Description : Select the correct statement about flumazenil: A. It is a CNS stimulant used as an antidote for benzodiazepine poisoning B. It is a CNS depressant but blocks the action of diazepam C. It has ... of its own but blocks the depressant effect of diazepam as well as stimulant effect of beta carbolines
Last Answer : D. It has no CNS effect of its own but blocks the depressant effect of diazepam as well as stimulant effect of beta carbolines
Description : Select the drug that antagonises diazepam action noncompetitively: A. Adenosine B. Flumazenil C. Bicuculline D. Valproic acid
Last Answer : C. Bicuculline
Description : Residual CNS depression is least marked after the use of the following anaesthetic: A. Diazepam B. Thiopentone sodium C. Lorazepam D. Propofo
Last Answer : D. Propofol
Description : The following drug has been used to stimulate respiratory and vasomotor centres as an expedient measure, because it has the least propensity to induce convulsions: A. Pentylenetetrazole B. Doxapram C. Bicuculline D. Amphetamine
Last Answer : B. Doxapram
Description : The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level
Last Answer : A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened
Description : Choose the drug that has been found to be more selective for the ω1 subtype of BZD receptor, and produces hypnotic action but little antianxiety, muscle relaxant or anticonvulsant actions: A. Zopiclone B. Zolpidem C. Flumazenil D. Melatonin
Last Answer : B. Zolpidem
Description : The following is a competitive antagonist of GABA but a noncompetitive antagonist of diazepam: A. Picrotoxin B. Muscimol C. Flumazenil D. Bicuculline
Last Answer : D. Bicuculline
Description : The anaesthetic action of thiopentone sodium is characterised by: A. Good muscle relaxation B. Poor analgesia C. Sensitization of heart to adrenaline D. No postoperative residual CNS depression
Last Answer : B. Poor analgesia
Description : Dexamphetamine produces an apparently paradoxical effect in: A. Addicts B. Athletes C. Parkinsonian patients D. Hyperkinetic children
Last Answer : Hyperkinetic children
Last Answer : . Hyperkinetic children
Description : elect the drug which relieves anxiety but neither reacts with benzodiazepine receptor nor produces any overt CNS effect: A. Oxazepam B. Thioproperazine C. Buspirone D. Chlordiazepoxide
Last Answer : C. Buspirone
Description : The following drug/drugs does/do not produce any overt CNS effect in normal individuals but exert(s) clear cut therapeutic effect at the same dose in the presence of a specific neurological/psychiatric disorder: A. Chlorpromazine B. Levodopa C. Imipramine D. All of the above
Last Answer : B. Levodopa
Description : Out of two anticholinesterases, drug X' is a tertiary amine while drug Y' is a quarternary ammonium compound. Then: A. Drug X' is likely to be more potent than Y' B. Drug X' will be more ... a miotic C. Drug Y' will be completely metabolized in the body D. Drug Y' will produce CNS effects
Last Answer : B. Drug ‘X’ will be more suitable to be used as a miotic
Description : Select the drug which should not be used to treat neurotic anxiety and tension syndromes despite having antianxiety action: A. Buspirone B. Chlorpromazine C. Diazepam D. Alprazolam
Last Answer : B. Chlorpromazine
Description : The following drug is not likely to produce dependence: A. Diazepam B. Chlorpromazine C. Pethidine D. Methadone
Description : The preferred drug for status epilepticus is: A. Intravenous diazepam B. Intravenous phenytoin sodium C. Intramuscular phenobarbitone D. Rectal diazepam
Last Answer : A. Intravenous diazepam
Description : A 3-year-old boy gets seizures whenever he develops fever. Which is the most appropriate strategy so that he does not develop febrile convulsions: A. Treat fever with paracetamol and ... Continuous diazepam prophylaxis for 3 years D. Intermittent diazepam prophylaxis started at the onset of fever
Last Answer : D. Intermittent diazepam prophylaxis started at the onset of fever
Description : The preferred drug for suppressing febrile convulsions is: A. Intramuscular phenobarbitone B. Intravenous phenytoin C. Rectal diazepam D. Oral sodium valproate
Last Answer : C. Rectal diazepam
Description : The drug used for controlling tetany is: A. Intravenous diazepam B. Intramuscular vitamin D C. Intravenous calcium gluconate D. Intravenous calcitonin
Last Answer : C. Intravenous calcium gluconate
Description : Select the correct statement about benzodiazepines (BZDs): A. All BZDs facilitate GABA mediated Cl¯ influx into neurones B. Different BZDs exert the same degrees of hypnotic, anxiolytic and anticonvulsant ... at all neuronal sites D. The muscle relaxant action of BZDs is not blocked by flumazenil
Last Answer : A. All BZDs facilitate GABA mediated Cl¯ influx into neurones
Description : A 92-year-old woman is an inpatient in the geriatric unit. She has multivascular dementia. She is more confused and agitated. She has been given lorazepam 4 mg intramuscularly. She is now unconscious ... A. Activated charcoal B. Flumazenil C. N-acetyl cysteine D. Naloxone E. Protamine sulphate
Last Answer : B. Flumazenil
Description : The most effective antidote for belladonna poisoning is: A. Neostigmine B. Physostigmine C. Pilocarpine D. Methacholine
Last Answer : B. Physostigmine
Description : The following is a competitive type of enzyme inhibitor: A. Acetazolamide B. Disulfiram C. Physostigmine D. Theophylline
Last Answer : C. Physostigmine
Description : Ranitidine differs from cimetidine in the following respect: A. It is less potent B. It is shorter acting C. It does not have antiandrogenic action D. It produces more CNS side effect
Last Answer : C. It does not have antiandrogenic action
