Description : The characteristic toxicity of ethambutol is: A. Hepatitis B. Visual defects C. Vestibular disturbance D. Renal damage
Last Answer : B. Visual defects
Description : The most important risk in the use of primaquine is the occurrence of the following reaction in certain recipients: A. Ventricular arrhythmia B. Agranulocytosis C. Haemolysis D. Anaphylaxis
Last Answer : C. Haemolysis
Description : The following is true of vancomycin except: A. It is a bactericidal antibiotic active primarily against gram positive bacteria B. It acts by inhibiting bacterial protein synthesis C. It is an alternative to penicillin for enterococcal endocarditis D. It can cause deafness as a dose related toxicity
Last Answer : B. It acts by inhibiting bacterial protein synthesis
Description : Folinic acid is specifically indicated for: A. Prophylaxis of neural tube defect in the offspring of women receiving anticonvulsant medication B. Counteracting toxicity of high dose methotrexate C. Pernicious anaemia D. Anaemia associated with renal failure
Last Answer : C. Pernicious anaemia
Description : Among all cardiac glycosides, digoxin is the most commonly used, because: A. It is the most potent and fastest acting glycoside B. It has the highest and most consistent oral ... so that dose adjustments are possible every 2-3 days and toxicity abates rather rapidly after discontinuatio
Last Answer : D. It has intermediate plasma half life so that dose adjustments are possible every 2-3 days and toxicity abates rather rapidly after discontinuatio
Description : The following is true of multidrug therapy of leprosy except: A. It has been highly successful in paucibacillary but not in multibacillary cases B. Relapse rate is very low in both paucibacillary ... use once a month D. Prevalence of lepra reaction is not higher compared to dapsone monotherapy
Last Answer : A. It has been highly successful in paucibacillary but not in multibacillary cases
Description : Which antileprotic drug suppresses lepra reaction and reversal reaction as well: A. Dapsone B. Rifampin C. Clofazimine D. Minocycline
Last Answer : C. Clofazimine
Description : If a multibacillary leprosy patient treated with standard fixed duration multidrug therapy relapses, he should be treated with: A. The same rifampin + dapsone + clofazimine regimen B. ... + minocycline C. Clofazimine + ofloxacin + clarithromycin D. Ofloxacin + minocycline + clarithromycin
Last Answer : . The same rifampin + dapsone + clofazimine regimen
Description : he multidrug therapy of leprosy is superior to monotherapy on the following account(s): A. It prevents emergence of dapsone resistance B. It is effective in cases with primary dapsone resistance C. It shortens the total duration of drug therapy and improves compliance D. All of the above
Last Answer : D. All of the above
Description : Currently, monotherapy of leprosy with dapsone is recommended for: A. Paucibacillary leprosy only B. Multibacillary leprosy only C. Both paucibacillary and multibacillary leprosy D. Neither paucibacillary nor multibacillary leprosy
Last Answer : D. Neither paucibacillary nor multibacillary leprosy
Description : Multidrug therapy with dapsone + rifampin ± clofazimine is the treatment of choice for: A. Multibacillary leprosy B. Paucibacillary leprosy C. Dapsone resistant leprosy D. All forms of leprosy
Last Answer : D. All forms of leprosy
Description : Menadione (vitamin K3) can produce kernicterus in neonates by: A. Inducing haemolysis B. Inhibiting glucuronidation of bilirubin C. Displacing plasma protein bound bilirubin D. Both ‘A’ and ‘B’ are correct
Last Answer : D. Both ‘A’ and ‘B’ are correct
Description : Which of the following adverse drug reactions is due to a specific genetic abnormality: A. Tetracycline induced sunburn like skin lesions B. Quinidine induced thrombocytopenia C. Metoclopramide induced muscle dystonia D. Primaquine induced massive haemolysis
Last Answer : D. Primaquine induced massive haemolysis
Description : The following is true of clarithromycin except: A. It produces less gastric irritation and pain than erythromycin B. It is the most active macrolide antibiotic against Helicobacter pylori ... terfenadine or cisapride to cause cardiac arrhythmias D. It exhibits dose dependent elimination kinetics
Last Answer : C. It does not interact with terfenadine or cisapride to cause cardiac arrhythmias
