Do non competitive inhibitors bind to the active site?

Do non competitive inhibitors bind to the active site?
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Which one of the following statements regarding enzyme inhibition is correct? (a) Competitive inhibition is seen when a substrate competes with an enzyme for binding to an inhibitor protein. (b) Competitive inhibition is seen when the substrate and the inhibitor compete for the active site on the enzyme. (c) Non-competitive inhibition of an enzyme can be overcome by adding large amount of substrate. (d) Non-competitive inhibitors often bind to the enzyme irreversibly.

Description : Which one of the following statements regarding enzyme inhibition is correct? (a) Competitive inhibition is seen when a substrate competes with an enzyme for binding to an inhibitor protein. (b ... large amount of substrate. (d) Non-competitive inhibitors often bind to the enzyme irreversibly.

Last Answer : (b) Competitive inhibition is seen when the substrate and the inhibitor compete for the active site on the enzyme

What is it called when an enzyme is blocked at its active site so the normal substrate can't bind? a. Competitive Inhibition b. Feedback Inhibition c. Noncompetitive Inhibition d. Pathway Modulation

Description : What is it called when an enzyme is blocked at its active site so the normal substrate can't bind? a. Competitive Inhibition b. Feedback Inhibition c. Noncompetitive Inhibition d. Pathway Modulation

Last Answer : a. Competitive Inhibition

Difference between competitive inhibitors and non-competitive inhibitors? -Biology

Description : Difference between competitive inhibitors and non-competitive inhibitors? -Biology

Last Answer : answer:

Vmax of an enzyme may be affected by (A) pH (B) Temperature (C) Non-competitive inhibitors (D) All of these

Description : Vmax of an enzyme may be affected by (A) pH (B) Temperature (C) Non-competitive inhibitors (D) All of these

Last Answer : Answer : D

Which inactivates an enzyme by occupying its active site? (A) Competitive inhibitor (B) Allosteric inhibitor (C) Non-competitive inhibitor (D) All of these

Description : Which inactivates an enzyme by occupying its active site? (A) Competitive inhibitor (B) Allosteric inhibitor (C) Non-competitive inhibitor (D) All of these

Last Answer : Answer : A

A substance unrelated to substrate but capable of reversibly changing activity of enzyme by binding to a site other than active site is called (a) Competitive inhibitor (b) Non-competitive inhibitor (c) Catalytic inhibitor (d) Allosteric modulator/inhibitor

Description : A substance unrelated to substrate but capable of reversibly changing activity of enzyme by binding to a site other than active site is called (a) Competitive inhibitor (b) Non-competitive inhibitor (c) Catalytic inhibitor (d) Allosteric modulator/inhibitor

Last Answer : Ans. ((d))

Select the option which is not correct with respect to enzyme action. (a) Substrate binds with enzyme at its active site. (b) Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate. (c) A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate. (d) Malonate is a competitive inhibitor of succinic dehydrogenase.

Description : Select the option which is not correct with respect to enzyme action. (a) Substrate binds with enzyme at its active site. (b) Addition of lot of succinate does not reverse the inhibition ... from that which binds the substrate. (d) Malonate is a competitive inhibitor of succinic dehydrogenase.

Last Answer : (b) Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.

Clinical significance of competitive inhibitors -Biology

Description : Clinical significance of competitive inhibitors -Biology

Last Answer : answer:

Competitive inhibitors (A) Decrease the Km (B) Decrease the Vmax (C) Increase the Km (D) Increase the Vmax

Description : Competitive inhibitors (A) Decrease the Km (B) Decrease the Vmax (C) Increase the Km (D) Increase the Vmax

Last Answer : Answer : C

Contrast and compare competitive inhibitors with noncompetitive inhibitors. Which can be overcome by the addition of more substrate?

Description : Contrast and compare competitive inhibitors with noncompetitive inhibitors. Which can be overcome by the addition of more substrate?

Last Answer : Competitive inhibitors reduce the productivity of enzymes by blocking substrates from entering active sites. This inhibition is what can be overcome by the addition of more substrate. Noncompetitive ... active site will become less and less effective at helping convert substrate to product.

