How do proton pump inhibitors work ?

1 Answer

Answer :

Proton pump inhibit is a group of drugs whose main function is to reduce chronic acid production in the stomach. Although there are different medications in this group , there is no evidence that one works better than the other. Proton pump inhibitors work by blocking gastric parietal cells in the stomach. The hydrogen / potassium adenosine triphosphate produced in the stomach by ingesting food protects us from gastric and ulcer diseases by affecting the enzyme system.

Related questions

Description : Which of the following medications represents the category proton (gastric acid) pump inhibitors? a) Omeprazole (Prilosec) Omeprazole decreases gastric acid by slowing the hydrogenpotassium-adenosine ... antagonist. d) Metronidazole (Flagyl) Metronidazole is an antibiotic, specifically an amebicide.

Last Answer : a) Omeprazole (Prilosec) Omeprazole decreases gastric acid by slowing the hydrogenpotassium-adenosine-triphosphatase pump on the surface of the parietal cells.

Description : Of the following categories of medications, which is used in combination with bismuth salts to eradicate Helicobacter pylori? a) Antibiotics Antibiotics and bismuth salts are given to eradicate ... antagonists Histamine-2 receptor antagonists are given to decrease the acid secretion in the stomach.

Last Answer : a) Antibiotics Antibiotics and bismuth salts are given to eradicate H. pylori.

Description : Proton pump inhibitors like omeprazole and lansoprazole contain the following ring system : (A) Pyrimidine (B)Benzimidazole (C) Benzothiazole (D) Oxindole

Last Answer : (B)Benzimidazole

Description : The fastest symptomatic relief as well as highest healing rates in reflux esophagitis are obtained with: A. Prokinetic drugs B. H2 receptor blockers C. Proton pump inhibitors D. Sodium alginate

Last Answer : C. Proton pump inhibitors

Description : The following class of gastric antisecretory drug also reduce gastric motility and have primary effect on juice volume, with less marked effect on acid and pepsin A. Histamine H2 blockers B. Anticholinergics C. Proton pump inhibitors D. Prostaglandins

Last Answer : B. Anticholinergics

Description : The following is true of proton pump inhibitors except: A. They are the most effective drugs for Zolinger Ellison syndrome B. Their prolonged use can cause atrophy of gastric mucosa C. They inhibit growth of H. pylori in stomach D. They have no effect on gastric motilit

Last Answer : B. Their prolonged use can cause atrophy of gastric mucosa

Description : The respiratory chain complexes acting as proton pump are (A) I, II and III (B) I, II and IV (C) I, III and IV (D) I and II

Last Answer : Answer : C

Description : Select the drug which is an inhibitor of gastric mucosal proton pump: A. Carbenoxolone sodium B. Sucralfate C. Famotidine D. Lansoprazole

Last Answer : D. Lansoprazole

Description : Histamine H2 blockers attenuate the gastric secretory response to acetylcholine and pentagastrin as well because: A. H2 blockers block gastric mucosal cholinergic and gastrin receptors as well B. H2 ... acetylcholine and gastrin all act through the phospholipase C-IP3:DAG pathway in gastric mucosa

Last Answer : C. Acetylcholine and gastrin act partly by releasing histamine in gastric mucosa

Description : What are some of the best or strongest DHT blockers/inhibitors?

Last Answer : partyrock, you might want to explain what DHT blockers do. I had no idea and had to look up what this meant. I have no experience with them.

Description : Difference between competitive inhibitors and non-competitive inhibitors? -Biology

Last Answer : answer:

Description : What are irreversible inhibitors? -Biology

Last Answer : answer:

Description : What are enzyme inhibitors? -Biology

Last Answer : answer:

Description : Clinical significance of competitive inhibitors -Biology

Last Answer : answer:

Description : Names of seed germination inhibitors. -Biology

Last Answer : answer:

Description : Names of seed germination inhibitors. -Biology

Last Answer : answer:

Description : $ Enzymes are special types of proteins. ! Those substances which interfere with the action of enzymes are called inhibitors.

Last Answer : $ Enzymes are special types of proteins. ! Those substances which interfere with the action of enzymes are ... wrong D. If both As and R are wrong.

Description : Do non competitive inhibitors bind to the active site?