Description : Lower dose of naloxone is required to: A. Antagonise the actions of nalorphine B. Antagonise the actions of pentazocine C. Precipitate withdrawal in mildly morphine dependent subjects D. Precipitate withdrawal in highly morphine dependent subjects
Last Answer : D. Precipitate withdrawal in highly morphine dependent subjects
Description : The most important toxicity of amphotericin B is: A. Nephrotoxicity B. Neurotoxicity C. Hepatotoxicity D. Bone marrow depression
Last Answer : A. Nephrotoxicity
Description : Strongyloid infections can also cause _________in man which can be zoonotic in nature. C A. hepatitis B. rumenitis C. dermatitis D. None of these
Last Answer : dermatitis
Description : ystemic corticosteroid therapy is not used routinely and is reserved only for severe cases of: A. Exfoliative dermatitis B. Posterior uveitis C. Acute rheumatic fever D. Hodgkin’s disease
Last Answer : C. Acute rheumatic feve
Description : Choose the correct statement(s) about auranofin: A. It is an orally active gold compound B. It is equally effective but less toxic than injected gold-sodium-thiomalate C. Its major adverse effect is dermatitis D. All of the above are correct
Last Answer : A. It is an orally active gold compound
Description : Cyclosporine has the following attributes except: A. It selectively suppresses humoral immunity without affecting cell mediated immunity B. It is more active as immunosuppressant when administered before antigen exposure ... It is not toxic to the bone marrow D. Its major toxicity is kidney damage
Last Answer : A. It selectively suppresses humoral immunity without affecting cell mediated immunity
Description : The characteristic toxicity of doxorubicin is: A. Kidney damage B. Liver damage C. Cardiomyopathy D. Pulmonary fibrosis
Last Answer : C. Cardiomyopathy
Description : Methotrexate has the following attributes except: A. It is cell cycle specific and kills cells in the S phase B. Its toxicity primarily affects bone marrow and epithelial structures C. Folic acid reverses its toxic effects D. It is the drug of choice for choriocarcinoma
Last Answer : C. Folic acid reverses its toxic effects
Description : Ethambutol is not used in children below 6 years of age because: A. Young children are intolerant to ethambutol B. Ethambutol causes growth retardation in young children C. It is ... induced visual impairment in young children D. In young children visual toxicity of ethambutol is irreversible
Last Answer : C. It is difficult to detect ethambutol induced visual impairment in young children
Description : A patient of bronchial asthma maintained on theophylline developed upper respiratory tract infection. Which antimicrobial if used can increase the risk of developing theophylline toxicity: A. Ampicillin B. Cephalexin C. Cotrimoxazole D. Erythromycin
Last Answer : D. Erythromycin
Description : The following tetracycline has the potential to cause vestibular toxicity: A. Minocycline B. Demeclocycline C. Doxycycline D. Tetracycline
Last Answer : D. Tetracycline
Description : The following drug given concurrently can enhance toxicity of digoxin: A. Phenobarbitone B. Metoclopramide C. Quinidine D. Magnesium hydroxide
Last Answer : C. Quinidine
Description : Select the most suitable antiarrhythmic drug for counteracting ventricular extrasystoles due to digoxin toxicity: A. Lignocaine B. Quinidine C. Verapamil D. Amiodarone
Last Answer : A. Lignocaine
Description : Potassium therapy tends to counteract the cardiac toxicity of digitalis by: A. Reducing the affinity of sarcolemal Na+ K+ATPase for digitalis B. Suppressing ectopic automaticity enhanced by digitalis C. Promoting A-V conduction D. Both 'A' and 'B' are correct
Last Answer : D. Both 'A' and 'B' are correct
Description : Infusion of potassium chloride is indicated in digitalis toxicity when the manifestation(s) is/are: A. Vomiting, hyperapnoea and visual disturbance B. Pulsus bigeminus with heart rate 110/min ... accidentally ingested 10 digoxin tablets D. 2:1 A-V block with occasional ventricular extrasystoles
Last Answer : B. Pulsus bigeminus with heart rate 110/min in a patient on maintenance digoxin therapy
Description : The nonselective MAO inhibitors are not used clinically as antidepressants because of their: A. Low antidepressant efficacy B. Higher toxicity C. Potential to interact with many foods and drugs D. Both 'B' and 'C' are correct
Last Answer : D. Both 'B' and 'C' are correct
Description : The following drug of abuse is a hallucinogen: A. Cocaine B. Cannabis C. Heroin D. Methaqualone (p. 403) 31.1 Which of the following is a selective MAO-B inhibitor: A. Selegiline