Choose the correct statement about allopurinol: A. It is a purine antimetabolite with antineoplastic activity B. It is a competitive inhibitor of xanthine oxidase C. It is inactive itself, but its metabolite alloxanthine is a competitive inhibitor of xanthine oxidase D. Both allopurinol as well as its metabolite alloxanthine are noncompetitive inhibitors of xanthine oxidase

Description : Choose the correct statement about allopurinol: A. It is a purine antimetabolite with antineoplastic activity B. It is a competitive inhibitor of xanthine oxidase C. It is inactive itself ... D. Both allopurinol as well as its metabolite alloxanthine are noncompetitive inhibitors of xanthine oxidase

Last Answer : B. It is a competitive inhibitor of xanthine oxidase

If an enzyme‘s active site becomes deformed, inhibition was likely responsible. a. Metabolic b. Competitive c. Noncompetitive d. Cellular

Description : If an enzyme‘s active site becomes deformed, inhibition was likely responsible. a. Metabolic b. Competitive c. Noncompetitive d. Cellular

Last Answer : c. Noncompetitive

Choose the correct statement(s) about retroviral protease inhibitors: A. They act at an early step in HIV replication B. They are more active in inhibiting HIV than zidovudine C. They inhibit CYP3A4 and interact with many other drugs D. Both 'B' and 'C' are correct

Description : Choose the correct statement(s) about retroviral protease inhibitors: A. They act at an early step in HIV replication B. They are more active in inhibiting HIV than zidovudine C. They inhibit CYP3A4 and interact with many other drugs D. Both 'B' and 'C' are correct

Last Answer : D. Both 'B' and 'C' are correct

In non-competitive enzyme action (A) Vmax is increased (B) Apparent km is increased (C) Apparent km is decreased (D) Concentration of active enzyme molecule is reduced

Description : In non-competitive enzyme action (A) Vmax is increased (B) Apparent km is increased (C) Apparent km is decreased (D) Concentration of active enzyme molecule is reduced

Last Answer : Answer : C

In reversible non-competitive enzyme activity inhibition (A) Vmax is increased (B) Km is increased (C) Km is decreased (D) Concentration of active enzyme is reduced

Description : In reversible non-competitive enzyme activity inhibition (A) Vmax is increased (B) Km is increased (C) Km is decreased (D) Concentration of active enzyme is reduced

Last Answer : Answer : D

The organophosphates produce irreversible inhibition of cholinesterase because: A. They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind acetylcholine B. Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules C. Phosphorylation results in rapid degradation of enzyme molecules D. They are neither metabolized nor excreted from the body

Description : The organophosphates produce irreversible inhibition of cholinesterase because: A. They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind ... degradation of enzyme molecules D. They are neither metabolized nor excreted from the body

Last Answer : B. Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules

The organophosphates produce irreversible inhibition of cholinesterase because: A. They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind acetylcholine B. Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules C. Phosphorylation results in rapid degradation of enzyme molecules D. They are neither metabolized nor excreted from the body

Description : The organophosphates produce irreversible inhibition of cholinesterase because: A. They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind ... degradation of enzyme molecules D. They are neither metabolized nor excreted from the body

Last Answer : B. Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules

Which of the following is NOT correct about hormones? A) Hormones are generally found across the animal kingdom. B) Hormones may be used at a distance from where the hormone is made. C) Hormones have a slower effect than that mediated by the nervous system. D) Hormones bind to receptor sites at a target cell. E) Hormones are directed to the target organ and avoid contact with non-target cells.

Description : Which of the following is NOT correct about hormones? A) Hormones are generally found across the animal kingdom. B) Hormones may be used at a distance from where the hormone is made. C) ... target cell. E) Hormones are directed to the target organ and avoid contact with non-target cells.

Last Answer : E) Hormones are directed to the target organ and avoid contact with non-target cells.

Which statement is NOT true about non-steroid (peptide) hormones? A) They are derived from peptides, proteins, polypeptides, and derivatives of amino acids. B) They bind to receptors on the cell surface. C) They form cyclic AMP inside the cell. D) They create an enzyme cascade effect. E) They enter the cell in order to have an effect.

Description : Which statement is NOT true about non-steroid (peptide) hormones? A) They are derived from peptides, proteins, polypeptides, and derivatives of amino acids. B) They bind to receptors on the cell surface. ... They create an enzyme cascade effect. E) They enter the cell in order to have an effect.

Last Answer : E) They enter the cell in order to have an effect.

Which statement is NOT true about steroid hormones? A) They include hormones such as estrogen. B) They do not bind to cell surface receptors. C) The hormone-receptor complex can enter the nucleus. D) The hormone-receptor complex can bind to chromatin. E) Steroid hormones act faster than non-steroid (peptide) hormones.

