Individual drugs of thiazide and related class of diuretics differ markedly from each other in the following respect? A. Diuretic efficacy B. Diuretic potency C. Side effects D. Propensity to cause hyperkalemia

Individual drugs of thiazide and related class of
diuretics differ markedly from each other in the
following respect?
A. Diuretic efficacy
B. Diuretic potency
C. Side effects
D. Propensity to cause hyperkalemia
by

1 Answer

Answer :

B. Diuretic potency
by

Related questions

Combined tablets of thiazide or high ceiling diuretics with potassium chloride are not recommended because: A. Potassium absorbed while diuresis is occurring is largely excreted out B. Potassium administered concurrently diminishes the diuretic action C. Potassium chloride in tablet formulation is likely to cause gut ulceration D. Both ‘A’ and ‘C’ are correct

Description : Combined tablets of thiazide or high ceiling diuretics with potassium chloride are not recommended because: A. Potassium absorbed while diuresis is occurring is largely excreted out B. Potassium administered concurrently ... is likely to cause gut ulceration D. Both A' and C' are correct

Last Answer : D. Both ‘A’ and ‘C’ are correct

As antihypertensives the thiazide diuretics have the following advantages except: A. High ceiling antihypertensive action B. Absence of CNS side effects C. Absence of tolerance development D. Low cost

Description : As antihypertensives the thiazide diuretics have the following advantages except: A. High ceiling antihypertensive action B. Absence of CNS side effects C. Absence of tolerance development D. Low cost

Last Answer : A. High ceiling antihypertensive action

Which of the following is a high potency antipsychotic drug having minimal sedative and autonomic effects and no propensity to cause weight gain: A. Chlorpromazine B. Triflupromazine C. Haloperidol D. Olanzapine

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Last Answer : C. Haloperido

Thiazide diuretics do not potentiate the antihypertensive action of one of the following drugs: A. Metoprolol B. Nifedipine C. Hydralazine D. Captopril

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Last Answer : B. Nifedipine

The following is not a feature of thiazide diuretics used as antihypertensive: A. They do not cause symptomatic postural hypotension B. The dose has to be titrated over a wide range according to the response C. They restore responsiveness to other antihypertensives when tolerance has developed D. They decrease renal calcium excretion which may improve calcium balance in elderly patients

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Last Answer : B. The dose has to be titrated over a wide range according to the response

The principles of antihypertensive drug usage enunciated in JNC VI and WHO-ISH guidelines include the following except: A. Therapy for grade I and II hypertension should be initiated with a single drug B. Dose of thiazide diuretic should be 12.5-25 mg hydrochlorothiazide or equivalent per day C. All subjects with BP higher than 140/90 mmHg should be put on antihypertensive medication immediately D. If the drug chosen initially fails to lower BP, it should be replaced by a drug/combination from another class

Description : The principles of antihypertensive drug usage enunciated in JNC VI and WHO-ISH guidelines include the following except: A. Therapy for grade I and II hypertension should be initiated with a single drug ... initially fails to lower BP, it should be replaced by a drug/combination from another class

Last Answer : C. All subjects with BP higher than 140/90 mmHg should be put on antihypertensive medication immediately

Which of the following categories of medications may result in seizure activity if withdrawn suddenly? a) Tranquilizers Abrupt withdrawal of tranquilizers may result in anxiety, tension, and even seizures if withdrawn suddenly. b) Adrenal corticosteroids Abrupt withdrawal of steroids may precipitate cardiovascular collapse. c) Antidepressants Monoamine oxidase inhibitors increase the hypotensive effects of anesthetics. d) Diuretics Thiazide diuretics may cause excessive respiratory depression during anesthesia due to an associated electrolyte imbalance.

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The primary site of action of thiazide diuretics is: A. Proximal tubule B. Ascending limb of loop of Henle C. Cortical diluting segment D. Collecting ducts

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Last Answer : C. Cortical diluting segment

Thiazide diuretics enhance K+ elimination in urine primarily by: A. Inhibiting proximal tubular K+ reabsorption B. Inhibiting Na+ K+-2Cl– cotransport in the ascending limb of loop of Henle C. Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K+ D. Potentiating the action of aldosterone

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Last Answer : C. Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K

Choose the correct statement about thiazide diuretics: A. They act in the proximal convoluted tubule B. They are uricosuric C. They augment corticomedullary osmotic gradient D. They induce diuresis in acidosis as well as alkalosis

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Last Answer : D. They induce diuresis in acidosis as well as alkalosis

Thiazide diuretics and furosemide have directionally opposite effect on the net renal excretion of the following substance: A. Uric acid B. Calcium C. Magnesium D. Bicarbonate