Last Answer : B. Cannabis
Description : The antipsychotic drug most likely to cause ocular toxicity on long-term use is: A. Thioridazine B. Haloperidol C. Flupenthixol D. Pimozide
Last Answer : A. Thioridazine
Description : Toxicity of local anaesthetics involves the following organs except: A. Heart B. Brain C. Kidney D. Skin and subcutaneous tissue (p. 324)
Last Answer : D. Dibucaine
Description : Adrenaline added to local anaesthetic solution for infiltration anaesthesia affords the following except: A. Prolongs the duration of local anaesthesia B. Makes the injection less painful C. Provides a more bloodless field for surgery D. Reduces systemic toxicity of the local anaesthetic
Last Answer : B. Makes the injection less painful
Description : Injection of adrenaline along with a local anaesthetic serves the following purpose: A. Lowers the concentration of the local anaesthetic to produce nerve block B. Prolongs the duration of local anaesthesia C. Increases the anaesthetised area D. Reduces the local toxicity of the local anaesthetic
Last Answer : B. Prolongs the duration of local anaesthesia
Description : Atropine is contraindicated in: A. Pulmonary embolism B. Digitalis toxicity C. Iridocyclitis D. Raised intraocular tension
Last Answer : D. Raised intraocular tension
Description : Drug cumulation is the basis of organ toxicity of the following drug when used for prolonged periods: A. Prednisolone B. Chloroquine C. Aspirin D. Hydralazine
Last Answer : B. Chloroquine
Description : Methemoglobinemia?
Last Answer : DefinitionMethemoglobinemia is a blood disorder in which an abnormal amount of hemoglobin builds up in the blood. Hemoglobin is the oxygen-carrying molecule found in red blood cells. In some cases of ... the condition themselves, but they carry the gene that causes the condition. It occurs when the
Description : Presence of nitrates in water in excess of 50 ppm causes (A) Methemoglobinemia (B) Gastroenteritis (C) Asphyxiation (D) Tooth decay
Last Answer : (A) Methemoglobinemia
Description : _____ is when an antimicrobial drug should harm the infectious agent but not the host. a. Selective toxicity b. Toxic dose c. Therapeutic dose d. Chemotherapeutic index
Last Answer : a. Selective toxicity
Description : regarding paracetamol toxicity: - Not toxic if dose exceed 150-180 mg - Cause vomiting and neuropathy - Therapeutic effect after 4 hours - Use Deferoxamine -the liver enzyme reach the max. Level 4-6 hours after ingestion
Last Answer : the liver enzyme reach the max. Level 4-6 hours after ingestion
Description : Toxicity of anaesthetic is assessed by: A. Dose which is given B. Percentage of solution C. Vasoconstrictions amount
Last Answer : A. Dose which is given
Description : A 75-year-old man had been receiving gentamicin (an aminoglycoside antibiotic) to treat an urinary tract infection. After three months of therapy patient's serum creatinine levels were 10 mg/ ... Type II allergic reaction b)Type III allergic reaction c) Pseudo allergic reaction d) Overdose toxicity
Last Answer : d) Overdose toxicity
Description : Choose the drug whose single oral dose affords clinical cure of uncomplicated malaria caused by chloroquine sensitive/resistant P.falciparum as well as P. vivax: A. Quinine B. Mefloquine C. Artesunate D. Proguanil
Last Answer : B. Mefloquine
Description : The most important reason for the thiazides being only moderately efficacious diuretics is: A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action B. Compensatory ... these drugs C. They decrease glomerular filtration D. They have relatively flat dose response curve
Last Answer : A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action
Description : What is true about human interferon α: A. It is used to treat HIV infection B. It is used to treat Kaposi‘s sarcoma in AIDS patients C. It is curative for hepatitis B virus infection D. It is active orally
Last Answer : B. It is used to treat Kaposi‘s sarcoma in AIDS patients
Description : Indicate the drug(s) that is/are used to treat chronic hepatitis B: A. Human interferon α B. Lamivudine C. Amantadine D. Both 'A' and 'B'
Last Answer : D. Both 'A' and 'B'
Description : Select the drug that is active against both HIV and hepatitis B virus: A. Lamivudine B. Indinavir C. Didanosine D. Efavirenz
Last Answer : A. Lamivudine
Description : Zidovudine inhibits the following virus/viruses: A. Human immunodeficiency virus B. Cytomegalovirus C. Hepatitis B virus D. Both 'A' and 'B'
Last Answer : A. Human immunodeficiency virus