Description : Which statement is NOT true about steroid hormones? A) They include hormones such as estrogen. B) They do not bind to cell surface receptors. C) The hormone-receptor complex can enter the ... complex can bind to chromatin. E) Steroid hormones act faster than non-steroid (peptide) hormones.

Last Answer : E) Steroid hormones act faster than non-steroid (peptide) hormones.

What are some of the best or strongest DHT blockers/inhibitors?

Description : What are some of the best or strongest DHT blockers/inhibitors?

Last Answer : partyrock, you might want to explain what DHT blockers do. I had no idea and had to look up what this meant. I have no experience with them.

What are irreversible inhibitors? -Biology

Description : What are irreversible inhibitors? -Biology

Last Answer : answer:

What are enzyme inhibitors? -Biology

Description : What are enzyme inhibitors? -Biology

Last Answer : answer:

Names of seed germination inhibitors. -Biology

Description : Names of seed germination inhibitors. -Biology

Last Answer : answer:

Names of seed germination inhibitors. -Biology

Description : Names of seed germination inhibitors. -Biology

Last Answer : answer:

How do proton pump inhibitors work ?

Description : How do proton pump inhibitors work ?

Last Answer : Proton pump inhibit is a group of drugs whose main function is to reduce chronic acid production in the stomach. Although there are different medications in this group , there is no evidence ... stomach by ingesting food protects us from gastric and ulcer diseases by affecting the enzyme system.

$ Enzymes are special types of proteins. ! Those substances which interfere with the action of enzymes are called inhibitors.

Description : $ Enzymes are special types of proteins. ! Those substances which interfere with the action of enzymes are called inhibitors.

Last Answer : $ Enzymes are special types of proteins. ! Those substances which interfere with the action of enzymes are ... wrong D. If both As and R are wrong.

Metabolic alkalosis can occur in (A) Severe diarrhoea (B) Renal failure (C) Recurrent vomiting (D) Excessive use of carbonic anhydrase inhibitors

Description : Metabolic alkalosis can occur in (A) Severe diarrhoea (B) Renal failure (C) Recurrent vomiting (D) Excessive use of carbonic anhydrase inhibitors

Last Answer : Answer : C

Example of growth inhibitors

Description : Example of growth inhibitors

Last Answer : Ans. Abscisic acid and Ethylene

Lowland applied nitrification inhibitors

Description : Lowland applied nitrification inhibitors

Last Answer : Ans. Oxamide (31%N) and Thiourea (36.8%N)

Which of the following statements about hypertension in diabetes patients is/are correct? A. Hypertension worsens the macrovascular disease of diabetes patients. B. Hypertension accelerates the progression of diabetic nephropathy. C. Hypertension is associated with sodium retention in diabetes patients. D. Angiotensin-converting enzyme (ACE) inhibitors should be used in all patients with chronic hyperglycemia, regardless of the presence of hypertension. E. Diuretics, as single-drug therapy, are not indicated in the treatment of hypertension in diabetes patients.

Description : Which of the following statements about hypertension in diabetes patients is/are correct? A. Hypertension worsens the macrovascular disease of diabetes patients. B. Hypertension accelerates the ... single-drug therapy, are not indicated in the treatment of hypertension in diabetes patients.

Last Answer : Answer: ABCDE DISCUSSION: All of the answers listed are correct. By damaging endothelial cells, hypertension worsens macrovascular disease in all patients but especially in diabetics. Hypertension ... is not indicated because the chronic state of dehydration in such patients may become worse

Tyramine induces release of noradrenaline from adrenergic nerve endings (a) By depolarizing the axonal membrane (b) By mobilizing Ca2+ (c) By a nonexocytotic process (d) Only in the presence of MAO inhibitors

Description : Tyramine induces release of noradrenaline from adrenergic nerve endings (a) By depolarizing the axonal membrane (b) By mobilizing Ca2+ (c) By a nonexocytotic process (d) Only in the presence of MAO inhibitors

Last Answer : Ans: C

Postural hypotension is a common adverse effect of which one of the following types of drugs ? (a) ACE inhibitors (b) Alpha-receptor blockers (c) Arteriolar dilators (d) ß1 – selective receptor blockers (e) Nonselective ß - blockers

Description : Postural hypotension is a common adverse effect of which one of the following types of drugs ? (a) ACE inhibitors (b) Alpha-receptor blockers (c) Arteriolar dilators (d) ß1 – selective receptor blockers (e) Nonselective ß - blockers

