Which one of the following statements about cefotetan is accurate? (a) It is active against MRSA strains (b) It is the drug of choice in community-acquired pneumonia (c) It is a fourth-generation cephalosporin (d) It decreases prothrombin time (e) Its antibacterial spectrum include Bacteroides fragilis

Which one of the following statements about cefotetan is accurate? (a) It is active against MRSA strains (b) It is the drug of choice in community-acquired pneumonia (c) It is a fourth-generation cephalosporin (d) It decreases prothrombin time (e) Its antibacterial spectrum include Bacteroides fragilis
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Ans: E
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Which one of the following statements about ampicillin is false? (a) Its activity is enhanced by sulbactam (b) It causes maculopapular rashes (c) It is the drug of choice for Listeria monocytogenes infection (d) It eradicates most strains of MRSA (e) Pseudomembranous colitis may occur with its use

Description : Which one of the following statements about ampicillin is false? (a) Its activity is enhanced by sulbactam (b) It causes maculopapular rashes (c) It is the drug of choice for Listeria monocytogenes infection (d) It eradicates most strains of MRSA (e) Pseudomembranous colitis may occur with its use

Last Answer : Ans: D

Cefotaxime has the following properties except (a) It is highly active against aerobic gram negative bacteria (b) It is the most active cephalosporin against Pseudomonas aeruginosa (c) It produces an active metabolite (d) It has achieved high cure rates in serious hospital acquired infections

Description : Cefotaxime has the following properties except (a) It is highly active against aerobic gram negative bacteria (b) It is the most active cephalosporin against Pseudomonas aeruginosa (c) It produces an active metabolite (d) It has achieved high cure rates in serious hospital acquired infections

Last Answer : Ans: B

Select the fourth generation cephalosporin among the following (a) Cefpirome (b) Ceftizoxime (c) Ceftazidime (d) Cefuroxime

Description : Select the fourth generation cephalosporin among the following (a) Cefpirome (b) Ceftizoxime (c) Ceftazidime (d) Cefuroxime

Last Answer : Ans: A

Clarithromycin and erythromycin have very similar spectrums of antimicrobial activity. The major advantage of clarithromytcin is that it (a) Eradicates mycoplasmal infections in a single dose (b) Is active against strains of streptococci that are resistant to erythromycin (c) Is more active against Mycobacterium avium complex (d) Does not inhibit live drug-metabolizing enzymes (e) Acts on methicillin-resistant strains of staphylococci

Description : Clarithromycin and erythromycin have very similar spectrums of antimicrobial activity. The major advantage of clarithromytcin is that it (a) Eradicates mycoplasmal infections in a single dose (b ... not inhibit live drug-metabolizing enzymes (e) Acts on methicillin-resistant strains of staphylococci

Last Answer : Ans: C

Chloramphenicol is more active than tetracyclines against (a) Bateroides fragilis (b) Treponema pallidum (c) Streptococci (d) Staphylococci

Description : Chloramphenicol is more active than tetracyclines against (a) Bateroides fragilis (b) Treponema pallidum (c) Streptococci (d) Staphylococci

Last Answer : Ans: A

Ciprofloxacin is not active against: A. H.influenzae B. E.coli C. Enterobacter spp. D. Bacteroides fragilis

Description : Ciprofloxacin is not active against: A. H.influenzae B. E.coli C. Enterobacter spp. D. Bacteroides fragilis

Last Answer : D. Bacteroides fragilis

The following antibiotic is highly active against anaerobic bacteria including Bacteroides fragilis: A. Ciprofloxacin B. Clarithromycin C. Clindamycin D. Tobramycin

Description : The following antibiotic is highly active against anaerobic bacteria including Bacteroides fragilis: A. Ciprofloxacin B. Clarithromycin C. Clindamycin D. Tobramycin

Last Answer : C. Clindamycin

This drug has activity against many strains of Pseudomomas aeruginosa. However, when it is used alone, resistance has emerged during the course of treatment. The drug should not be used in penicillinallergic patients. Its activity against gramnegative rods is enhanced if it is given in combination with tazobactam (a) Amoxicillin (b) Aztreonam (c) Imipenem (d) Piperacillin (e) Vancomycin