Last Answer : Feel Free to Answer

Description : Metabolic alkalosis can occur in (A) Severe diarrhoea (B) Renal failure (C) Recurrent vomiting (D) Excessive use of carbonic anhydrase inhibitors

Last Answer : Answer : C

Description : Vmax of an enzyme may be affected by (A) pH (B) Temperature (C) Non-competitive inhibitors (D) All of these

Last Answer : Answer : D

Description : Competitive inhibitors (A) Decrease the Km (B) Decrease the Vmax (C) Increase the Km (D) Increase the Vmax

Last Answer : Answer : C

Description : Example of growth inhibitors

Last Answer : Ans. Abscisic acid and Ethylene

Description : Lowland applied nitrification inhibitors

Last Answer : Ans. Oxamide (31%N) and Thiourea (36.8%N)

Description : Which of the following statements about hypertension in diabetes patients is/are correct? A. Hypertension worsens the macrovascular disease of diabetes patients. B. Hypertension accelerates the ... single-drug therapy, are not indicated in the treatment of hypertension in diabetes patients.

Last Answer : Answer: ABCDE DISCUSSION: All of the answers listed are correct. By damaging endothelial cells, hypertension worsens macrovascular disease in all patients but especially in diabetics. Hypertension ... is not indicated because the chronic state of dehydration in such patients may become worse

Description : Tyramine induces release of noradrenaline from adrenergic nerve endings (a) By depolarizing the axonal membrane (b) By mobilizing Ca2+ (c) By a nonexocytotic process (d) Only in the presence of MAO inhibitors

Last Answer : Ans: C

Description : Postural hypotension is a common adverse effect of which one of the following types of drugs ? (a) ACE inhibitors (b) Alpha-receptor blockers (c) Arteriolar dilators (d) ß1 – selective receptor blockers (e) Nonselective ß - blockers

Last Answer : Ans: B

Description : Cylcoocygenase-II specific inhibitors block the following (a) Production of cytoprotective prostaglandins (b) Tumor necrosis factor - a (c) Production of prostaglandins responsible for pain and inflammation

Last Answer : Ans: C

Description : Scarification of seeds is done for removing (a) Dormancy (b) Germination inhibitors (c) Growth (d) Embryo

Last Answer : Ans:(a)

Description : What are the inhibitors of phosphofructokinase? 

Last Answer : ATP, Citrate, Glucocorticoids. 

Description : Which plant hormones are known as  growth inhibitors?

Last Answer : Abscisic acid and Ethylene

Description : The bacterial RNA polymerase inhibitors rifampicin and streptolydigin each bind to the same subunitof the enzyme, but their overall effect on the activity of the enzyme is different. Why is this so?

Last Answer : Each of these inhibitors binds exclusively to the β-subunit of RNA polymerase. This subunit is involved in both initiation and elongation of RNA chain growth. Rifampicin binds to the subunit in such ... on elongation. Streptolydigin, on the other hand, binds in a manner that blocks both activities. 

Description : Urine volume is increased with: a. carbonic anhydrase inhibitors b. hyperglycaemia c. increased aldosterone secretion d. damage to the posterior pituitary

Last Answer : damage to the posterior pituitary

Description : At the adrenergic synapse, the concentration of adrenaline in synaptic cleft: a. increased by cocaine which inhibit reuptake of adrenaline b. decreased by MAO (monoamine oxidase) - inhibitors c. controlled chiefly by the activity of the enzyme COMT d. increased by noradrenaline receptor blockers

Last Answer : increased by cocaine which inhibit reuptake of adrenaline

Description : Low temperature helps to _________ growth inhibitors: a. Increase b. Decrease c. Store d. Produce

Last Answer : Decrease

Description : Insecticides are specific inhibitors of— (A) Excretory system (B) Digestive system (C) Nervous system (D) Blood Circulatory system

Last Answer : (D) Blood Circulatory system

Description : ‘Pusa Neem’ (Neem-oil coated urea)— product used as inhibitors for slow release, was designated and reported by—(A) Dr. Rajendra Prasad and Colleagues (B) Dr. R.S. Paroda (C) Dr. G.B. Singh (D) Dr. M.S. Randhawa

Last Answer : (A) Dr. Rajendra Prasad and Colleagues

Description : Many _________ in super optimal concentrations also act as growth inhibitors : a. Auxins b. Gibberellins c. Cytokinins d. All of above

Last Answer : Auxins

Description : Which one of the following statements regarding enzyme inhibition is correct? (a) Competitive inhibition is seen when a substrate competes with an enzyme for binding to an inhibitor protein. (b ... large amount of substrate. (d) Non-competitive inhibitors often bind to the enzyme irreversibly.

