Choose the correct statement about thiazide diuretics:
A. They act in the proximal convoluted tubule
B. They are uricosuric
C. They augment corticomedullary osmotic
gradient
D. They induce diuresis in acidosis as well as
alkalosis

1 Answer

Answer :

D. They induce diuresis in acidosis as well as
alkalosis

Related questions

Description : The primary site of action of thiazide diuretics is: A. Proximal tubule B. Ascending limb of loop of Henle C. Cortical diluting segment D. Collecting ducts

Last Answer : C. Cortical diluting segment

Description : Combined tablets of thiazide or high ceiling diuretics with potassium chloride are not recommended because: A. Potassium absorbed while diuresis is occurring is largely excreted out B. Potassium administered concurrently ... is likely to cause gut ulceration D. Both A' and C' are correct

Last Answer : D. Both ‘A’ and ‘C’ are correct

Description : Select the diuretic which is orally active, efficacious in acidosis as well as alkalosis, causes diuresis even in renal failure and has additional carbonic anhydrase inhibitory action: A. Mannitol B. Benzthiazide C. Indapamide D. Furosemide

Last Answer : D. Furosemide

Description : The following diuretic abolishes the corticomedullary osmotic gradient in the kidney: A. Acetazolamide B. Furosemide C. Hydrochlorothiazide D. Spironolactone

Last Answer : B. Furosemide

Description : Thiazide diuretics enhance K+ elimination in urine primarily by: A. Inhibiting proximal tubular K+ reabsorption B. Inhibiting Na+ K+-2Cl- cotransport in the ascending limb of loop of Henle C ... in the distal tubular fluid to exchange with interstitial K+ D. Potentiating the action of aldosterone

Last Answer : C. Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K

Description : The Na+ retaining action of aldosterone is exerted on the: A. Proximal convoluted tubule B. Ascending limb of loop of Henle C. Cortical diluting segment D. Distal convoluted tubul

Last Answer : D. Distal convoluted tubule

Description : Choose the correct statement about osmotic diuretics: A. They are large molecular weight substances which form colloidal solution B. Their primary site of action is collecting ducts in the ... C. They increase water excretion without increasing salt excretion D. They can lower intraocular pressure

Last Answer : D. They can lower intraocular pressure

Description : Match the items given in column I with those in column II and select the correct option given below. Column I Column II (Function) (Part of excretory system) A. Ultrafiltration (i) Henle's loop B. Concentration (ii) Ureter of urine C. ... (ii) (iii) (c) (v) (iv) (i) (ii) (d) (v) (iv) (i) (iii)

Last Answer : (b) (iv) (i) (ii) (iii)

Description : Assertion `:-` Proximal convoluted tubule is lined by brush-bordered cuboidal epithelium. Reason `:-` PCT is main site of selective reabsorption of us

Last Answer : Assertion `:-` Proximal convoluted tubule is lined by brush-bordered cuboidal epithelium. Reason `:-` ... D. If both Assertion & Reason are false.

Description : Removal of proximal convoluted tubule from the nephron will be result in

Last Answer : Removal of proximal convoluted tubule from the nephron will be result in A. More concentrated urine B. ... C. No urine formation D. More diluted urine

Description : Removal of proximal convoluted tubule from the nephron will be result in

Last Answer : Removal of proximal convoluted tubule from the nephron will be result in A. No urine formation B. ... D. No change in quality and quantity of urine

Description : In a normal nephron: a. the descending loop of Henle is impermeable to water b. anti-diuretic hormone (ADH) increases the permeability of collecting ducts to water c. all the filtered ... in the proximal tubule d. nearly all the filtered protein is reabsorbed in the proximal convoluted tubule

Last Answer : nearly all the filtered protein is reabsorbed in the proximal convoluted tubule

Description : Reabsorption of useful substances from glomerular filtrate occurs in (a) collecting tube (b) loop of Henle (c) proximal convoluted tubule (d) distal convoluted tubule.

Last Answer : (c) proximal convoluted tubule

Description : Brush border is characteristic of (a) neck of nephron (b) collecting tube (c) proximal convoluted tubule (d) all of these.

Last Answer : (c) proximal convoluted tubule

Description : The maximum amount of electrolytes and water (70 – 80 percent) from the glomerular filtrate is reabsorbed in which part of the nephron? (a) Ascending limb of loop of Henle (b) Distal convoluted tubule (c) Proximal convoluted tubule (d) Descending limb of loop of Henle

Last Answer : (c) Proximal convoluted tubule

Description : Removal of proximal convoluted tubule from the nephron will result in (a) no change in quality and quantity of urine (b) no urine formation (c) more diluted urine (d) more concentrated urine.