Description : This drug has activity against many strains of Pseudomomas aeruginosa. However, when it is used alone, resistance has emerged during the course of treatment. The drug should not be used in ... with tazobactam (a) Amoxicillin (b) Aztreonam (c) Imipenem (d) Piperacillin (e) Vancomycin

Last Answer : Ans: D

Widespread and prolonged used of an antibiotic leads to emergence of drug resistant strains because antibiotics (a) Induce mutation in the bacteria (b) Promote conjugation among bacteria (c) Allow resistant strains to propagate preferentially (d) All of the above

Description : Widespread and prolonged used of an antibiotic leads to emergence of drug resistant strains because antibiotics (a) Induce mutation in the bacteria (b) Promote conjugation among bacteria (c) Allow resistant strains to propagate preferentially (d) All of the above

Last Answer : Ans: C

Beta – lactamase production by strains of Haemophilus influenzae, Moraxella catarrhalis, and Neissera gonorrhoeae confers resistance against penicillin G.which one of the following antibiotics is most likely to be effective against all strains of each of the above organisms? (a) Ampicillin (b) Ceftriaxone (c) Clindamycin (d) Gentamicin (e) Piperacillin

Description : Beta - lactamase production by strains of Haemophilus influenzae, Moraxella catarrhalis, and Neissera gonorrhoeae confers resistance against penicillin G.which one of the following antibiotics is most likely to be ... ? (a) Ampicillin (b) Ceftriaxone (c) Clindamycin (d) Gentamicin (e) Piperacillin

Last Answer : Ans: B

Which one of the following drugs is most likely to be effective against multidrug – resistant strains of M tuberculosis, including those resistant to streptomycin? (a) Amikacin (b) Clarithromycin (c) Gentamicin (d) Meropenem (e) Spectinomycin

Description : Which one of the following drugs is most likely to be effective against multidrug – resistant strains of M tuberculosis, including those resistant to streptomycin? (a) Amikacin (b) Clarithromycin (c) Gentamicin (d) Meropenem (e) Spectinomycin

Last Answer : Ans: A

Bleomycin is used in most effective drug combination regiment for the chemotherapy of testicular carcinoma. Which one of the following statements about the drug is accurate? (a) Acts mainly in the M phase of the cell cycle (b) Derived from the bark of yew trees (c) Myelosuppression is dose-limiting (d) Peripheral neuropathy occurs in more than 50% of patients (e) Pulmonary infiltrates and fibrosis may occur

Description : Bleomycin is used in most effective drug combination regiment for the chemotherapy of testicular carcinoma. Which one of the following statements about the drug is accurate? (a) Acts mainly in the ... neuropathy occurs in more than 50% of patients (e) Pulmonary infiltrates and fibrosis may occur

Last Answer : Ans: E

Compared to older tetracyclines, doxycycline produces a lower incidence of superinfection diarrhoea because (a) It is completely absorbed in the small intestines so that drug concentration in the colonic contents is low (b) It is inactivated by the gut microflora (c) It is not active against the microbes of the normal gut flora (d) It is a potent tetracycline and inhibits the superinfection causing microbes as well

Description : Compared to older tetracyclines, doxycycline produces a lower incidence of superinfection diarrhoea because (a) It is completely absorbed in the small intestines so that drug concentration in the colonic ... (d) It is a potent tetracycline and inhibits the superinfection causing microbes as well

Last Answer : Ans: A

The mechanism of antibacterial action of tetracycline involves (a) Binding to a component of the 50S ribosomal subunit (b) Inhibition of translocase activity (c) Blockade of binding of aminoacyl – tRNA to bacterial ribosomes (d) Selective inhibition of ribosomal peptidyl transferases (e) Inhibition of DNA–dependent RNA polymerase

Description : The mechanism of antibacterial action of tetracycline involves (a) Binding to a component of the 50S ribosomal subunit (b) Inhibition of translocase activity (c) Blockade of binding of ... (d) Selective inhibition of ribosomal peptidyl transferases (e) Inhibition of DNA-dependent RNA polymerase

Last Answer : Ans: C

Choose the correct statement about famciclovir: A. It is active against acyclovir resistant strains of herpes simplex virus B. It does not need conversion to an active metabolite C. It is used orally to treat genital herpes simplex D. It is the drug of choice for cytomegalovirus retinitis

Description : Choose the correct statement about famciclovir: A. It is active against acyclovir resistant strains of herpes simplex virus B. It does not need conversion to an active metabolite C. It is used orally to treat genital herpes simplex D. It is the drug of choice for cytomegalovirus retinitis

Last Answer : C. It is used orally to treat genital herpes simplex

Impetigo is a skin disease caused by a. a species of Haemophilus. b. a species of Chlamydia. c. Bacteroides fragilis. d. Staphylococcus aureus.

