An AIDS patient treated with zidovudine + lamivudine
+ nelfinavir developed intolerable adverse effects.
Then:
A. Dose of all three drugs should be reduced to
half
B. All three drugs should be stopped or substituted simultaneously
C. The drugs should be stopped one by one
D. Two drugs sh

1 Answer

Answer :

B. All three drugs should be stopped or substituted simultaneously

Related questions

Description : The following anti-HIV drug should not be combined with zidovudine because of mutual antagonism: A. Stavudine B. Lamivudine C. Nevirapine D. Ritonavir

Last Answer : A. Stavudine

Description : Select the correc: combination of drugs for the treatment of patients suffering from Hepatitis C : (A) Interferon with Ribavirin (B) Interferon with Zidovudine (C) Interferon with Stavudine (D) Interferon with Lamivudine

Last Answer : (B) Interferon with Zidovudine

Description : Which one of the following drugs is most effective in preventing transmission of HIV virus from the mother to the foetus? (A) Lamivudine (B) Zidovudine (C) Indinavir (D) Ribavirin

Last Answer : (B) Zidovudine

Description : Antiretroviral therapy is not recommended in asymptomatic HIV infected subjects with CD4 cell count more than 350/µl because of the following reason(s): A. All antiretroviral drugs lose efficacy after ... C. The treated subjects may produce and transmit drug resistant virus D. All of the above

Last Answer : D. All of the above

Description : 60-year-old patient with creatinine clearance 50 ml/min has to be treated with gentamicin. His daily dose of gentamicin should be reduced to the following percentage of the usual adult dose: A. 70% B. 50% C. 40% D. 30%

Last Answer : B. 50%

Description : A 60-year-old patient with creatinine clearance 50 ml/min has to be treated with gentamicin. His daily dose of gentamicin should be reduced to the following percentage of the usual adult dose: A. 70% B. 50% C. 40% D. 30%

Last Answer : B. 50%

Description : The HIV titer of an AIDS patient was found to be reduced but still detectable after 6 months of tripple drug anti-HIV therapy. The best course of action in this patient is: A. Continue the ... 2 drugs and continue one previously used drug D. Replace one drug and continue two previously used drugs

Last Answer : B. Replace all 3 drugs with a set of another 3 drugs

Description : What is true of DOTS strategy for treatment of tuberculosis: A. It consists of an initial intensive phase and a later continuation phase B. The dose of antitubercular drugs is reduced ... patient himself is made responsible for administering antitubercular drugs D. All of the above are correct

Last Answer : A. It consists of an initial intensive phase and a later continuation phase

Description : 6 A patient of chronic bronchial asthma was maintained on oral prednisolone 20 mg/day for 3 months. It was decided to switch him over to inhaled beclomethasone dipropionate 200 μg 4 times a day. What should ... week and then tapered D. Its dose should be doubled for one week and then tapered (p. 2

Last Answer : C. It should be given at the same dose for one week and then tapered

Description : According to current guidelines, previously untreated symptomatic HIV patients should be treated with: A. Zidovudine alone B. Zidovudine + zalcitabine C. Zidovudine + indinavir D. Any two nucleoside reverse transcriptase inhibitors + one protease inhibito

Last Answer : D. Any two nucleoside reverse transcriptase inhibitors + one protease inhibitor

Description : A higher incidence of adverse effects to cotrimoxazole occurs when this drug is used for: A. Typhoid fever B. Whooping cough C. Pneumocystis carinii pneumonia in AIDS patients D. Chancroid

Last Answer : C. Pneumocystis carinii pneumonia in AIDS patients

Description : Choose the correct statement(s) about retroviral protease inhibitors: A. They act at an early step in HIV replication B. They are more active in inhibiting HIV than zidovudine C. They inhibit CYP3A4 and interact with many other drugs D. Both 'B' and 'C' are correct

Last Answer : D. Both 'B' and 'C' are correct

Description : The most important reason for using a combination of chemotherapeutic agents in the treatment of tuberculosis is: A. To prevent development of resistance to the drugs B. To obtain bactericidal effect C. To broaden the spectrum of activity D. To reduce adverse effects of the drugs

Last Answer : A. To prevent development of resistance to the drugs

Description : Which of the following adverse effects of neuroleptic drugs is positively correlated to the antipsychotic potency of the different compounds: A. Sedation B. Extrapyramidal motor disturbances C. Postural hypotension D. Lowering of seizure threshold

Last Answer : B. Extrapyramidal motor disturbances

Description : The constellation of adverse effects associated with nonsteroidal antiinflammatory drugs include the following except: A. Sedation B. Gastric irritation C. Fluid retention D. Rashes

