Description : Which of the following is an atypical neuroleptic drug: A. Loxapine B. Olanzapine C. Pimozide D. Flupenthixol
Last Answer : B. Olanzapin
Description : Which of the following is a high potency antipsychotic drug having minimal sedative and autonomic effects and no propensity to cause weight gain: A. Chlorpromazine B. Triflupromazine C. Haloperidol D. Olanzapine
Last Answer : C. Haloperido
Description : Which of the following is a long acting neuroleptic having specific antidopaminergic action, but little adrenergic or cholinergic blocking activity: A. Triflupromazine B. Thioridazine C. Clozapine D. Pimozide
Last Answer : D. Pimozide
Description : The following antipsychotic drug has weak dopamine D2 but additional 5-HT2 blocking activity and benefits both positive and negative symptoms of schizophrenia: A. Loxapine B. Clozapine C. Pimozide D. Penfluridol
Last Answer : B. Clozapin
Description : Blockade of both dopamine D2 and serotonin 5-HT2A/2C receptors is a distinctive feature of: A. Pimozide B. Haloperidol C. Ketanserin D. Clozapine
Last Answer : D. Clozapine
Description : A manic patient has been brought to the hospital with nonstop talking, singing, uncontrolable behaviour and apparent loss of contact with reality. Which of the following is the most appropriate drug ... control of his symptoms: A. Lithium carbonate B. Phenobarbitone C. Haloperidol D. Valproic acid
Last Answer : C. Haloperidol
Description : The following is correct about antipsychotic drugs except: A. They only control symptoms of schizophrenia without affecting the basic disorder B. Combination of two or more antipsychotic drugs is ... psychosis high potency drugs are preferred over low potency drugs D. They donot produce dependence
Last Answer : B. Combination of two or more antipsychotic drugs is more efficacious than any single drug
Description : The extrapyramidal adverse effect of antipsychotic drug therapy which does not respond to central anticholinergics is: A. Parkinsonism B. Acute muscle dystonia C. Rabbit syndrome D. Tardive dyskinesia
Last Answer : D. Tardive dyskinesia
Description : Olanzapine has the following features except: A. It is an antipsychotic drug with weak D2 receptor blocking action B. It has potent 5-HT2 blocking and antimuscarinic actions C. It lowers seizure threshold D. It produces prominent extrapyramidal side effects
Last Answer : D. It produces prominent extrapyramidal side effect
Description : Fluphenazine differs from chlorpromazine in the following respects except: A. It has higher antipsychotic efficacy B. It is less sedative C. It is less likely to precipitate seizures in epileptics D. It causes more prominent extrapyramidal side effect
Last Answer : A. It has higher antipsychotic efficacy
Description : Choose the phenothiazine compound which has selective labyrinthine suppressant action, is used for vomiting and vertigo, but not in schizophrenia: A. Triflupromazine B. Prochlorperazine C. Trifluoperazine D. Thioridazine
Last Answer : B. Prochlorperazine
Description : Currently, the first choice drug for open angle glaucoma is: A. Miotic eye drops B. Ocular α2 adrenergic agonists C. Ocular prostaglandin analogues D. Ocular β adrenergic blockers
Last Answer : D. Ocular β adrenergic blockers
Description : Compared to other antipsychotic drugs, the distinctive feature of penfluridol is: A. Very long duration of action B. Weak dopamine D2 blocking activity C. Lack of extrapyramidal side effects D. Additional 5-HT2 receptor blocking activity
Last Answer : A. Very long duration of action
Description : Methotrexate has the following attributes except: A. It is cell cycle specific and kills cells in the S phase B. Its toxicity primarily affects bone marrow and epithelial structures C. Folic acid reverses its toxic effects D. It is the drug of choice for choriocarcinoma
Last Answer : C. Folic acid reverses its toxic effects
Description : The following drug given concurrently can enhance toxicity of digoxin: A. Phenobarbitone B. Metoclopramide C. Quinidine D. Magnesium hydroxide
Last Answer : C. Quinidine
Description : Select the most suitable antiarrhythmic drug for counteracting ventricular extrasystoles due to digoxin toxicity: A. Lignocaine B. Quinidine C. Verapamil D. Amiodarone
Last Answer : A. Lignocaine
Description : The following drug of abuse is a hallucinogen: A. Cocaine B. Cannabis C. Heroin D. Methaqualone (p. 403) 31.1 Which of the following is a selective MAO-B inhibitor: A. Selegiline
Last Answer : B. Cannabis
Description : Drug cumulation is the basis of organ toxicity of the following drug when used for prolonged periods: A. Prednisolone B. Chloroquine C. Aspirin D. Hydralazine