Last Answer : Ans: B

Cylcoocygenase-II specific inhibitors block the following (a) Production of cytoprotective prostaglandins (b) Tumor necrosis factor - a (c) Production of prostaglandins responsible for pain and inflammation

Description : Cylcoocygenase-II specific inhibitors block the following (a) Production of cytoprotective prostaglandins (b) Tumor necrosis factor - a (c) Production of prostaglandins responsible for pain and inflammation

Last Answer : Ans: C

Scarification of seeds is done for removing (a) Dormancy (b) Germination inhibitors (c) Growth (d) Embryo

Description : Scarification of seeds is done for removing (a) Dormancy (b) Germination inhibitors (c) Growth (d) Embryo

Last Answer : Ans:(a)

What are the inhibitors of phosphofructokinase?

Description : What are the inhibitors of phosphofructokinase? 

Last Answer : ATP, Citrate, Glucocorticoids. 

Which plant hormones are known as growth inhibitors?

Description : Which plant hormones are known as  growth inhibitors?

Last Answer : Abscisic acid and Ethylene

RNA polymerase inhibitors - Why is this so?

Description : The bacterial RNA polymerase inhibitors rifampicin and streptolydigin each bind to the same subunitof the enzyme, but their overall effect on the activity of the enzyme is different. Why is this so?

Last Answer : Each of these inhibitors binds exclusively to the β-subunit of RNA polymerase. This subunit is involved in both initiation and elongation of RNA chain growth. Rifampicin binds to the subunit in such ... on elongation. Streptolydigin, on the other hand, binds in a manner that blocks both activities. 

Urine volume is increased with: a. carbonic anhydrase inhibitors b. hyperglycaemia c. increased aldosterone secretion d. damage to the posterior pituitary

Description : Urine volume is increased with: a. carbonic anhydrase inhibitors b. hyperglycaemia c. increased aldosterone secretion d. damage to the posterior pituitary

Last Answer : damage to the posterior pituitary

At the adrenergic synapse, the concentration of adrenaline in synaptic cleft: a. increased by cocaine which inhibit reuptake of adrenaline b. decreased by MAO (monoamine oxidase) - inhibitors c. controlled chiefly by the activity of the enzyme COMT d. increased by noradrenaline receptor blockers

Description : At the adrenergic synapse, the concentration of adrenaline in synaptic cleft: a. increased by cocaine which inhibit reuptake of adrenaline b. decreased by MAO (monoamine oxidase) - inhibitors c. controlled chiefly by the activity of the enzyme COMT d. increased by noradrenaline receptor blockers

Last Answer : increased by cocaine which inhibit reuptake of adrenaline

Low temperature helps to _________ growth inhibitors: a. Increase b. Decrease c. Store d. Produce

Description : Low temperature helps to _________ growth inhibitors: a. Increase b. Decrease c. Store d. Produce

Last Answer : Decrease

Insecticides are specific inhibitors of— (A) Excretory system (B) Digestive system (C) Nervous system (D) Blood Circulatory system

Description : Insecticides are specific inhibitors of— (A) Excretory system (B) Digestive system (C) Nervous system (D) Blood Circulatory system

Last Answer : (D) Blood Circulatory system

‘Pusa Neem’ (Neem-oil coated urea)— product used as inhibitors for slow release, was designated and reported by—(A) Dr. Rajendra Prasad and Colleagues (B) Dr. R.S. Paroda (C) Dr. G.B. Singh (D) Dr. M.S. Randhawa

Description : ‘Pusa Neem’ (Neem-oil coated urea)— product used as inhibitors for slow release, was designated and reported by—(A) Dr. Rajendra Prasad and Colleagues (B) Dr. R.S. Paroda (C) Dr. G.B. Singh (D) Dr. M.S. Randhawa

Last Answer : (A) Dr. Rajendra Prasad and Colleagues

Many _________ in super optimal concentrations also act as growth inhibitors : a. Auxins b. Gibberellins c. Cytokinins d. All of above

Description : Many _________ in super optimal concentrations also act as growth inhibitors : a. Auxins b. Gibberellins c. Cytokinins d. All of above

Last Answer : Auxins

Which of the following medications represents the category proton (gastric acid) pump inhibitors? a) Omeprazole (Prilosec) Omeprazole decreases gastric acid by slowing the hydrogenpotassium-adenosine-triphosphatase pump on the surface of the parietal cells. b) Sucralfate (Carafate) Sucralfate is a cytoprotective drug. c) Famotidine (Pepcid) Famotidine is a histamine-2 receptor antagonist. d) Metronidazole (Flagyl) Metronidazole is an antibiotic, specifically an amebicide.

