Description : A bactericidal antibiotic has the following characteristic(s): A. Pronounced postantibiotic effect B. Large difference between MBC and MIC values C. Efficacy in the absence of host defence D. All of the above
Last Answer : C. Efficacy in the absence of host defence
Description : The basis for use of β-adrenergic blockers in congestive heart failure (CHF) is: A. They exert positive inotropic effect in CHF B. They counteract deleterious effect of sympathetic overactivity on the myocardium C. They exert antiischaemic effect on the heart D. They prevent cardiac arrhythmias
Last Answer : B. They counteract deleterious effect of sympathetic overactivity on the myocardium
Description : The basis for use of β -adrenergic blockers in congestive heart failure (CHF) is: A. They exert positive inotropic effect in CHF B. They counteract deleterious effect of sympathetic overactivity on the myocardium C. They exert antiischaemic effect on the heart D. They prevent cardiac arrhythmias
Description : Important microbiological features of ciprofloxacin include the following except: A. Long postantibiotic effect B. Marked suppression of intestinal anaerobes C. MBC values close to MIC values D. Slow development of resistance
Last Answer : B. Marked suppression of intestinal anaerobes
Description : The fluoroquinolones have improved over nalidixic acid in the following respect(s): A. They have higher antimicrobial potency B. They have extended antimicrobial spectrum C. Development of bacterial resistance against them is slow and infrequent D. All of the above
Last Answer : D. All of the above
Description : Indicate the enzyme(s) inhibited by fluoroquinolones: A. Both 'A' and 'C' B. Topoisomerase II C. Topoisomerase IV D. DNA gyrase
Last Answer : D. DNA gyrase
Description : The β-lactam antibiotic(s) that prolong(s) bleeding time by altering surface receptors on platelets is/are: A. Carbenicillin B. Piperacillin C. Cefotaxime D. Both `A’ and `B’ are correct
Last Answer : A. Carbenicillin
Description : The following fluoroquinolones have augmented activity against gram positive bacteria except: A. Lomefloxacin B. Levofloxacin C. Gatifloxacin D. Moxifloxacin
Last Answer : A. Lomefloxacin
Description : The most common mechanism of development of resistance to fluoroquinolones is: A. Chromosomal mutation altering affinity of target site B. Plasmid transfer C. Acquisition of drug destroying enzyme D. Acquisition of alternative metabolic pathway
Last Answer : A. Chromosomal mutation altering affinity of target site
Description : The following drug/drugs does/do not produce any overt CNS effect in normal individuals but exert(s) clear cut therapeutic effect at the same dose in the presence of a specific neurological/psychiatric disorder: A. Chlorpromazine B. Levodopa C. Imipramine D. All of the above
Last Answer : B. Levodopa
Description : The following statements are true about imipenem except: A. It is a β-lactam antibiotic, but neither a penicillin nor a cephalosporin B. It is rapidly degraded in the kidney C. It is safe in epileptics D. It is always given in combination with cilastatin
Last Answer : C. It is safe in epileptics
Description : Cross resistance among different members of the following class of antimicrobials is absent / incomplete or unidirectional: A. Aminoglycosides B. Macrolides C. Tetracyclines D. Both ‘B’ and ‘C’ are correct
Last Answer : A. Aminoglycosides
Description : Select the class of antibiotics which act by interfering with bacterial protein synthesis, but are bactericidal: A. Tetracyclines B. Aminoglycosides C. Macrolides D. Lincosamides
Last Answer : B. Aminoglycosides
Description : Drug destroying type of bacterial resistance is important for the following antibiotics except: A. Cephalosporins B. Tetracyclines C. Chloramphenicol D. Aminoglycosides
Last Answer : B. Tetracyclines
Description : The following is true of selegiline: A. It does not exert antiparkinsonian action unless combined with levodopa B. It overcomes the on-off ' effect in levodopa treated advanced parkinsonian ... D. At doses used in parkinsonism it does not interfere with peripheral metabolism of dietary amines
Last Answer : . At doses used in parkinsonism it does not interfere with peripheral metabolism of dietary amines
Description : Select the drug that primarily reduces the static component of urinary obstruction in benign hypertrophy of prostate and takes more than 3 months to exert its beneficial effect: A. Tamsulosin B. Terazosin C. Finasteride D. Amphetamine
Last Answer : C. Finasteride
Description : Atropine does not exert relaxant/antispasmodic effect on the following muscle: A. Intestinal B. Ureteric C. Bronchial D. Laryngeal