Last Answer : A. Sedation

Description : A patient of vivax malaria was treated with the standard dose of chloroquine. After 6 weeks he reported back with a relapse. Which drug will you use to treat the relapse episode: A. Chloroquine B. Primaquine C. Pyrimethamine + sulfadoxine D. Mefloquin

Last Answer : A. Chloroquine

Description : A patient of liver cirrhosis with ascitis was treated with hydrochlorothiazide 50 mg twice daily. He responded initially, but over a couple of months the diuretic action gradually diminished ... Add spironolactone 50 mg thrice daily D. Substitute hydrochlorothiazide by spironolactone 50 mg 6 hourly

Last Answer : C. Add spironolactone 50 mg thrice daily

Description : A patient being treated with 20 mg prednisolone daily has to be shifted on to dexamethasone. What should be his daily dose of dexamethasone: A. 0.75 mg B. 3 mg C. 10 mg D. 40 mg

Last Answer : B. 3 mg

Description : Which of the following statement(s) is/are true concerning the management of a patient with hemophilia A undergoing an elective surgical operation? a. Concentrates of factor VIII should be given ... observed e. A new recombinant preparation of factor VIII offers the advantage of being virus-free

Last Answer : Answer: b, c, e Although the half-life of factor VIII is 2.9 days in normal individuals, the half-life of factor VIII concentrates is 9 to l8 hours. Levels of 80% to ... infection in the hemophilia population. A new recombinant preparation of factor VIII offers the advantage of being virus-free

Description : Clarithromycin is used for the following: A. Multidrug resistant M.tuberculosis infection B. M.avium complex infection in AIDS patient C. M.tuberculosis infection in a patient who develops jaundice due to first line antitubercular drugs D. Both ‘A’ and ‘B’ are correct

Last Answer : B. M.avium complex infection in AIDS patient

Description : In a patient of hypertension, the dose of propranolol that normalized blood pressure, reduced resting heart rate to 50/min. Which of the following β blockers will be most suitable for him as an ... so that heart rate is not markedly reduced: A. Pindolol B. Celiprolol C. Bisoprolol D. Atenolol

Last Answer : A. Pindolol

Description : In a patient of hypertension, the dose of propranolol that normalized blood pressure, reduced resting heart rate to 50/min. Which of the following β blockers will be most suitable for him as an ... so that heart rate is not markedly reduced: A. Pindolol B. Celiprolol C. Bisoprolol D. Atenolol

Last Answer : A. Pindolol

Description : Mycobact. tuberculosis infection in a HIV infected patient is treated with: A. The same antitubercular regimen as HIV negative patient B. Four first line antitubercular drugs for 2 months followed ... line antitubercular drugs for 9 months D. Clarithromycin + Ciprofloxacin + Rifabutin for 12 months

Last Answer : B. Four first line antitubercular drugs for 2 months followed by a longer continuation phase of 7 months with rifampin + isoniazid

Description : In an asthma patient treated with systemic corticosteroids, bronchodilator drugs: A. Are not needed B. Are contraindicated C. May be used on ‘as and when required’ basis D. Are ineffective

Last Answer : C. May be used on ‘as and when required’ basis

Description : Select the drug which directly inhibits HIV-reverse transcriptase without the need for intracellular activation by phosphorylation: A. Nelfinavir B. Nevirapine C. Stavudine D. Didanosine

Last Answer : B. Nevirapine

Description : Which of the following is associated with Hyperuricaemia? 1) is usually due to an excess purine consumption 2) occurs in association with acute lymphoblastic leukaemia 3) in primary gout is inherited in ... with low dose aspirin therapy 5) can be treated with uricosuric drugs even in renal failure

Last Answer : Answers-2 Hyperuricaemia may be due to increased purine intake, urate production or reduced urate clearance, and is most commonly due to the latter. Therefore it can occur in association with enhanced ... . Many of the uricosuric drugs may be detrimental in renal failure and may not be effective.

Description : A patient of pulmonary tuberculosis treated with rifampin + isoniazid + pyrazinamide developed parasthesias, weakness, dizziness, ataxia and depressed tendon reflexes. Which of the following ... with thiacetazone C. Substitute pyrazinamide with ethambutol D. Substitute rifampin with streptomycin

Last Answer : A. Temporarily discontinue isoniazid and add pyridoxine

Description : A patient of congestive heart failure was being treated with furosemide and digoxin. He developed urinary tract infection. Which of the following antimicrobials should be avoided: A. Ampicillin B. Gentamicin C. Norfloxacin D. Cotrimoxazole

Last Answer : B. Gentamicin

Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route ... suitable: A. Sublingual B. Oral C. Intravenous bolus injection D. Slow intravenous infusion