Description : Which of the following medications represents the category proton (gastric acid) pump inhibitors? a) Omeprazole (Prilosec) Omeprazole decreases gastric acid by slowing the hydrogenpotassium-adenosine ... antagonist. d) Metronidazole (Flagyl) Metronidazole is an antibiotic, specifically an amebicide.

Last Answer : a) Omeprazole (Prilosec) Omeprazole decreases gastric acid by slowing the hydrogenpotassium-adenosine-triphosphatase pump on the surface of the parietal cells.

Of the following categories of medications, which is used in combination with bismuth salts to eradicate Helicobacter pylori? a) Antibiotics Antibiotics and bismuth salts are given to eradicate H. pylori. b) Antacids Antacids are given to manage gastric acidity. c) Proton pump inhibitors Proton pump inhibitors are given to decrease acid secretion. d) Histamine-2 receptor antagonists Histamine-2 receptor antagonists are given to decrease the acid secretion in the stomach.

Description : Of the following categories of medications, which is used in combination with bismuth salts to eradicate Helicobacter pylori? a) Antibiotics Antibiotics and bismuth salts are given to eradicate ... antagonists Histamine-2 receptor antagonists are given to decrease the acid secretion in the stomach.

Last Answer : a) Antibiotics Antibiotics and bismuth salts are given to eradicate H. pylori.

Which of the following adrenergic inhibitors acts directly on the blood vessels, producing vasodilation? a) Prazosin hydrochloride (Minipress) Minipress is a peripheral vasodilator acting directly on the blood vessel. It is not used in angina and coronary artery disease, however, because it induces tachycardia if not preceded by administration of propranolol and a diuretic.

Description : Which of the following adrenergic inhibitors acts directly on the blood vessels, producing vasodilation? a) Prazosin hydrochloride (Minipress) Minipress is a peripheral vasodilator acting ... through centrally mediated alpha-adrenergic stimulation in the brain, producing blood pressure reduction.

Last Answer : a) Prazosin hydrochloride (Minipress) Minipress is a peripheral vasodilator acting directly on the blood vessel. It is not used in angina and coronary artery disease, however, because it induces tachycardia if not preceded by administration of propranolol and a diuretic.

Which of the following categories of medications may result in seizure activity if withdrawn suddenly? a) Tranquilizers Abrupt withdrawal of tranquilizers may result in anxiety, tension, and even seizures if withdrawn suddenly. b) Adrenal corticosteroids Abrupt withdrawal of steroids may precipitate cardiovascular collapse. c) Antidepressants Monoamine oxidase inhibitors increase the hypotensive effects of anesthetics. d) Diuretics Thiazide diuretics may cause excessive respiratory depression during anesthesia due to an associated electrolyte imbalance.

Description : Which of the following categories of medications may result in seizure activity if withdrawn suddenly? a) Tranquilizers Abrupt withdrawal of tranquilizers may result in anxiety, tension, ... may cause excessive respiratory depression during anesthesia due to an associated electrolyte imbalance.

Last Answer : a) Tranquilizers Abrupt withdrawal of tranquilizers may result in anxiety, tension, and even seizures if withdrawn suddenly.

Proton pump inhibitors like omeprazole and lansoprazole contain the following ring system : (A) Pyrimidine (B)Benzimidazole (C) Benzothiazole (D) Oxindole

Description : Proton pump inhibitors like omeprazole and lansoprazole contain the following ring system : (A) Pyrimidine (B)Benzimidazole (C) Benzothiazole (D) Oxindole

Last Answer : (B)Benzimidazole

When taking Mono Amino Oxidase Inhibitors (MAOI); which drugs are contra indicated: I. Barbiturate II. Local anaesthetic III. Pethidine IV. Acetyl salicylic acid A. All of the above B. None of the above C. I, II and III D. II, III and IV

Description : When taking Mono Amino Oxidase Inhibitors (MAOI); which drugs are contra indicated: I. Barbiturate II. Local anaesthetic III. Pethidine IV. Acetyl salicylic acid A. All of the above B. None of the above C. I, II and III D. II, III and IV

Last Answer : C. I, II and III