Last Answer : D. Laryngeal
Description : Important microbiological features of ciprofloxacin include the following except (a) Long postantibiotic effect (b) Marked suppression of intestinal anaerobes (c) MBC values close to MIC values (d) Slow development of resistance
Last Answer : Ans: B
Description : Aminoglycoside antibiotics exert the following action(s) on sensitive bacteria: A. Induce synthesis of defective proteins B. Make bacterial cell membrane more leaky C. Augment their own carrier mediated entry into the bacteria D. All of the above
Description : Methylxanthines exert the following action(s) at cellular/molecular level: A. Intracellular release of Ca2+ B. Antagonism of adenosine C. Inhibition of phosphodiesterase D. All of the above
Description : Choose the correct statement about long acting calcium channel blocking drugs as antihypertensives: A. They are the most effective drugs in suppressing hypertensive left ventricular hypertrophy B. They ... more than β blockers D. They have no beneficial effect in hypertensive/diabetic nephropath
Last Answer : B. They are as effective as diuretics or β blockers in reducing cardiovascular/total mortality
Description : Which aminoglycoside antibiotic causes more hearing loss than vestibular disturbance as toxic effect: A. Streptomycin B. Gentamicin C. Kanamycin D. Sisomicin
Last Answer : C. Kanamycin
Description : A patient treated with capsule oxytetracycline 500 mg 6 hourly complained of epigastric pain. Which of the following measures will you recommend to counteract the side effect: A. Take the capsules ... capsules D. None of the above measures is suitable. Change the antibiotic if pain is distressing
Last Answer : D. None of the above measures is suitable. Change the antibiotic if pain is distressing
Description : The following drug reduces the effect of oral anticoagulants: A. Broad spectrum antibiotic B. Cimetidine C. Aspirin D. Oral contraceptive
Last Answer : D. Oral contraceptive
Description : Adrenergic neurone blocking drugs: A. Block the action of adrenaline on neuronal α2 adrenoceptors B. Block both α and β adrenoceptor mediated effects of injected adrenaline C. Do not block any effect of injected adrenaline D. Do not block the effects of sympathetic nerve
Last Answer : C. Do not block any effect of injected adrenaline
Description : Adrenergic β 1 selective blockers offer the following advantages except: A. Lower propensity to cause bronchospasm B. Less prone to produce cold hands and feet as side effect C. Withdrawal is less likely to exacerbate angina pectoris D. Less liable to impair exercise capacity
Last Answer : C. Withdrawal is less likely to exacerbate angina pectoris
Description : Adrenergic neurone blocking drugs: A. Block the action of adrenaline on neuronal α2 adrenoceptors B. Block both α and β adrenoceptor mediated effects of injected adrenaline C. Do not block any effect of injected adrenaline D. Do not block the effects of sympathetic nerve stimulation
Description : Vinca alkaloids exert antitumor activity by: A. Activating topoisomerase II to cause breaks in DNA strands B. Crosslinking DNA strands C. Inhibiting DNA mediated RNA synthesis D. Inhibiting polymerization of tubulin to form intracellular microtubules
Last Answer : D. Inhibiting polymerization of tubulin to form intracellular microtubules
Description : Alkylating agents exert cytotoxic action by inducing: A. Breakage of DNA strand B. Cross linking of DNA strands C. Abnormal pairing of purine and pyrimidine bases D. All of the above
Description : The most important mechanism by which tetracycline antibiotics exert antimicrobial action is: A. They chelate Ca2+ ions and alter permeability of bacterial cell membrane B. They bind to 30S ribosomes ... peptide chain in the bacteria D. They interfere with DNA mediated RNA synthesis in bacteria
Last Answer : B. They bind to 30S ribosomes and inhibit bacterial protein synthesis
Description : The following is true of sulfonamides except: A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble B. They are primarily metabolized by acetylation ... in the urinary tract D. Used alone, they have become therapeutically unreliable for serious infections
Last Answer : A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble
Description : Cyclic nucleotides exert the following action on salt transport across intestinal mucosal cells: A. Both cyclic AMP and cyclic GMP enhance Cland HCO3 - secretion B. Cyclic AMP enhances but cyclic GMP ... Cl- reabsorption D. Both cyclic AMP and cyclic GMP enhance Na+ and Cl- reabsorption
Last Answer : A. Both cyclic AMP and cyclic GMP enhance Cland HCO3 – secreti
