptors. Prostaglandins are believed to increase sensitivity to pain receptors by enhancing the pain-provoking ... opioid medications inhibit the transmission of noxious stimuli by mimicking enkephalin and endorphin.
Last Answer : a) increase sensitivity of pain receptors. Prostaglandins are believed to increase sensitivity to pain receptors by enhancing the pain-provoking effect of bradykinin.
Description : Select the correct statement about Naloxone: A. It equally blocks μ, κ and δ opioid receptors B. It blocks μ receptors at lower doses than those needed for others C. It blocks κ receptors at lower doses than those needed for others D. It blocks δ receptors at lower doses than those needed for others
Last Answer : B. It blocks μ receptors at lower doses than those needed for others
Description : The following is true of loperamide except: A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action B. It acts on the opioid receptors in the gut C. It increases ... of the intestines D. It inhibits intestinal secretion by binding to calmodulin in the mucosal cells
Last Answer : A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action
Description : 4 Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas: A. They are used to control diarrhoea irrespective of its etiology B. They should ... antimicrobial therapy of diarrhoea D. They are the drugs of choice in irritable bowel syndrome diarrhoea
Last Answer : B. They should be used only as a short-term measure after ensuring that enteroinvasive organisms are not involved
Description : The opioid antidiarrhoeal drugs act by the following mechanism(s): A. They relax the intestinal smooth muscle B. They inhibit intestinal peristalsis C. They promote clearance of intestinal pathogens Aim4aiims.in D. All of the above
Last Answer : B. They inhibit intestinal peristalsis
Description : The following statement is true about endogenous opioid peptides: A. They activate only μ opioid recepors B. They do not occur in peripheral tissues C. They mediate stress induced analgesia D. Naloxone fails to antagonise their actio
Last Answer : C. They mediate stress induced analgesia
Description : Select the opioid antagonist that is preferred for long term opioid blockade therapy of post addicts: A. Nalorphine B. Naloxone C. Naltrexone D. Nalbuphine
Last Answer : C. Naltrexone
Description : The following are pure opioid antagonists except: A. Nalmfene B. Nalbuphine C. Naloxone D. Naltrexone
Last Answer : B. Nalbuphine
Description : Features of µ (Mu) opioid receptor include the following except: A. Acts by inhibiting cAMP formation B. Mediates miotic action C. Mediates low ceiling respiratory depression D. Mediates high ceiling supraspinal analgesia
Last Answer : C. Mediates low ceiling respiratory depression
Description : An opioid analgesic is preferred over aspirin like analgesic in the following condition: A. Acute gout B. Burn C. Toothache D. Neuralgi
Last Answer : B. Burn
Description : Apraclonidine is a clonidine congener which is used: A. To suppress opioid withdrawal syndrome B. To suppress menopausal syndrome C. As Analgesic D. To reduce intraocular tension
Last Answer : D. To reduce intraocular tension
Description : Select the receptor that is located intracellularly: A. Opioid μ receptor B. Steroid receptor C. Prostaglandin receptor D. Angiotensin receptor
Last Answer : B. Steroid receptor
Description : The most important receptor involved in cytotoxic drug induced vomiting is: A. Histamine H1 receptor B. Serotonin 5-HT3 receptor C. Dopamine D2 receptor D. Opioid μ receptor
Last Answer : B. Serotonin
Description : The following is true of simvastatin except: A. It is more potent than lovastatin B. At the highest recommended dose, it causes greater LDL-cholesterol lowering than lovastatin C. It does not undergo ... metabolism in liver D. It can raise HDL-cholesterol level when the same is low at base line
Last Answer : C. It does not undergo first pass metabolism in liver
Description : Che following is true of desmopressin except: A. It is nonselective V1 and V2 receptor agonist B. It is more potent and longer acting than arginine vasopressin (AVP) C. It is preferred over AVP for treatment of diabetes insipidus D. It can be administered orally
Last Answer : A. It is nonselective V1 and V2 receptor agonist
Description : Zolpidem differs from diazepam in that: A. It is safer in overdose than diazepam B. Its hypnotic action shows little fading on repeated nightly use C. It causes more marked suppression of REM sleep D. It has more potent muscle relaxant action
Last Answer : B. Its hypnotic action shows little fading on repeated nightly use
Description : Labetalol has: A. More potent β adrenergic blocking than α blocking activity B. More potent α adrenergic blocking than β blocking activity C. Equal α and β adrenergic blocking activity D. β1 agonistic activity in addition to α and β adrenergic blockade
Last Answer : A. More potent β adrenergic blocking than α blocking activity
Description : Out of two anticholinesterases, drug X' is a tertiary amine while drug Y' is a quarternary ammonium compound. Then: A. Drug X' is likely to be more potent than Y' B. Drug X' will be more ... a miotic C. Drug Y' will be completely metabolized in the body D. Drug Y' will produce CNS effects
Last Answer : B. Drug ‘X’ will be more suitable to be used as a miotic
Description : The quarternary analogues of belladonna alkaloids are preferred over the natural alkaloids for antisecretory/ antispasmodic indications because: A. They have additional nicotinic receptor blocking activity B. They are ... of CNS and ocular effects D. Dose to dose they are more potent than atropine
Last Answer : C. They are devoid of CNS and ocular effects
Description : Hyoscine differs from atropine in that it: A. Exerts depressant effects on the CNS at relatively low doses B. Exerts more potent effects on the heart than on the eye C. Is longer acting D. Has weaker antimotion sickness activity
Last Answer : A. Exerts depressant effects on the CNS at relatively low doses
Description : Features of atorvastatin include the following: A. Dose to dose most potent HMG-CoA reductase inhibitor B. Higher ceiling of LDL-cholesterol lowering action than lovastatin C. Antioxidant property D. All of the above
Last Answer : D. All of the above
Description : Choose the correct statement about amiloride: A. It antagonises the action of aldosterone B. It can be used to treat lithium induced diabetes insipidus C. It increases calcium loss in urine D. It is dose to dose less potent than triamterene
Last Answer : B. It can be used to treat lithium induced diabetes insipidus
Description : The following is true of sevoflurane except: A. It induces anaesthesia rapidly B. It is nonpungent C. It produces prolonged postanaesthetic psychomotor impairment D. It is less potent than halothane
Last Answer : C. It produces prolonged postanaesthetic psychomotor impairment
Description : Fluconazole differs from ketoconazole in that: A. It is not active by the oral route B. It is a more potent inhibitor of drug metabolism C. It is not effective in cryptococcal meningitis D. It is unlikely to produce anti-androgenic side effects
Last Answer : D. It is unlikely to produce anti-androgenic side effects