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Last Answer : B. Calcium

Thiazide diuretics are the preferred first line antihypertensives for the following category of patients: A. Young hypertensives B. Physically and sexually active male hypertensives C. Elderly obese hypertensives D. Diabetic hypertensives

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Last Answer : C. Elderly obese hypertensives

The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: A. Reduction of circulating blood volume B. Reduction in cardiac output C. Decreased sympathetic tone D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

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Last Answer : D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

Monitoring of blood levels of diuretic drugs is not practised because: A. No sensitive methods for measuring blood levels of diuretics are available B. It is easier to measure the effect of these drugs C. Response to diuretics is not related to their blood levels D. Diuretics need activation in the body

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Last Answer : B. It is easier to measure the effect of these drugs

Monitoring of blood levels of diuretic drugs is not practised because: A. No sensitive methods for measuring blood levels of diuretics are available B. It is easier to measure the effect of these drugs C. Response to diuretics is not related to their blood levels D. Diuretics need activation in the body

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Last Answer : B. It is easier to measure the effect of these drugs

The most appropriate measure to overcome diminished responsiveness to furosemide after its longterm use is: A. Switching over to parenteral administration of furosemide B. Addition of a thiazide diuretic C. Addition of acetazolamide D. Potassium supplementation

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The following is not itself an efficacious diuretic, and is used only as an adjuvant/corrective to other diuretics: A. Acetazolamide B. Metolazone C. Spironolactone D. Indapamide

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Which of the following adverse effects of neuroleptic drugs is positively correlated to the antipsychotic potency of the different compounds: A. Sedation B. Extrapyramidal motor disturbances C. Postural hypotension D. Lowering of seizure threshold

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Last Answer : B. Extrapyramidal motor disturbances

The distinctive features of azithromycin include the following except: A. Efficacy against organisms which have developed resistance to erythromycin B. Marked tissue distribution and intracellular penetration C. Long terminal elimination half-life D. Low propensity to drug interactions due to inhibition of cytochrome P450 enzymes

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Select the diuretic which is similar in efficacy and pattern of electrolyte excretion to furosemide, but is 40 times more potent dose to dose: A. Piretanide B. Bumetanide C. Xipamide D. Metolazone

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Last Answer : B. Bumetanide

Antiretroviral therapy is not recommended in asymptomatic HIV infected subjects with CD4 cell count more than 350/µl because of the following reason(s): A. All antiretroviral drugs lose efficacy after some time B. Adverse effects of antiretroviral drugs compromise the quality of life of asymptomatic subjects C. The treated subjects may produce and transmit drug resistant virus D. All of the above

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Last Answer : D. All of the above

Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)

Description : Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)

Last Answer : C. Diazepam (pentobarbitone)

Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)

Description : Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)

Last Answer : C. Diazepam (pentobarbitone)

Amphetamine potentiates the following class of drugs: A. Diuretics B. Analgesics C. Neuroleptics D. Antihypertensives

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Last Answer : B. Analgesics

Amphetamine potentiates the following class of drugs: A. Diuretics B. Analgesics C. Neuroleptics D. Antihypertensives

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Last Answer : B. Analgesics

A fixed dose combination preparation meant for internal use must not contain the following class of drug: A. Thiazide diuretic B. Fluoroquinolone antimicrobial C. Corticosteroid D. H2 blocker

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Last Answer : C. Corticosteroid

Paraaminosalicylic acid is a second line antitubercular drug because of the following feature(s): A. Low antitubercular efficacy B. Frequent side effects C. Bulky daily dose D. All of the above

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Last Answer : D. All of the above

The most important drawback of sucralfate in the treatment of duodenal ulcer is: A. Low ulcer healing efficacy B. Poor relief of ulcer pain C. High incidence of side effects D. Need for taking a big tablet four times a day

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Last Answer : D. Need for taking a big tablet four times a day

Though bromocriptine acts directly on dopamine receptors, it is used in parkinsonism only as a supplement to levodopa because: A. It has low efficacy B. It produces marked dyskinesias C. Used alone, its effective doses produce intolerable side effects D. Its therapeutic effect takes long time to develop

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Last Answer : C. Used alone, its effective doses produce intolerable side effect

Adrenergic β1 selective blockers offer the following advantages except: A. Lower propensity to cause bronchospasm B. Less prone to produce cold hands and feet as side effect C. Withdrawal is less likely to exacerbate angina pectoris D. Less liable to impair exercise capacity

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Last Answer : C. Withdrawal is less likely to exacerbate angina pectoris

