What is the therapeutic function of purmorphamine?

What is the therapeutic function of purmorphamine?
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1 Answer

Answer :

Purmorphamine, under the IUPAC name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine, is a cell-permeable 6,9-trisubstituted purine which directly binds and activates Smoothened (in HEK293T cell：IC50= ~ 1.5 μM ).So it has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. I found the answer from the website of BOC Sciences.
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he current therapeutic indication of acetazolamide is: A. Congestive heart failure B. Renal insufficiency C. Cirrhosis of liver D. Glaucoma

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n a failing heart therapeutic dose of digoxin has no effect on the following parameter: A. Cardiac output B. Heart rate C. Tone of ventricular fibres D. Cardiac vagal tone

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Last Answer : B. 0.5–0.8 mEq/L