Which fibrinolytic agent(s) selectively activate(s) fibrin bound plasminogen rather than circulating plasminogen: A. Urokinase B. Streptokinase C. Alteplase D. Both ‘A’ and ‘C

Which fibrinolytic agent(s) selectively activate(s)
fibrin bound plasminogen rather than circulating
plasminogen:
A. Urokinase
B. Streptokinase
C. Alteplase
D. Both ‘A’ and ‘C
by

1 Answer

Answer :

C. Alteplase
by

Related questions

Fibrinolytic therapy is based on activation of plasminogen, the inactive proteolytic enzyme of plasma that binds to fibrin during the formation of thrombosis. Activation of plasminogen to plasmin results in selective thrombolysis at the fibrin clot surface. Which of the following statement(s) is/are true concerning agents used in thrombolytic therapy? a. Streptokinase is a bacterial protein which is antigenic in humans, resulting in allergic reactions in up to l5% of cases b. Tissue plasminogen activator acts directly on plasmin without an intermediate drug–plasmin complex c. The half-life of urokinase, streptokinase, and TPA all exceed 30 minutes d. Streptokinase is significantly cheaper than urokinase or TPA

Description : Fibrinolytic therapy is based on activation of plasminogen, the inactive proteolytic enzyme of plasma that binds to fibrin during the formation of thrombosis. Activation of plasminogen to plasmin results ... TPA all exceed 30 minutes d. Streptokinase is significantly cheaper than urokinase or TPA

Last Answer : Answer: a, b, d Streptokinase is a bacterial protein produced by group C b-hemolytic streptococci. It is therefore antigenic in humans and can be associated with allergic reaction in ... one agent over the other. Streptokinase however, is markedly less expensive than either urokinase or TPA

Select the fibrinolytic drug(s) that is/are antigenic: A. Streptokinase B. Urokinase C. Alteplase D. Both ‘A’ and ‘B’

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Last Answer : A. Streptokinase

Thrombolytic therapy has become a useful adjunct in the management of peripheral arterial occlusion. In this setting, direct intraarterial administration rather than intravenous has been advocated to decrease the risk of systemic bleeding. Which of the following true statement(s) concerning the use of thrombolytic agents for arterial occlusion is/are true? a. A standard technique involves infusing high-dose urokinase, 4000 units per minute for 1–2 hours, directly into the clot by a catheter embedded in the thrombus b. If progress is made, further fibrinolytic therapy is given at 1000 to 2000 units per minute until clot lysis has occurred c. The usual infusion time by the above-stated technique is usually in excess of 24 hours d. Successful clot lysis occurs more frequently in arterial graf

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The first protein synthesized by recombinant DNA technology was (A) Streptokinase (B) Human growth hormone (C) Tissue plasminogen activator (D) Human insulin

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Which of the following thrombolytic agents would be appropriate at this time? (a) Anisoylated plasminogen streptokinase activator complex (APSAC) (b) Streptokinase (SK) (c) Recombinant tissue-type plasminogen activator (t-PA)

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Which one of the followings is a plasminogen activator? (A) Tranexamic acid (B) Streptokinase (C) Aminocaproic acid (D) None of the above

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Hemostasis and the cessation of bleeding require which of the following processes? A. Adherence of platelets to exposed subendothelial glycoproteins and collagen with subsequent aggregation of platelets and formation of a hemostatic plug. B. Interaction of tissue factor with factor VII circulating in the plasma. C. The production of thrombin via the coagulation cascade with conversion of fibrinogen to fibrin. D. Cross-linking of fibrin by factor XIII.

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Tranexaemic acid is a specific antidote of: A. Fibrinolytic drugs B. Organophosphates C. Barbitur

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A patient has an episode of hematemesis following streptokinase infused for the treatment of deep vein thrombosis. Which of the following drugs would be most effective in controlling the bleeding episode: A. Vitamin K B. Noradrenaline C. Epsilon aminocaproic acid D. Rutin

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Streptokinase therapy of myocardial infarction is contraindicated in the presence of the following except: A. Peptic ulcer B. Ventricular extrasystoles C. History of recent trauma D. Severe hypertension

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The most important complication of streptokinase therapy is: A. Hypotension B. Bleeding C. Fever D. Anaphylaxis

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