Last Answer : (c) more diluted urine

Description : The part of nephron involved in active reabsorption of sodium is (a) distal convoluted tubule (b) proximal convoluted tubule (c) Bowman’s capsule (d) descending limb of Henle’s loop.

Last Answer : (b) proximal convoluted tubule

Description : Cuboidal epithelium with brush border of microvilli is found in (a) lining of intestine (b) ducts of salivary glands (c) proximal convoluted tubule of nephron (d) Eustachian tube

Last Answer : c) proximal convoluted tubule of nephron

Description : The following is not a feature of thiazide diuretics used as antihypertensive: A. They do not cause symptomatic postural hypotension B. The dose has to be titrated over a wide range ... has developed D. They decrease renal calcium excretion which may improve calcium balance in elderly patients

Last Answer : B. The dose has to be titrated over a wide range according to the response

Description : Aminoglycoside antibiotics exert the following action(s) on sensitive bacteria: A. Induce synthesis of defective proteins B. Make bacterial cell membrane more leaky C. Augment their own carrier mediated entry into the bacteria D. All of the above

Last Answer : D. All of the above

Description : Individual drugs of thiazide and related class of diuretics differ markedly from each other in the following respect? A. Diuretic efficacy B. Diuretic potency C. Side effects D. Propensity to cause hyperkalemia

Last Answer : B. Diuretic potency

Description : Thiazide diuretics and furosemide have directionally opposite effect on the net renal excretion of the following substance: A. Uric acid B. Calcium C. Magnesium D. Bicarbonate

Last Answer : B. Calcium

Description : Thiazide diuretics are the preferred first line antihypertensives for the following category of patients: A. Young hypertensives B. Physically and sexually active male hypertensives C. Elderly obese hypertensives D. Diabetic hypertensives

Last Answer : C. Elderly obese hypertensives

Description : As antihypertensives the thiazide diuretics have the following advantages except: A. High ceiling antihypertensive action B. Absence of CNS side effects C. Absence of tolerance development D. Low cost

Last Answer : A. High ceiling antihypertensive action

Description : Thiazide diuretics do not potentiate the antihypertensive action of one of the following drugs: A. Metoprolol B. Nifedipine C. Hydralazine D. Captopril

Last Answer : B. Nifedipine

Description : The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: A. Reduction of circulating blood volume B. Reduction in cardiac output C. Decreased sympathetic tone D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

Last Answer : D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

Description : ndapamide differs from other diuretics in that: A. It has selective antihypertensive action at doses which cause little diuresis B. It is a more efficacious antihypertensive C. Its antihypertensive action develops more rapidly D. All of the above

Last Answer : A. It has selective antihypertensive action at doses which cause little diuresis

Description : The Na+-Cl– symport in the early distal convoluted tubule of the kidney is inhibited by: A. Thiazides B. Metolazone C. Xipamide D. All of the above

Last Answer : D. All of the above

Description : Choose the correct statement about magaldrate: A. It is a mixture of magnesium and aluminium hydroxides B. It has a rapid as well as sustained acid neutralizing action C. Its acid neutralizing capacity is 2 m Eq/g D. It causes systemic alkalosis

Last Answer : B. It has a rapid as well as sustained acid neutralizing action

Description : The most important reason for the thiazides being only moderately efficacious diuretics is: A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action B. Compensatory ... these drugs C. They decrease glomerular filtration D. They have relatively flat dose response curve

Last Answer : A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action

Description : Metabolic effects that generally attend antiinflammatory doses of aspirin include the following except: A. Increased CO2 production B. Hepatic glycogen depletion C. Metabolic acidosis D. Compensated respiratory alkalosis

Last Answer : C. Metabolic acidosis

Description : High molecular weight, pharmacodynamically inert, nonantigenic substances which form colloidal solution are used as: A. Osmotic purgatives B. Osmotic diuretics C. Plasma expanders D. All of the above

Last Answer : C. Plasma expanders

Description : Choose the correct statement about long acting calcium channel blocking drugs as antihypertensives: A. They are the most effective drugs in suppressing hypertensive left ventricular hypertrophy B. They ... more than β blockers D. They have no beneficial effect in hypertensive/diabetic nephropath

Last Answer : B. They are as effective as diuretics or β blockers in reducing cardiovascular/total mortality

Description : Choose the correct statement about lactulose: A. It stimulates myenteric neurones to enhance gut peristalsis B. Administered orally it acts as a purgative within 2-4 hours C. It is an osmotic laxative that produces soft but formed stools D. All of the above are correct

Last Answer : C. It is an osmotic laxative that produces soft but formed stools

Description : Which one of the following statements in regard to the excretion by the human kidneys is correct? (a) Descending limb of loop of Henle is impermeable to water. (b) Distal convoluted tubule is ... reabsorbed by the renal tubules. (d) Ascending limb of loop of Henle is impermeable to electrolytes.