Description : As antihypertensives the thiazide diuretics have the following advantages except: A. High ceiling antihypertensive action B. Absence of CNS side effects C. Absence of tolerance development D. Low cost
Last Answer : A. High ceiling antihypertensive action
Description : Which of the following is not a CNS depressant but increases the tendency to fall asleep at night: A. Pyridoxine B. Diphenhydramine C. Melatonin D. Ethanol
Last Answer : C. Melatonin
Description : Down regulation of receptors can occur as a consequence of: A. Continuous use of agonists B. Continuous use of antagonists C. Chronic use of CNS depressants D. Denervation
Last Answer : A. Continuous use of agonists
Description : The quarternary analogues of belladonna alkaloids are preferred over the natural alkaloids for antisecretory/ antispasmodic indications because: A. They have additional nicotinic receptor blocking activity B. They are ... of CNS and ocular effects D. Dose to dose they are more potent than atropine
Last Answer : C. They are devoid of CNS and ocular effects
Description : Hyoscine differs from atropine in that it: A. Exerts depressant effects on the CNS at relatively low doses B. Exerts more potent effects on the heart than on the eye C. Is longer acting D. Has weaker antimotion sickness activity
Last Answer : A. Exerts depressant effects on the CNS at relatively low doses
Description : Drugs effective in bipolar illness include the following except: A. Olanzapine B. Diazepam C. Sodium valproate D. Lamotrigine
Last Answer : B. Diazepam
Description : Diabetic and other types of neuropathic pain often responds to: A. Chlorpromazine B. Diazepam C. Imipramine D. Lithium
Last Answer : C. Imipramine
Description : The following statement(s) is/are correct in relation to diazepam and chlorpromazine: A. Both have anticonvulsant property B. Both do not carry abuse liability C. Both have antianxiety action D. All of the above are correc
Last Answer : C. Both have antianxiety action
Description : Despite having anticonvulsant action, diazepam is not used in the treatment of epilepsy because: A. It is not effective orally B. It causes sedation C. Its anticonvulsant action wanes off with chronic use D. Both ‘B’ and ‘C’ are correct
Last Answer : D. Both ‘B’ and ‘C’ are correct
Description : Diazepam is indicated in the following conditions except: A. Generalized tonic-clonic (grand mal) epilepsy B. Tetanus C. Febrile convulsions D. Cardiac catheterization
Last Answer : A. Generalized tonic-clonic (grand mal) epilepsy
Description : Zolpidem differs from diazepam in that: A. It is safer in overdose than diazepam B. Its hypnotic action shows little fading on repeated nightly use C. It causes more marked suppression of REM sleep D. It has more potent muscle relaxant action
Last Answer : B. Its hypnotic action shows little fading on repeated nightly use
Description : At a single hypnotic dose, the pharmacokinetics of diazepam is characterised by: A. Slow elimination and little redistribution B. Slow elimination with marked redistribution C. Rapid elimination and marked redistribution D. Ultra rapid elimination
Last Answer : B. Slow elimination with marked redistribution
Description : Hypnotic dose of diazepam produces the following action: A. Tachycardia B. Constipation C. Hyperalgesia D. Decreased nocturnal gastric secretion
Last Answer : D. Decreased nocturnal gastric secretion
Description : Select the anaesthetic that increases cardiac output and blood pressure: A. Halothane B. Fentanyl C. Ketamine D. Diazepam
Last Answer : C. Ketamine
Description : Diazepam is used as a muscle relaxant for: A. Deep intra-abdominal operation B. Tracheal intubation C. Tetanus D. Diagnosis of myasthenia gravis
Last Answer : C. Tetanus
Description : Which of the following drugs exhibits ‘therapeutic window’ phenomenon: A. Captopril B. Furosemide C. Diazepam D. Imipramine
Last Answer : D. Imipramine
Description : Select the drug which directly inhibits HIV-reverse transcriptase without the need for intracellular activation by phosphorylation: A. Nelfinavir B. Nevirapine C. Stavudine D. Didanosine
Last Answer : B. Nevirapine
Description : Select the drug which tends to reverse insulin resistance by increasing cellular glucose transporters: A. Glibenclamide B. Rosiglitazone C. Acarbose D. Prednisolone
Last Answer : B. Rosiglitazone
Description : In a comatose patient suspected of poisoning, which of the following findings would be against the drug being morphine: A. Mydriasis B. Marked respiratory depression C. Cyanosis D. Fall in blood pressure
Last Answer : A. Mydriasis
Description : A 30-year-old woman suffering from endogenous depression improved after one month of treatment with amitriptyline. How long the drug should be continued: A. 1-2 weeks B. 6-12 months C. 2-3 years D. Life long
Last Answer : B. 6-12 months
Description : The major constraint in the long term use of benzodiazepines for treatment of generalized anxiety disorder is: A. Development of tolerance to antianxiety action of the benzodiazepines B. Possibility of drug dependence C. Cardiovascular depression D. Likelyhood of overdose toxicit
Last Answer : B. Possibility of drug dependence
Description : Selective inhibition of conditioned avoidance response in animals by a drug indicates that the drug is likely to be effective in: A. Anxiety B. Major depression C. Schizophrenia D. Manic-depressive illness
Last Answer : C. Schizophrenia
Description : Depolarizing neuromuscular blockers differ from competitive blockers in the following attributes except: A. They induce contraction of isolated frog rectus abdominis muscle B. Ether anaesthesia ... produces well sustained contraction D. Neostigmine does not reverse block produced by them
Last Answer : B. Ether anaesthesia intensifies block produced by them