Description : Impetigo is a skin disease caused by a. a species of Haemophilus. b. a species of Chlamydia. c. Bacteroides fragilis. d. Staphylococcus aureus.

Last Answer : d. Staphylococcus aureus.

Cefotaxime has the following properties except: A. It is highly active against aerobic gram negative bacteria B. It is the most active cephalosporin against Pseudomonas aeruginosa C. It produces an active metabolite D. It has achieved high cure rates in serious hospital acquired infections

Description : Cefotaxime has the following properties except: A. It is highly active against aerobic gram negative bacteria B. It is the most active cephalosporin against Pseudomonas aeruginosa C. It produces an active metabolite D. It has achieved high cure rates in serious hospital acquired infections

Last Answer : B. It is the most active cephalosporin against Pseudomonas aeruginosa

Features of phenoxymethyl penicillin include the following: A. It is acid stable and orally active B. Its antibacterial spectrum is similar to that of benzyl penicillin C. It is used for less serious penicillin G sensitive infections D. All of the above are correct

Description : Features of phenoxymethyl penicillin include the following: A. It is acid stable and orally active B. Its antibacterial spectrum is similar to that of benzyl penicillin C. It is used for less serious penicillin G sensitive infections D. All of the above are correct

Last Answer : D. All of the above are correct

The drug of choice for scarlet fever is (a) Tetracycline (b) Sulfonamides (c) Penicillin (d) Chloromycetin (e) Novobiocin

Description : The drug of choice for scarlet fever is (a) Tetracycline (b) Sulfonamides (c) Penicillin (d) Chloromycetin (e) Novobiocin

Last Answer : Ans: C

Which of the following statements about vancomycin is accurate? (a) It is bacteriostatic (b) It binds to PBPs (c) It is not susceptible to penicillinase (d) It has the advantage of oral bioavailability (e) Staphylococcal enterocolitis occurs commonly with its use

Description : Which of the following statements about vancomycin is accurate? (a) It is bacteriostatic (b) It binds to PBPs (c) It is not susceptible to penicillinase (d) It has the advantage of oral bioavailability (e) Staphylococcal enterocolitis occurs commonly with its use

Last Answer : Ans: C

The drug of choice for treatment of methicillin resistant Staphylococcus aureus infection is (a) Cloxacillin (b) Vancomycin (c) Erythromycin (d) Amikacin

Description : The drug of choice for treatment of methicillin resistant Staphylococcus aureus infection is (a) Cloxacillin (b) Vancomycin (c) Erythromycin (d) Amikacin

Last Answer : Ans: B

Benzathine penicillin injected once every 4 weeks for 5 years or more is the drug of choice for (a) Agranulocytosis patients (b) Prophylaxis of bacterial endocarditis in patients with valvular defects (c) Prophylaxis of rheumatic fever (d) Treatment of anthrax

Description : Benzathine penicillin injected once every 4 weeks for 5 years or more is the drug of choice for (a) Agranulocytosis patients (b) Prophylaxis of bacterial endocarditis in patients with valvular defects (c) Prophylaxis of rheumatic fever (d) Treatment of anthrax

Last Answer : Ans: C

Currently the drug of choice for emperic treatment of typhoid fever is (a) Chloramphenicol (b) Cotrimoxaxole (c) Ciprofloxacin (d) Ampicillin

Description : Currently the drug of choice for emperic treatment of typhoid fever is (a) Chloramphenicol (b) Cotrimoxaxole (c) Ciprofloxacin (d) Ampicillin