Last Answer : (c) Nearly 99 per cent of the glomerular filtrate is reabsorbed by the renal tubules.

Description : Thiazide diuretics inhibit (A) Carbonic anhydrase (B) Aldosterone secretion (C) ADH secretion (D) Sodium reabsorption in distal tubules

Last Answer : Answer : D

Description : Which one of the following is lest likely to be useful in the therapy of hypercalcemia? (a) Calcitonin (b) Glucocorticoids (c) Plicamycin (d) Parenteral infusion of phosphate (e) Thiazide diuretics

Last Answer : Ans: E

Description : Which of the following categories of medications may result in seizure activity if withdrawn suddenly? a) Tranquilizers Abrupt withdrawal of tranquilizers may result in anxiety, tension, ... may cause excessive respiratory depression during anesthesia due to an associated electrolyte imbalance.

Last Answer : a) Tranquilizers Abrupt withdrawal of tranquilizers may result in anxiety, tension, and even seizures if withdrawn suddenly.

Description : Which of the following is Type B ADRS? a) Hypoglycaemia caused by Insulin b) Dryness of mouth caused by Atropine c) Anaemia in patient with G6PD deficiency caused by Primaquine d) Hyperglycaemia caused by thiazide diuretics

Last Answer : c) Anaemia in patient with G6PD deficiency caused by Primaquine 

Description : The following statement is not true of sulbactam: A. It is a broad spectrum β-lactamase inhibitor B. It does not augment the activity of ampicillin against bacteria that are sensitive ... β-lactamases D. Combined with ampicillin, it is highly effective against penicillinase producing N. gonorrhoeae

Last Answer : C. It induces chromosomal β-lactamases

Description : Osmotic diuresis?

Last Answer : DefinitionOsmotic diuresis is increased urination due to the presence of certain substances in the fluid filtered by the kidneys. (This fluid eventually becomes urine.)Causes, incidence, and risk factorsHigh blood sugar (glucose) can cause osmotic diuresis, as can medications such as Mannitol.

Description : Oncotic pressure refers to a) the osmotic pressure exerted by proteins. Oncotic pressure is a pulling pressure exerted by proteins, such as albumin. b) the number of dissolved particles contained in a ... . Osmotic pressure is the amount of pressure needed to stop the flow of water by osmosis.

Last Answer : a) the osmotic pressure exerted by proteins. Oncotic pressure is a pulling pressure exerted by proteins, such as albumin.

Description : Assertion `:-` Antidiuretic hormone, increases the water permeability of distal convoluted tubule. Reason `:-` In the absence of ADH, water re-absorpt

Last Answer : Assertion `:-` Antidiuretic hormone, increases the water permeability of distal convoluted tubule. Reason ... . If both Assertion & Reason are false.

Description : Which of the following causes an increase in sodium reabsorption in the distal convoluted tubule

Last Answer : Which of the following causes an increase in sodium reabsorption in the distal convoluted tubule ... levels D. Decrease in antidiuretic hormone levels

Description : The final concentration of the fluid to produce a markedly hypertonic urine takes place in (a) Loop of Henle (b) Distal convoluted tubule (c) Collecting tubule (d) Both (b) and (c)

Last Answer : Ans:(c)

Description : The fluid reaching the distal convoluted tubule from the ascending limb of Henle's loop is (a) isotonic in respect of plasma (b) hypotonic in respect of plasma (c) hypertonic in respect of plasma (d) variable

Last Answer : Ans:(a)

Description : Anti-diuretic diuretic hormone (ADH) a. is synthesized by the posterior lobe of the pituitary gland b. is released by neurosecretion c. its secretion is increased by a low plasma osmolarity d. increases the permeability of the distal convoluted tubule

Last Answer : is released by neurosecretion

Description : Which of the following causes an increase in sodium reabsorption in the distal convoluted tubule? (a) Increase in aldosterone levels (b) Increase in antidiuretic hormone levels (c) Decrease in aldosterone levels (d) Decrease in antidiuretic hormone levels

Last Answer : (a) Increase in aldosterone levels

Description : Which one of the following correctly explains the function of a specific part of the human nephron? (a) Podocytes : create minute spaces (slit pores) for the filtration of blood into the ... blood capillaries (d) Afferent arteriole : carries the blood away from the glomerulus towards renal vein.

Last Answer : (a) Podocytes : create minute spaces (slit pores) for the filtration of blood into the Bowman’s capsule

Description : Which one of the four parts mentioned below does not constitute a part of single uriniferous tubule? (a) Distal convoluted tubule (b) Collecting duct (c) Bowman’s capsule (d) Loop of Henle

Last Answer : (b) Collecting duct