Description : Irrespective of the type, all laxatives exert the following action: A. Increase the content of solids in the faeces B. Increase the water content of faeces C. Reduce absorption of nutrients D. Increase intestinal motility
Last Answer : B. Increase the water content of faeces
Description : The following drugs exert their action through the GABAA-benzodiazepine–receptor Cl¯ channel complex except: A. Baclofen B. Zolpidem C. Bicuculline D. Phenobarbitone
Last Answer : A. Baclofen
Description : Select the correct statement about benzodiazepines (BZDs): A. All BZDs facilitate GABA mediated Cl¯ influx into neurones B. Different BZDs exert the same degrees of hypnotic, anxiolytic and anticonvulsant ... at all neuronal sites D. The muscle relaxant action of BZDs is not blocked by flumazenil
Last Answer : A. All BZDs facilitate GABA mediated Cl¯ influx into neurones
Description : Barbiturates exert the following actions except: A. Anticonvulsant B. Analgesic C. Antianxiety D. Respiratory depressant
Last Answer : B. Analgesic
Description : Estrogens exert the following actions except: A. Cornification of vaginal epithelium B. Proliferation of endometrium C. Maturation of graafian follicle D. Anabolism
Last Answer : C. Maturation of graafian follicle
Description : Corticosteroids exert antiinflammatory action by inhibiting the following enzyme: A. Cyclooxygenase B. Lipoxygenase C. Phospholipase-A D. Phosphodiesterase
Last Answer : C. Phospholipase-A
Description : ntithyroid drugs exert the following action: A. Inhibit thyroxine synthesis B. Block the action of thyroxine on pituitary C. Block the action of TSH on thyroid D. Block the action of thyroxine on peripheral tissues
Last Answer : A. Inhibit thyroxine synthesis
Description : Antithyroid drugs exert the following action: A. Inhibit thyroxine synthesis B. Block the action of thyroxine on pituitary C. Block the action of TSH on thyroid D. Block the action of thyroxine on peripheral tissues
Last Answer : . Inhibit thyroxine synthesis
Description : Select the antibiotic(s) that can be used to treat nonspecific urethritis due to Chlamydia trachomatis: A. Azithromycin B. Doxycycline C. Clindamycin D. Both 'A' and 'B' are correct
Last Answer : D. Both 'A' and 'B' are correct
Description : Antibacterial agents can be classified with regard to their structure, mechanism of action, and activity pattern against various types of bacterial pathogens. Which of the following ... are both bacteriostatic d. Sulfonamides and trimethoprim act synergistically to inhibit purine synthesis
Last Answer : Answer: a, b, d Penicillins, cephalosporins, and monobactams possess a b-lactam ring of some type and act to bind bacterial division plate proteins, thus inhibiting cell wall ... act in different mechanisms to inhibit protein synthesis, therefore two agents in combination act synergistically
Description : Low dose therapy with the following category of antihypertensive drugs has been found to be more advantageous in the long-term than high dose therapy with the same drugs: A. β adrenergic blockers B. α1 adrenergic blockers C. Central sympatholytics D. Diuretics
Last Answer : D. Diuretics
Description : The preferred class of drugs for long term treatment of severe anxiety disorder with intermittent panic attacks is: A. Phenothiazine (chlorpromazine like) B. Azapirone (buspirone like) C. β-blocker (propranolol like) D. Selective serotonin reuptake inhibitor (sertraline like)
Last Answer : DD. Selective serotonin reuptake inhibitor (sertraline like)
Description : Which of the following would you classify as a pharmacodynamics interaction? a) ACE inhibitors with potassium-sparing diuretics cause life-threatening hyperkalaemia b) Antacids reduce the absorption ... Increased bleeding due to cimetidine and warfarin d) Probenecid increases half-life of penicillin
Last Answer : a) ACE inhibitors with potassium-sparing diuretics cause life-threatening hyperkalaemia
Description : Select the drug which is used to treat antibiotic associated pseudomembranous enterocolitis and is a component of anti-H.pylori triple drug regimen: A. Amoxicillin B. Vancomycin C. Metronidazole D. Clotrimazole
Last Answer : C. Metronidazole
Description : Indicate the antifungal antibiotic which is used intravenously for systemic mycosis: A. Griseofulvin B. Nystatin C. Amphotericin B D. Hamycin
Last Answer : C. Amphotericin
Description : Select the macrolide antibiotic having clinically useful antileprotic activity: A. Azithromycin B. Clarithromycin C. Erythromycin D. Roxithromycin
Last Answer : B. Clarithromycin
Description : ‘Red man syndrome’ has been associated with rapid intravenous injection of the following antibiotic: A. Vancomycin B. Clindamycin C. Cefoperazone D. Piperacillin
Last Answer : A. Vancomycin