Last Answer : Ans: C

Distinctive features of gatifloxacin include the following except: A. Higher affinity for the enzyme topoisomerase IV B. Activity restricted to gram negative bacteria C. Potential to prolong QTc interval D. Employed to treat community acquired pneumonia

Description : Distinctive features of gatifloxacin include the following except: A. Higher affinity for the enzyme topoisomerase IV B. Activity restricted to gram negative bacteria C. Potential to prolong QTc interval D. Employed to treat community acquired pneumonia

Last Answer : B. Activity restricted to gram negative bacteria

A high school student presents with headache, fever, and cough of 2 day’s duration. Sputum is scant and nonpurulent and a Gram stain reveals many white cells but no organisms. Since this patient appears to have atypical pneumonia. You should initiate treatment with (a) Cefazolin (b) Clindamycin (c) Erythromycin (d) Gentamicin (e) Trovafloxacin

Description : A high school student presents with headache, fever, and cough of 2 day's duration. Sputum is scant and nonpurulent and a Gram stain reveals many white cells but no organisms. Since this ... initiate treatment with (a) Cefazolin (b) Clindamycin (c) Erythromycin (d) Gentamicin (e) Trovafloxacin

Last Answer : Ans: C

Amoxicillin + Clavulanic acid is active against the following organism except (a) Methicillin resistant Staph. aureus (b) Penicillinase producing Staph. aureus (c) Penicillinase producing n. gonorrhoeae (d) ß-lactamase producing E. coli

Description : Amoxicillin + Clavulanic acid is active against the following organism except (a) Methicillin resistant Staph. aureus (b) Penicillinase producing Staph. aureus (c) Penicillinase producing n. gonorrhoeae (d) ß-lactamase producing E. coli

Last Answer : Ans: A

Choose the correct statement(s) about cefepime: A. It is a 4th generation cephalosporin B. It is active against many bacteria resistant to 3rd generation celphalosporins C. It is active by the oral route D. Both 'A' and 'B' are correct

Description : Choose the correct statement(s) about cefepime: A. It is a 4th generation cephalosporin B. It is active against many bacteria resistant to 3rd generation celphalosporins C. It is active by the oral route D. Both 'A' and 'B' are correct

Last Answer : D. Both 'A' and 'B' are correct

In the empiric treatment of severe bacterial infections of unidentified entiology, this drug, often used in combination with an aminoglycoside, provides coverage against many staphylococci (a) Amoxicillin (b) Clavulanic acid (c) Erythromycin (d) Nafcillin (e) Tetracycline

Description : In the empiric treatment of severe bacterial infections of unidentified entiology, this drug, often used in combination with an aminoglycoside, provides coverage against many staphylococci (a) Amoxicillin (b) Clavulanic acid (c) Erythromycin (d) Nafcillin (e) Tetracycline

Last Answer : Ans: D

Aminoglycoside antibiotics have the following common property (a) They are primarily active against gramnegative bacilli (b) They are more active in acidic medium (c) They readily enter cells and are distributed in total body water (d) They are nearly completely metabolized in liver

Description : Aminoglycoside antibiotics have the following common property (a) They are primarily active against gramnegative bacilli (b) They are more active in acidic medium (c) They readily enter cells and are distributed in total body water (d) They are nearly completely metabolized in liver

Last Answer : Ans: A

Piperacillin differs from carbenicillin in the following respect(s) (a) It is more active against pseudomonas aeruginosa (b) It is active against Klebsiella also (c) It is acid resistant (d) Both (a) and (b)

Description : Piperacillin differs from carbenicillin in the following respect(s) (a) It is more active against pseudomonas aeruginosa (b) It is active against Klebsiella also (c) It is acid resistant (d) Both (a) and (b)

Last Answer : Ans: D

An advantage of bleomycin over most antineoplastic drugs is its (a) Rapid onset of action (b) Lack of toxicity to all normal cells (c) Relative lack of bone marrow toxicity (d) Very broad spectrum of activity (e) Both (a) and (b)

Description : An advantage of bleomycin over most antineoplastic drugs is its (a) Rapid onset of action (b) Lack of toxicity to all normal cells (c) Relative lack of bone marrow toxicity (d) Very broad spectrum of activity (e) Both (a) and (b)