Last Answer : (b) Competitive inhibition is seen when the substrate and the inhibitor compete for the active site on the enzyme

Description : Which of the following adrenergic inhibitors acts directly on the blood vessels, producing vasodilation? a) Prazosin hydrochloride (Minipress) Minipress is a peripheral vasodilator acting ... through centrally mediated alpha-adrenergic stimulation in the brain, producing blood pressure reduction.

Last Answer : a) Prazosin hydrochloride (Minipress) Minipress is a peripheral vasodilator acting directly on the blood vessel. It is not used in angina and coronary artery disease, however, because it induces tachycardia if not preceded by administration of propranolol and a diuretic.

Description : Which of the following categories of medications may result in seizure activity if withdrawn suddenly? a) Tranquilizers Abrupt withdrawal of tranquilizers may result in anxiety, tension, ... may cause excessive respiratory depression during anesthesia due to an associated electrolyte imbalance.

Last Answer : a) Tranquilizers Abrupt withdrawal of tranquilizers may result in anxiety, tension, and even seizures if withdrawn suddenly.

Description : Contrast and compare competitive inhibitors with noncompetitive inhibitors. Which can be overcome by the addition of more substrate?

Last Answer : Competitive inhibitors reduce the productivity of enzymes by blocking substrates from entering active sites. This inhibition is what can be overcome by the addition of more substrate. Noncompetitive ... active site will become less and less effective at helping convert substrate to product.

Description : When taking Mono Amino Oxidase Inhibitors (MAOI); which drugs are contra indicated: I. Barbiturate II. Local anaesthetic III. Pethidine IV. Acetyl salicylic acid A. All of the above B. None of the above C. I, II and III D. II, III and IV

Last Answer : C. I, II and III

Description : Drugs contraindicated with Monoaminoxidase Inhibitors (MAOI):VERY IMP AND CONTROVERSIAL QUESTION A. Barbiturates B. Pethidine C. Local Anaesthesia with felypressin D. Narcotic analgetics E. Salicylic acid

Last Answer : B. Pethidine

Description : Amino acid synthesis inhibitors a). Sulfonyl ureas b). Amides c). Triazines d). all

Last Answer : a). Sulfonyl ureas

Description : Choose the correct statement(s) about retroviral protease inhibitors: A. They act at an early step in HIV replication B. They are more active in inhibiting HIV than zidovudine C. They inhibit CYP3A4 and interact with many other drugs D. Both 'B' and 'C' are correct

Last Answer : D. Both 'B' and 'C' are correct

Description : According to current guidelines, previously untreated symptomatic HIV patients should be treated with: A. Zidovudine alone B. Zidovudine + zalcitabine C. Zidovudine + indinavir D. Any two nucleoside reverse transcriptase inhibitors + one protease inhibito

Last Answer : D. Any two nucleoside reverse transcriptase inhibitors + one protease inhibitor

Description : Select the first line hypolipidemic drug/drugs for treating hypertriglyceridemia in a subject with normal cholesterol level: A. Fibrates B. HMG-CoA reductase inhibitors C. Nicotinic acid D. Both 'A' and 'C' are correc

Last Answer : D. Both 'A' and 'C' are correct

Description : The rare but characteristic adverse effect of HMGCoA reductase inhibitors is: A. Onycolysis B. Myopathy C. Alopecia D. Oculomucocutaneous syndrome

Last Answer : B. Myopathy

Description : Examples of pulses that have a high content of trypsin inhibitors are: a. Black gram dal and lentil b. Cow pea & red gram c. Green gram & Bengal gram d. Soyabean & kidney bean

Last Answer : d. Soyabean & kidney bean

Description : Angiotensin converting enzyme inhibitors are contraindicated in: A. High renin hypertensives B. Diabetics C. Congestive heart failure patients D. Pregnant women

Last Answer : D. Pregnant women