Last Answer : B. Chloroquine
Description : Adaptive changes in brain monoamine turnover due to blockade of noradrenaline/5-HT reuptake is credited with the following effect: A. Antipsychotic B. Antianxiety C. Antiparkinsonian D. Antidepressant
Last Answer : D. Antidepressant
Description : Clozapine is considered to be an atypical neuroleptic because: A. It has weak antidopaminergic action but high antipsychotic efficacy B. Its side effect profile is different from that of chlorpromazine C. It is not a phenothiazine derivative D. Both ‘A’ and ‘B’ are correct
Last Answer : D. Both ‘A’ and ‘B’ are correct
Description : The following action of chlorpromazine is not based on its antidopaminergic property: A. Antipsychotic B. Hyperprolactinemic C. Antiemetic D. Hypotensive
Last Answer : D. Hypotensive
Description : Which of the following adverse effects of neuroleptic drugs is positively correlated to the antipsychotic potency of the different compounds: A. Sedation B. Extrapyramidal motor disturbances C. Postural hypotension D. Lowering of seizure threshold
Last Answer : B. Extrapyramidal motor disturbances
Description : The following is true of vancomycin except: A. It is a bactericidal antibiotic active primarily against gram positive bacteria B. It acts by inhibiting bacterial protein synthesis C. It is an alternative to penicillin for enterococcal endocarditis D. It can cause deafness as a dose related toxicity
Last Answer : B. It acts by inhibiting bacterial protein synthesis
Description : The following tetracycline has the potential to cause vestibular toxicity: A. Minocycline B. Demeclocycline C. Doxycycline D. Tetracycline
Last Answer : D. Tetracycline
Description : Concurrent use of the following drug is likely to cause failure of oral contraception: A. Isoniazid B. Rifampicin C. Cimetidine D. Propranolol
Last Answer : C. Cimetidin
Description : Which of the following is not likely to be the cause of failure of antimicrobial therapy of an acute infection: A. Improper selection of drug and dose B. Acquisition of resistance during treatment C. Failure to drain the pus D. Uncontrolled diabetes mellitus
Last Answer : B. Acquisition of resistance during treatment
Description : The following antiepileptic drug is likely to cause hyponatremia as a side effect, especially in elderly patients: A. Primidone B. Carbamazepine C. Phenytoin D. Sodium valproate
Last Answer : B. Carbamazepine
Description : Surface anaesthesia is used for the following except: A. Ocular tonometry B. Urethral dilatation C. Tooth extraction D. Anal fissure
Last Answer : C. Tooth extraction
Description : Dorzolamide is a: A. Topically applied ocular carbonic anhydrase inhibitor B. Second generation sulfonylurea hypoglycaemic C. Topical sulfonamide antibacterial D. Luminal amoebicide
Last Answer : A. Topically applied ocular carbonic anhydrase inhibitor
Description : Timolol eye drops are preferred over pilocarpine eye drops by glaucoma patients because: A. Timolol is more effective than pilocarpine B. Timolol acts by enhancing uveo-scleral outflow C. Timolol produces less ocular side effects D. There are no contraindications to timolol
Last Answer : C. Timolol produces less ocular side effects
Description : The quarternary analogues of belladonna alkaloids are preferred over the natural alkaloids for antisecretory/ antispasmodic indications because: A. They have additional nicotinic receptor blocking activity B. They are ... of CNS and ocular effects D. Dose to dose they are more potent than atropine
Last Answer : C. They are devoid of CNS and ocular effects
Description : Long-term hydralazine therapy is likely to cause: A. Gynaecomastia B. Thrombocytopenia C. Haemolytic anaemia D. Lupus erythematosus
Last Answer : D. Lupus erythematosus
Description : If fever is accompanied by ________, drug toxicity is more likely than allergy and is much more serious. a) Granulocytopenia b) Thrombocytopenia c) Histamine d) Leukopenia e) Hypotension
Last Answer : Ans: A
Description : A 75-year-old man had been receiving gentamicin (an aminoglycoside antibiotic) to treat an urinary tract infection. After three months of therapy patient's serum creatinine levels were 10 mg/ ... Type II allergic reaction b)Type III allergic reaction c) Pseudo allergic reaction d) Overdose toxicity
Last Answer : d) Overdose toxicity
Description : The percentage of patients over the age of 70 admitted to the hospital with delirium is about a) 25%. About 25% of patients over the age of 70 admitted to the hospital have delirium. The cause is ... delirium. d) 50%. About 25% of patients over the age of 70 admitted to the hospital have delirium.