Last Answer : Ans: C

Methicillin resistant staphylococci do not respond to ß-lactam antibiotics because (a) They produce a ß-lactamase which destroys methicillin and related drugs (b) They elaborate an amidase which destroys methicillin and related drugs (c) They have acquired a penicillin binding protein which has low affinity for ß-lactam antibiotics (d) They are less permeable to ß-lactam antibiotics

Description : Methicillin resistant staphylococci do not respond to ß-lactam antibiotics because (a) They produce a ß-lactamase which destroys methicillin and related drugs (b) They elaborate an amidase which destroys ... low affinity for ß-lactam antibiotics (d) They are less permeable to ß-lactam antibiotics

Last Answer : Ans: C

What is the most important reason for restricted clinical use of chloramphenicol ? (a) Its narrow spectrum of activity (b) Emergence of chloramphenicol resistance (c) Its potential to cause bone marrow depression (d) Its potential to cause superinfections

Description : What is the most important reason for restricted clinical use of chloramphenicol ? (a) Its narrow spectrum of activity (b) Emergence of chloramphenicol resistance (c) Its potential to cause bone marrow depression (d) Its potential to cause superinfections

Last Answer : Ans: C

The most important reason for highly restricted use of penicillin G injections in present day therapeutics is its (a) Narrow spectrum of activity (b) Potential to cause hypersensitivity reaction (c) Short duration of action (d) Neurotoxicity

Description : The most important reason for highly restricted use of penicillin G injections in present day therapeutics is its (a) Narrow spectrum of activity (b) Potential to cause hypersensitivity reaction (c) Short duration of action (d) Neurotoxicity

Last Answer : Ans: B

Superinfections are more common with (a) Use of narrow spectrum antibiotics (b) Short courses of antibiotics (c) Use of antibiotics that are completely absorbed from the small intestines (d) Use of antibiotic combinations covering both gram positive and gram negative bacteria

Description : Superinfections are more common with (a) Use of narrow spectrum antibiotics (b) Short courses of antibiotics (c) Use of antibiotics that are completely absorbed from the small intestines (d) Use of antibiotic combinations covering both gram positive and gram negative bacteria

Last Answer : Ans: D

What is true of cefpirome: A. It is a fourth generation cephalosporin B. It easily penetrates porin channels of gram negative bacteria C. It inhibits type I β-lactamase producing enterobacteriaceae D. All of the above

Description : What is true of cefpirome: A. It is a fourth generation cephalosporin B. It easily penetrates porin channels of gram negative bacteria C. It inhibits type I β-lactamase producing enterobacteriaceae D. All of the above

Last Answer : . All of the above

Select the fourth generation cephalosporin among the following: A. Cefpirome B. Ceftizoxime C. Ceftazidime D. Cefuroxime

Description : Select the fourth generation cephalosporin among the following: A. Cefpirome B. Ceftizoxime C. Ceftazidime D. Cefuroxime

Last Answer : A. Cefpirome

A woman has an upper respiratory infection. Six years ago, she experienced an episode of bronchospasm follwing penicillin V therapy. The cultures now reveal a strain of streptococcus pneumoniae that is sensitive to all of the following drugs. Which of these drugs would be the best choice for this patient? (a) Amoxicillin/clavulanate (b) Erythromycin (c) Ampicillin (d) cefaclor (e) Cyclacillin

Description : A woman has an upper respiratory infection. Six years ago, she experienced an episode of bronchospasm follwing penicillin V therapy. The cultures now reveal a strain of streptococcus pneumoniae that is ... ? (a) Amoxicillin/clavulanate (b) Erythromycin (c) Ampicillin (d) cefaclor (e) Cyclacillin

Last Answer : Ans: B

Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas (a) They are used to control diarrhoea irrespective of its etiology (b) They should be used only as a short-term measure after ensuring that enteroinvasive organisms are not involved (c) They are used as adjuvants to antimicrobial therapy of diarrhoea (d) They are the drugs of choice in irritable bowel syndrome diarrhoea

Description : Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas (a) They are used to control diarrhoea irrespective of its etiology (b) They should be ... therapy of diarrhoea (d) They are the drugs of choice in irritable bowel syndrome diarrhoea