Adrenergic β 1 selective blockers offer the following advantages except: A. Lower propensity to cause bronchospasm B. Less prone to produce cold hands and feet as side effect C. Withdrawal is less likely to exacerbate angina pectoris D. Less liable to impair exercise capacity

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Last Answer : C. Withdrawal is less likely to exacerbate angina pectoris

Raised plasma aldosterone level in CHF contributes to disease progression by exerting the following effects except: A. Fibrotic remodeling of myocardium B. Hyperkalemia and hypermagnesemia C. Increasing cardiac preload by Na+ and water retention D. Enhancing cardiotoxicity of sympathetic overactivity

Description : Raised plasma aldosterone level in CHF contributes to disease progression by exerting the following effects except: A. Fibrotic remodeling of myocardium B. Hyperkalemia and hypermagnesemia C. ... cardiac preload by Na+ and water retention D. Enhancing cardiotoxicity of sympathetic overactivity

Last Answer : B. Hyperkalemia and hypermagnesemia

The fluoroquinolones have improved over nalidixic acid in the following respect(s): A. They have higher antimicrobial potency B. They have extended antimicrobial spectrum C. Development of bacterial resistance against them is slow and infrequent D. All of the above

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Last Answer : D. All of the above

The following is correct about antipsychotic drugs except: A. They only control symptoms of schizophrenia without affecting the basic disorder B. Combination of two or more antipsychotic drugs is more efficacious than any single drug C. In treating psychosis high potency drugs are preferred over low potency drugs D. They donot produce dependence

Description : The following is correct about antipsychotic drugs except: A. They only control symptoms of schizophrenia without affecting the basic disorder B. Combination of two or more antipsychotic drugs is ... psychosis high potency drugs are preferred over low potency drugs D. They donot produce dependence

Last Answer : B. Combination of two or more antipsychotic drugs is more efficacious than any single drug

The most important reason for the thiazides being only moderately efficacious diuretics is: A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action B. Compensatory increase in reabsorption at sites not affected by these drugs C. They decrease glomerular filtration D. They have relatively flat dose response curve

Description : The most important reason for the thiazides being only moderately efficacious diuretics is: A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action B. Compensatory ... these drugs C. They decrease glomerular filtration D. They have relatively flat dose response curve

Last Answer : A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action

Low dose therapy with the following category of antihypertensive drugs has been found to be more advantageous in the long-term than high dose therapy with the same drugs: A. β adrenergic blockers B. α1 adrenergic blockers C. Central sympatholytics D. Diuretics

Description : Low dose therapy with the following category of antihypertensive drugs has been found to be more advantageous in the long-term than high dose therapy with the same drugs: A. β adrenergic blockers B. α1 adrenergic blockers C. Central sympatholytics D. Diuretics

Last Answer : D. Diuretics

Choose the correct statement about long acting calcium channel blocking drugs as antihypertensives: A. They are the most effective drugs in suppressing hypertensive left ventricular hypertrophy B. They are as effective as diuretics or β blockers in reducing cardiovascular/total mortality C. They compromise quality of life more than β blockers D. They have no beneficial effect in hypertensive/diabetic nephropath

Description : Choose the correct statement about long acting calcium channel blocking drugs as antihypertensives: A. They are the most effective drugs in suppressing hypertensive left ventricular hypertrophy B. They ... more than β blockers D. They have no beneficial effect in hypertensive/diabetic nephropath

Last Answer : B. They are as effective as diuretics or β blockers in reducing cardiovascular/total mortality

Which of the following statements most closely describes the current status of angiotensin converting enzyme inhibitors in congestive heart failure: A. They are the first choice drugs unless contraindicated B. They are used when diuretics alone fail C. They are a substitute for digitalis D. They are to be used as adjuncts only in resistant cases

Description : Which of the following statements most closely describes the current status of angiotensin converting enzyme inhibitors in congestive heart failure: A. They are the first choice drugs unless contraindicated B. ... substitute for digitalis D. They are to be used as adjuncts only in resistant cases

Last Answer : D. They are to be used as adjuncts only in resistant cases

Select the diuretic that can cause gynaecomastia, hirsutism and menstrual disturbance as a side effect on long-term use: A. Amiloride B. Spironolactone C. Metolazone D. Acetazolamide

Description : Select the diuretic that can cause gynaecomastia, hirsutism and menstrual disturbance as a side effect on long-term use: A. Amiloride B. Spironolactone C. Metolazone D. Acetazolamide

Last Answer : B. Spironolactone

Select the correct statement regarding the antiemetic efficacy of the three prokinetic drugs metoclopramide, domperidone and cisapride: A. Cisapride is the most effective B. Metoclopramide is the most effective C. Domperidone is the most effective D. All three are equally efficacious