Last Answer : a) 25%. About 25% of patients over the age of 70 admitted to the hospital have delirium. The cause is often reversible and treatable (as in drug toxicity, vitamin B12 deficiency or thyroid disease) or chronic and irreversible. Depression may produce impairment of attention and memory.
Description : Cyclosporine has the following attributes except: A. It selectively suppresses humoral immunity without affecting cell mediated immunity B. It is more active as immunosuppressant when administered before antigen exposure ... It is not toxic to the bone marrow D. Its major toxicity is kidney damage
Last Answer : A. It selectively suppresses humoral immunity without affecting cell mediated immunity
Description : The characteristic toxicity of doxorubicin is: A. Kidney damage B. Liver damage C. Cardiomyopathy D. Pulmonary fibrosis
Last Answer : C. Cardiomyopathy
Description : The most important toxicity of amphotericin B is: A. Nephrotoxicity B. Neurotoxicity C. Hepatotoxicity D. Bone marrow depression
Last Answer : A. Nephrotoxicity
Description : The most important dose dependent toxicity of dapsone is: A. Methemoglobinemia B. Haemolysis C. Hepatitis D. Dermatitis
Last Answer : B. Haemolysi
Description : The characteristic toxicity of ethambutol is: A. Hepatitis B. Visual defects C. Vestibular disturbance D. Renal damage
Last Answer : B. Visual defects
Description : Ethambutol is not used in children below 6 years of age because: A. Young children are intolerant to ethambutol B. Ethambutol causes growth retardation in young children C. It is ... induced visual impairment in young children D. In young children visual toxicity of ethambutol is irreversible
Last Answer : C. It is difficult to detect ethambutol induced visual impairment in young children
Description : A patient of bronchial asthma maintained on theophylline developed upper respiratory tract infection. Which antimicrobial if used can increase the risk of developing theophylline toxicity: A. Ampicillin B. Cephalexin C. Cotrimoxazole D. Erythromycin
Last Answer : D. Erythromycin
Description : Folinic acid is specifically indicated for: A. Prophylaxis of neural tube defect in the offspring of women receiving anticonvulsant medication B. Counteracting toxicity of high dose methotrexate C. Pernicious anaemia D. Anaemia associated with renal failure
Last Answer : C. Pernicious anaemia
Description : Potassium therapy tends to counteract the cardiac toxicity of digitalis by: A. Reducing the affinity of sarcolemal Na+ K+ATPase for digitalis B. Suppressing ectopic automaticity enhanced by digitalis C. Promoting A-V conduction D. Both 'A' and 'B' are correct
Last Answer : D. Both 'A' and 'B' are correct
Description : Infusion of potassium chloride is indicated in digitalis toxicity when the manifestation(s) is/are: A. Vomiting, hyperapnoea and visual disturbance B. Pulsus bigeminus with heart rate 110/min ... accidentally ingested 10 digoxin tablets D. 2:1 A-V block with occasional ventricular extrasystoles
Last Answer : B. Pulsus bigeminus with heart rate 110/min in a patient on maintenance digoxin therapy
Description : Among all cardiac glycosides, digoxin is the most commonly used, because: A. It is the most potent and fastest acting glycoside B. It has the highest and most consistent oral ... so that dose adjustments are possible every 2-3 days and toxicity abates rather rapidly after discontinuatio
Last Answer : D. It has intermediate plasma half life so that dose adjustments are possible every 2-3 days and toxicity abates rather rapidly after discontinuatio
Description : The nonselective MAO inhibitors are not used clinically as antidepressants because of their: A. Low antidepressant efficacy B. Higher toxicity C. Potential to interact with many foods and drugs D. Both 'B' and 'C' are correct
Last Answer : D. Both 'B' and 'C' are correct
Description : Toxicity of local anaesthetics involves the following organs except: A. Heart B. Brain C. Kidney D. Skin and subcutaneous tissue (p. 324)
Last Answer : D. Dibucaine
Description : Adrenaline added to local anaesthetic solution for infiltration anaesthesia affords the following except: A. Prolongs the duration of local anaesthesia B. Makes the injection less painful C. Provides a more bloodless field for surgery D. Reduces systemic toxicity of the local anaesthetic
Last Answer : B. Makes the injection less painful