Last Answer : Ans: B

Tetracyclines are still the first choice drugs for the following disease. (a) Granuloma linguinale (b) Chancroid (c) Syphilis (d) Gonorrhoea in patients allergic to penicillin

Description : Tetracyclines are still the first choice drugs for the following disease. (a) Granuloma linguinale (b) Chancroid (c) Syphilis (d) Gonorrhoea in patients allergic to penicillin

Last Answer : Ans: A

Chloramphenicol is more active than tetracyclines against: A. Bateroides fragilis B. Treponema pallidum C. Streptococci D. Staphylococci

Description : Chloramphenicol is more active than tetracyclines against: A. Bateroides fragilis B. Treponema pallidum C. Streptococci D. Staphylococci

Last Answer : a

Which one of the following antibiotics is a potent inducer of hepatic drug-metabolizing enzymes? (a) Ciprofloxacin (b) Cyclosporine (c) Erythromycin (d) Rifampin (e) Tetracycline

Description : Which one of the following antibiotics is a potent inducer of hepatic drug-metabolizing enzymes? (a) Ciprofloxacin (b) Cyclosporine (c) Erythromycin (d) Rifampin (e) Tetracycline

Last Answer : Ans: D

The primary mechanism underlying the resistance of gram-positive organisms to macrolide antibiotics is (a) Methylation of binding sites on the 50S ribosomal subunit (b) Formation of esterases that hydrolyze the lactone ring (c) Increased activity of efflux mechanisms (d) Formation of drug-inactivating acetyltranferases (e) Decreased drug permeability of the cytoplasmic membrane

Description : The primary mechanism underlying the resistance of gram-positive organisms to macrolide antibiotics is (a) Methylation of binding sites on the 50S ribosomal subunit (b) Formation of ... ) Formation of drug-inactivating acetyltranferases (e) Decreased drug permeability of the cytoplasmic membrane

Last Answer : Ans: A

Isoniazid is a primary antitubercular agent that (a) Requires pyridoxine supplementation (b) May discolor the tears, saliva, urine or feces orange-red (c) Causes ocular complications that are reversible if the drug is discontinued (d) May be ototoxic and nephrotoxic (e) Should never be used due to hepatotoxic potential

Description : Isoniazid is a primary antitubercular agent that (a) Requires pyridoxine supplementation (b) May discolor the tears, saliva, urine or feces orange-red (c) Causes ocular complications that are reversible if ... (d) May be ototoxic and nephrotoxic (e) Should never be used due to hepatotoxic potential

Last Answer : Ans: A

Which of the following community-acquired pneumonias demonstrates the highest occurrence during summer and fall? a) Legionnaires’ disease Legionnaires’ disease accounts for 15% of community-acquired pneumonias. b) Streptococcal (pneumococcal) pneumonia Streptococcal pneumonia demonstrates the highest occurrence in winter months. c) Mycoplasma pneumonia Mycoplasma pneumonia demonstrates the highest occurrence in fall and early winter. d) Viral pneumonia Viral pneumonia demonstrates the greatest incidence during winter months.

Description : Which of the following community-acquired pneumonias demonstrates the highest occurrence during summer and fall? a) Legionnaires' disease Legionnaires' disease accounts for 15% of community-acquired ... . d) Viral pneumonia Viral pneumonia demonstrates the greatest incidence during winter months.

Last Answer : a) Legionnaires’ disease Legionnaires’ disease accounts for 15% of community-acquired pneumonias.

Important microbiological features of ciprofloxacin include the following except (a) Long postantibiotic effect (b) Marked suppression of intestinal anaerobes (c) MBC values close to MIC values (d) Slow development of resistance

Description : Important microbiological features of ciprofloxacin include the following except (a) Long postantibiotic effect (b) Marked suppression of intestinal anaerobes (c) MBC values close to MIC values (d) Slow development of resistance

Last Answer : Ans: B

The following antibiotic is a first line drug for treatment of Mycobacterium avium complex infection in AIDS patients (a) Clindamycin (b) Clarithromycin (c) Roxithromycin (d) Erythromycin

Description : The following antibiotic is a first line drug for treatment of Mycobacterium avium complex infection in AIDS patients (a) Clindamycin (b) Clarithromycin (c) Roxithromycin (d) Erythromycin

Last Answer : Ans: B