Last Answer : D. Slow intravenous infusion

Description : A 75-year-old man had been receiving gentamicin (an aminoglycoside antibiotic) to treat an urinary tract infection. After three months of therapy patient's serum creatinine levels were 10 mg/ ... Type II allergic reaction b)Type III allergic reaction c) Pseudo allergic reaction d) Overdose toxicity

Last Answer : d) Overdose toxicity 

Description : Indicate the drug(s) that is/are used to treat chronic hepatitis B: A. Human interferon α B. Lamivudine C. Amantadine D. Both 'A' and 'B'

Last Answer : D. Both 'A' and 'B'

Description : Select the drug that is active against both HIV and hepatitis B virus: A. Lamivudine B. Indinavir C. Didanosine D. Efavirenz

Last Answer : A. Lamivudine

Description : Currently, monotherapy with zidovudine is recommended for: A. Asymptomatic HIV positive subjects with CD4 cell count more than 200/μl B. Asymptomatic HIV positive subjects with CD4 cell count less than 200/μl C. HIV positive subjects with opportunistic infection D. None of the above

Last Answer : D. None of the above

Description : Zidovudine inhibits the following virus/viruses: A. Human immunodeficiency virus B. Cytomegalovirus C. Hepatitis B virus D. Both 'A' and 'B'

Last Answer : A. Human immunodeficiency virus

Description : The following is true of mefloquine: A. P. falciparum does not develop resistance to mefloquine B. Concurrent use of β blockers with mefloquine is contraindicated C. Neuropsychiatric reactions are the most important adverse effects of mefloquine D. All of the above

Last Answer : C. Neuropsychiatric reactions are the most important adverse effects of mefloquine

Description : Adverse effects of ketoconazole include the following except: A. Gynaecomastia B. Oligozoospermia C. Kidney damage D. Menstrual irregularities

Last Answer : C. Kidney damage

Description : Clavulanic acid is combined with amoxicillin because: A. It kills bacteria that are not killed by amoxicillin B. It retards renal excretion of amoxicillin C. It counteracts the adverse effects of amoxicillin D. It inhibits beta lactamases that destroy amoxicillin

Last Answer : D. It inhibits beta lactamases that destroy amoxicillin

Description : Adverse effects of ciprofloxacin are referable primarily to the following except: A. Gastrointestinal tract B. Kidney C. Skin D. Nervous system

Last Answer : B. Kidney

Description : Which of the following adverse effects of levodopa has a delayed onset and increases in severity with continued therapy: A. Nausea and vomiting B. Postural hypotension C. Cardiac arrhythmia D. Abnormal movements

Last Answer : D. Abnormal movements

Description : Parenteral testosterone therapy in a boy can cause the following adverse effects except: A. Gynaecomastia B. Acne C. Cholestatic jaundice D. Precocious puberty

Last Answer : C. Cholestatic jaundice

Description : The drugs used to treat Mycobact. avium complex infection in AIDS patients include the following except: A. Isoniazid B. Clarithromycin C. Ethambutol D. Ciprofloxacin

Last Answer : A. Isoniazid

Description : The most important reason for the thiazides being only moderately efficacious diuretics is: A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action B. Compensatory ... these drugs C. They decrease glomerular filtration D. They have relatively flat dose response curve

Last Answer : A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action

Description : Low dose therapy with the following category of antihypertensive drugs has been found to be more advantageous in the long-term than high dose therapy with the same drugs: A. β adrenergic blockers B. α1 adrenergic blockers C. Central sympatholytics D. Diuretics

Last Answer : D. Diuretics

Description : Which of the following drugs has mild antiparkinsonian action of its own, prolongs levodopa action and allows reduction of its dose by about 25%: A. Benserazide B. Selegiline C. Amantadine D. Pyridoxine

Last Answer : B. Selegiline

Description : The following drug/drugs does/do not produce any overt CNS effect in normal individuals but exert(s) clear cut therapeutic effect at the same dose in the presence of a specific neurological/psychiatric disorder: A. Chlorpromazine B. Levodopa C. Imipramine D. All of the above

Last Answer : B. Levodopa

Description : Fixed dose combination formulations are not necessarily appropriate for: A. Drugs administered in standard doses B. Drugs acting by the same mechanism C. Antitubercular drugs D. Antihypertensive drugs

Last Answer : C. Antitubercular drugs

Description : The dose of the following class of drugs has to be adjusted by repeated measurement of the affected physiological parameter: A. Oral contraceptives B. Antiepileptics C. Antidepressants D. Oral anticoagulants

Last Answer : D. Oral anticoagulants