Description : Select the correct statement regarding the antiemetic efficacy of the three prokinetic drugs metoclopramide, domperidone and cisapride: A. Cisapride is the most effective B. Metoclopramide is the most effective C. Domperidone is the most effective D. All three are equally efficacious

Last Answer : B. Metoclopramide is the most effective

Advantages of angiotensin converting enzyme inhibitors as antihypertensive include the following except: A. They tend to reverse left ventricular hypertrophy B. Their efficacy is not reduced by nonsteroidal antiinflammatory drugs C. They do not worsen blood lipid profile D. They do not impair work performance

Description : Advantages of angiotensin converting enzyme inhibitors as antihypertensive include the following except: A. They tend to reverse left ventricular hypertrophy B. Their efficacy is not reduced by nonsteroidal ... . They do not worsen blood lipid profile D. They do not impair work performance

Last Answer : B. Their efficacy is not reduced by nonsteroidal antiinflammatory drugs

The nonselective MAO inhibitors are not used clinically as antidepressants because of their: A. Low antidepressant efficacy B. Higher toxicity C. Potential to interact with many foods and drugs D. Both 'B' and 'C' are correct

Description : The nonselective MAO inhibitors are not used clinically as antidepressants because of their: A. Low antidepressant efficacy B. Higher toxicity C. Potential to interact with many foods and drugs D. Both 'B' and 'C' are correct

Last Answer : D. Both 'B' and 'C' are correct

Thiazide diuretics inhibit (A) Carbonic anhydrase (B) Aldosterone secretion (C) ADH secretion (D) Sodium reabsorption in distal tubules

Description : Thiazide diuretics inhibit (A) Carbonic anhydrase (B) Aldosterone secretion (C) ADH secretion (D) Sodium reabsorption in distal tubules

Last Answer : Answer : D

Which one of the following is lest likely to be useful in the therapy of hypercalcemia? (a) Calcitonin (b) Glucocorticoids (c) Plicamycin (d) Parenteral infusion of phosphate (e) Thiazide diuretics

Description : Which one of the following is lest likely to be useful in the therapy of hypercalcemia? (a) Calcitonin (b) Glucocorticoids (c) Plicamycin (d) Parenteral infusion of phosphate (e) Thiazide diuretics

Last Answer : Ans: E

Which of the following is Type B ADRS? a) Hypoglycaemia caused by Insulin b) Dryness of mouth caused by Atropine c) Anaemia in patient with G6PD deficiency caused by Primaquine d) Hyperglycaemia caused by thiazide diuretics

Description : Which of the following is Type B ADRS? a) Hypoglycaemia caused by Insulin b) Dryness of mouth caused by Atropine c) Anaemia in patient with G6PD deficiency caused by Primaquine d) Hyperglycaemia caused by thiazide diuretics

Last Answer : c) Anaemia in patient with G6PD deficiency caused by Primaquine 

Nonsteroidal antiinflammatory drugs reduce the diuretic action of furosemide by: A. Preventing prostaglandin mediated intrarenal haemodynamic actions B. Blocking the action in ascending limb of loop of Henle. C. Enhancing salt and water reabsorption in distal tubule D. Increasing aldosterone secretion

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Last Answer : A. Preventing prostaglandin mediated intrarenal haemodynamic actions

Select the correct statement about combining antihypertensive drugs: A. Antihypertensive combinations should always be preferred over single drugs B. Combinations of antihypertensives with similar pattern of haemodynamic action are superior to those with dissimilar pattern C. Antihypertensives which act on different regulatory systems maintaining blood pressure should be combined D. A diuretic must be included whenever antihypertensives are combined

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Last Answer : C. Antihypertensives which act on different regulatory systems maintaining blood pressure should be combined

Long-term thiazide therapy can cause hyperglycaemia by: A. Reducing insulin release B. Interfering with glucose utilization in tissues C. Increasing sympathetic activity D. Increasing corticosteroid secretion

Description : Long-term thiazide therapy can cause hyperglycaemia by: A. Reducing insulin release B. Interfering with glucose utilization in tissues C. Increasing sympathetic activity D. Increasing corticosteroid secretion

Last Answer : A. Reducing insulin release

Beneficial effect/effects of diuretics in CHF patients include the following: A. Symptomatic relief B. Regression of pathological changes C. Prolongation of life expectancy D. Both ‘A’ and ‘C’

Description : Beneficial effect/effects of diuretics in CHF patients include the following: A. Symptomatic relief B. Regression of pathological changes C. Prolongation of life expectancy D. Both ‘A’ and ‘C’

Last Answer : A. Symptomatic relief